Paula Morón Muñoz - Profile on Academia.edu (original) (raw)
Papers by Paula Morón Muñoz
Plants
The raspberry (Rubus idaeus L.) fruit is characterized by its richness in functional molecules an... more The raspberry (Rubus idaeus L.) fruit is characterized by its richness in functional molecules and high nutritional value, but the high rate of fruit softening limits its quality during postharvest. Raspberry drupelets have a particular ripening regulation, depending partially on the effect of ethylene produced from the receptacle. However, the possible role of abscisic acid (ABA) in the modulation of quality parameters during the ripening of raspberry is unclear. This study characterized the fruit quality-associated parameters and hormonal contents during fruit development in two seasons. The quality parameters showed typical changes during ripening: a drastic loss of firmness, increase in soluble solids content, loss of acidity, and turning to a red color from the large green stage to fully ripe fruit in both seasons. A significant increase in the ABA content was observed during the ripening of drupelets and receptacles, with the higher content in the receptacle of ripe and overri...
The Journal of Object Technology
Modeling the behavior of complex systems that operate in real environments, deal with physical el... more Modeling the behavior of complex systems that operate in real environments, deal with physical elements, or interact with humans is a challenging task. It involves the explicit representation of aspects of behavioral uncertainty that are inherent in the system, but generally neglected in software models. In this paper, we focus on the explicit representation of the behavior of objects of complex systems, considering their motivations, randomness, and the different types of underlying uncertainty that affect their actions. We show how such uncertain behaviors can be effectively modeled in UML and OCL, and how the specifications produced can be used to simulate and analyze these systems.
Proceedings of the 25th International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings
A digital twin is a virtual replica of a system defined at a certain level of fidelity, and synch... more A digital twin is a virtual replica of a system defined at a certain level of fidelity, and synchronized at a specific frequency. Digital twins are often used to replicate physical systems whose simulations are usually computationally costly. One of the solutions proposed in the literature to this problem is to define a hierarchy of multi-fidelity digital twins, where we use one twin or another depending on the specific purpose. However, one of the challenges of this proposal is the need to determine whether these twins are equivalent to each other and the physical system according to their purpose. In this work, we explore different methods to measure this equivalence by analyzing the state and behavior of the twins using high-level software models. CCS CONCEPTS • Software and its engineering → Operational analysis.
Proceedings of the 25th International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings
A common problem in the development of digital twin systems is the validation that the behavior o... more A common problem in the development of digital twin systems is the validation that the behavior of both twins, the physical and the digital, is the same, or at least similar enough given the requirements of the digital twin system. In this paper, we propose a method for the alignment of the traces of both twins. Traces are sequences of snapshots that capture the progressive states of each entity. Our approach is based on a bioinformatic algorithm that we adapt and use for the alignment of snapshots. Additionally, we include a set of measures to evaluate the quality of these alignments and reason about the level of fidelity of the digital twin system. Two case studies are used to demonstrate our proposal and evaluate its accuracy and effectiveness. • Software and its engineering → Operational analysis.
Proceedings of the 25th International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings
A digital twin is a virtual replica of a system at a certain level of fidelity, synchronized at a... more A digital twin is a virtual replica of a system at a certain level of fidelity, synchronized at a specific frequency. Digital twins often replicate physical systems whose simulations are usually computationally costly. One of the solutions to this problem proposed in the literature is to define a hierarchy of multi-fidelity digital twins, where we use one twin or another depending on the specific purpose. However, one of the challenges of this proposal is the need to determine whether the different twins are equivalent to each other and the physical system. In this thesis, we explore different methods to measure this equivalence by analyzing the state and behavior of the twins with the aid of high-level software models. CCS CONCEPTS • Software and its engineering → Operational analysis.
