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Papers by Paulina Valenzuela

Maderas Ciencia Y Tecnologia, 2012

FEMS Microbiology Letters, 2016

Piscirickettsia salmonis is a fastidious intracellular pathogen responsible for high mortality ra... more Piscirickettsia salmonis is a fastidious intracellular pathogen responsible for high mortality rates in farmed salmonids, with serious economic consequences for the Chilean aquaculture industry. Oxytetracycline and florfenicol are the most frequently used antibiotics against P. salmonis, but routine use could contribute to drug resistance. This study identified differentiated florfenicol susceptibilities in two P. salmonis strains, LF-89 and AUSTRAL-005. The less susceptible isolate, AUSTRAL-005, also showed a high ethidium bromide efflux rate, indicating a higher activity of general efflux pump genes than LF-89. The P. salmonis genome presented resistance nodulation division (RND) family members, a family containing typical multidrug resistance-related efflux pumps in Gram-negative bacteria. Additionally, efflux pump acrAB genes were overexpressed in AUSTRAL-005 following exposure to the tolerated maximal concentration of florfenicol, in contrast to LF-89. These results indicate that tolerated maximum concentrations of florfenicol can modulate RND gene expression and increase efflux pump activity. We propose that the acrAB efflux pump is essential for P. salmonis survival at critical florfenicol concentrations and for the generation of antibiotic-resistant bacterial strains.

Revista De Salud Publica, Apr 30, 2013

Maderas. Ciencia y tecnología, 2015

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Revista de salud pública (Bogotá, Colombia)

The health promotion in the university context emerges as an important initiative to facilitate t... more The health promotion in the university context emerges as an important initiative to facilitate the development of healthy lifestyle behaviors in this environment where students, faculty and university staff spend and share a significant part of their lives. The movement of Health Promoting Universities (HPU) has over 20 years of experience, but still lacks a common language that allows effective communication between those who are interested in its planning and implementation. The purpose of this paper is to develop the most relevant concepts in the context of the international movement of UPS. This document is organized into five anchor dimensions: [1]The university and health promotion, [2] The University and its social responsibility, [3] The University, inequality and inequity, [4] The University and evidence in health promotion, and [5] Strategies to develop a HPU. It is hoped that this glossary for HPU encourages the development of a common language between those who promote ...

ISIE '97 Proceeding of the IEEE International Symposium on Industrial Electronics, 1997

This paper presents the second version of a software package to work with Petri nets. The softwar... more This paper presents the second version of a software package to work with Petri nets. The software permits one to edit, to simulate and to validate generalized and stochastic Petri nets. The program can be used to model any discrete dynamic system; in particular this paper deals with flexible manufacturing systems (FMS). The software uses the editor and the simulator

Maderas. Ciencia y tecnología, 2012

Revista médica de Chile, 1999

Este libro compila más de 15 artículos de diferentes especialistas sobre la dirección escolar en ... more Este libro compila más de 15 artículos de diferentes especialistas sobre la dirección escolar en Chile, dando un panorama completo de los estudios realizados en el país en esta estratégica materia.