Pavão Pavão - Academia.edu (original) (raw)
Papers by Pavão Pavão
European Journal of Pharmacology, 1997
. The known effects of a novel stomach pentadecapeptide BPC157 10 mg or 10 ngrkg , namely its sal... more . The known effects of a novel stomach pentadecapeptide BPC157 10 mg or 10 ngrkg , namely its salutary activity against ethanol Ž . Ž . Ž . 96%, i.g. -induced gastric lesions simultaneously applied i.p. and in blood pressure maintenance given i.v. , were investigated in rats G Ž .Ž . challenged with a combination of N -nitro-L-arginine methylester L-NAME 5 mgrkg i.v. , a competitive inhibitor of endothelium Ž . Ž . Ž . nitric oxide NO -generation and NO precursor, L-arginine 200 mgrkg i.v. D-arginine was ineffective . In the gastric lesions assay, NO agents were given 5 min before ethanol injury and BPC 157 medication. Given alone, BPC157 had an antiulcer effect, as did L-arginine, but L-NAME had no effect. L-NAME completely abolished the effect of L-arginine, whereas it only attenuated the effect of BPC 157. After application of the combination of L-NAME q L-arginine, the BPC157 effect was additionally impaired. In blood pressure studies, Ž . Ž compared with L-arginine, pentadecapeptide BPC 157 without effect on basal normal values had both a mimicking effect impaired L-NAME-blood pressure increase, when applied prophylactically and decreased already raised L-NAME values, given at the time of the Ž . . Ž maximal L-NAME-blood pressure increase i.e., 10 min after L-NAME and preventive activity L-arginine-induced moderate blood . pressure decrease was prevented by BPC 157 pretreatment . When BPC 157 was given 10 min after L-NAME q L-arginine combination, Ž . which still led to a blood pressure increase, its previously clear effect noted in L-NAME treated rats disappeared. In vitro, in gastric Ž . mucosa from rat stomach tissue homogenates, BPC 157, given in the same dose 100 mM as L-arginine, induced a comparable generation Ž . of NO. But, BPC 157 effect could not be inhibited by L-NAME, even when L-NAME was given in a tenfold 100 versus 1000 mM higher dose than that needed for inhibition of the L-arginine effect. NO synthesis was blunted when the pentadecapeptide BPC 157 and L-arginine were combined. In summary, BPC 157 could interfere with the effects of NO on both gastric mucosal integrity and blood pressure maintenance in a specific way, especially with L-arginine, having a more prominent andror particularly different effect from that of NO. q 1997 Elsevier Science B.V.
A Atividade Prática Supervisionada (ATPS) é um procedimento metodológico de ensino-aprendizagem d... more A Atividade Prática Supervisionada (ATPS) é um procedimento metodológico de ensino-aprendizagem desenvolvido por meio de etapas, acompanhadas pelo professor, e que tem por objetivos: Favorecer a autoaprendizagem do aluno. Estimular a corresponsabilidade do aluno pelo seu aprendizado. Promover o estudo, a convivência e o trabalho em grupo. Auxiliar no desenvolvimento das competências requeridas para o exercício profissional. Promover a aplicação da teoria na solução de situações que simulam a realidade.
European Journal of Pharmacology, 1997
. The known effects of a novel stomach pentadecapeptide BPC157 10 mg or 10 ngrkg , namely its sal... more . The known effects of a novel stomach pentadecapeptide BPC157 10 mg or 10 ngrkg , namely its salutary activity against ethanol Ž . Ž . Ž . 96%, i.g. -induced gastric lesions simultaneously applied i.p. and in blood pressure maintenance given i.v. , were investigated in rats G Ž .Ž . challenged with a combination of N -nitro-L-arginine methylester L-NAME 5 mgrkg i.v. , a competitive inhibitor of endothelium Ž . Ž . Ž . nitric oxide NO -generation and NO precursor, L-arginine 200 mgrkg i.v. D-arginine was ineffective . In the gastric lesions assay, NO agents were given 5 min before ethanol injury and BPC 157 medication. Given alone, BPC157 had an antiulcer effect, as did L-arginine, but L-NAME had no effect. L-NAME completely abolished the effect of L-arginine, whereas it only attenuated the effect of BPC 157. After application of the combination of L-NAME q L-arginine, the BPC157 effect was additionally impaired. In blood pressure studies, Ž . Ž compared with L-arginine, pentadecapeptide BPC 157 without effect on basal normal values had both a mimicking effect impaired L-NAME-blood pressure increase, when applied prophylactically and decreased already raised L-NAME values, given at the time of the Ž . . Ž maximal L-NAME-blood pressure increase i.e., 10 min after L-NAME and preventive activity L-arginine-induced moderate blood . pressure decrease was prevented by BPC 157 pretreatment . When BPC 157 was given 10 min after L-NAME q L-arginine combination, Ž . which still led to a blood pressure increase, its previously clear effect noted in L-NAME treated rats disappeared. In vitro, in gastric Ž . mucosa from rat stomach tissue homogenates, BPC 157, given in the same dose 100 mM as L-arginine, induced a comparable generation Ž . of NO. But, BPC 157 effect could not be inhibited by L-NAME, even when L-NAME was given in a tenfold 100 versus 1000 mM higher dose than that needed for inhibition of the L-arginine effect. NO synthesis was blunted when the pentadecapeptide BPC 157 and L-arginine were combined. In summary, BPC 157 could interfere with the effects of NO on both gastric mucosal integrity and blood pressure maintenance in a specific way, especially with L-arginine, having a more prominent andror particularly different effect from that of NO. q 1997 Elsevier Science B.V.
A Atividade Prática Supervisionada (ATPS) é um procedimento metodológico de ensino-aprendizagem d... more A Atividade Prática Supervisionada (ATPS) é um procedimento metodológico de ensino-aprendizagem desenvolvido por meio de etapas, acompanhadas pelo professor, e que tem por objetivos: Favorecer a autoaprendizagem do aluno. Estimular a corresponsabilidade do aluno pelo seu aprendizado. Promover o estudo, a convivência e o trabalho em grupo. Auxiliar no desenvolvimento das competências requeridas para o exercício profissional. Promover a aplicação da teoria na solução de situações que simulam a realidade.