Perola Plapler - Academia.edu (original) (raw)
Papers by Perola Plapler
Revista da Associação Médica Brasileira
Women and men can have the same illnesses, but with different prevalence and reactions to symptom... more Women and men can have the same illnesses, but with different prevalence and reactions to symptoms. OBJECTIVE: This study aimed to emphasize that distinct traits between men and women require a different approach for each of them. METHODS: PubMed and Google Scholar were searched using the following terms: Disability Evaluations, Women's health, Osteoporosis, Osteoarthritis, and Lymphedema, Pregnancy. RESULTS/CONCLUSION: Disease management can go beyond the symptoms, assessing the long-term consequences and possibly the disabilities they can generate, compromising the quality of life of the person, his/her family members, and eventually caregivers.
SPRINGER LONDON LTD, 2018
Diário Oficial do Estado de São Paulo. Poder Executivo - Seção II, 2017
Current Rheumatology Reports, 2021
Purpose of ReviewOsteoarthritis (OA) is the most common forms of arthritis in the general populat... more Purpose of ReviewOsteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure.Recent FindingsThis article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly ...
Clinics, 2019
Osteoarthritis (OA) or osteoarthrosis is a low-grade, progressive inflammatory disease that may e... more Osteoarthritis (OA) or osteoarthrosis is a low-grade, progressive inflammatory disease that may entail joint degeneration (1) that affects all joint structures, notably the cartilage of synovial joints. OA evolves into joint insufficiency, characterized by changes in articular cartilage, with fibrillation and fissure zones, microfractures, cysts, subchondral sclerosis and formation of osteophytes on joint edges. These changes lead to chronic pain and functional constraints of the affected joints, in addition to the physical and psychological sequelae that often manifest in individuals with OA, causing greatly reduced quality of life. OA is the most common joint disease (2,3) and affects mainly the knees, hips, hands and feet. In the USA, it is estimated that 36.4% of individuals over 60 years old have OA in their knees (4). This disease of great medical and economic importance is responsible for the inability to perform labor in approximately 15% of the adult population of the world. In Brazil, OA is currently the third most common disease of those who are insured for Social Security and receiving disease aid, corresponding to 65% of the
Rev Hosp Clin Fac Med Univ Sao Paulo, Jun 1, 1997
Osteoporose e a alteracao metabolica mais frequente acometendo ossos e e uma das doencas mais com... more Osteoporose e a alteracao metabolica mais frequente acometendo ossos e e uma das doencas mais comuns em mulheres apos a menopausa. Pode ser definida como uma condicao clinica, na qual existe uma perda ossea significativa, com uma reducao da massa ossea alem da considerada normal para pacientes da mesma idade e sexo, comprometendo a integridade do arcabouco osseo, diminuindo sua resistencia e propiciando fraturas dos ossos acometidos, mesmo aos minimos esforcos. E considerada como uma doenca silenciosa ate que surgem as primeiras fraturas. A prevencao e fundamental, assim como o tratamento de reabilitacao, associado ao tratamento medicamentoso. Os exercicios fisicos sao importantes nao so na prevencao da propria osteoporose, assim como na prevencao de quedas que podem levar a fraturas
Acta Fisiátrica, 2015
Osteoarthritis is the most common articular disease that causes pain to its sufferers. Shockwave ... more Osteoarthritis is the most common articular disease that causes pain to its sufferers. Shockwave therapy is among the many treatments that can be used. Objective: The objective of this study was to observe the influence of shockwave therapy on the intensity of pain in elderly women with knee OA. Method: In this study, 40 elderly females (69.57 ± 6.42 years) were submitted to weekly shockwave therapy with 2000 impulses at 2.5 to 4.0 bar, at a frequency of 8Hz, at the location most painful to touch in the knee, the medial articular interline, for three consecutive weeks. The effect of its application on the pain was evaluated by the visual analogue scale before and after the treatment. Results: There was a significant reduction (p < 0.0001) of pain intensity in the volunteers, going from 7.86 ± 1.07 cm to 5.32 ± 2.26 cm. Conclusion: The application of shockwave therapy has been shown to reduce pain in elderly females with osteoarthritis.
