Paul Bowman - Academia.edu (original) (raw)

Papers by Paul Bowman

JOMEC Journal

This is the editorial for the 'Martial Arts Studies' issue of JOMEC Journal, published in June 20... more This is the editorial for the 'Martial Arts Studies' issue of JOMEC Journal, published in June 2014. It briefly introduces the emergent field of martial arts studies, comments on its current manner of development, and suggests that a useful way to characterize works of martial arts studies (as opposed to 'studies of martial arts') relates to their interdisciplinarity. Based on this, it indicates some of the key features of current work in martial arts studies and reflects on the wider value and potential contributions of this emerging interdisciplinary nexus vis-à-vis the academic fields and disciplines from which it is emerging and back into which it is likely to feed. In this light, the editorial proposes that the present collection of articles makes an important contribution to the ongoing development of martial arts studies.

Blood

The multicenter AML02 trial randomly assigns patients to receive high-dose or low-dose cytarabine... more The multicenter AML02 trial randomly assigns patients to receive high-dose or low-dose cytarabine (A), daunorubicin (D), and etoposide (E) as Induction I; all subsequent therapy is risk-adapted. Pharmacokinetic, pharmacodynamic, and gene expression studies are performed after exposure to high-dose or low-dose cytarabine. Patients with no response (NR, ≥ 25% bone marrow blasts) to Induction I receive low-dose ADE + gemtuzumab ozogamicin (GO) as Induction II, whereas all others receive ADE. Minimal residual disease (MRD) is monitored by flow cytometry and is defined as ≥ 0.1% cells with leukemia-associated immunophenotypes among bone marrow mononuclear cells. Patients who are MRD+ after induction therapy receive GO as a single agent before consolidation chemotherapy or stem cell transplantation. Among the 112 patients enrolled since October 2002, 37 had -7, FAB M6 or M7, FLT3 internal tandem duplication (ITD), or MDS or treatment-related AML and were classified as high-risk (HR); 32 h...

Blood

Asparaginase therapy is an important component of treatment for childhood acute lymphoblastic leu... more Asparaginase therapy is an important component of treatment for childhood acute lymphoblastic leukemia (ALL). However, immune responses to asparaginase during treatment can lead to suboptimal asparaginase exposure and possibly to worse outcome. Potential factors that can affect the incidence of asparaginase allergies include the pharmaceutical formulation of asparaginase, the number of asparaginase doses, treatment schedule, concurrent medications, ALL lineage, and racial ancestry. While genetic variations in the Human Leukocyte Antigen (HLA) genes have been implicated in allergic reactions to several drugs, no investigation has determined the influence of HLA on asparaginase allergies. Asparaginase allergy data from children with ALL who were enrolled on either SJCRH protocols [Total XIIIA (n =91), Total XV (n =320) and Total XVI (n =130)] or Children’s Oncology Group (COG) protocols [POG-9906 (n= 125) and AALL0232 (n= 1,204)] were used to investigate the influence of HLA class II ...

Pacific Asia Journal of the Association for Information Systems

This paper presents a case study on the research and development of an RFID-based work-inprogress... more This paper presents a case study on the research and development of an RFID-based work-inprogress container tracking system at a confectionery manufacturer. We report on the management of the RFID project, the system design and the economic evaluation of the solution as compared to the situation before implementing RFID. We discuss the case from a practitioner's view as well as from an academic view regarding the theoretical implications that can be drawn from it. The lessons learned from the project can help other companies to better anticipate the challenges they may experience and make them aware of the possible ways to cope with such challenges prior to starting an RFID implementation.

Journal of clinical apheresis, Jan 29, 2017

Hyperleukocytosis, defined as white blood cell (WBC) count above 100 × 109 /L, has high early mor... more Hyperleukocytosis, defined as white blood cell (WBC) count above 100 × 109 /L, has high early morbidity and mortality from leukostasis-related complications, namely intracranial hemorrhage and pulmonary distress. Initiating chemotherapy without prior leukocytoreduction may lead to tumor lysis syndrome (TLS). Therapeutic leukocytapheresis (TL) is used as one leukocytoreductive intervention; however, its safety and efficacy in pediatric leukemia has not been established. The purpose of this study is to evaluate safety of TL in pediatric patients and assess the efficacy of TL in reducing WBC count in pediatric leukemia. Retrospective chart review was conducted on 14 patients with acute lymphoblastic leukemia (ALL) and 5 with acute myeloid leukemia (AML) who underwent TL during the period 2000-2014 at a single institution. Mean WBC count of 19 patients who received TL was 483.2 × 109 /L (547.1 in ALL, 304.3 in AML); a portion of patients presented with central nervous system symptoms (1...

