Pawan Kumar - Academia.edu (original) (raw)

Papers by Pawan Kumar

Research paper thumbnail of Effect of Environmental Conditions on Single and Double Diode PV System : A Comparative Study

In this paper, a single and a double/bypass diode based photovoltaic (PV) systems are designed in... more In this paper, a single and a double/bypass diode based photovoltaic (PV) systems are designed in MATLAB/Simulink GUI environment based on mathematical modeling of above PV systems. A detailed comparative study of transient analysis for single and double/bypass PV systems has been done with a RL load. The effect of realistic conditions i.e. variable wind speed and irradiation level on single and double/bypass diode PV system is investigated, the obtained results show the satisfactory performance for realistic model of PV system. Keywords—Solar photovoltaic system, Single diode PV system, Double/bypass diode PV system, Realistic PV system, Green energy.

Research paper thumbnail of In-situ Exchange Bias Study of Co/CoO/Co/CoO Multilayer Structure

ABSTRACT The exchange bias property has been studied in the multilayer structure (Co/CoO/Co/CoO).... more ABSTRACT The exchange bias property has been studied in the multilayer structure (Co/CoO/Co/CoO). The multilayer structure is characterized in-situ using RHEED, XRR and MOKE techniques during its growth. Independent magnetic contribution of top and bottom Co layers has been separated out by fitting hysteresis loop with an adequate mathematical function.

Research paper thumbnail of Advanced MRI Techniques in the Evaluation of Complex Cystic Breast Lesions

Breast cancer : basic and clinical research, 2016

The purpose of this research work was to evaluate complex cystic breast lesions by advanced MRI t... more The purpose of this research work was to evaluate complex cystic breast lesions by advanced MRI techniques and correlating imaging with histologic findings. In a cross-sectional design from September 2013 to August 2015, 50 patients having sonographically detected complex cystic lesions of the breast were included in the study. Morphological characteristics were assessed. Dynamic contrast-enhanced MRI along with diffusion-weighted imaging and MR spectroscopy were used to further classify lesions into benign and malignant categories. All the findings were correlated with histopathology. Of the 50 complex cystic lesions, 32 proved to be benign and 18 were malignant on histopathology. MRI features of heterogeneous enhancement on CE-MRI (13/18), Type III kinetic curve (13/18), reduced apparent diffusion coefficient (18/18), and tall choline peak (17/18) were strong predictors of malignancy. Thirteen of the 18 lesions showed a combination of Type III curve, reduced apparent diffusion coe...

Research paper thumbnail of Higher Order Aberrations and Visual Outcomes in Wavefront-Optimized Sub-Bowman’s Keratomileusis

Asia-Pacific Journal of Ophthalmology, 2015

The aim of this study was to compare the outcomes of wavefront-optimized sub-Bowman keratomileusi... more The aim of this study was to compare the outcomes of wavefront-optimized sub-Bowman keratomileusis (SBK) performed using the 150 KHz IntraLase femtosecond (IFS) laser (Abbot Medical Optics) with those using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome (Moria SA). A prospective comparative clinical trial. Fifty patients had bilateral wavefront-optimized SBK performed for myopia or myopic astigmatism. In 25 patients, the flap was created with the 150 KHz IFS laser (group 1) and in the other 25 with the Moria One Use-Plus SBK mechanical microkeratome (group 2). All other treatment parameters were the same. Results were reported for 1 eye per patient in each group (ie, 25 eyes in each group). Efficacy, refractive stability, predictability, and safety profiles were comparable between the 2 groups. Although higher order aberrations (HOAs) increased significantly in both groups after laser in situ keratomileusis, intergroup comparison revealed that group 1 was associated with a significantly higher induction of both total HOAs [mean root mean square (RMS), 0.63 ± 0.20 in group 1 vs 0.52 ± 0.14 in group 2; P = 0.031] and spherical aberrations (RMS, 0.37 ± 0.17 in group 1 vs 0.22 ± 0.09 in group 2; P < 0.001) as compared with group 2. Flaps created using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome were associated with significantly lower induction of total HOAs and spherical aberrations as compared with 150 KHz IFS flaps at the end of 3 months follow-up.

Research paper thumbnail of Neuropeptide α-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitro

Inflammation Research, 2010

Objective and design a-Melanoycte stimulating hormone (a-MSH), a neuropeptide hormone with report... more Objective and design a-Melanoycte stimulating hormone (a-MSH), a neuropeptide hormone with reported antimicrobial and immuno-modulatory properties in vitro, has previously been detected in the cerebrospinal fluid of children with bacterial meningitis. We investigated the therapeutic effects of a-MSH administration on Neisseria meningitidis infection of human meningeal cell cultures in vitro. Materials and methods Meningeal cell lines (n = 2) were infected with meningococci (10 2 -10 8 cfu/monolayer), isolated bacterial outer membranes (OM; 1 lg/ml) or lipooligosaccharide (LOS; 1 lg/ml) with and without a-MSH (10 -5 -10 lM). Bacterial adherence was quantified at 6 h, and cytokine production and microbicidal activity of a-MSH for meningococci were assessed at 24 h. Results Compared with infection by meningococci alone, a-MSH (10 lM) up-regulated secretion of IL-6 and IL-8 (mean values increased from *33 to 60 ng/ml), RANTES (mean values increased from *26 to 105 ng/ml) and GM-CSF (mean values increased from *0.3 to 1 ng/ml; P \ 0.05). Upregulated secretion correlated with a neuropeptide-mediated rapid and [5-fold increase (P \ 0.05) in bacterial adherence to cells and was dependent on OM components including LOS acting synergistically with a-MSH. Meningococci were resistant to the anti-microbial activity of a-MSH at all concentrations tested. Conclusions Our study demonstrates that a potentially therapeutic neuropeptide exerts pro-inflammatory effects during meningococcal infection in vitro and its use in the treatment of meningitis is contra-indicated.

Research paper thumbnail of Taxonomic studies of genus Opogona Zeller (Lepidoptera: Tineidae) with brief account of wing venation and genitalia

Journal of Insect Science, 2009

Research paper thumbnail of Midgut serine proteases and alternative host plant utilization in Pieris brassicae L

Frontiers in Physiology, 2015

Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larv... more Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larvae of P. brassicae also feed prolifically on garden nasturtium (Tropaeolum majus L., of the family Tropaeolaceae). Proteolytic digestion was studied in larvae feeding on multiple hosts. Fourth instars were collected from cauliflower fields before transfer onto detached, aerial tissues of selected host plants in the lab. Variable levels of midgut proteases were detected in larvae fed on different hosts using protein substrates (casein and recombinant RBCL cloned from cauliflower) and diagnostic, synthetic substrates. Qualitative changes in midgut trypsin activities and quantitative changes in midgut chymotrypsin activities were implicated in physiological adaptation of larvae transferred to T. majus. Midgut proteolytic activities were inhibited to different extents by serine protease inhibitors, including putative trypsin inhibitors isolated from herbivore-attacked and herbivore-free leaves of cauliflower (CfTI) and T. majus (TpTI). Transfer of larvae to T. majus significantly influenced feeding parameters but not necessarily when transferred to different tissues of the same host. Results obtained are relevant for devising sustainable pest management strategies, including transgenic approaches using genes encoding plant protease inhibitors.

Research paper thumbnail of A Ready-to-Eat Antioxidant Rich Appetizer Based on Coleus aromaticus : Its Development and Shelf Life Evaluation

Journal of Food Processing, 2014

Antioxidant rich products are valued due to their health benefits and appetizers are required in ... more Antioxidant rich products are valued due to their health benefits and appetizers are required in several pathological and geographical stress situations such as prolonged exposure to altitude. The paper deals with the development of a shelf stable RTE (ready-to-eat) antioxidant rich herbal appetizer convenient to the consumer. Using ginger and Karpurvalli (Coleus aromaticus) as two independent variables, a central composite design with 13 experimental combinations was obtained. These combinations were processed by concentration and dehydration into the appetizer RTE munches using preprocessed ingredients and evaluated for antioxidant activity, vitamin C, and sensory characteristics. The product optimized using Design Expert Statistical Software had the proximate composition of 11.4% fat, 2.3% protein, and 75.0% carbohydrates, supplying about 82.36 Kcals per munch of 20 g. The munches packed in metalized polyester pouches had a shelf life of 10 months at 28 ± 5 ∘ C as well as 37 ∘ C storage. The RTE appetizer based on Coleus aromaticus was developed with excellent sensory properties and shelf stability.

Research paper thumbnail of Utilization of Energy Sources in Hybrid PV/FC Power Assisted Water Pumping System

2015 Ieee International Conference on Computational Intelligence Communication Technology, Feb 1, 2015

In this paper, the mathematical analysis of solar photovoltaic (PV) system and proton exchange me... more In this paper, the mathematical analysis of solar photovoltaic (PV) system and proton exchange membrane fuel cell (PEMFC) system is presented. The renewable energy (RE) sources e.g. PV system and PEMFC are integrated for hybrid PV/FC power generation. The PV system is considered as primary electrical power generating RE source, and the PEMFC is utilized as power backup source in unfavorable environmental conditions of PV system. Furthermore, in cloudy days, the solar PV system is not capable to generate sufficient power to the load applications due to this a PEMFC can be utilized for power generation. For transient analysis of this hybrid PV/FC power generating system, a water pump load is considered. A Fuzzy logic based maximum power point tracking (MPPT) technique is proposed to achieve maximum power point (MPP) through the PV system. A three phase induction motor (IM) is taken for water pumping system (WPS) application and the complete proposed system is designed in MATLAB/Simulink environment.