Revista Brasileira de Reumatologia, 2007
Recentes avanços na densitometria clínica têm incorporado novas tecnologias, técnicas de aquisiçã... more Recentes avanços na densitometria clínica têm incorporado novas tecnologias, técnicas de aquisição, aperfeiçoamento dos relatórios, novos bancos de dados e alterações de terminologia. O estabelecimento desses novos conceitos tem implicação na avaliação clínica individual dos pacientes, assim como influência potencial no direcionamento de políticas públicas de saúde. No sentido de clarificar novos conceitos e incorporá-los no dia-a-dia da prática médica em nosso país, a Sociedade Brasileira de Densitometria Clínica (SBDens) periodicamente reúne especialistas para estabelecer recomendações com base em revisões da literatura científica, levando em conta possíveis adaptações às condições próprias brasileiras. Essas recomendações, quando caracterizadas como posições oficiais de uma sociedade médica, têm várias e importantes funções. Em primeiro lugar, artigo origiNal origiNal article
Rev. Hosp. Clin. Fac. Med. …, 1997
Resumo: Foram estudados dois grupos: Grupo I-treze voluntarios normais atletas competitivos do se... more Resumo: Foram estudados dois grupos: Grupo I-treze voluntarios normais atletas competitivos do sexo masculino, idade media: 25+ ou-2, 1 anos (18-30); Grupo 2-dezessete voluntarios, sexo masculino, normais sedentarios, idade media: 31, 2 anos (23-46). Todos ...
... Densitometria Clínica Sociedade Brasileira de Geriatria Sociedade Brasileira do Estudo do Met... more ... Densitometria Clínica Sociedade Brasileira de Geriatria Sociedade Brasileira do Estudo do Metabolismo Ósseo e Mineral Relação dos médicos participantes: Dr. Aarão Mendes Pinto Neto Dr. Alberto Soares Dr. Almir Urbanetz Dr. Antônio Carlos de Araújo e Souza Dr. Antônio ...
… de São Paulo, Vol. São Paulo: …, 1996
... de estu-dar quantitativamente as ondulações da fibra colágena do tendão patelar humano, em ad... more ... de estu-dar quantitativamente as ondulações da fibra colágena do tendão patelar humano, em adultos e crianças, divi-dindo-o em ... e aumentando sua birrefringência, quan-do avaliadas ao microscópio de polarização(9). Foi utilizado um microscópio óptico Carl Zeiss®, para ...
Pain, 1997
This study examined the effects of intravenous administration of sodium amytal (SA), a medium act... more This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root injury (with findings strictly limited to the distribution of the involved nerve) were compared to 15 patients with Complex Regional Pain Syndromes (one of whom had documented nerve injury). The Complex Regional Pain Syndromes (CRPS) patients were characterized by the presence of severe diffuse limb pain and extraterritorial sensory, sudomotor and vasomotor abnormalities (i.e., not confined to the site of injury or the distribution of the injured nerve). The CRPS patients were different from the normal controls and the non-CRPS patients in their tendency to warm significantly many of their limbs (not just the symptomatic ones). SSR were reduced or lost in a few limbs only in all three groups, irrespective of the increase or decrease of limb temperature and the side of symptoms. We argue that the enhanced thermogenic effect of SA in CRPS patients is due to generalized central changes of thermoregulatory control specifically in this group.
Acta Ortopedica Brasileira, 2018
Objetivo: Avaliar o perfil dos pacientes com fraturas osteoporoticas atendidos em hospital de ate... more Objetivo: Avaliar o perfil dos pacientes com fraturas osteoporoticas atendidos em hospital de atendimento terciario ortopedico. Metodos: Setenta pacientes com fraturas osteoporoticas (FO) foram comparados a 50 pacientes acompanhados ambulatorialmente por osteoartrite (OA) atraves de questionarios. Resultados: O grupo FO apresentaram idade media maior (p 1 ano), queda nos ultimos 12 meses, fratura por causa da queda e necessitam de mais auxilio (p < 0,05); menor Lawton & Brody AIVD (Atividades instrumentais da vida diaria, p < 0,05), reportando menos deficiencia de membros inferiores, patologia nos pes, fraqueza muscular, hipotireoidismo e consumo de vitamina D que pacientes do grupo OA. Raca branca, quedas e fraturas previas aumentam o risco de fraturas osteoporoticas em 10,5, 11,4 e 4,1 vezes respectivamente. A chance de fratura reduziu 29% a cada aumento de uma unidade no Lawton & Brody AIVD. Casados fraturam menos que outros estados civis. Conclusao: conjuntamente, a etnia,...