Deconstructing Popular Culture, 2008

Deconstructing Popular Culture, 2008

Postcolonial Studies, Aug 24, 2010

Brit J Dermatol, 2006

Background Keratinocytes undergo a defined programme of proliferation and differentiation during ... more Background Keratinocytes undergo a defined programme of proliferation and differentiation during normal stratification of the epidermis. Anomalies in the signalling pathways controlling this process probably contribute to the pathogenesis of hyperproliferative dermatological diseases, including psoriasis and basal cell carcinoma (BCC). We have previously proposed that protein kinase D (PKD) is a proproliferative signalling enzyme in keratinocytes and have speculated that abnormalities in its levels or regulation may contribute to hyperproliferative disorders of the skin. Objectives To determine if hyperproliferative human skin disorders are characterized by abnormal protein expression or distribution of PKD, normal human epidermis was compared with BCC and uninvolved and involved psoriatic epidermis. Methods To examine protein expression, immunohistochemical analysis of human samples and Western blotting of neoplastic mouse keratinocytes was performed. Western analysis of neoplastic mouse cells using a phosphospecific PKD antibody allowed estimation of PKD activation status. Results Normal human epidermis demonstrated predominant PKD protein expression in the stratum basalis, the proliferative epidermal compartment, with decreased relative expression throughout the suprabasal strata. Uninvolved psoriatic skin showed a similar pattern, but in contrast, psoriatic lesions demonstrated a diffuse distribution of PKD staining throughout all strata. The majority of BCCs examined showed significant PKD protein levels and, in those biopsies in which the levels could be compared, elevated PKD levels relative to normal epidermis. PKD levels and activation status were also increased in a neoplastic mouse keratinocyte cell line. Conclusions PKD was elevated or misdistributed in the hyperproliferative human skin disorders, BCC and psoriasis, as well as neoplastic mouse keratinocytes. We speculate that PKD exerts proproliferative and ⁄or antidifferentiative effects in the epidermis, and that anomalous distribution and ⁄or activation of PKD may be involved in precipitating or sustaining the disease process in BCC and psoriasis.

It is also possible that your web browser is not configured or not able to display style sheets. ... more It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...

JOMEC Journal

This is the editorial for the 'Martial Arts Studies' issue of JOMEC Journal, published in June 20... more This is the editorial for the 'Martial Arts Studies' issue of JOMEC Journal, published in June 2014. It briefly introduces the emergent field of martial arts studies, comments on its current manner of development, and suggests that a useful way to characterize works of martial arts studies (as opposed to 'studies of martial arts') relates to their interdisciplinarity. Based on this, it indicates some of the key features of current work in martial arts studies and reflects on the wider value and potential contributions of this emerging interdisciplinary nexus vis-à-vis the academic fields and disciplines from which it is emerging and back into which it is likely to feed. In this light, the editorial proposes that the present collection of articles makes an important contribution to the ongoing development of martial arts studies.

Blood

The multicenter AML02 trial randomly assigns patients to receive high-dose or low-dose cytarabine... more The multicenter AML02 trial randomly assigns patients to receive high-dose or low-dose cytarabine (A), daunorubicin (D), and etoposide (E) as Induction I; all subsequent therapy is risk-adapted. Pharmacokinetic, pharmacodynamic, and gene expression studies are performed after exposure to high-dose or low-dose cytarabine. Patients with no response (NR, ≥ 25% bone marrow blasts) to Induction I receive low-dose ADE + gemtuzumab ozogamicin (GO) as Induction II, whereas all others receive ADE. Minimal residual disease (MRD) is monitored by flow cytometry and is defined as ≥ 0.1% cells with leukemia-associated immunophenotypes among bone marrow mononuclear cells. Patients who are MRD+ after induction therapy receive GO as a single agent before consolidation chemotherapy or stem cell transplantation. Among the 112 patients enrolled since October 2002, 37 had -7, FAB M6 or M7, FLT3 internal tandem duplication (ITD), or MDS or treatment-related AML and were classified as high-risk (HR); 32 h...