The Journal of Object Technology
The correctness of software built through model transformations highly depends on the correctness... more The correctness of software built through model transformations highly depends on the correctness of these transformations. Different approaches have been proposed to ensure the correctness of model transformations by checking if pairs of input-output models satisfy a set of contracts. If a contract is not satisfied, at least one transformation rule must contain a bug. Localizing the rules that contain bugs is key for repairing the model transformation. Among others, Spectrum-Based Fault Localization (SBFL) is a dynamic technique to locate the faulty component of a software, and it has already been applied in the context of model transformations considering the rules as the components. As a result, this technique proposes an order (a so-called suspiciousness ranking) in which the rules should be inspected in order to locate the bug. However, SBFL relies on so-called suspiciousness formulae that were created in different domains, so none of them offers a perfect behavior in the context of model transformations. Indeed, some of the rankings for model transformations present many ties, so the tester is uncertain as of which rule to inspect first in the ties. In this paper, we explore how SBFL can be combined with static information in a hybrid approach in order to improve the results obtained from SBFL, specially in the case of ties in the rankings. Our evaluation shows the potential of the hybrid approach to improve previous SBFL results for model transformations.
Plant Science
Epigenetic regulation is crucial to ensure a coordinated control of the different events that occ... more Epigenetic regulation is crucial to ensure a coordinated control of the different events that occur during fruit development and ripening. Sirtuins are NAD + -dependent histone deacetylases involved in the regulation of gene expression of many biological processes. However, their implications in the Rosaceae family remains unexplored. Accordingly, in this work, we demonstrated the phylogenetic divergence of both sirtuins among Rosaceae species. We then characterized the expression pattern of both SRT1 and SRT2 in selected pome and stone fruit species. Both SRT1 and SRT2 significantly changed during the fruit development and ripening of apple, nectarine and pear fruit, displaying a different expression profile. Such differences could explain in part their different ripening behaviour. To further unravel the role of sirtuins on the fruit development and ripening processes, a deeper analysis was performed using pear as a fruit model. In pear, PbSRT1 gene expression levels were negatively correlated with specific hormones (i.e. abscisic acid, indole-3-acetic acid, gibberellin A1 and zeatin) during the first phases of fruit development. PbSRT2 seemed to directly mediate pear ripening in an ethylene-independent manner. This hypothesis was further reinforced by treating the fruit with the ethylene inhibitor 1methylcyclopropene (1-MCP). Instead, enhanced PbSRT2 along pear growth/ripening positively correlated with the accumulation of major sugars (R 2 > 0.94), reinforcing the idea that sugar metabolism may be a target of epigenetic modifications during fruit ripening. Overall, the results from this study point out, for the first time, the importance that sirtuins have in the regulation of fruit growth and ripening of pear fruit by likely regulating hormonal and sugar metabolism.
Maguaré, 2005
Se estudiaron 21 dimensiones en craneo y mandibula para analizar el dimorfi smo sexual en una mue... more Se estudiaron 21 dimensiones en craneo y mandibula para analizar el dimorfi smo sexual en una muestra de poblacion contemporanea de Medellin, utilizando con fi nes comparativos tres metodos diferentes de estima del dimorfi smo sexual. La magnitud de este, estimada mediante la t de Student proporciono un numero ligeramente mayor de dimensiones dimorficas que el test de Kolmogorov-Smirnov (KS) para muestras independientes. Sin embargo, la t de Student mostro resultados similares a los del test de la F (ANOVA) aplicado por Rosique et al. (2004) en un estudio precedente. El calculo del MDI (Mean Distance Index) fue superior al 5% en las dimensiones diagnosticadas simultaneamente como dimorfi cas por los tres test de signifi cacion (t, F y KS). El test de Kolmogorov-Smirnov se evidencio como recomendable para estimar el dimorfi smo sexual, frente a los otros tests, para varias dimensiones. Tanto el analisis univariado como el analisis discriminante evidenciaron un mayor poder diagnostico...
Tree Physiology, 2021
Mastic trees (Pistacia lentiscus L.) are dioecious perennial plants that are highly adapted to Me... more Mastic trees (Pistacia lentiscus L.) are dioecious perennial plants that are highly adapted to Mediterranean climates but display a high sensitivity to winter periods. In order to understand how sex, leaf phenology and ecological context could condition sensitivity to winter and associated mechanisms to acclimate to these conditions, photoinhibition and photo-oxidative stress markers were examined in mastic trees (P. lentiscus) from a natural population growing in the Garraf Natural Park for a consecutive 12-month period (seasonal study), as well as in three populations naturally growing in the Montseny Natural Park, including the highest altitudes described for this species, during winter (altitudinal study). Results from these studies indicate that both the winter period and higher elevation influenced the degree of photoinhibition, but this was not conditioned by sex. In fact, winter photoinhibition occurred transiently even though it was accompanied by chlorophyll loss and malon...
