Peng Huan - Academia.edu (original) (raw)
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CSIC (Consejo Superior de Investigaciones CientÃficas-Spanish National Research Council)
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Polymer cross-linking was explored as an approach for increasing the relaxivity of macromolecular... more Polymer cross-linking was explored as an approach for increasing the relaxivity of macromolecular contrast agents for magnetic resonance imaging. Poly(ethylene glycol) methyl ether methacrylate, N-(2-aminoethyl) methacrylamide hydrochloride, and the cross-linker ethylene glycol dimethacrylate were copolymerized under free radical conditions. By tuning the cross-linker content and reaction concentration, it was possible to obtain 10 nm nanogels in a single synthetic step. The pendant amine moieties were functionalized with an isothiocyanate derivative of diethylenetriaminepentaacetic acid (DTPA) and Gd(III) was chelated. In comparison with a linear control polymer prepared under the same conditions in the absence of the cross-linking agent, the nanogel contrast agent did exhibit enhanced relaxivity with an r 1 of 20.8 AE 0.2 at 20 MHz and 17.5 AE 0.4 at 60 MHz (corresponding to the clinical field strength of 1.5 T).
Polymer cross-linking was explored as an approach for increasing the relaxivity of macromolecular... more Polymer cross-linking was explored as an approach for increasing the relaxivity of macromolecular contrast agents for magnetic resonance imaging. Poly(ethylene glycol) methyl ether methacrylate, N-(2-aminoethyl) methacrylamide hydrochloride, and the cross-linker ethylene glycol dimethacrylate were copolymerized under free radical conditions. By tuning the cross-linker content and reaction concentration, it was possible to obtain 10 nm nanogels in a single synthetic step. The pendant amine moieties were functionalized with an isothiocyanate derivative of diethylenetriaminepentaacetic acid (DTPA) and Gd(III) was chelated. In comparison with a linear control polymer prepared under the same conditions in the absence of the cross-linking agent, the nanogel contrast agent did exhibit enhanced relaxivity with an r 1 of 20.8 AE 0.2 at 20 MHz and 17.5 AE 0.4 at 60 MHz (corresponding to the clinical field strength of 1.5 T).