Research paper thumbnail of State Merging in LR Parser under Count based Reduction

International Journal of Computer Applications, Aug 20, 2014

An LR parser shows error only during scanning input symbol. Error is never shown during the reduc... more An LR parser shows error only during scanning input symbol. Error is never shown during the reduction of a handle (substring of stack) into nonterminal. It is because a symbol is put into the stack only when it is guaranteed to be the correct one. If the method of reduction of a handle is known then errors can also be shown during reduction. Hence a wrong symbol can be shifted on the stack and error can be detected during reduce operation. It may permit the merging of few states. The simplest type of reduction scheme is to remove few symbols (the number of symbols equal to the length of the handle) from the top of the stack and push the corresponding nonterminal on the stack. In this paper, a state merging scheme is proposed under this method of reduction.

Research paper thumbnail of Unique fixed point theorems on generalized cone metric spaces

Advances in Inequalities and Applications, Apr 18, 2014

Research paper thumbnail of Parametric conversion of a lower hybrid wave into a whistler in a plasma

Physics of Plasmas, May 1, 2008

A large amplitude lower hybrid wave parametrically decays into a whistler wave and a low frequenc... more A large amplitude lower hybrid wave parametrically decays into a whistler wave and a low frequency lower hybrid wave in a plasma. The density perturbation due to the low frequency wave couples with the oscillatory velocity due to the pump wave to produce a nonlinear current, driving the whistler. The pump and whistler exert a low frequency ponderomotive force on electrons, driving the lower hybrid decay wave. The growth rate of the parametric instability scales linearly with the amplitude of the pump wave. It decreases with the electron cyclotron frequency. The process is relevant to beam plasma systems where lower hybrid waves are excited with greater ease and the whistler sideband wave can be seen outside the plasma as electromagnetic emission.

Research paper thumbnail of Toxic Epidermal Necrolysis Induced by Diclofenac Sodium in a Dental Patient: A Case Report

Diclofenac sodium is a widely prescribed non-steroidal anti-inflammatory drug in dental practice.... more Diclofenac sodium is a widely prescribed non-steroidal anti-inflammatory drug in dental practice. Propionic acid derivatives and oxicams have been reported to be associated with erythema multiforme and Steven-Johnson syndrome. Here the authors present a rare case report of toxic epidermal necrolysis (TEN) induced by diclofenac sodium. The patient presented in dental clinic with toothache for which planned tooth extraction was done under antibiotic cover. Post extraction, patient was prescribed diclofenac sodium (50 mg b.i.d) for 3 days. The patient reported with generalized pruritic rashes with exfoliated skin to the extent of > 25%. Diclofenac was stopped promptly. The clinical condition of patient was monitored and multidisciplinary management was done to tackle emergency. No rechallenge was given. Although diclofenac sodium-induced TEN is a rare adverse effect, physicians and dentists must be careful prescribing diclofenac due to its life threatening adverse drug effect.

Research paper thumbnail of Impact of domestic air pollution from cooking fuel on respiratory allergies in children in India

Asian Pacific Journal of Allergy and Immunology Launched By the Allergy and Immunology Society of Thailand, 2009

This study undertaken in India was aimed at identifying the effects of the indoor air pollutants ... more This study undertaken in India was aimed at identifying the effects of the indoor air pollutants SO 2 , NO 2 and total suspended particulate mater (SPM) generated from fuel used for cooking on respiratory allergy in children in Delhi. A total of 3,456 children were examined (59.2% male and 40.8% female). Among these, 31.2% of the children's families were using biomass fuels for cooking and 68.8% were using liquefied petroleum gas. Levels of indoor SO 2 , NO 2 and SPM, measured using a Handy Air Sampler (Low Volume Sampler), were 4.60 ± 5.66 μg/m 3 , 30.70 ± 23.95 μg/m 3 and 705 ± 441.6 μg/m 3 , respectively. The mean level of indoor SO 2 was significantly higher (p = 0.016) for families using biomass fuels (coal, wood, cow dung cakes and kerosene) for cooking as compared to families using LP gas. The mean level of indoor NO 2 for families using biomass fuels for cooking was significantly higher in I.T.O. (p = 0.003) and Janakpuri (p = 0.007), while indoor SPM was significantly higher in Ashok Vihar (p = 0.039) and I.T.O. (p = 0.001), when compared to families using LP gas. Diagnoses of asthma, rhinitis and upper respiratory tract infection (URTI) were made in 7.7%, 26.1% and 22.1% of children, respectively. Respiratory allergies in children, which included asthma, rhinitis and URTI, could be associated with both types of fuels (liquefied petroleum gas [LPG] and biomass) used for cooking in the different study areas. This study suggests that biomass fuels increased the concentrations of indoor air pollutants that cause asthma, rhinitis and URTI in children. LP gas smoke was also associated with respiratory allergy.

