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Papers by Peter Mikulecky

Research paper thumbnail of Improved mTBI outcomes with a BCI Amplified CRT Training: A retrospective chart review

This study is a retrospective chart review of 200 clients who participated in a non-verbal restor... more This study is a retrospective chart review of 200 clients who participated in a non-verbal restorative Cognitive Remediation Training (rCRT) program. The program was applied to effect proper neural functional remodeling needed to support resilient, flexible and adaptable behaviors after encountering a mild to medium closed head traumatic brain injury (mTBI). The r CRT training program focused on improving functional performance in executive cognitive control networks as defined by fMRI studies. All rCRT training activities were delivered in a semi-game-like manner, incorporating a Brain Computer Interface (BCI) that provided in-the-moment neural network performance integrity metrics (nPIMs) used to adjust the level of play required to properly engage long-term potentiation (LTP) and long term depreciation (LTD) network learning rules.This study reports on t-test and Reliable Change Index (RCI) changes found within cognitive abilities’ performance metrics derived from the Woodcock Jo...

Research paper thumbnail of Improved Sobriety Rates After Brain-Computer Interface-Based Cognitive Remediation Training

Cureus, 2022

Up to 80% of individuals seeking treatment fail in their attempts at sobriety. This study investi... more Up to 80% of individuals seeking treatment fail in their attempts at sobriety. This study investigated whether 1) a cognitive remediation therapy (CRT) program augmented with a brain-computer interface (BCI) to influence brain performance metrics would increase participants' self-agency by restoring cognitive control performance; and 2) that ability increase would produce increased sobriety rates, greater than published treatment rates. The study employed a retrospective chart review structured to replicate a switching replication methodology (i.e., waitlist group) using a pre-test and post-test profile analysis quasiexperimental design. Participants' records were organized into treatment and non-treatment groups. Adult poly-substance users were recruited from alcohol and other drugs (AOD) use outpatient programs and AOD use treatment centers in the United States. Participants volunteered for pre-and post-testing without treatment (n = 121) or chose to enter the treatment program (n = 200). The treatment group engaged in a 48session BCI/CRT augmented treatment program. Pre-and post-treatment measures comprised 14 areas from the Woodcock-Johnson Cognitive Abilities III Assessment Battery. An 18-month follow-up assessment measured maintenance of sobriety. After testing the difference for all variables across time between test groups, a significant multivariate effect was found. In addition, at 18 months post-treatment, 89% of the treatment group maintained sobriety, compared to 31% of the non-treatment group. Consistent with addiction neurobehavioral imbalance models, traditional treatment programs augmented with BCI/CRT training, focused on improving cognitive control abilities, may strengthen self-control and improve sobriety rates.

Research paper thumbnail of Improved Mild Closed Head Traumatic Brain Injury Outcomes With a Brain-Computer Interface Amplified Cognitive Remediation Training

Research paper thumbnail of Der Lackmustest für Säuren und Basen

Übungsbuch Chemie für Dummies

Research paper thumbnail of Elektronen in Redoxreaktionen nachweisen

Übungsbuch Chemie für Dummies

Research paper thumbnail of Zehn Formeln, die Sie sich ins Gehirn brennen lassen sollten

Research paper thumbnail of Wissenschaftlich mit Zahlen umgehen

Übungsbuch Chemie für Dummies

Research paper thumbnail of Jetzt wird's organisch

Research paper thumbnail of Chemische Gleichungen in den Griff bekommen

Research paper thumbnail of Der Top-Ten-Teil

Research paper thumbnail of Zehn nervige Ausnahmen von den chemischen Regeln

Research paper thumbnail of Geschwindigkeit und Gleichgewicht erforschen

Research paper thumbnail of Chemistry Workbook For Dummies

Page 1. Page 2. Chemistry Workbook FOR DUMmIES‰ by Peter J. Mikulecky, PhD, Katherine Brutlag, Mi... more Page 1. Page 2. Chemistry Workbook FOR DUMmIES‰ by Peter J. Mikulecky, PhD, Katherine Brutlag, Michelle Rose Gilman, and Brian Peterson Page 3. Chemistry Workbook For Dummies® Published by Wiley Publishing, Inc. 111 River St. ...

