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Papers by Paul Joachim Bloch Thorsen
Pilot and Feasibility Studies, Mar 2, 2022
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and... more Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety, and depression lead to numerous detrimental outcomes, including reduced quality of life, psychiatric, and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence-based treatment, between 40-50% of patients continue to report significant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity-based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS. Methods/design: The study is based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. Feasibility and acceptability of the physical activity intervention (confident, active, and happy youth) will be evaluated in an uncontrolled open-label trial using qualitative and quantitative data. Twenty youths with anxiety and/or depressive symptoms will be recruited. Acceptability of assessment procedures, the intervention, and perceived benefits and barriers to participation will be assessed, and qualitative interviews with participants, caregivers, and referring specialists will explore contextual and practical factors associated with intervention delivery. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline, and post-intervention and change in anxiety and depression will be assessed. Discussion: This study will contribute to the development of supplementary physical treatment interventions for youth with anxiety and depression in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of anxiety and depression. This work will be in preparation for a future definitive randomized controlled trial (RCT) of this approach, in line with the MRC Framework. Trial registration: ClnicalTrials.gov, NCT05 049759. Registered on August 19, 2021. Retrospectively registered.
PubMed, Oct 5, 2006
Background: Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT... more Background: Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT-interval corrected for heart rate (QTc). The typical clinical presentation is the occurrence of syncope or cardiac arrest in young and otherwise healthy individuals. Cardiac events can be precipitated by environmental factors and use of certain drugs. The purpose of the present study is to provide guidelines regarding risk factors that may worsen the syndrome, based on available literature. Material and methods: PubMed was searched for all literature in English from 1966 through 2004 on the Long QT syndrome. The articles and their literature references were examined. Additional information was achieved from experienced colleagues and from some key sites on the internet. Results: The symptoms of the Long QT syndrome are tachycardia, syncope or cardiac arrest, often related to psychological or physical stress in young, usually healthy individuals. The syndrome can be inherited or acquired and is commonly caused by mutations in the potassium channel or by lack of inactivation of the sodium channels. The most common causes of acquired conditions are electrolyte abnormalities, intracranial disease, dietary deficiencies, myocardial infarction, dilated cardiomyopathy, mitral valve prolapse, bradycardia, severe malnutrition among anorexic patients and the use of medication. Interpretation: It is important to have knowledge about the Long QT Syndrome. The treatment is primarily to remove potential risk factors and medically to give beta-blockers or insert pacemakers or cardiac defibrillators.
Research Square (Research Square), May 15, 2023
Background: Physical activity is identi ed as a key modi able factor towards good short-and long-... more Background: Physical activity is identi ed as a key modi able factor towards good short-and long-term mental health and has shown positive effects on anxiety and depression in children and adolescents. However, physical activity-based interventions are not a part of standard mental health care and evidence on the effect of such interventions is still lacking. A transdiagnostic, physical activity-based intervention was developed as a supplement to routine clinical care for youth in specialized child and adolescent mental health services. Methods/design: The feasibility of the physical activity intervention (Con dent, Active and Happy Youth) was evaluated in an open-label study by assessing the recruitment process, acceptability, intervention suitability, contentment and preliminary intervention effects in the form of youth and parent rated anxiety and depressive symptoms. Physical activity levels were objectively measured using Actigraph TM physical activity sensors, and progression to a de nitive study was evaluated in accordance with a-priori criteria. Results: In total 21 of 25 eligible youth consented to participate, two dropped out of the intervention while 19 completed (76% of eligible participants). The retention rate among consenting participants was 89% and mean attendance to sessions was 83%. The suitability of the intervention was rated as good by youth and their parents, and intervention contentment was rated high. Effects on youth and parent-rated symptom measures following the intervention were negligible, except for parent-rated anxiety symptoms assessed at 10-month follow-up. Accelerometer data indicated lower levels of moderate to vigorous activity during sessions, than intended. No adverse effects were noted. Conclusion: This feasibility study met the predetermined progression criteria to a de nitive study. Thus, a larger trial with longer follow-up should be conducted to explore the effect of the intervention.
Research Square (Research Square), Oct 1, 2021
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and... more Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety and depression leads to numerous detrimental outcomes, including reduced quality of life, psychiatric and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence based treatment, between 40-50 % continue to report signi cant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS. Methods/design: The study is based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. Feasibility and acceptability of the physical activity intervention (Con dent, Active and Happy Youth) will be evaluated in an uncontrolled open-label trial using qualitative and quantitative data. Twenty youths with anxiety and/or depressive symptoms will be recruited. Acceptability of assessment procedures, the intervention, and perceived bene ts and barriers to participation will be assessed, and qualitative interviews with participants, caregivers and referring specialists will explore contextual and practical factors associated with intervention delivery. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline and post-intervention and change in anxiety and depression will be assessed. Discussion: This study will contribute to the development of supplementary physical treatment interventions for youth with anxiety and depression in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of anxiety and depression. This work will be in preparation for a future de nitive RCT of this approach, in line with the MRC framework.