Acta Ortopédica Brasileira
Objective: To evaluate the profile of patients with osteoporotic fractures treated at a tertiary ... more Objective: To evaluate the profile of patients with osteoporotic fractures treated at a tertiary orthopedic hospital. Methods: Using questionnaires, 70 patients with osteoporotic fractures (OF) were compared with 50 outpatients with multiple osteoarthritis (OA) followed through an outpatient clinic. Results: The OF group was older (p <0.001), less heavy (p=0.003), had lower BMI (p=0.006), was more likely to be white (p=0.011), was less likely to be married (p=0.008), and had previous falls, previous fractures, old fractures (>1 year), falls in the last 12 months, fractures due to falls, and needed more assistance (p<0.05). They also had lower Lawton & Brody Instrumental Activities of Daily Living scores (p <0.05) and reported less lower limb disability, foot pathology, muscle weakness, hypothyroidism, and vitamin D intake than patients in the OA group. White race, previous falls, and previous fractures increase the risk of osteoporotic fractures by 10.5, 11.4, and 4.1 ti...
Journal of Pain Research
Traditionally, musculoskeletal pain management has focused on the use of conventional treatments ... more Traditionally, musculoskeletal pain management has focused on the use of conventional treatments to relieve pain. However, multi-modal integrative medicine including alternative/complementary treatments is becoming more widely used and integrated into treatment guidelines around the world. The uptake of this approach varies according to country, with generally a higher uptake in developed countries and in females aged more than 40 years. Integral to the concept described here, is that the body has an innate ability to selfheal, which can be optimized by the use of integrative medical strategies. Stress triggers for acute or recurring musculoskeletal pain are diverse and can range from physical to psychological. The mechanism by which the body responds to triggers and initiates the self-healing processes is complex, but five body networks or processes are thought to be integral: the nervous system, microcirculation/vasodilation, immune modulation, muscular relaxation/ contraction and psychological balance. Multi-modal integrative medicine approaches include nutritional/dietary modification, postural/muscular training exercises, and cognitive behavioral mind/body techniques. This article will review the self-healing concept and provide plausible scientific evidence where available.
Drug Design, Development and Therapy, 2016
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common type of medication ... more Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common type of medication used in the treatment of acute pain. Ketorolac trometamol (KT) is a nonnarcotic, peripherally acting nonsteroidal anti-inflammatory drug with analgesic effects comparable to certain opioids. Objective: The aim of this study was to compare the efficacy of KT and naproxen (NA) in the treatment of acute low back pain (LBP) of moderate-to-severe intensity. Patients and methods: In this 10-day, Phase III, randomized, double-blind, double-dummy, noninferiority trial, participants with acute LBP of moderate-to-severe intensity as determined through a visual analog scale (VAS) were randomly assigned in a 1:1 ratio to receive sublingual KT 10 mg three times daily or oral NA 250 mg three times daily. From the second to the fifth day of treatment, if patient had VAS 40 mm, increased dosage to four times per day was allowed. The primary end point was the reduction in LBP as measured by VAS. We also performed a post hoc superiority analysis. Results: KT was not inferior to NA for the reduction in LBP over 5 days of use as measured by VAS scores (P=0.608 for equality of variance; P=0.321 for equality of means) and by the Roland-Morris Disability Questionnaire (P=0.180 for equality of variance test; P=0.446 for equality of means) using 95% confidence intervals. The percentage of participants with improved pain relief 60 minutes after receiving the first dose was higher in the KT group (24.2%) than in the NA group (6.5%; P=0.049). The most common adverse effects were heartburn, nausea, and vomiting. Conclusion: KT is not inferior in efficacy and delivers faster pain relief than NA.
Revista da Associação Médica Brasileira
Women and men can have the same illnesses, but with different prevalence and reactions to symptom... more Women and men can have the same illnesses, but with different prevalence and reactions to symptoms. OBJECTIVE: This study aimed to emphasize that distinct traits between men and women require a different approach for each of them. METHODS: PubMed and Google Scholar were searched using the following terms: Disability Evaluations, Women's health, Osteoporosis, Osteoarthritis, and Lymphedema, Pregnancy. RESULTS/CONCLUSION: Disease management can go beyond the symptoms, assessing the long-term consequences and possibly the disabilities they can generate, compromising the quality of life of the person, his/her family members, and eventually caregivers.