Research paper thumbnail of AP Biology for Dummies

Page 1. *-~~~z=zgsxr~?. Prepare with two full-length practice tests t. Get complete answer exptan... more Page 1. *-~~~z=zgsxr~?. Prepare with two full-length practice tests t. Get complete answer exptanationsforallquesuons „ Review the exan, format and types of questions you'll face Peter Mikuleeky, PhD Michelle Rose Gilman ...

Research paper thumbnail of In der Elektrochemie auf Draht sein

Research paper thumbnail of Chemie mit Atomkernen

Research paper thumbnail of Sich in Lösung begeben

Research paper thumbnail of Übungsbuch Chemie für Dummies

Research paper thumbnail of Mal heiß, mal kalt: Kolligative Eigenschaften

Übungsbuch Chemie für Dummies, 2017

Research paper thumbnail of Identification of the Hfq-binding site on DsrA RNA: Hfq binds without altering DsrA secondary structure

RNA, 2003

DsrA RNA regulates the translation of two global regulatory proteins in Escherichia coli. DsrA ac... more DsrA RNA regulates the translation of two global regulatory proteins in Escherichia coli. DsrA activates the translation of RpoS while repressing the translation of H-NS. The RNA-binding protein Hfq is necessary for DsrA to function in vivo. Although Hfq binds to DsrA in vitro, the role of Hfq in DsrA-mediated regulation is not known. One hypothesis was that Hfq acts as an RNA chaperone by unfolding DsrA, thereby facilitating interactions with target RNAs. To test this hypothesis, we have examined the structure of DsrA bound to Hfq in vitro. Comparison of free DsrA to DsrA bound to Hfq by RNase footprinting, circular dichroism, and thermal melt profiles shows that Hfq does not alter DsrA secondary structures, but might affect its tertiary conformation. We identify the site on DsrA where Hfq binds, which is a structural element in the middle of DsrA. In addition, we show that although long poly(U) RNAs compete with DsrA for binding to Hfq, a short poly(U) stretch present in DsrA is n...

Research paper thumbnail of Improved mTBI outcomes with a BCI Amplified CRT Training: A retrospective chart review

This study is a retrospective chart review of 200 clients who participated in a non-verbal restor... more This study is a retrospective chart review of 200 clients who participated in a non-verbal restorative Cognitive Remediation Training (rCRT) program. The program was applied to effect proper neural functional remodeling needed to support resilient, flexible and adaptable behaviors after encountering a mild to medium closed head traumatic brain injury (mTBI). The r CRT training program focused on improving functional performance in executive cognitive control networks as defined by fMRI studies. All rCRT training activities were delivered in a semi-game-like manner, incorporating a Brain Computer Interface (BCI) that provided in-the-moment neural network performance integrity metrics (nPIMs) used to adjust the level of play required to properly engage long-term potentiation (LTP) and long term depreciation (LTD) network learning rules.This study reports on t-test and Reliable Change Index (RCI) changes found within cognitive abilities’ performance metrics derived from the Woodcock Jo...

Research paper thumbnail of Improved Sobriety Rates After Brain-Computer Interface-Based Cognitive Remediation Training

Cureus, 2022

Up to 80% of individuals seeking treatment fail in their attempts at sobriety. This study investi... more Up to 80% of individuals seeking treatment fail in their attempts at sobriety. This study investigated whether 1) a cognitive remediation therapy (CRT) program augmented with a brain-computer interface (BCI) to influence brain performance metrics would increase participants' self-agency by restoring cognitive control performance; and 2) that ability increase would produce increased sobriety rates, greater than published treatment rates. The study employed a retrospective chart review structured to replicate a switching replication methodology (i.e., waitlist group) using a pre-test and post-test profile analysis quasiexperimental design. Participants' records were organized into treatment and non-treatment groups. Adult poly-substance users were recruited from alcohol and other drugs (AOD) use outpatient programs and AOD use treatment centers in the United States. Participants volunteered for pre-and post-testing without treatment (n = 121) or chose to enter the treatment program (n = 200). The treatment group engaged in a 48session BCI/CRT augmented treatment program. Pre-and post-treatment measures comprised 14 areas from the Woodcock-Johnson Cognitive Abilities III Assessment Battery. An 18-month follow-up assessment measured maintenance of sobriety. After testing the difference for all variables across time between test groups, a significant multivariate effect was found. In addition, at 18 months post-treatment, 89% of the treatment group maintained sobriety, compared to 31% of the non-treatment group. Consistent with addiction neurobehavioral imbalance models, traditional treatment programs augmented with BCI/CRT training, focused on improving cognitive control abilities, may strengthen self-control and improve sobriety rates.