Tidsskrift for Den Norske Laegeforening, Oct 5, 2006
Lang QT-syndrom er en sjelden tilstand. Syndromet medfører en forlengelse av QTintervallet, korri... more Lang QT-syndrom er en sjelden tilstand. Syndromet medfører en forlengelse av QTintervallet, korrigert for hjertefrekvens (QT) på EKG. Den typiske kliniske presentasjonen er synkope eller brå hjertedød hos ellers friske unge individer. Anfall kan fremprovoseres av enkelte medikamenter og miljøfaktorer. Formålet med denne studien har vaert å samle kjent kunnskap om lang QT-syndrom, og gi retningslinjer angående risikofaktorer som kan forverre tilstanden.
![Research paper thumbnail of [Risk factors for sudden cardiac death related to the long QT syndrome]](https://attachments.academia-assets.com/84261825/thumbnails/1.jpg)
](Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Jan 5, 2006
Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT-interval co... more Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT-interval corrected for heart rate (QTc). The typical clinical presentation is the occurrence of syncope or cardiac arrest in young and otherwise healthy individuals. Cardiac events can be precipitated by environmental factors and use of certain drugs. The purpose of the present study is to provide guidelines regarding risk factors that may worsen the syndrome, based on available literature. PubMed was searched for all literature in English from 1966 through 2004 on the Long QT syndrome. The articles and their literature references were examined. Additional information was achieved from experienced colleagues and from some key sites on the internet. The symptoms of the Long QT syndrome are tachycardia, syncope or cardiac arrest, often related to psychological or physical stress in young, usually healthy individuals. The syndrome can be inherited or acquired and is commonly caused by mutations in the...
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and... more Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety and depression leads to numerous detrimental outcomes, including reduced quality of life, psychiatric and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence based treatment, between 40-50 % continue to report significant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS.Met...
Pilot and Feasibility Studies, Mar 2, 2022
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and... more Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety, and depression lead to numerous detrimental outcomes, including reduced quality of life, psychiatric, and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence-based treatment, between 40-50% of patients continue to report significant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity-based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS. Methods/design: The study is based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. Feasibility and acceptability of the physical activity intervention (confident, active, and happy youth) will be evaluated in an uncontrolled open-label trial using qualitative and quantitative data. Twenty youths with anxiety and/or depressive symptoms will be recruited. Acceptability of assessment procedures, the intervention, and perceived benefits and barriers to participation will be assessed, and qualitative interviews with participants, caregivers, and referring specialists will explore contextual and practical factors associated with intervention delivery. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline, and post-intervention and change in anxiety and depression will be assessed. Discussion: This study will contribute to the development of supplementary physical treatment interventions for youth with anxiety and depression in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of anxiety and depression. This work will be in preparation for a future definitive randomized controlled trial (RCT) of this approach, in line with the MRC Framework. Trial registration: ClnicalTrials.gov, NCT05 049759. Registered on August 19, 2021. Retrospectively registered.
PubMed, Oct 5, 2006
Background: Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT... more Background: Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT-interval corrected for heart rate (QTc). The typical clinical presentation is the occurrence of syncope or cardiac arrest in young and otherwise healthy individuals. Cardiac events can be precipitated by environmental factors and use of certain drugs. The purpose of the present study is to provide guidelines regarding risk factors that may worsen the syndrome, based on available literature. Material and methods: PubMed was searched for all literature in English from 1966 through 2004 on the Long QT syndrome. The articles and their literature references were examined. Additional information was achieved from experienced colleagues and from some key sites on the internet. Results: The symptoms of the Long QT syndrome are tachycardia, syncope or cardiac arrest, often related to psychological or physical stress in young, usually healthy individuals. The syndrome can be inherited or acquired and is commonly caused by mutations in the potassium channel or by lack of inactivation of the sodium channels. The most common causes of acquired conditions are electrolyte abnormalities, intracranial disease, dietary deficiencies, myocardial infarction, dilated cardiomyopathy, mitral valve prolapse, bradycardia, severe malnutrition among anorexic patients and the use of medication. Interpretation: It is important to have knowledge about the Long QT Syndrome. The treatment is primarily to remove potential risk factors and medically to give beta-blockers or insert pacemakers or cardiac defibrillators.