The Journal of Object Technology, 2020
The logic of the UML and OCL modeling languages is based on crisp values, e.g., true or false. Ho... more The logic of the UML and OCL modeling languages is based on crisp values, e.g., true or false. However, when modeling systems that work in physical environments or where human actors are involved, different users may have subjective opinions about the reality that they perceive, and thus may need to assign different levels of confidence to the logic predicates of the models. These different views, or opinions, may also be subject to uncertainty when there is a lack of knowledge about the system, adding the dimension of ignorance to the traditional belief-disbelief dichotomy. This paper proposes an extension of the OCL/UML datatype Boolean that enables the representation of subjective uncertain opinions, together with a set of logical operators for reasoning with uncertain propositions in order to reach better informed decisions. The proposal has been implemented as an extension of the UML-based Specification Environment (USE) tool, and validated with several applications and case studies.
Journal of Politics in Latin America, 2011
This article argues that in Colombia, decentralization and electoral reforms adopted in the late ... more This article argues that in Colombia, decentralization and electoral reforms adopted in the late 1980s and in the 1991 Constitution – designed to improve democratic quality – brought about a gradual deinstitutionalization of this country's traditional party system as an unintended consequence. Building upon resource-based theories of party configuration, we contend that in developing countries, where resources are usually crucial for party aggregation, “democratizing” reforms designed to distribute power and resources in the political system can reduce local candidates’ incentives to join and remain loyal to political parties, particularly when those parties’ reputations are weak. In Colombia, these reforms (i) reduced the power of intermediate-level party leaders over the distribution of selective incentives, making these leaders less important for local politicians, and (ii) gave more political and financial autonomy to local candidates, reducing their need to join parties in ...
Revista chilena de pediatria, 2018
Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organi... more Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation. To report a case of vitiligo as a manifestation of cutaneous chronic GVHD, a low prevalence sign, which recognition could help to suspect this severe compli cation. 8 years old male, diagnosed with acute lymphoblastic leukemia (ALL) at 3 years old, had a combined medullary and central nervous system (NCS) relapse with minimal positive disease 3 years afterwards. After 4 years ALL was diagnosed, he received an allogeneic bone marrow transplant. Seven months after the BMT he prese...
Plant science : an international journal of experimental plant biology, 2018
Although most studies to extend vase life in cut flowers have focused on flower senescence thus f... more Although most studies to extend vase life in cut flowers have focused on flower senescence thus far, flower opening is a complex process of major biological significance in the determination of flower commercialization. In order to better understand flower opening, this study evaluated to what extent photoinhibition and photo-oxidative stress are associated with tepal de-greening during flower opening in lilies (Lilium "Litouwen"). We estimated the degree of photoinhibition, the capacity for photo- and antioxidant protection, and the extent of lipid peroxidation at four flower opening stages, from closed flowers to anthesis. Additionally, we evaluated to what extent and by which mechanisms related to photo- and antioxidant protection, Promalin® (a combination of gibberellins and cytokinins) delays flower opening. Results showed that chlorophyll content decreased progressively during flower opening, while a sharp decrease of the maximum PSII efficiency (Fv/Fm ratio) was obs...
Journal of Child and Family Studies, 2017
Gestural Representation of Emotions: A Comparative Study on Chilean and American Women
Journal of Child and Family Studies, 2017
Emotions and their expression are adaptive processes, relevant to maintaining personal welfare an... more Emotions and their expression are adaptive processes, relevant to maintaining personal welfare and to structuring social relations through the verbal and nonverbal communication of feelings and needs to others. Emotional representation refers to the ability to intentionally and deliberately produce facial and bodily movements to convey an emotion. Although this representation possesses universal aspects, its richness lies in its cultural variability. This study seeks to describe and compare the intensity of the facial and bodily representation of six emotions in 120 Chilean and American women from different socioeconomic groups. The study adopts an investigatory, descriptive, cross-sectional and comparative design. A socio-demographic questionnaire and an assessment of emotional gestures in adults were applied. For the assessment, the women’s responses to six short stories related to the emotions of happiness, sadness, anger, fear, pride and shame were filmed and coded by independent coders from both countries. The results indicate that Chilean women are more intense when representing happiness and pride with their faces, whereas American women are more intense when representing happiness and anger with their bodies. In addition, differences emerge based on socioeconomic status. In both countries, a higher socioeconomic status is associated with greater intensity in the representation of emotions. The results and their implications are discussed.