Research paper thumbnail of Efficient regular expression pattern matching for network intrusion detection systems using modified word-based automata

Proceedings of the Fifth International Conference on Security of Information and Networks, Oct 25, 2012

Research paper thumbnail of Endothelial cells expressing Bcl-2 promote tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion

Laboratory Investigation, 2008

Research paper thumbnail of Barriers to Career Development of Doctors in District Hospitals

In hospital doctors are the key human resource for providing the health care services to patients... more In hospital doctors are the key human resource for providing the health care services to patients. Doctors are not only health care providers but they also fulfill the role of managers and leaders in health care organizations.

Research paper thumbnail of Implications of electron acceleration for high-energy radiation from gamma-ray bursts

In recent work we suggested that photons of energy >100 MeV detected from GRBs by the Fermi Satel... more In recent work we suggested that photons of energy >100 MeV detected from GRBs by the Fermi Satellite are produced via synchrotron emission in the external forward shock with a weak magnetic field - consistent with shock compressed upstream magnetic field of a few tens of micro-Gauss. Here we investigate whether electrons can be accelerated to energies such that they radiate synchrotron photons with energy up to about 10 GeV in this particular scenario. We do this using two methods: (i) we check if these electrons can be confined to the shock front; and (ii) we calculate radiative losses while they are being accelerated. We find that these electrons remain confined to the shock front, as long as the upstream magnetic field is >~ 10 micro-Gauss, and don't suffer substantial radiative losses, the only condition required is that the external reverse shock emission be not too bright: peak flux less than 1 Jy in order to produce photons of 100 MeV, and less than ~100 mJy for producing 1-GeV photons. We also find that the acceleration time for electrons radiating at 100 MeV is a few seconds (in observer frame), and the acceleration time is somewhat longer for electrons radiating at a few GeV. This could explain the lack of >100 MeV photons for the first few seconds after the trigger time for long GRBs reported by the Fermi Satellite, and also the slight lag between photons of GeV and 100 MeV energies. We model the onset of the external forward shock light curve in this scenario and find it consistent with the sharp rise observed in the 100-MeV light curve of GRB080916C and similar bursts.

Research paper thumbnail of Tortricids (Lepidoptera: Tortricidae) as new records from North-West Shivaliks (India)

Journal of Entomological Research, 2008

Page 1. www.IndianJournals.com Members Copy, Not for Commercial Sale Downloaded From IP - 66.249.... more Page 1. www.IndianJournals.com Members Copy, Not for Commercial Sale Downloaded From IP - 66.249.67.58 on dated 8-Jan-2011 J. ent. Res., 32 (4) : 349-354 (2008) Tortricids (Lepidoptera: Tortricidae) as new records from North-West Shivaliks (India) ...

Research paper thumbnail of Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

Int J Obesity, 1999

Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The b... more Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The basis for this atherogenic property of Lp(a) and the factors that influence its cross-population levels, however, remain poorly understood. To investigate the relationship between serum Lp(a) and metabolic and anthropometric parameters in a healthy Kuwaiti population. Cross-sectional study. 177 (72 male, 105 female) randomly recruited healthy Kuwait Arabs aged 17-60 y Metabolic parameters in serum: Lp(a), apo(a) phenotypes, lipids and lipoproteins, glucose and urate. Anthropometric parameters: body mass index (BMI) and waist:hip-ratio (WHR). The distribution of Lp(a) concentrations was positively skewed (median 153 mg/l, range 0-1086). Women had higher concentrations-(194, 0-1086) than men (117, 0-779), P = 0.069. Lp(a) and insulin concentrations were significantly higher when the men and women were obese. In all subjects, there were significant correlations between Lp(a) and BMI (r = 0.23), total cholesterol (TC) (r = 0.17) and LDL (r = 0.20). Lp(a) correlated only with glucose in men (r = 0.28). In women it correlated with age (r = 0.20), BMI (r = 0.30), BP (r = 0.20), TC (r = 0.20) and LDL (r = 0.26). Multivariate analyses confirmed BMI and low-density lipoprotein (LDL) as the significant determinants of serum Lp(a). On apo (a) phenotyping, 114 (67%), 51 (30%) and 6 (4%) had single, double and null phenotypes respectively. The isoforms and their corresponding kringle IV repeat numbers were: F (14 repeats in 3%, mean Lp(a) 497 mg/l); S1 (19 repeats in 14%, mean 245 mg/l); S2 (23 repeats in 16%, mean 264 mg/l); S3 (27 repeats in 35%, mean 236 mg/l); and S4 (35 repeats in 28%, mean 235 mg/l). The results from the Kuwaiti population studied suggest that: (1) serum Lp(a) concentrations and distribution are similar to the pattern in Caucasians and Asians but not African-Americans or Africans; (2) serum Lp(a) is variably influenced by BMI and LDL--the impact of either factor differs between the sexes; (3) there is a high frequency of the single-banded phenotype; (4) contrary to reports in some Caucasian and Asian populations, there is no simple relationship between kringle IV repeat numbers and plasma Lp(a) concentrations.