Research Square (Research Square), May 15, 2023
Background: Physical activity is identi ed as a key modi able factor towards good short-and long-... more Background: Physical activity is identi ed as a key modi able factor towards good short-and long-term mental health and has shown positive effects on anxiety and depression in children and adolescents. However, physical activity-based interventions are not a part of standard mental health care and evidence on the effect of such interventions is still lacking. A transdiagnostic, physical activity-based intervention was developed as a supplement to routine clinical care for youth in specialized child and adolescent mental health services. Methods/design: The feasibility of the physical activity intervention (Con dent, Active and Happy Youth) was evaluated in an open-label study by assessing the recruitment process, acceptability, intervention suitability, contentment and preliminary intervention effects in the form of youth and parent rated anxiety and depressive symptoms. Physical activity levels were objectively measured using Actigraph TM physical activity sensors, and progression to a de nitive study was evaluated in accordance with a-priori criteria. Results: In total 21 of 25 eligible youth consented to participate, two dropped out of the intervention while 19 completed (76% of eligible participants). The retention rate among consenting participants was 89% and mean attendance to sessions was 83%. The suitability of the intervention was rated as good by youth and their parents, and intervention contentment was rated high. Effects on youth and parent-rated symptom measures following the intervention were negligible, except for parent-rated anxiety symptoms assessed at 10-month follow-up. Accelerometer data indicated lower levels of moderate to vigorous activity during sessions, than intended. No adverse effects were noted. Conclusion: This feasibility study met the predetermined progression criteria to a de nitive study. Thus, a larger trial with longer follow-up should be conducted to explore the effect of the intervention.
Research Square (Research Square), Oct 1, 2021
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and... more Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety and depression leads to numerous detrimental outcomes, including reduced quality of life, psychiatric and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence based treatment, between 40-50 % continue to report signi cant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS. Methods/design: The study is based on the UK Medical Council Research Framework (MRC) for developing and evaluating complex interventions. Feasibility and acceptability of the physical activity intervention (Con dent, Active and Happy Youth) will be evaluated in an uncontrolled open-label trial using qualitative and quantitative data. Twenty youths with anxiety and/or depressive symptoms will be recruited. Acceptability of assessment procedures, the intervention, and perceived bene ts and barriers to participation will be assessed, and qualitative interviews with participants, caregivers and referring specialists will explore contextual and practical factors associated with intervention delivery. Physical activity will be measured using the Actigraph GT3X+ monitor at baseline and post-intervention and change in anxiety and depression will be assessed. Discussion: This study will contribute to the development of supplementary physical treatment interventions for youth with anxiety and depression in contact with CAMHS. The goal is to examine new avenues of treatment that ultimately may improve upon current treatment outcomes of anxiety and depression. This work will be in preparation for a future de nitive RCT of this approach, in line with the MRC framework.
Tidsskrift for Den Norske Laegeforening, Oct 5, 2006
Lang QT-syndrom er en sjelden tilstand. Syndromet medfører en forlengelse av QTintervallet, korri... more Lang QT-syndrom er en sjelden tilstand. Syndromet medfører en forlengelse av QTintervallet, korrigert for hjertefrekvens (QT) på EKG. Den typiske kliniske presentasjonen er synkope eller brå hjertedød hos ellers friske unge individer. Anfall kan fremprovoseres av enkelte medikamenter og miljøfaktorer. Formålet med denne studien har vaert å samle kjent kunnskap om lang QT-syndrom, og gi retningslinjer angående risikofaktorer som kan forverre tilstanden.
Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række, Jan 5, 2006
Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT-interval co... more Long QT syndrome is a rare condition. The syndrome is characterised by a prolonged QT-interval corrected for heart rate (QTc). The typical clinical presentation is the occurrence of syncope or cardiac arrest in young and otherwise healthy individuals. Cardiac events can be precipitated by environmental factors and use of certain drugs. The purpose of the present study is to provide guidelines regarding risk factors that may worsen the syndrome, based on available literature. PubMed was searched for all literature in English from 1966 through 2004 on the Long QT syndrome. The articles and their literature references were examined. Additional information was achieved from experienced colleagues and from some key sites on the internet. The symptoms of the Long QT syndrome are tachycardia, syncope or cardiac arrest, often related to psychological or physical stress in young, usually healthy individuals. The syndrome can be inherited or acquired and is commonly caused by mutations in the...
Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and... more Background: Anxiety and depressive disorders in children and adolescents are highly prevalent and account for more than half of all youth psychiatric disorders. Left untreated, anxiety and depression leads to numerous detrimental outcomes, including reduced quality of life, psychiatric and somatic comorbidity and even reduced lifespan. This puts a large strain on child and adolescent mental healthcare services (CAMHS) to provide effective treatments. However, even when provided the best evidence based treatment, between 40-50 % continue to report significant symptom burdens. Thus, there is an immediate need for supplemental and/or new treatment approaches. Physical activity as a supplementary treatment may be such an approach. However, research investigating this approach within this population is scant. This protocol paper describes the development and feasibility trial of a physical activity based intervention targeting anxiety and depressive symptoms in youth treated in CAMHS.Met...