Pau Nolis - Academia.edu (original) (raw)
Papers by Pau Nolis
Research in Veterinary Science, Dec 1, 2022
Follicular fluid is formed from the transudation of theca and granulosa cells in the growing foll... more Follicular fluid is formed from the transudation of theca and granulosa cells in the growing follicular antrum. Its main function is to provide an optimal intrafollicular microenvironment to modulate oocyte maturation. The aim of this study was to determine the metabolomic profile of preovulatory follicular fluid (PFF) in jennies. For this purpose, PFF was collected from 10 follicles of five jennies in heat. Then, PFF samples were analysed by nuclear magnetic resonance (NMR) and heteronuclear single quantum correlation (2D 1 H/ 13 C HSQC). Our study revealed the presence of at least 27 metabolites in the PFF of jennies (including common amino acids, carboxylic acids, amino acid derivatives, alcohols, saccharides, fatty acids, and lactams):
Magnetic Resonance in Chemistry, Feb 27, 2019
Scientific Reports, Mar 17, 2021
Magnetic Resonance in Chemistry, Feb 20, 2017
Selective refocusing (GSERF or the recent PSYCHEDELIC) experiments were originally designed to de... more Selective refocusing (GSERF or the recent PSYCHEDELIC) experiments were originally designed to determine all proton-proton coupling constants (J) for a selected proton resonance. They work for isolated signals on which selective excitation can be successfully applied but, as it happens in other selective experiments, fail for overlapped signals. To circumvent this limitation, a doubly-selective TOCSY-GSERF scheme is presented for the measurement of Jin protons resonating in crowded regions. This new experiment takes advantage of the editing features of an initial TOCSY transfer to uncover hidden resonances that become accessible to perform the subsequent frequency-selective refocusing. Copyright © 2016 John Wiley & Sons, Ltd.
Scientific Reports, Dec 6, 2021
La Ressonància Magnètica Nuclear (RMN) és una tècnica analítica que permet determinar l'estru... more La Ressonància Magnètica Nuclear (RMN) és una tècnica analítica que permet determinar l'estructura 3D de molècules en solució. Un dels objectius de la recerca portada a terme al Servei de Ressonància Magnètica Nuclear de la UAB és millorar la metodologia d'obtenció de dades per reduir el temps d'anàlisi i d'aquesta manera reduir el seu cost. Es proposen dues estratègies: l'espectroscòpia de temps compartit (TS), i l'estratègia de múltiples adquisicions en un sol experiment (MFA), les quals s'han implementat amb èxit en experiments rutinaris.La Resonancia Magnética Nuclear (RMN) es una técnica analítica que permite determinar la estructura 3D de moléculas en solución. Uno de los objetivos de la investigación llevada a cabo en el Servicio de Resonancia Magnética Nuclear de la UAB es mejorar la metodología de obtención de datos para reducir el tiempo de análisis y de esta manera reducir su coste. Se proponen dos estrategias: la espectroscopia de tiempo compa...
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Background Metabolomic approaches, which include the study of low molecular weight molecules, is ... more Background Metabolomic approaches, which include the study of low molecular weight molecules, is an emerging -omics technology useful for the identification of biomarkers. In this field, nuclear magnetic resonance (NMR) spectroscopy approach has already been used to uncover (in)fertility biomarkers in the seminal plasma (SP) of several mammalian species. However, NMR studies profiling SP metabolome to uncover in vivo fertility biomarkers are yet to be carried out in pigs. Thus, this study aimed to evaluate the putative relationship between the presence/concentration of SP-metabolites and in vivo fertility outcomes. To this end, 24 entire ejaculates (three ejaculates per boar) were collected from artificial insemination (AI)-boars throughout a year (one ejaculate every four months). Immediately after collection, ejaculates were centrifuged (1,500×g for 10 min twice) to obtain SP-samples and were stored (− 80°C) for subsequent metabolomic analysis by NMR spectroscopy. Fertility outcom...