SPRINGER LONDON LTD, 2018
Diário Oficial do Estado de São Paulo. Poder Executivo - Seção II, 2017
Current Rheumatology Reports, 2021
Purpose of ReviewOsteoarthritis (OA) is the most common forms of arthritis in the general populat... more Purpose of ReviewOsteoarthritis (OA) is the most common forms of arthritis in the general population, accounting for more pain and functional disability than any other musculoskeletal disease. There are currently no approved disease modifying drugs for OA. In the absence of effective pharmacotherapy, many patients with OA turn to nutritional supplements and nutraceuticals, including collagen derivatives. Collagen hydrolyzates and ultrahydrolyzates are terms used to describe collagens that have been broken down into small peptides and amino acids in the presence of collagenases and high pressure.Recent FindingsThis article reviews the relevant literature and serves as a White Paper on collagen hydrolyzates and ultrahydrolyzates as emerging supplements often advertised to support joint health in OA. Collagen hydrolyzates have demonstrated some evidence of efficacy in a handful of small scale clinical trials, but their ability to treat and reverse advanced joint disease remains highly ...
Clinics, 2019
Osteoarthritis (OA) or osteoarthrosis is a low-grade, progressive inflammatory disease that may e... more Osteoarthritis (OA) or osteoarthrosis is a low-grade, progressive inflammatory disease that may entail joint degeneration (1) that affects all joint structures, notably the cartilage of synovial joints. OA evolves into joint insufficiency, characterized by changes in articular cartilage, with fibrillation and fissure zones, microfractures, cysts, subchondral sclerosis and formation of osteophytes on joint edges. These changes lead to chronic pain and functional constraints of the affected joints, in addition to the physical and psychological sequelae that often manifest in individuals with OA, causing greatly reduced quality of life. OA is the most common joint disease (2,3) and affects mainly the knees, hips, hands and feet. In the USA, it is estimated that 36.4% of individuals over 60 years old have OA in their knees (4). This disease of great medical and economic importance is responsible for the inability to perform labor in approximately 15% of the adult population of the world. In Brazil, OA is currently the third most common disease of those who are insured for Social Security and receiving disease aid, corresponding to 65% of the
Rev Hosp Clin Fac Med Univ Sao Paulo, Jun 1, 1997
Osteoporose e a alteracao metabolica mais frequente acometendo ossos e e uma das doencas mais com... more Osteoporose e a alteracao metabolica mais frequente acometendo ossos e e uma das doencas mais comuns em mulheres apos a menopausa. Pode ser definida como uma condicao clinica, na qual existe uma perda ossea significativa, com uma reducao da massa ossea alem da considerada normal para pacientes da mesma idade e sexo, comprometendo a integridade do arcabouco osseo, diminuindo sua resistencia e propiciando fraturas dos ossos acometidos, mesmo aos minimos esforcos. E considerada como uma doenca silenciosa ate que surgem as primeiras fraturas. A prevencao e fundamental, assim como o tratamento de reabilitacao, associado ao tratamento medicamentoso. Os exercicios fisicos sao importantes nao so na prevencao da propria osteoporose, assim como na prevencao de quedas que podem levar a fraturas
Acta Fisiátrica, 2015
Osteoarthritis is the most common articular disease that causes pain to its sufferers. Shockwave ... more Osteoarthritis is the most common articular disease that causes pain to its sufferers. Shockwave therapy is among the many treatments that can be used. Objective: The objective of this study was to observe the influence of shockwave therapy on the intensity of pain in elderly women with knee OA. Method: In this study, 40 elderly females (69.57 ± 6.42 years) were submitted to weekly shockwave therapy with 2000 impulses at 2.5 to 4.0 bar, at a frequency of 8Hz, at the location most painful to touch in the knee, the medial articular interline, for three consecutive weeks. The effect of its application on the pain was evaluated by the visual analogue scale before and after the treatment. Results: There was a significant reduction (p < 0.0001) of pain intensity in the volunteers, going from 7.86 ± 1.07 cm to 5.32 ± 2.26 cm. Conclusion: The application of shockwave therapy has been shown to reduce pain in elderly females with osteoarthritis.