Expediente - Apresentação - Sumário
Tcc Em Re Vista, Aug 30, 2013
Frontiers in Plant Science, 2016
Stimulus content effect on the visual cortex with functional MRI
Proceedings of the IEEE 24th Annual Northeast Bioengineering Conference (Cat. No.98CH36210)
Cortical activity in disparity vergence eye-movements: a fMRI study
Proceedings of the IEEE 24th Annual Northeast Bioengineering Conference (Cat. No.98CH36210), 1998
Employing fMRI techniques, cortical activity related with disparity vergence eye movements has be... more Employing fMRI techniques, cortical activity related with disparity vergence eye movements has been identified. The gyri precentralis, the gyrus cinguli and the precuneus appeared to be involved in these eye movements under very different conditions. In addition, the prediction operator in vergence eye movements presented additional activity in all the previous regions plus the gyrus frontalis superior. From this preliminary
The New England journal of medicine, 2015
Background The current Ebola virus disease (EVD) outbreak has resulted in more than 24,000 cases ... more Background The current Ebola virus disease (EVD) outbreak has resulted in more than 24,000 cases and 10,000 deaths. We present a preliminary report from two phase 1 trials of an attenuated, replication-competent, recombinant vesicular stomatitis virus (rVSV)-based vaccine candidate to prevent EVD. Methods We conducted two phase 1, placebo-controlled, double-blind, dose-escalation trials of an rVSV-based vaccine candidate expressing the glycoprotein of a Zaire strain of Ebola virus (ZEBOV). A total of 26 adults at each site (52 participants in all) were consecutively enrolled into groups of 13 each. Three volunteers in each group received an intramuscular injection of placebo, and 10 received an intramuscular injection of the rVSV-ZEBOV vaccine at a dose of either 3 million plaque-forming units (PFU) or 20 million PFU. Safety and immunogenicity were assessed for the 28 days after vaccination. Results The most common adverse events were injection-site pain, myalgia, and fatigue; no ev...
Plants
The raspberry (Rubus idaeus L.) fruit is characterized by its richness in functional molecules an... more The raspberry (Rubus idaeus L.) fruit is characterized by its richness in functional molecules and high nutritional value, but the high rate of fruit softening limits its quality during postharvest. Raspberry drupelets have a particular ripening regulation, depending partially on the effect of ethylene produced from the receptacle. However, the possible role of abscisic acid (ABA) in the modulation of quality parameters during the ripening of raspberry is unclear. This study characterized the fruit quality-associated parameters and hormonal contents during fruit development in two seasons. The quality parameters showed typical changes during ripening: a drastic loss of firmness, increase in soluble solids content, loss of acidity, and turning to a red color from the large green stage to fully ripe fruit in both seasons. A significant increase in the ABA content was observed during the ripening of drupelets and receptacles, with the higher content in the receptacle of ripe and overri...
The Journal of Object Technology
Modeling the behavior of complex systems that operate in real environments, deal with physical el... more Modeling the behavior of complex systems that operate in real environments, deal with physical elements, or interact with humans is a challenging task. It involves the explicit representation of aspects of behavioral uncertainty that are inherent in the system, but generally neglected in software models. In this paper, we focus on the explicit representation of the behavior of objects of complex systems, considering their motivations, randomness, and the different types of underlying uncertainty that affect their actions. We show how such uncertain behaviors can be effectively modeled in UML and OCL, and how the specifications produced can be used to simulate and analyze these systems.
Proceedings of the 25th International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings
A digital twin is a virtual replica of a system defined at a certain level of fidelity, and synch... more A digital twin is a virtual replica of a system defined at a certain level of fidelity, and synchronized at a specific frequency. Digital twins are often used to replicate physical systems whose simulations are usually computationally costly. One of the solutions proposed in the literature to this problem is to define a hierarchy of multi-fidelity digital twins, where we use one twin or another depending on the specific purpose. However, one of the challenges of this proposal is the need to determine whether these twins are equivalent to each other and the physical system according to their purpose. In this work, we explore different methods to measure this equivalence by analyzing the state and behavior of the twins using high-level software models. CCS CONCEPTS • Software and its engineering → Operational analysis.
