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Peter Kasa

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Papers by Peter Kasa

Research paper thumbnail of Histochemical and Electronmicroscopic Study of the Brain of the AF64A-Treated Rat

Research paper thumbnail of Structure with Gaba-Like and Gad-Like Immunoreactivity in the Cervical Sympathetic Ganglion Complex of Adult Rats

Cell and Tissue Research, 1990

Research paper thumbnail of Electron histochemical evidence of different types of mossy fibre endings in the cerebellar cortex

Experientia, 1969

ABSTRACT

Research paper thumbnail of Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat

Brain Research, Aug 3, 2001

The axonal transport of presenilin-1 was investigated in a spinal cord-sciatic nerve-neuromuscula... more The axonal transport of presenilin-1 was investigated in a spinal cord-sciatic nerve-neuromuscular junction model system in the rat. The technique of unilateral sciatic nerve ligation, using double ligatures, was combined with immunohistochemical staining and Western blotting to examine the axonal transport of the protein. Immunohistochemical studies involving the use of polyclonal antibodies for either the N-terminal or the C-terminal domain of presenilin-1 furnished evidence that both fragments may be present not only in the neuronal cell bodies, but also in the motoric and sensory axons and the motoric axon terminals at the neuromuscular junctions. After double ligation of the sciatic nerve for 6, 12 or 24 h, progressive immunostaining of presenilin-1 occurred above the upper ligature and to a lesser extent below the lower ligature. Double staining of the sciatic nerve for presenilin-1 and for amyloid precursor protein revealed overlapping immunoreactivity. Western blotting confirmed the accumulation of the |20-kDa C-terminal and |25-kDa N-terminal fragments and the full-length 45-kDa holoprotein of presenilin-1 both above and below the ligature. It is concluded that besides the larger amounts of C-terminal and N-terminal fragments, a smaller quantity of intact presenilin-1 may be present and conveyed bidirectionally in the sciatic nerve of the rat. These results lend further support to the suggestion that presenilin-1 may leave the trans-Golgi network and be found in the axons and axon terminals of the various neurons.

Research paper thumbnail of Presynaptic axonal amyloid-b induces caspase-3 activation and neurodegeneration in the postsynaptic neuron

CITATIONS 2 READS 18 5 authors, including:

Research paper thumbnail of 73 β-Amyloid precursor protein immunoreactivity does not increases in the cortex and hippocampus of the rat brain in consequence of cholinergic hypoactivity

Research paper thumbnail of Uhrastructural Localization of Acetylcholinestcrase in the Cerebellar Cortex with Special Reference to the Intersynaptic Organelles

Histochemistry Cell Biol, 1968

Research paper thumbnail of Amyloid-β1-42 treatment does not have a specific effect on cholinergic neurons in in vitro basal forebrain neuronal cultures of rat

Acta Biologica Hungarica, 2002

Research paper thumbnail of Histochemical localization of acetylcholinesterase in the cat cerebellar cortex

Journal of Neurochemistry

Research paper thumbnail of Electron microscope localization of acetylcholinesterase in the superior cervical ganglion of the rat

Research paper thumbnail of Experimental allergic neuritis. Histochemical evidence for changes of acetylcholinesterase activity in somatic nerves of rabbit

Research paper thumbnail of Effects of long -lasting GABA microinfusion and hypoglossal nerve implantation on the ACh-system in the superior cervical ganglion of adult rat

Research paper thumbnail of Cholinotoxic effects of aluminium in rat brain

Journal of Neurochemistry

Research paper thumbnail of The role of human galanin (hGAL1-30), hGAL1-19 and hGAL17-30 in the release of acetylcholine in the striatum: a neuropharmacological study

Research paper thumbnail of Role of Leu(34)-Met(35) in neurotoxicity caused by human beta-amyloid (1-42) peptide in vitro

Research paper thumbnail of Changes of acetylcholine content in different brain regions after in vivo administration of -bungarotoxin