Research paper thumbnail of Effect of Environmental Conditions on Single and Double Diode PV System : A Comparative Study

In this paper, a single and a double/bypass diode based photovoltaic (PV) systems are designed in... more In this paper, a single and a double/bypass diode based photovoltaic (PV) systems are designed in MATLAB/Simulink GUI environment based on mathematical modeling of above PV systems. A detailed comparative study of transient analysis for single and double/bypass PV systems has been done with a RL load. The effect of realistic conditions i.e. variable wind speed and irradiation level on single and double/bypass diode PV system is investigated, the obtained results show the satisfactory performance for realistic model of PV system. Keywords—Solar photovoltaic system, Single diode PV system, Double/bypass diode PV system, Realistic PV system, Green energy.

Research paper thumbnail of In-situ Exchange Bias Study of Co/CoO/Co/CoO Multilayer Structure

ABSTRACT The exchange bias property has been studied in the multilayer structure (Co/CoO/Co/CoO).... more ABSTRACT The exchange bias property has been studied in the multilayer structure (Co/CoO/Co/CoO). The multilayer structure is characterized in-situ using RHEED, XRR and MOKE techniques during its growth. Independent magnetic contribution of top and bottom Co layers has been separated out by fitting hysteresis loop with an adequate mathematical function.

Research paper thumbnail of Advanced MRI Techniques in the Evaluation of Complex Cystic Breast Lesions

Breast cancer : basic and clinical research, 2016

The purpose of this research work was to evaluate complex cystic breast lesions by advanced MRI t... more The purpose of this research work was to evaluate complex cystic breast lesions by advanced MRI techniques and correlating imaging with histologic findings. In a cross-sectional design from September 2013 to August 2015, 50 patients having sonographically detected complex cystic lesions of the breast were included in the study. Morphological characteristics were assessed. Dynamic contrast-enhanced MRI along with diffusion-weighted imaging and MR spectroscopy were used to further classify lesions into benign and malignant categories. All the findings were correlated with histopathology. Of the 50 complex cystic lesions, 32 proved to be benign and 18 were malignant on histopathology. MRI features of heterogeneous enhancement on CE-MRI (13/18), Type III kinetic curve (13/18), reduced apparent diffusion coefficient (18/18), and tall choline peak (17/18) were strong predictors of malignancy. Thirteen of the 18 lesions showed a combination of Type III curve, reduced apparent diffusion coe...

Research paper thumbnail of Higher Order Aberrations and Visual Outcomes in Wavefront-Optimized Sub-Bowman’s Keratomileusis

Asia-Pacific Journal of Ophthalmology, 2015

The aim of this study was to compare the outcomes of wavefront-optimized sub-Bowman keratomileusi... more The aim of this study was to compare the outcomes of wavefront-optimized sub-Bowman keratomileusis (SBK) performed using the 150 KHz IntraLase femtosecond (IFS) laser (Abbot Medical Optics) with those using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome (Moria SA). A prospective comparative clinical trial. Fifty patients had bilateral wavefront-optimized SBK performed for myopia or myopic astigmatism. In 25 patients, the flap was created with the 150 KHz IFS laser (group 1) and in the other 25 with the Moria One Use-Plus SBK mechanical microkeratome (group 2). All other treatment parameters were the same. Results were reported for 1 eye per patient in each group (ie, 25 eyes in each group). Efficacy, refractive stability, predictability, and safety profiles were comparable between the 2 groups. Although higher order aberrations (HOAs) increased significantly in both groups after laser in situ keratomileusis, intergroup comparison revealed that group 1 was associated with a significantly higher induction of both total HOAs [mean root mean square (RMS), 0.63 ± 0.20 in group 1 vs 0.52 ± 0.14 in group 2; P = 0.031] and spherical aberrations (RMS, 0.37 ± 0.17 in group 1 vs 0.22 ± 0.09 in group 2; P < 0.001) as compared with group 2. Flaps created using the Moria Evo 3 One Use-Plus SBK mechanical microkeratome were associated with significantly lower induction of total HOAs and spherical aberrations as compared with 150 KHz IFS flaps at the end of 3 months follow-up.

Research paper thumbnail of Neuropeptide α-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitro

Inflammation Research, 2010

Objective and design a-Melanoycte stimulating hormone (a-MSH), a neuropeptide hormone with report... more Objective and design a-Melanoycte stimulating hormone (a-MSH), a neuropeptide hormone with reported antimicrobial and immuno-modulatory properties in vitro, has previously been detected in the cerebrospinal fluid of children with bacterial meningitis. We investigated the therapeutic effects of a-MSH administration on Neisseria meningitidis infection of human meningeal cell cultures in vitro. Materials and methods Meningeal cell lines (n = 2) were infected with meningococci (10 2 -10 8 cfu/monolayer), isolated bacterial outer membranes (OM; 1 lg/ml) or lipooligosaccharide (LOS; 1 lg/ml) with and without a-MSH (10 -5 -10 lM). Bacterial adherence was quantified at 6 h, and cytokine production and microbicidal activity of a-MSH for meningococci were assessed at 24 h. Results Compared with infection by meningococci alone, a-MSH (10 lM) up-regulated secretion of IL-6 and IL-8 (mean values increased from *33 to 60 ng/ml), RANTES (mean values increased from *26 to 105 ng/ml) and GM-CSF (mean values increased from *0.3 to 1 ng/ml; P \ 0.05). Upregulated secretion correlated with a neuropeptide-mediated rapid and [5-fold increase (P \ 0.05) in bacterial adherence to cells and was dependent on OM components including LOS acting synergistically with a-MSH. Meningococci were resistant to the anti-microbial activity of a-MSH at all concentrations tested. Conclusions Our study demonstrates that a potentially therapeutic neuropeptide exerts pro-inflammatory effects during meningococcal infection in vitro and its use in the treatment of meningitis is contra-indicated.