The Journal of Physical Chemistry C, 2018
Inorganic Chemistry, 2016
International Journal of Hydrogen Energy, 2015
![Research paper thumbnail of Efficient cysteine labelling of peptides with N-succinimidyl 4-[ 18F]fluorobenzoate: Stability study and in vivo biodistribution in rats by positron emission tomography (PET)](https://attachments.academia-assets.com/120417303/thumbnails/1.jpg)
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The Journal of Physical Chemistry C, 2013
![Research paper thumbnail of Experimental Evidence of Na2[B12H12] and Na Formation in the Desorption Pathway of the 2NaBH4+ MgH2System](https://attachments.academia-assets.com/120417312/thumbnails/1.jpg)
](The Journal of Physical Chemistry C, 2011
We report in the present work the desorption pathway of the 2NaBH 4 + MgH 2 system. Measurements ... more We report in the present work the desorption pathway of the 2NaBH 4 + MgH 2 system. Measurements on samples heat treated up to 450 °C for different times have been performed by ex-situ X-ray powder diffraction (XRPD) and solid state magic angle spinning (MAS) nuclear magnetic resonance (NMR). Ex-situ X-ray powder diffraction experiments conducted on full desorbed samples allowed to identify nanocrystalline MgB 2 and metallic Na as dehydrogenation products. 11 B and 23 Na NMR analyses have been also carried out in order to evaluate the structural evolution of decomposed materials. Our measurements show that the local structure of MgB 2 was influenced by the replace of Mg with Na atoms in the Mg sites. Moreover, amorphous Na 2 [B 12 H 12 ] was detected in the partially desorbed sample and in the final products of the decomposition reaction. The presence of the [B 12 H 12 ] 2-anion was confirmed by both direct comparison with the 11 B{ 1 H} NMR spectrum of pure Na 2 [B 12 H 12 ] and dynamic Cross Polarization experiments.
The Journal of Physical Chemistry C, 2010
Tetrahedron: Asymmetry, 2010
Efficient and stereoselective synthetic routes have been developed for the preparation of chiral ... more Efficient and stereoselective synthetic routes have been developed for the preparation of chiral N-monoprotected cyclobutane bicyclic ureas in which one of the NH groups is protected as a benzyl or tert-butyl carbamate. Ureas in both enantiomeric forms were obtained from a common chiral precursor via the selective manipulation of functional groups. These compounds have been subjected to a structural study
Scripta Materialia, 2011
A novel method to enhance the reaction kinetics of the reactive hydride composite 2NaBH 4 + MgH 2... more A novel method to enhance the reaction kinetics of the reactive hydride composite 2NaBH 4 + MgH 2 is described. It has been discovered that short-term exposure to a moist atmosphere has a very beneficial effect on the desorption reaction of the 2NaBH 4 + MgH 2 mixture. By this procedure it is possible to achieve, after drying, both faster desorption kinetics and greater amounts of released hydrogen compared to ball-milled material without further treatment.
Organic Letters, 2009
Three new bis(cyclobutane) beta-dipeptides have been synthesized from appropriate derivatives of ... more Three new bis(cyclobutane) beta-dipeptides have been synthesized from appropriate derivatives of cis- and trans-2-aminocyclobutane-1-carboxylic acid, respectively. The predominance of eight-membered hydrogen-bonded rings has been manifested for (trans,trans)- and (trans,cis)-beta-dipeptides while the formation of six-membered rings is preferred for the (cis,trans)- beta-dipeptide similarly to the previously described (cis,cis)-diastereomer.
Research in Veterinary Science, Dec 1, 2022
Follicular fluid is formed from the transudation of theca and granulosa cells in the growing foll... more Follicular fluid is formed from the transudation of theca and granulosa cells in the growing follicular antrum. Its main function is to provide an optimal intrafollicular microenvironment to modulate oocyte maturation. The aim of this study was to determine the metabolomic profile of preovulatory follicular fluid (PFF) in jennies. For this purpose, PFF was collected from 10 follicles of five jennies in heat. Then, PFF samples were analysed by nuclear magnetic resonance (NMR) and heteronuclear single quantum correlation (2D 1 H/ 13 C HSQC). Our study revealed the presence of at least 27 metabolites in the PFF of jennies (including common amino acids, carboxylic acids, amino acid derivatives, alcohols, saccharides, fatty acids, and lactams):
Magnetic Resonance in Chemistry, Feb 27, 2019
Scientific Reports, Mar 17, 2021
Magnetic Resonance in Chemistry, Feb 20, 2017
Selective refocusing (GSERF or the recent PSYCHEDELIC) experiments were originally designed to de... more Selective refocusing (GSERF or the recent PSYCHEDELIC) experiments were originally designed to determine all proton-proton coupling constants (J) for a selected proton resonance. They work for isolated signals on which selective excitation can be successfully applied but, as it happens in other selective experiments, fail for overlapped signals. To circumvent this limitation, a doubly-selective TOCSY-GSERF scheme is presented for the measurement of Jin protons resonating in crowded regions. This new experiment takes advantage of the editing features of an initial TOCSY transfer to uncover hidden resonances that become accessible to perform the subsequent frequency-selective refocusing. Copyright © 2016 John Wiley & Sons, Ltd.