Proceedings of the 25th International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings
A common problem in the development of digital twin systems is the validation that the behavior o... more A common problem in the development of digital twin systems is the validation that the behavior of both twins, the physical and the digital, is the same, or at least similar enough given the requirements of the digital twin system. In this paper, we propose a method for the alignment of the traces of both twins. Traces are sequences of snapshots that capture the progressive states of each entity. Our approach is based on a bioinformatic algorithm that we adapt and use for the alignment of snapshots. Additionally, we include a set of measures to evaluate the quality of these alignments and reason about the level of fidelity of the digital twin system. Two case studies are used to demonstrate our proposal and evaluate its accuracy and effectiveness. • Software and its engineering → Operational analysis.
Proceedings of the 25th International Conference on Model Driven Engineering Languages and Systems: Companion Proceedings
A digital twin is a virtual replica of a system at a certain level of fidelity, synchronized at a... more A digital twin is a virtual replica of a system at a certain level of fidelity, synchronized at a specific frequency. Digital twins often replicate physical systems whose simulations are usually computationally costly. One of the solutions to this problem proposed in the literature is to define a hierarchy of multi-fidelity digital twins, where we use one twin or another depending on the specific purpose. However, one of the challenges of this proposal is the need to determine whether the different twins are equivalent to each other and the physical system. In this thesis, we explore different methods to measure this equivalence by analyzing the state and behavior of the twins with the aid of high-level software models. CCS CONCEPTS • Software and its engineering → Operational analysis.
The Journal of Object Technology
The correctness of software built through model transformations highly depends on the correctness... more The correctness of software built through model transformations highly depends on the correctness of these transformations. Different approaches have been proposed to ensure the correctness of model transformations by checking if pairs of input-output models satisfy a set of contracts. If a contract is not satisfied, at least one transformation rule must contain a bug. Localizing the rules that contain bugs is key for repairing the model transformation. Among others, Spectrum-Based Fault Localization (SBFL) is a dynamic technique to locate the faulty component of a software, and it has already been applied in the context of model transformations considering the rules as the components. As a result, this technique proposes an order (a so-called suspiciousness ranking) in which the rules should be inspected in order to locate the bug. However, SBFL relies on so-called suspiciousness formulae that were created in different domains, so none of them offers a perfect behavior in the context of model transformations. Indeed, some of the rankings for model transformations present many ties, so the tester is uncertain as of which rule to inspect first in the ties. In this paper, we explore how SBFL can be combined with static information in a hybrid approach in order to improve the results obtained from SBFL, specially in the case of ties in the rankings. Our evaluation shows the potential of the hybrid approach to improve previous SBFL results for model transformations.
Plant Science
Epigenetic regulation is crucial to ensure a coordinated control of the different events that occ... more Epigenetic regulation is crucial to ensure a coordinated control of the different events that occur during fruit development and ripening. Sirtuins are NAD + -dependent histone deacetylases involved in the regulation of gene expression of many biological processes. However, their implications in the Rosaceae family remains unexplored. Accordingly, in this work, we demonstrated the phylogenetic divergence of both sirtuins among Rosaceae species. We then characterized the expression pattern of both SRT1 and SRT2 in selected pome and stone fruit species. Both SRT1 and SRT2 significantly changed during the fruit development and ripening of apple, nectarine and pear fruit, displaying a different expression profile. Such differences could explain in part their different ripening behaviour. To further unravel the role of sirtuins on the fruit development and ripening processes, a deeper analysis was performed using pear as a fruit model. In pear, PbSRT1 gene expression levels were negatively correlated with specific hormones (i.e. abscisic acid, indole-3-acetic acid, gibberellin A1 and zeatin) during the first phases of fruit development. PbSRT2 seemed to directly mediate pear ripening in an ethylene-independent manner. This hypothesis was further reinforced by treating the fruit with the ethylene inhibitor 1methylcyclopropene (1-MCP). Instead, enhanced PbSRT2 along pear growth/ripening positively correlated with the accumulation of major sugars (R 2 > 0.94), reinforcing the idea that sugar metabolism may be a target of epigenetic modifications during fruit ripening. Overall, the results from this study point out, for the first time, the importance that sirtuins have in the regulation of fruit growth and ripening of pear fruit by likely regulating hormonal and sugar metabolism.