Research paper thumbnail of Taxonomic studies of genus Opogona Zeller (Lepidoptera: Tineidae) with brief account of wing venation and genitalia

Journal of Insect Science, 2009

Research paper thumbnail of Midgut serine proteases and alternative host plant utilization in Pieris brassicae L

Frontiers in Physiology, 2015

Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larv... more Pieris brassicae L. is a serious pest of cultivated crucifers in several parts of the world. Larvae of P. brassicae also feed prolifically on garden nasturtium (Tropaeolum majus L., of the family Tropaeolaceae). Proteolytic digestion was studied in larvae feeding on multiple hosts. Fourth instars were collected from cauliflower fields before transfer onto detached, aerial tissues of selected host plants in the lab. Variable levels of midgut proteases were detected in larvae fed on different hosts using protein substrates (casein and recombinant RBCL cloned from cauliflower) and diagnostic, synthetic substrates. Qualitative changes in midgut trypsin activities and quantitative changes in midgut chymotrypsin activities were implicated in physiological adaptation of larvae transferred to T. majus. Midgut proteolytic activities were inhibited to different extents by serine protease inhibitors, including putative trypsin inhibitors isolated from herbivore-attacked and herbivore-free leaves of cauliflower (CfTI) and T. majus (TpTI). Transfer of larvae to T. majus significantly influenced feeding parameters but not necessarily when transferred to different tissues of the same host. Results obtained are relevant for devising sustainable pest management strategies, including transgenic approaches using genes encoding plant protease inhibitors.

Research paper thumbnail of A Ready-to-Eat Antioxidant Rich Appetizer Based on Coleus aromaticus : Its Development and Shelf Life Evaluation

Journal of Food Processing, 2014

Antioxidant rich products are valued due to their health benefits and appetizers are required in ... more Antioxidant rich products are valued due to their health benefits and appetizers are required in several pathological and geographical stress situations such as prolonged exposure to altitude. The paper deals with the development of a shelf stable RTE (ready-to-eat) antioxidant rich herbal appetizer convenient to the consumer. Using ginger and Karpurvalli (Coleus aromaticus) as two independent variables, a central composite design with 13 experimental combinations was obtained. These combinations were processed by concentration and dehydration into the appetizer RTE munches using preprocessed ingredients and evaluated for antioxidant activity, vitamin C, and sensory characteristics. The product optimized using Design Expert Statistical Software had the proximate composition of 11.4% fat, 2.3% protein, and 75.0% carbohydrates, supplying about 82.36 Kcals per munch of 20 g. The munches packed in metalized polyester pouches had a shelf life of 10 months at 28 ± 5 ∘ C as well as 37 ∘ C storage. The RTE appetizer based on Coleus aromaticus was developed with excellent sensory properties and shelf stability.

Research paper thumbnail of Utilization of Energy Sources in Hybrid PV/FC Power Assisted Water Pumping System

2015 Ieee International Conference on Computational Intelligence Communication Technology, Feb 1, 2015

In this paper, the mathematical analysis of solar photovoltaic (PV) system and proton exchange me... more In this paper, the mathematical analysis of solar photovoltaic (PV) system and proton exchange membrane fuel cell (PEMFC) system is presented. The renewable energy (RE) sources e.g. PV system and PEMFC are integrated for hybrid PV/FC power generation. The PV system is considered as primary electrical power generating RE source, and the PEMFC is utilized as power backup source in unfavorable environmental conditions of PV system. Furthermore, in cloudy days, the solar PV system is not capable to generate sufficient power to the load applications due to this a PEMFC can be utilized for power generation. For transient analysis of this hybrid PV/FC power generating system, a water pump load is considered. A Fuzzy logic based maximum power point tracking (MPPT) technique is proposed to achieve maximum power point (MPP) through the PV system. A three phase induction motor (IM) is taken for water pumping system (WPS) application and the complete proposed system is designed in MATLAB/Simulink environment.