Scientific Reports, Dec 6, 2021
La Ressonància Magnètica Nuclear (RMN) és una tècnica analítica que permet determinar l'estru... more La Ressonància Magnètica Nuclear (RMN) és una tècnica analítica que permet determinar l'estructura 3D de molècules en solució. Un dels objectius de la recerca portada a terme al Servei de Ressonància Magnètica Nuclear de la UAB és millorar la metodologia d'obtenció de dades per reduir el temps d'anàlisi i d'aquesta manera reduir el seu cost. Es proposen dues estratègies: l'espectroscòpia de temps compartit (TS), i l'estratègia de múltiples adquisicions en un sol experiment (MFA), les quals s'han implementat amb èxit en experiments rutinaris.La Resonancia Magnética Nuclear (RMN) es una técnica analítica que permite determinar la estructura 3D de moléculas en solución. Uno de los objetivos de la investigación llevada a cabo en el Servicio de Resonancia Magnética Nuclear de la UAB es mejorar la metodología de obtención de datos para reducir el tiempo de análisis y de esta manera reducir su coste. Se proponen dos estrategias: la espectroscopia de tiempo compa...
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world's repository for small molecule cr... more An entry from the Cambridge Structural Database, the world's repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Background Metabolomic approaches, which include the study of low molecular weight molecules, is ... more Background Metabolomic approaches, which include the study of low molecular weight molecules, is an emerging -omics technology useful for the identification of biomarkers. In this field, nuclear magnetic resonance (NMR) spectroscopy approach has already been used to uncover (in)fertility biomarkers in the seminal plasma (SP) of several mammalian species. However, NMR studies profiling SP metabolome to uncover in vivo fertility biomarkers are yet to be carried out in pigs. Thus, this study aimed to evaluate the putative relationship between the presence/concentration of SP-metabolites and in vivo fertility outcomes. To this end, 24 entire ejaculates (three ejaculates per boar) were collected from artificial insemination (AI)-boars throughout a year (one ejaculate every four months). Immediately after collection, ejaculates were centrifuged (1,500×g for 10 min twice) to obtain SP-samples and were stored (− 80°C) for subsequent metabolomic analysis by NMR spectroscopy. Fertility outcom...
The Journal of Physical Chemistry C, 2018
Inorganic Chemistry, 2016
International Journal of Hydrogen Energy, 2015
The Journal of Physical Chemistry C, 2013
The Journal of Physical Chemistry C, 2011
We report in the present work the desorption pathway of the 2NaBH 4 + MgH 2 system. Measurements ... more We report in the present work the desorption pathway of the 2NaBH 4 + MgH 2 system. Measurements on samples heat treated up to 450 °C for different times have been performed by ex-situ X-ray powder diffraction (XRPD) and solid state magic angle spinning (MAS) nuclear magnetic resonance (NMR). Ex-situ X-ray powder diffraction experiments conducted on full desorbed samples allowed to identify nanocrystalline MgB 2 and metallic Na as dehydrogenation products. 11 B and 23 Na NMR analyses have been also carried out in order to evaluate the structural evolution of decomposed materials. Our measurements show that the local structure of MgB 2 was influenced by the replace of Mg with Na atoms in the Mg sites. Moreover, amorphous Na 2 [B 12 H 12 ] was detected in the partially desorbed sample and in the final products of the decomposition reaction. The presence of the [B 12 H 12 ] 2-anion was confirmed by both direct comparison with the 11 B{ 1 H} NMR spectrum of pure Na 2 [B 12 H 12 ] and dynamic Cross Polarization experiments.
The Journal of Physical Chemistry C, 2010
Tetrahedron: Asymmetry, 2010
Efficient and stereoselective synthetic routes have been developed for the preparation of chiral ... more Efficient and stereoselective synthetic routes have been developed for the preparation of chiral N-monoprotected cyclobutane bicyclic ureas in which one of the NH groups is protected as a benzyl or tert-butyl carbamate. Ureas in both enantiomeric forms were obtained from a common chiral precursor via the selective manipulation of functional groups. These compounds have been subjected to a structural study
Scripta Materialia, 2011
A novel method to enhance the reaction kinetics of the reactive hydride composite 2NaBH 4 + MgH 2... more A novel method to enhance the reaction kinetics of the reactive hydride composite 2NaBH 4 + MgH 2 is described. It has been discovered that short-term exposure to a moist atmosphere has a very beneficial effect on the desorption reaction of the 2NaBH 4 + MgH 2 mixture. By this procedure it is possible to achieve, after drying, both faster desorption kinetics and greater amounts of released hydrogen compared to ball-milled material without further treatment.
Organic Letters, 2009
Three new bis(cyclobutane) beta-dipeptides have been synthesized from appropriate derivatives of ... more Three new bis(cyclobutane) beta-dipeptides have been synthesized from appropriate derivatives of cis- and trans-2-aminocyclobutane-1-carboxylic acid, respectively. The predominance of eight-membered hydrogen-bonded rings has been manifested for (trans,trans)- and (trans,cis)-beta-dipeptides while the formation of six-membered rings is preferred for the (cis,trans)- beta-dipeptide similarly to the previously described (cis,cis)-diastereomer.