Maguaré, 2005
Se estudiaron 21 dimensiones en craneo y mandibula para analizar el dimorfi smo sexual en una mue... more Se estudiaron 21 dimensiones en craneo y mandibula para analizar el dimorfi smo sexual en una muestra de poblacion contemporanea de Medellin, utilizando con fi nes comparativos tres metodos diferentes de estima del dimorfi smo sexual. La magnitud de este, estimada mediante la t de Student proporciono un numero ligeramente mayor de dimensiones dimorficas que el test de Kolmogorov-Smirnov (KS) para muestras independientes. Sin embargo, la t de Student mostro resultados similares a los del test de la F (ANOVA) aplicado por Rosique et al. (2004) en un estudio precedente. El calculo del MDI (Mean Distance Index) fue superior al 5% en las dimensiones diagnosticadas simultaneamente como dimorfi cas por los tres test de signifi cacion (t, F y KS). El test de Kolmogorov-Smirnov se evidencio como recomendable para estimar el dimorfi smo sexual, frente a los otros tests, para varias dimensiones. Tanto el analisis univariado como el analisis discriminante evidenciaron un mayor poder diagnostico...
Tree Physiology, 2021
Mastic trees (Pistacia lentiscus L.) are dioecious perennial plants that are highly adapted to Me... more Mastic trees (Pistacia lentiscus L.) are dioecious perennial plants that are highly adapted to Mediterranean climates but display a high sensitivity to winter periods. In order to understand how sex, leaf phenology and ecological context could condition sensitivity to winter and associated mechanisms to acclimate to these conditions, photoinhibition and photo-oxidative stress markers were examined in mastic trees (P. lentiscus) from a natural population growing in the Garraf Natural Park for a consecutive 12-month period (seasonal study), as well as in three populations naturally growing in the Montseny Natural Park, including the highest altitudes described for this species, during winter (altitudinal study). Results from these studies indicate that both the winter period and higher elevation influenced the degree of photoinhibition, but this was not conditioned by sex. In fact, winter photoinhibition occurred transiently even though it was accompanied by chlorophyll loss and malon...
The Journal of Object Technology, 2020
The logic of the UML and OCL modeling languages is based on crisp values, e.g., true or false. Ho... more The logic of the UML and OCL modeling languages is based on crisp values, e.g., true or false. However, when modeling systems that work in physical environments or where human actors are involved, different users may have subjective opinions about the reality that they perceive, and thus may need to assign different levels of confidence to the logic predicates of the models. These different views, or opinions, may also be subject to uncertainty when there is a lack of knowledge about the system, adding the dimension of ignorance to the traditional belief-disbelief dichotomy. This paper proposes an extension of the OCL/UML datatype Boolean that enables the representation of subjective uncertain opinions, together with a set of logical operators for reasoning with uncertain propositions in order to reach better informed decisions. The proposal has been implemented as an extension of the UML-based Specification Environment (USE) tool, and validated with several applications and case studies.
Journal of Politics in Latin America, 2011
This article argues that in Colombia, decentralization and electoral reforms adopted in the late ... more This article argues that in Colombia, decentralization and electoral reforms adopted in the late 1980s and in the 1991 Constitution – designed to improve democratic quality – brought about a gradual deinstitutionalization of this country's traditional party system as an unintended consequence. Building upon resource-based theories of party configuration, we contend that in developing countries, where resources are usually crucial for party aggregation, “democratizing” reforms designed to distribute power and resources in the political system can reduce local candidates’ incentives to join and remain loyal to political parties, particularly when those parties’ reputations are weak. In Colombia, these reforms (i) reduced the power of intermediate-level party leaders over the distribution of selective incentives, making these leaders less important for local politicians, and (ii) gave more political and financial autonomy to local candidates, reducing their need to join parties in ...
Revista chilena de pediatria, 2018
Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organi... more Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation. To report a case of vitiligo as a manifestation of cutaneous chronic GVHD, a low prevalence sign, which recognition could help to suspect this severe compli cation. 8 years old male, diagnosed with acute lymphoblastic leukemia (ALL) at 3 years old, had a combined medullary and central nervous system (NCS) relapse with minimal positive disease 3 years afterwards. After 4 years ALL was diagnosed, he received an allogeneic bone marrow transplant. Seven months after the BMT he prese...
