Payal Deepak - Academia.edu (original) (raw)

Papers by Payal Deepak

International journal of pharmaceutics, Mar 1, 2024

International Journal of Nanomedicine, Oct 31, 2023

DOAJ (DOAJ: Directory of Open Access Journals), Oct 1, 2013

International Journal of Pharmaceutics

CRC Press eBooks, Mar 21, 2023

Leflunomide is a disease modifying anti-rheumatic drug (DMARD), which effectively reduces the sig... more Leflunomide is a disease modifying anti-rheumatic drug (DMARD), which effectively reduces the signs and symptoms of active rheumatoid arthritis (RA) in adults, while inhibiting joint damage and improving physical function. Direct compression was employed for the formulation of tablets. The powder blends of different tablet formulations were screened for preformulation studies like angle of repose, loose bulk density, tapped density, compressibility index and hausner’s ratio. The tablets were tested for physical characteristics such as thickness, hardness, friability, weight variation and drug content. The matrix swelling behavior was also investigated. As the time increases, the swelling index was increased; later on it decreases gradually due to dissolution of outermost gelled layer of tablet into dissolution medium. All the evaluated physical parameters of the fabricated tablets were found to be within the acceptable limits.

INDONESIAN JOURNAL OF PHARMACY, 2013

Polymeric micelles (PMs) have been the most popular and promising topic of many researches in the... more Polymeric micelles (PMs) have been the most popular and promising topic of many researches in the field of drug delivery and targeting for the past two decades. Polymeric micelles are the selfassembled nano-sized colloidal particles which are made up of amphiphilic block copolymers i.e. polymers consisting of hydrophobic block and hydrophilic block. In this highlight, we give an overview of the structure of micelles and polymeric micelles followed by a summary of the methods used for their preparation. We then focus on several kinds of PMs based on intermolecular forces such as polyion complex micelles (PICMs), non-covalently connected micelles (NCCMs) and recently developed smart polymeric assemblies which can respond to the application of external stimuli such as a change in temperature, pH, redox and light to afford novel nanomaterials. The types of polymers used in the preparation of PMs have also been highlighted so as to facilitate its use in drug delivery and targeting. These...

International Journal of Biological Macromolecules, 2021

Electrospinning is emerging as a versatile technique nanofibers fabrication because due to their ... more Electrospinning is emerging as a versatile technique nanofibers fabrication because due to their unique properties such as large surface area to volume ratio, porosity and maintaining moist wound environment, the nanofibers are able to deliver sustained drug release and oxygen to the wound for rapid healing of diabetic wound. The present work was aimed to prepare and evaluate silk fibroin-curcumin based nanofiber in combination with polycaprolactone (PCL) and polyvinyl alcohol (PVA) which helped to strengthen the wound healing properties of nanofiber. Silk fibroin is a naturally occurring polymer was selected one polymer for making nanofibrous mat due to its unique properties such as biodegradability, permeability, oxygen supply and maintain moisture content in the wound. SEM results showed diameters of fibers varied in the range between 200 and 350 nm and their tensile strength ranged from 12.41 to 16.80 MP. The nanofibers were causing sustained release of curcumin for many hours. The in-vivo wound healing studies in streptozotocin-induced diabetic mice showed rapid wound healing efficacy as compared to conventional formulations. Furthermore, the histopathological studies evidenced its ability to restore the normal skin structure and histological conditions of tissues. The silk fibroin-based nanofiber wound dressing, therefore appears to be an ideal preparation, in combination with curcumin, because it blends the anti-oxidant, anti-inflammatory properties of curcumin. Therefore, it was concluded that the silk fibroin-based nanofiber loaded with curcumin has great healing potential in diabetic wound.

Current Drug Delivery, 2021

Cardiovascular diseases cover various disorders like ischemic heart disease, hyperlipidemia, athe... more Cardiovascular diseases cover various disorders like ischemic heart disease, hyperlipidemia, atherosclerosis, myocardial infarction, hypertension, etc. There are many synthetic drugs available for the treatment of cardiovascular therapy. However, they have several drawbacks like high dosing, toxicity, elevated blood potassium levels, low blood pressure, gastrointestinal issues, etc. To overcome these side effects of synthetic drugs, targeting the drug to the specific cardiac tissue is the best novel method in cardiovascular therapy. The highest targeting efficacy of ligand- based therapy with proper mechanisms and improved expandability provides a novel therapeutic strategy in cardiovascular diseases. Ligand therapy is more cost-effective compared to cell- based therapy. The surface area of protein is much larger than the orally bioavailable drug. Therefore, the targeting of various less active drug molecules to the particular ligand can be possible. The efficacy of ligands to induc...

Journal of Drug Delivery Science and Technology, 2020

The present research work focuses on the fabrication and in vitro characterization of leflunomide... more The present research work focuses on the fabrication and in vitro characterization of leflunomide loaded sustained release matrix tablets using different concentration of hydrophilic polymer, hydrophobic polymer and a combination of both. Leflunomide is a disease modifying anti-rheumatic drug (DMARD). Direct compression method was employed for the formulation of tablets. The powder blends of different tablet formulations were screened for preformulation studies like angle of repose, loose bulk density, tapped density, compressibility index and hausner's ratio. The tablets were tested for physical characteristics such as thickness, hardness, friability, weight variation and drug content. The matrix swelling behavior was also investigated. All the evaluated physical parameters of the fabricated tablets were found to be within the acceptable limits. All the formulations showed good matrix integrity and retarded the release of drug at the end of 24 h. In vitro drug release studies (...