Research paper thumbnail of State Merging in LR Parser under Count based Reduction

International Journal of Computer Applications, Aug 20, 2014

An LR parser shows error only during scanning input symbol. Error is never shown during the reduc... more An LR parser shows error only during scanning input symbol. Error is never shown during the reduction of a handle (substring of stack) into nonterminal. It is because a symbol is put into the stack only when it is guaranteed to be the correct one. If the method of reduction of a handle is known then errors can also be shown during reduction. Hence a wrong symbol can be shifted on the stack and error can be detected during reduce operation. It may permit the merging of few states. The simplest type of reduction scheme is to remove few symbols (the number of symbols equal to the length of the handle) from the top of the stack and push the corresponding nonterminal on the stack. In this paper, a state merging scheme is proposed under this method of reduction.

Research paper thumbnail of Unique fixed point theorems on generalized cone metric spaces

Advances in Inequalities and Applications, Apr 18, 2014

Research paper thumbnail of Parametric conversion of a lower hybrid wave into a whistler in a plasma

Physics of Plasmas, May 1, 2008

A large amplitude lower hybrid wave parametrically decays into a whistler wave and a low frequenc... more A large amplitude lower hybrid wave parametrically decays into a whistler wave and a low frequency lower hybrid wave in a plasma. The density perturbation due to the low frequency wave couples with the oscillatory velocity due to the pump wave to produce a nonlinear current, driving the whistler. The pump and whistler exert a low frequency ponderomotive force on electrons, driving the lower hybrid decay wave. The growth rate of the parametric instability scales linearly with the amplitude of the pump wave. It decreases with the electron cyclotron frequency. The process is relevant to beam plasma systems where lower hybrid waves are excited with greater ease and the whistler sideband wave can be seen outside the plasma as electromagnetic emission.

Research paper thumbnail of Toxic Epidermal Necrolysis Induced by Diclofenac Sodium in a Dental Patient: A Case Report

Diclofenac sodium is a widely prescribed non-steroidal anti-inflammatory drug in dental practice.... more Diclofenac sodium is a widely prescribed non-steroidal anti-inflammatory drug in dental practice. Propionic acid derivatives and oxicams have been reported to be associated with erythema multiforme and Steven-Johnson syndrome. Here the authors present a rare case report of toxic epidermal necrolysis (TEN) induced by diclofenac sodium. The patient presented in dental clinic with toothache for which planned tooth extraction was done under antibiotic cover. Post extraction, patient was prescribed diclofenac sodium (50 mg b.i.d) for 3 days. The patient reported with generalized pruritic rashes with exfoliated skin to the extent of > 25%. Diclofenac was stopped promptly. The clinical condition of patient was monitored and multidisciplinary management was done to tackle emergency. No rechallenge was given. Although diclofenac sodium-induced TEN is a rare adverse effect, physicians and dentists must be careful prescribing diclofenac due to its life threatening adverse drug effect.

Research paper thumbnail of Impact of domestic air pollution from cooking fuel on respiratory allergies in children in India

Asian Pacific Journal of Allergy and Immunology Launched By the Allergy and Immunology Society of Thailand, 2009

This study undertaken in India was aimed at identifying the effects of the indoor air pollutants ... more This study undertaken in India was aimed at identifying the effects of the indoor air pollutants SO 2 , NO 2 and total suspended particulate mater (SPM) generated from fuel used for cooking on respiratory allergy in children in Delhi. A total of 3,456 children were examined (59.2% male and 40.8% female). Among these, 31.2% of the children's families were using biomass fuels for cooking and 68.8% were using liquefied petroleum gas. Levels of indoor SO 2 , NO 2 and SPM, measured using a Handy Air Sampler (Low Volume Sampler), were 4.60 ± 5.66 μg/m 3 , 30.70 ± 23.95 μg/m 3 and 705 ± 441.6 μg/m 3 , respectively. The mean level of indoor SO 2 was significantly higher (p = 0.016) for families using biomass fuels (coal, wood, cow dung cakes and kerosene) for cooking as compared to families using LP gas. The mean level of indoor NO 2 for families using biomass fuels for cooking was significantly higher in I.T.O. (p = 0.003) and Janakpuri (p = 0.007), while indoor SPM was significantly higher in Ashok Vihar (p = 0.039) and I.T.O. (p = 0.001), when compared to families using LP gas. Diagnoses of asthma, rhinitis and upper respiratory tract infection (URTI) were made in 7.7%, 26.1% and 22.1% of children, respectively. Respiratory allergies in children, which included asthma, rhinitis and URTI, could be associated with both types of fuels (liquefied petroleum gas [LPG] and biomass) used for cooking in the different study areas. This study suggests that biomass fuels increased the concentrations of indoor air pollutants that cause asthma, rhinitis and URTI in children. LP gas smoke was also associated with respiratory allergy.

Research paper thumbnail of Efficient regular expression pattern matching for network intrusion detection systems using modified word-based automata

Proceedings of the Fifth International Conference on Security of Information and Networks, Oct 25, 2012

Research paper thumbnail of Endothelial cells expressing Bcl-2 promote tumor metastasis by enhancing tumor angiogenesis, blood vessel leakiness and tumor invasion

Laboratory Investigation, 2008

Research paper thumbnail of Barriers to Career Development of Doctors in District Hospitals

In hospital doctors are the key human resource for providing the health care services to patients... more In hospital doctors are the key human resource for providing the health care services to patients. Doctors are not only health care providers but they also fulfill the role of managers and leaders in health care organizations.