Revista Brasileira de Reumatologia, 2007
Recentes avanços na densitometria clínica têm incorporado novas tecnologias, técnicas de aquisiçã... more Recentes avanços na densitometria clínica têm incorporado novas tecnologias, técnicas de aquisição, aperfeiçoamento dos relatórios, novos bancos de dados e alterações de terminologia. O estabelecimento desses novos conceitos tem implicação na avaliação clínica individual dos pacientes, assim como influência potencial no direcionamento de políticas públicas de saúde. No sentido de clarificar novos conceitos e incorporá-los no dia-a-dia da prática médica em nosso país, a Sociedade Brasileira de Densitometria Clínica (SBDens) periodicamente reúne especialistas para estabelecer recomendações com base em revisões da literatura científica, levando em conta possíveis adaptações às condições próprias brasileiras. Essas recomendações, quando caracterizadas como posições oficiais de uma sociedade médica, têm várias e importantes funções. Em primeiro lugar, artigo origiNal origiNal article
Rev. Hosp. Clin. Fac. Med. …, 1997
Resumo: Foram estudados dois grupos: Grupo I-treze voluntarios normais atletas competitivos do se... more Resumo: Foram estudados dois grupos: Grupo I-treze voluntarios normais atletas competitivos do sexo masculino, idade media: 25+ ou-2, 1 anos (18-30); Grupo 2-dezessete voluntarios, sexo masculino, normais sedentarios, idade media: 31, 2 anos (23-46). Todos ...
... Densitometria Clínica Sociedade Brasileira de Geriatria Sociedade Brasileira do Estudo do Met... more ... Densitometria Clínica Sociedade Brasileira de Geriatria Sociedade Brasileira do Estudo do Metabolismo Ósseo e Mineral Relação dos médicos participantes: Dr. Aarão Mendes Pinto Neto Dr. Alberto Soares Dr. Almir Urbanetz Dr. Antônio Carlos de Araújo e Souza Dr. Antônio ...
… de São Paulo, Vol. São Paulo: …, 1996
... de estu-dar quantitativamente as ondulações da fibra colágena do tendão patelar humano, em ad... more ... de estu-dar quantitativamente as ondulações da fibra colágena do tendão patelar humano, em adultos e crianças, divi-dindo-o em ... e aumentando sua birrefringência, quan-do avaliadas ao microscópio de polarização(9). Foi utilizado um microscópio óptico Carl Zeiss®, para ...
Pain, 1997
This study examined the effects of intravenous administration of sodium amytal (SA), a medium act... more This study examined the effects of intravenous administration of sodium amytal (SA), a medium action barbiturate, on cutaneous limb temperatures and sympathetic skin responses (SSR) to electrical stimulation. Eight normal volunteers and 13 patients with musculoskeletal pain, somatoform pain disorders or nerve/root injury (with findings strictly limited to the distribution of the involved nerve) were compared to 15 patients with Complex Regional Pain Syndromes (one of whom had documented nerve injury). The Complex Regional Pain Syndromes (CRPS) patients were characterized by the presence of severe diffuse limb pain and extraterritorial sensory, sudomotor and vasomotor abnormalities (i.e., not confined to the site of injury or the distribution of the injured nerve). The CRPS patients were different from the normal controls and the non-CRPS patients in their tendency to warm significantly many of their limbs (not just the symptomatic ones). SSR were reduced or lost in a few limbs only in all three groups, irrespective of the increase or decrease of limb temperature and the side of symptoms. We argue that the enhanced thermogenic effect of SA in CRPS patients is due to generalized central changes of thermoregulatory control specifically in this group.
Acta Ortopedica Brasileira, 2018
Objetivo: Avaliar o perfil dos pacientes com fraturas osteoporoticas atendidos em hospital de ate... more Objetivo: Avaliar o perfil dos pacientes com fraturas osteoporoticas atendidos em hospital de atendimento terciario ortopedico. Metodos: Setenta pacientes com fraturas osteoporoticas (FO) foram comparados a 50 pacientes acompanhados ambulatorialmente por osteoartrite (OA) atraves de questionarios. Resultados: O grupo FO apresentaram idade media maior (p 1 ano), queda nos ultimos 12 meses, fratura por causa da queda e necessitam de mais auxilio (p < 0,05); menor Lawton & Brody AIVD (Atividades instrumentais da vida diaria, p < 0,05), reportando menos deficiencia de membros inferiores, patologia nos pes, fraqueza muscular, hipotireoidismo e consumo de vitamina D que pacientes do grupo OA. Raca branca, quedas e fraturas previas aumentam o risco de fraturas osteoporoticas em 10,5, 11,4 e 4,1 vezes respectivamente. A chance de fratura reduziu 29% a cada aumento de uma unidade no Lawton & Brody AIVD. Casados fraturam menos que outros estados civis. Conclusao: conjuntamente, a etnia,...