Research paper thumbnail of Presynaptic axonal amyloid-b induces caspase-3 activation and neurodegeneration in the postsynaptic neuron

It is assumed that the amyloid-beta peptide (A ABSTRACT β) contributes to the neurodegen- eration... more It is assumed that the amyloid-beta peptide (A ABSTRACT β) contributes to the neurodegen- eration in Alzheimer's disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Aβ protein may be an activator of caspase-3 and could initiate a series of cascade events, which results in neurofi brillary degeneration in a postsynaptic cell. We report here that the axonic Aβ in the AD brain may be associated with caspase-3 activation. Our data suggest that caspase-3 in fact has a signifi cant role in the widespread neuronal cell death that occurs in AD brain. A subset of pyramidal cells in hippocampus area CA1 demonstrated widespread accumulation of tau- protein. Individual postsynaptic neurons contained intracellular activated caspase-3 and were co-localized with neurofi brillary tangles. The results presented here support the suggestion that caspase-3 activation may lead to the neuronal cell death...

Research paper thumbnail of Correlation between feeding behavior and cholinergic activity in teleost fish

Neurochemistry International

Research paper thumbnail of Characterization of the M1 (cortical) type of muscarinic cholinergic receptors in the brain of the carp (Cyprinus carpio L.)

Neurochemistry International

Research paper thumbnail of PS-1 is Transported from the Moto-Neurons to Their Axon Terminals

Advances in Behavioral Biology, 2002

... Henrietta Papp and Magdolna Pakaski, Alzheimer's Disease Research Centre, Department of ... more ... Henrietta Papp and Magdolna Pakaski, Alzheimer's Disease Research Centre, Department of Psychiatry. ... This work was supported by OTKA (T022683, T030339 and T032458), ETT (T-11/011/2000) and a Szechenyi Professorship to PK REFERENCES 1. DM Kovacs, H J ...

Research paper thumbnail of Histochemical and Electronmicroscopic Study of the Brain of the AF64A-Treated Rat

Research paper thumbnail of Structure with Gaba-Like and Gad-Like Immunoreactivity in the Cervical Sympathetic Ganglion Complex of Adult Rats

Cell and Tissue Research, 1990

Research paper thumbnail of Electron histochemical evidence of different types of mossy fibre endings in the cerebellar cortex

Experientia, 1969

ABSTRACT

Research paper thumbnail of Presenilin-1 and its N-terminal and C-terminal fragments are transported in the sciatic nerve of rat

Brain Research, Aug 3, 2001

The axonal transport of presenilin-1 was investigated in a spinal cord-sciatic nerve-neuromuscula... more The axonal transport of presenilin-1 was investigated in a spinal cord-sciatic nerve-neuromuscular junction model system in the rat. The technique of unilateral sciatic nerve ligation, using double ligatures, was combined with immunohistochemical staining and Western blotting to examine the axonal transport of the protein. Immunohistochemical studies involving the use of polyclonal antibodies for either the N-terminal or the C-terminal domain of presenilin-1 furnished evidence that both fragments may be present not only in the neuronal cell bodies, but also in the motoric and sensory axons and the motoric axon terminals at the neuromuscular junctions. After double ligation of the sciatic nerve for 6, 12 or 24 h, progressive immunostaining of presenilin-1 occurred above the upper ligature and to a lesser extent below the lower ligature. Double staining of the sciatic nerve for presenilin-1 and for amyloid precursor protein revealed overlapping immunoreactivity. Western blotting confirmed the accumulation of the |20-kDa C-terminal and |25-kDa N-terminal fragments and the full-length 45-kDa holoprotein of presenilin-1 both above and below the ligature. It is concluded that besides the larger amounts of C-terminal and N-terminal fragments, a smaller quantity of intact presenilin-1 may be present and conveyed bidirectionally in the sciatic nerve of the rat. These results lend further support to the suggestion that presenilin-1 may leave the trans-Golgi network and be found in the axons and axon terminals of the various neurons.