Research paper thumbnail of Implications of electron acceleration for high-energy radiation from gamma-ray bursts

In recent work we suggested that photons of energy >100 MeV detected from GRBs by the Fermi Satel... more In recent work we suggested that photons of energy >100 MeV detected from GRBs by the Fermi Satellite are produced via synchrotron emission in the external forward shock with a weak magnetic field - consistent with shock compressed upstream magnetic field of a few tens of micro-Gauss. Here we investigate whether electrons can be accelerated to energies such that they radiate synchrotron photons with energy up to about 10 GeV in this particular scenario. We do this using two methods: (i) we check if these electrons can be confined to the shock front; and (ii) we calculate radiative losses while they are being accelerated. We find that these electrons remain confined to the shock front, as long as the upstream magnetic field is >~ 10 micro-Gauss, and don't suffer substantial radiative losses, the only condition required is that the external reverse shock emission be not too bright: peak flux less than 1 Jy in order to produce photons of 100 MeV, and less than ~100 mJy for producing 1-GeV photons. We also find that the acceleration time for electrons radiating at 100 MeV is a few seconds (in observer frame), and the acceleration time is somewhat longer for electrons radiating at a few GeV. This could explain the lack of >100 MeV photons for the first few seconds after the trigger time for long GRBs reported by the Fermi Satellite, and also the slight lag between photons of GeV and 100 MeV energies. We model the onset of the external forward shock light curve in this scenario and find it consistent with the sharp rise observed in the 100-MeV light curve of GRB080916C and similar bursts.

Research paper thumbnail of Tortricids (Lepidoptera: Tortricidae) as new records from North-West Shivaliks (India)

Journal of Entomological Research, 2008

Page 1. www.IndianJournals.com Members Copy, Not for Commercial Sale Downloaded From IP - 66.249.... more Page 1. www.IndianJournals.com Members Copy, Not for Commercial Sale Downloaded From IP - 66.249.67.58 on dated 8-Jan-2011 J. ent. Res., 32 (4) : 349-354 (2008) Tortricids (Lepidoptera: Tortricidae) as new records from North-West Shivaliks (India) ...

Research paper thumbnail of Metabolic and anthropometric determinants of serum Lp(a) concentrations and Apo(a) polymorphism in a healthy Arab population

Int J Obesity, 1999

Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The b... more Blood lipoprotein(a) Lp(a) concentrations are an important risk factor for atherosclerosis. The basis for this atherogenic property of Lp(a) and the factors that influence its cross-population levels, however, remain poorly understood. To investigate the relationship between serum Lp(a) and metabolic and anthropometric parameters in a healthy Kuwaiti population. Cross-sectional study. 177 (72 male, 105 female) randomly recruited healthy Kuwait Arabs aged 17-60 y Metabolic parameters in serum: Lp(a), apo(a) phenotypes, lipids and lipoproteins, glucose and urate. Anthropometric parameters: body mass index (BMI) and waist:hip-ratio (WHR). The distribution of Lp(a) concentrations was positively skewed (median 153 mg/l, range 0-1086). Women had higher concentrations-(194, 0-1086) than men (117, 0-779), P = 0.069. Lp(a) and insulin concentrations were significantly higher when the men and women were obese. In all subjects, there were significant correlations between Lp(a) and BMI (r = 0.23), total cholesterol (TC) (r = 0.17) and LDL (r = 0.20). Lp(a) correlated only with glucose in men (r = 0.28). In women it correlated with age (r = 0.20), BMI (r = 0.30), BP (r = 0.20), TC (r = 0.20) and LDL (r = 0.26). Multivariate analyses confirmed BMI and low-density lipoprotein (LDL) as the significant determinants of serum Lp(a). On apo (a) phenotyping, 114 (67%), 51 (30%) and 6 (4%) had single, double and null phenotypes respectively. The isoforms and their corresponding kringle IV repeat numbers were: F (14 repeats in 3%, mean Lp(a) 497 mg/l); S1 (19 repeats in 14%, mean 245 mg/l); S2 (23 repeats in 16%, mean 264 mg/l); S3 (27 repeats in 35%, mean 236 mg/l); and S4 (35 repeats in 28%, mean 235 mg/l). The results from the Kuwaiti population studied suggest that: (1) serum Lp(a) concentrations and distribution are similar to the pattern in Caucasians and Asians but not African-Americans or Africans; (2) serum Lp(a) is variably influenced by BMI and LDL--the impact of either factor differs between the sexes; (3) there is a high frequency of the single-banded phenotype; (4) contrary to reports in some Caucasian and Asian populations, there is no simple relationship between kringle IV repeat numbers and plasma Lp(a) concentrations.