Acta Ortopédica Brasileira
Objective: To evaluate the profile of patients with osteoporotic fractures treated at a tertiary ... more Objective: To evaluate the profile of patients with osteoporotic fractures treated at a tertiary orthopedic hospital. Methods: Using questionnaires, 70 patients with osteoporotic fractures (OF) were compared with 50 outpatients with multiple osteoarthritis (OA) followed through an outpatient clinic. Results: The OF group was older (p <0.001), less heavy (p=0.003), had lower BMI (p=0.006), was more likely to be white (p=0.011), was less likely to be married (p=0.008), and had previous falls, previous fractures, old fractures (>1 year), falls in the last 12 months, fractures due to falls, and needed more assistance (p<0.05). They also had lower Lawton & Brody Instrumental Activities of Daily Living scores (p <0.05) and reported less lower limb disability, foot pathology, muscle weakness, hypothyroidism, and vitamin D intake than patients in the OA group. White race, previous falls, and previous fractures increase the risk of osteoporotic fractures by 10.5, 11.4, and 4.1 ti...
Journal of Pain Research
Traditionally, musculoskeletal pain management has focused on the use of conventional treatments ... more Traditionally, musculoskeletal pain management has focused on the use of conventional treatments to relieve pain. However, multi-modal integrative medicine including alternative/complementary treatments is becoming more widely used and integrated into treatment guidelines around the world. The uptake of this approach varies according to country, with generally a higher uptake in developed countries and in females aged more than 40 years. Integral to the concept described here, is that the body has an innate ability to selfheal, which can be optimized by the use of integrative medical strategies. Stress triggers for acute or recurring musculoskeletal pain are diverse and can range from physical to psychological. The mechanism by which the body responds to triggers and initiates the self-healing processes is complex, but five body networks or processes are thought to be integral: the nervous system, microcirculation/vasodilation, immune modulation, muscular relaxation/ contraction and psychological balance. Multi-modal integrative medicine approaches include nutritional/dietary modification, postural/muscular training exercises, and cognitive behavioral mind/body techniques. This article will review the self-healing concept and provide plausible scientific evidence where available.
Drug Design, Development and Therapy, 2016
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common type of medication ... more Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most common type of medication used in the treatment of acute pain. Ketorolac trometamol (KT) is a nonnarcotic, peripherally acting nonsteroidal anti-inflammatory drug with analgesic effects comparable to certain opioids. Objective: The aim of this study was to compare the efficacy of KT and naproxen (NA) in the treatment of acute low back pain (LBP) of moderate-to-severe intensity. Patients and methods: In this 10-day, Phase III, randomized, double-blind, double-dummy, noninferiority trial, participants with acute LBP of moderate-to-severe intensity as determined through a visual analog scale (VAS) were randomly assigned in a 1:1 ratio to receive sublingual KT 10 mg three times daily or oral NA 250 mg three times daily. From the second to the fifth day of treatment, if patient had VAS 40 mm, increased dosage to four times per day was allowed. The primary end point was the reduction in LBP as measured by VAS. We also performed a post hoc superiority analysis. Results: KT was not inferior to NA for the reduction in LBP over 5 days of use as measured by VAS scores (P=0.608 for equality of variance; P=0.321 for equality of means) and by the Roland-Morris Disability Questionnaire (P=0.180 for equality of variance test; P=0.446 for equality of means) using 95% confidence intervals. The percentage of participants with improved pain relief 60 minutes after receiving the first dose was higher in the KT group (24.2%) than in the NA group (6.5%; P=0.049). The most common adverse effects were heartburn, nausea, and vomiting. Conclusion: KT is not inferior in efficacy and delivers faster pain relief than NA.