Blood

Asparaginase therapy is an important component of treatment for childhood acute lymphoblastic leu... more Asparaginase therapy is an important component of treatment for childhood acute lymphoblastic leukemia (ALL). However, immune responses to asparaginase during treatment can lead to suboptimal asparaginase exposure and possibly to worse outcome. Potential factors that can affect the incidence of asparaginase allergies include the pharmaceutical formulation of asparaginase, the number of asparaginase doses, treatment schedule, concurrent medications, ALL lineage, and racial ancestry. While genetic variations in the Human Leukocyte Antigen (HLA) genes have been implicated in allergic reactions to several drugs, no investigation has determined the influence of HLA on asparaginase allergies. Asparaginase allergy data from children with ALL who were enrolled on either SJCRH protocols [Total XIIIA (n =91), Total XV (n =320) and Total XVI (n =130)] or Children’s Oncology Group (COG) protocols [POG-9906 (n= 125) and AALL0232 (n= 1,204)] were used to investigate the influence of HLA class II ...

Pacific Asia Journal of the Association for Information Systems

This paper presents a case study on the research and development of an RFID-based work-inprogress... more This paper presents a case study on the research and development of an RFID-based work-inprogress container tracking system at a confectionery manufacturer. We report on the management of the RFID project, the system design and the economic evaluation of the solution as compared to the situation before implementing RFID. We discuss the case from a practitioner's view as well as from an academic view regarding the theoretical implications that can be drawn from it. The lessons learned from the project can help other companies to better anticipate the challenges they may experience and make them aware of the possible ways to cope with such challenges prior to starting an RFID implementation.

Journal of clinical apheresis, Jan 29, 2017

Hyperleukocytosis, defined as white blood cell (WBC) count above 100 × 109 /L, has high early mor... more Hyperleukocytosis, defined as white blood cell (WBC) count above 100 × 109 /L, has high early morbidity and mortality from leukostasis-related complications, namely intracranial hemorrhage and pulmonary distress. Initiating chemotherapy without prior leukocytoreduction may lead to tumor lysis syndrome (TLS). Therapeutic leukocytapheresis (TL) is used as one leukocytoreductive intervention; however, its safety and efficacy in pediatric leukemia has not been established. The purpose of this study is to evaluate safety of TL in pediatric patients and assess the efficacy of TL in reducing WBC count in pediatric leukemia. Retrospective chart review was conducted on 14 patients with acute lymphoblastic leukemia (ALL) and 5 with acute myeloid leukemia (AML) who underwent TL during the period 2000-2014 at a single institution. Mean WBC count of 19 patients who received TL was 483.2 × 109 /L (547.1 in ALL, 304.3 in AML); a portion of patients presented with central nervous system symptoms (1...

Deconstructing Popular Culture, 2008

Deconstructing Popular Culture, 2008

Postcolonial Studies, Aug 24, 2010

Brit J Dermatol, 2006

Background Keratinocytes undergo a defined programme of proliferation and differentiation during ... more Background Keratinocytes undergo a defined programme of proliferation and differentiation during normal stratification of the epidermis. Anomalies in the signalling pathways controlling this process probably contribute to the pathogenesis of hyperproliferative dermatological diseases, including psoriasis and basal cell carcinoma (BCC). We have previously proposed that protein kinase D (PKD) is a proproliferative signalling enzyme in keratinocytes and have speculated that abnormalities in its levels or regulation may contribute to hyperproliferative disorders of the skin. Objectives To determine if hyperproliferative human skin disorders are characterized by abnormal protein expression or distribution of PKD, normal human epidermis was compared with BCC and uninvolved and involved psoriatic epidermis. Methods To examine protein expression, immunohistochemical analysis of human samples and Western blotting of neoplastic mouse keratinocytes was performed. Western analysis of neoplastic mouse cells using a phosphospecific PKD antibody allowed estimation of PKD activation status. Results Normal human epidermis demonstrated predominant PKD protein expression in the stratum basalis, the proliferative epidermal compartment, with decreased relative expression throughout the suprabasal strata. Uninvolved psoriatic skin showed a similar pattern, but in contrast, psoriatic lesions demonstrated a diffuse distribution of PKD staining throughout all strata. The majority of BCCs examined showed significant PKD protein levels and, in those biopsies in which the levels could be compared, elevated PKD levels relative to normal epidermis. PKD levels and activation status were also increased in a neoplastic mouse keratinocyte cell line. Conclusions PKD was elevated or misdistributed in the hyperproliferative human skin disorders, BCC and psoriasis, as well as neoplastic mouse keratinocytes. We speculate that PKD exerts proproliferative and ⁄or antidifferentiative effects in the epidermis, and that anomalous distribution and ⁄or activation of PKD may be involved in precipitating or sustaining the disease process in BCC and psoriasis.

It is also possible that your web browser is not configured or not able to display style sheets. ... more It is also possible that your web browser is not configured or not able to display style sheets. In this case, although the visual presentation will be degraded, the site should continue to be functional. We recommend using the latest version of Microsoft or Mozilla web browser to ...