Research paper thumbnail of Improved Mild Closed Head Traumatic Brain Injury Outcomes With a Brain-Computer Interface Amplified Cognitive Remediation Training

Research paper thumbnail of Der Lackmustest für Säuren und Basen

Übungsbuch Chemie für Dummies

Research paper thumbnail of Elektronen in Redoxreaktionen nachweisen

Übungsbuch Chemie für Dummies

Research paper thumbnail of Zehn Formeln, die Sie sich ins Gehirn brennen lassen sollten

Research paper thumbnail of Wissenschaftlich mit Zahlen umgehen

Übungsbuch Chemie für Dummies

Research paper thumbnail of Jetzt wird's organisch

Research paper thumbnail of Chemische Gleichungen in den Griff bekommen

Research paper thumbnail of Der Top-Ten-Teil

Research paper thumbnail of Zehn nervige Ausnahmen von den chemischen Regeln

Research paper thumbnail of Geschwindigkeit und Gleichgewicht erforschen

Research paper thumbnail of Chemistry Workbook For Dummies

Page 1. Page 2. Chemistry Workbook FOR DUMmIES‰ by Peter J. Mikulecky, PhD, Katherine Brutlag, Mi... more Page 1. Page 2. Chemistry Workbook FOR DUMmIES‰ by Peter J. Mikulecky, PhD, Katherine Brutlag, Michelle Rose Gilman, and Brian Peterson Page 3. Chemistry Workbook For Dummies® Published by Wiley Publishing, Inc. 111 River St. ...

Research paper thumbnail of AP Biology for Dummies

Page 1. *-~~~z=zgsxr~?. Prepare with two full-length practice tests t. Get complete answer exptan... more Page 1. *-~~~z=zgsxr~?. Prepare with two full-length practice tests t. Get complete answer exptanationsforallquesuons „ Review the exan, format and types of questions you'll face Peter Mikuleeky, PhD Michelle Rose Gilman ...

Research paper thumbnail of In der Elektrochemie auf Draht sein

Research paper thumbnail of Chemie mit Atomkernen

Research paper thumbnail of Sich in Lösung begeben

Research paper thumbnail of Übungsbuch Chemie für Dummies

Research paper thumbnail of Mal heiß, mal kalt: Kolligative Eigenschaften

Übungsbuch Chemie für Dummies, 2017

Research paper thumbnail of Identification of the Hfq-binding site on DsrA RNA: Hfq binds without altering DsrA secondary structure

RNA, 2003

DsrA RNA regulates the translation of two global regulatory proteins in Escherichia coli. DsrA ac... more DsrA RNA regulates the translation of two global regulatory proteins in Escherichia coli. DsrA activates the translation of RpoS while repressing the translation of H-NS. The RNA-binding protein Hfq is necessary for DsrA to function in vivo. Although Hfq binds to DsrA in vitro, the role of Hfq in DsrA-mediated regulation is not known. One hypothesis was that Hfq acts as an RNA chaperone by unfolding DsrA, thereby facilitating interactions with target RNAs. To test this hypothesis, we have examined the structure of DsrA bound to Hfq in vitro. Comparison of free DsrA to DsrA bound to Hfq by RNase footprinting, circular dichroism, and thermal melt profiles shows that Hfq does not alter DsrA secondary structures, but might affect its tertiary conformation. We identify the site on DsrA where Hfq binds, which is a structural element in the middle of DsrA. In addition, we show that although long poly(U) RNAs compete with DsrA for binding to Hfq, a short poly(U) stretch present in DsrA is n...