Research paper thumbnail of Presynaptic axonal amyloid-b induces caspase-3 activation and neurodegeneration in the postsynaptic neuron

CITATIONS 2 READS 18 5 authors, including:

Research paper thumbnail of 73 β-Amyloid precursor protein immunoreactivity does not increases in the cortex and hippocampus of the rat brain in consequence of cholinergic hypoactivity

Research paper thumbnail of Uhrastructural Localization of Acetylcholinestcrase in the Cerebellar Cortex with Special Reference to the Intersynaptic Organelles

Histochemistry Cell Biol, 1968

Research paper thumbnail of Amyloid-β1-42 treatment does not have a specific effect on cholinergic neurons in in vitro basal forebrain neuronal cultures of rat

Acta Biologica Hungarica, 2002

Research paper thumbnail of Histochemical localization of acetylcholinesterase in the cat cerebellar cortex

Journal of Neurochemistry

Research paper thumbnail of Electron microscope localization of acetylcholinesterase in the superior cervical ganglion of the rat

Research paper thumbnail of Experimental allergic neuritis. Histochemical evidence for changes of acetylcholinesterase activity in somatic nerves of rabbit

Research paper thumbnail of Effects of long -lasting GABA microinfusion and hypoglossal nerve implantation on the ACh-system in the superior cervical ganglion of adult rat

Research paper thumbnail of Cholinotoxic effects of aluminium in rat brain

Journal of Neurochemistry

Research paper thumbnail of The role of human galanin (hGAL1-30), hGAL1-19 and hGAL17-30 in the release of acetylcholine in the striatum: a neuropharmacological study

Research paper thumbnail of Role of Leu(34)-Met(35) in neurotoxicity caused by human beta-amyloid (1-42) peptide in vitro

Research paper thumbnail of Changes of acetylcholine content in different brain regions after in vivo administration of -bungarotoxin

Research paper thumbnail of Presynaptic axonal amyloid-b induces caspase-3 activation and neurodegeneration in the postsynaptic neuron

It is assumed that the amyloid-beta peptide (A ABSTRACT β) contributes to the neurodegen- eration... more It is assumed that the amyloid-beta peptide (A ABSTRACT β) contributes to the neurodegen- eration in Alzheimer's disease (AD). Activation of an apoptotic pathway may play a key role in this process. The apoptotic signal may be driven by caspases. The presynaptic Aβ protein may be an activator of caspase-3 and could initiate a series of cascade events, which results in neurofi brillary degeneration in a postsynaptic cell. We report here that the axonic Aβ in the AD brain may be associated with caspase-3 activation. Our data suggest that caspase-3 in fact has a signifi cant role in the widespread neuronal cell death that occurs in AD brain. A subset of pyramidal cells in hippocampus area CA1 demonstrated widespread accumulation of tau- protein. Individual postsynaptic neurons contained intracellular activated caspase-3 and were co-localized with neurofi brillary tangles. The results presented here support the suggestion that caspase-3 activation may lead to the neuronal cell death...

Research paper thumbnail of Correlation between feeding behavior and cholinergic activity in teleost fish

Neurochemistry International

Research paper thumbnail of Characterization of the M1 (cortical) type of muscarinic cholinergic receptors in the brain of the carp (Cyprinus carpio L.)

Neurochemistry International

Research paper thumbnail of PS-1 is Transported from the Moto-Neurons to Their Axon Terminals

Advances in Behavioral Biology, 2002

... Henrietta Papp and Magdolna Pakaski, Alzheimer's Disease Research Centre, Department of ... more ... Henrietta Papp and Magdolna Pakaski, Alzheimer's Disease Research Centre, Department of Psychiatry. ... This work was supported by OTKA (T022683, T030339 and T032458), ETT (T-11/011/2000) and a Szechenyi Professorship to PK REFERENCES 1. DM Kovacs, H J ...

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