Plant science : an international journal of experimental plant biology, 2018
Although most studies to extend vase life in cut flowers have focused on flower senescence thus f... more Although most studies to extend vase life in cut flowers have focused on flower senescence thus far, flower opening is a complex process of major biological significance in the determination of flower commercialization. In order to better understand flower opening, this study evaluated to what extent photoinhibition and photo-oxidative stress are associated with tepal de-greening during flower opening in lilies (Lilium "Litouwen"). We estimated the degree of photoinhibition, the capacity for photo- and antioxidant protection, and the extent of lipid peroxidation at four flower opening stages, from closed flowers to anthesis. Additionally, we evaluated to what extent and by which mechanisms related to photo- and antioxidant protection, Promalin® (a combination of gibberellins and cytokinins) delays flower opening. Results showed that chlorophyll content decreased progressively during flower opening, while a sharp decrease of the maximum PSII efficiency (Fv/Fm ratio) was obs...
Journal of Child and Family Studies, 2017
Gestural Representation of Emotions: A Comparative Study on Chilean and American Women
Journal of Child and Family Studies, 2017
Emotions and their expression are adaptive processes, relevant to maintaining personal welfare an... more Emotions and their expression are adaptive processes, relevant to maintaining personal welfare and to structuring social relations through the verbal and nonverbal communication of feelings and needs to others. Emotional representation refers to the ability to intentionally and deliberately produce facial and bodily movements to convey an emotion. Although this representation possesses universal aspects, its richness lies in its cultural variability. This study seeks to describe and compare the intensity of the facial and bodily representation of six emotions in 120 Chilean and American women from different socioeconomic groups. The study adopts an investigatory, descriptive, cross-sectional and comparative design. A socio-demographic questionnaire and an assessment of emotional gestures in adults were applied. For the assessment, the women’s responses to six short stories related to the emotions of happiness, sadness, anger, fear, pride and shame were filmed and coded by independent coders from both countries. The results indicate that Chilean women are more intense when representing happiness and pride with their faces, whereas American women are more intense when representing happiness and anger with their bodies. In addition, differences emerge based on socioeconomic status. In both countries, a higher socioeconomic status is associated with greater intensity in the representation of emotions. The results and their implications are discussed.
Expediente - Apresentação - Sumário
Tcc Em Re Vista, Aug 30, 2013
Frontiers in Plant Science, 2016
Stimulus content effect on the visual cortex with functional MRI
Proceedings of the IEEE 24th Annual Northeast Bioengineering Conference (Cat. No.98CH36210)
Cortical activity in disparity vergence eye-movements: a fMRI study
Proceedings of the IEEE 24th Annual Northeast Bioengineering Conference (Cat. No.98CH36210), 1998
Employing fMRI techniques, cortical activity related with disparity vergence eye movements has be... more Employing fMRI techniques, cortical activity related with disparity vergence eye movements has been identified. The gyri precentralis, the gyrus cinguli and the precuneus appeared to be involved in these eye movements under very different conditions. In addition, the prediction operator in vergence eye movements presented additional activity in all the previous regions plus the gyrus frontalis superior. From this preliminary
The New England journal of medicine, 2015
Background The current Ebola virus disease (EVD) outbreak has resulted in more than 24,000 cases ... more Background The current Ebola virus disease (EVD) outbreak has resulted in more than 24,000 cases and 10,000 deaths. We present a preliminary report from two phase 1 trials of an attenuated, replication-competent, recombinant vesicular stomatitis virus (rVSV)-based vaccine candidate to prevent EVD. Methods We conducted two phase 1, placebo-controlled, double-blind, dose-escalation trials of an rVSV-based vaccine candidate expressing the glycoprotein of a Zaire strain of Ebola virus (ZEBOV). A total of 26 adults at each site (52 participants in all) were consecutively enrolled into groups of 13 each. Three volunteers in each group received an intramuscular injection of placebo, and 10 received an intramuscular injection of the rVSV-ZEBOV vaccine at a dose of either 3 million plaque-forming units (PFU) or 20 million PFU. Safety and immunogenicity were assessed for the 28 days after vaccination. Results The most common adverse events were injection-site pain, myalgia, and fatigue; no ev...