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Research paper thumbnail of Protein Kinase C

Springer eBooks, 1986

Anoxic LTP is a long-lasting increase in synaptic effectiveness that follows a transient anoxic e... more Anoxic LTP is a long-lasting increase in synaptic effectiveness that follows a transient anoxic episode. Such postsynaptic persistent hyperexcitability is found particularly at the hippocampal Schaffer collateral/commissural–CA1 cell synapse.1–6 The mechanisms underlying anoxic LTP has been extensively investigated but not completely understood. With the use of extraand intracellular recording techniques in vitro, Ben-Ari and his colleagues have found that the induction of anoxic LTP is voltage, NMDA receptor and redox state dependent.1,2,7 Recently, we demonstrated that the induction of anoxic LTP is prevented by intracellular injection of the Ca2+ chelator BAPTA into the postsynaptic CA1 neurons.4 Thus a rise in intraneuronal Ca2+ seems to be responsible for a chain of events resulting in an anoxic LTP. However, which Ca2+-dependent processes are essential for the induction of anoxic LTP is still awaiting elucidation. Because the activation of Ca2+-dependent protein kinase (PKC) cascades is known to play an important role in the long-lasting use-dependent strengthening and reduction in synaptic efficacy, such as long-term potentiation (LTP) in the hippocampus and longterm depression (LTD) in the cerebellum,8,9 it is of particular interest to examine whether the induction of anoxic LTP also required the activation of PKC. The present study was undertaken to elucidate this possibility by examining the effect of specific PKC inhibitors on the induction of anoxic LTP in the CA1 neurons of rat hippocampal slices in vitro.

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Research paper thumbnail of Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity

Journal of Biological Chemistry, 1985

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Research paper thumbnail of Purification and Biochemical Characterization of a Mammalian Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase

Journal of Biological Chemistry, 1995

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Research paper thumbnail of A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3‐kinase

FEBS Letters, 1994

The mammalian Ptdlns 3‐kinase is shown to be inhibited by low nanomolar concentrations of demetho... more The mammalian Ptdlns 3‐kinase is shown to be inhibited by low nanomolar concentrations of demethoxyviridin, an antifungal agent structurally related to wortmannin. The inhibitory potency of both compounds could be observed in purified Ptdlns 3‐kinase whether or not the regulatory subunit (p85α) was present, suggesting that the inhibitors bind to the catalytic subunit (p110) of the Ptdlns 3‐kinase. These inhibitors also show similar potency against the intrinsic p85‐phosphorylating activity of the p110‐kinase. However, the structurally related Ptdlns 3‐kinase from Saccharomyces cerevisae (Vps34p) is not inhibited by either compound. Both inhibitors target the mammalian Ptdlns 3‐kinase in vitro and in vivo, implying that these compounds should be useful in suppressing Ptdlns 3‐kinase in mammalian systems. The inhibitors did not affect the mammalian Ptdlns 4‐kinase, but they are able to inhibit a membrane‐associated Ptdlns 4‐kinase from Schizosacchromyces pombe.

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Research paper thumbnail of Branched chain 2‐oxo‐acid dehydrogenase complex of rat liver

FEBS Letters, 1978

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Research paper thumbnail of Differential Regulation of Protein Kinase C Isoenzymes during Sphinganine Potentiation of Retinoic Acid-Induced Granulocytic Differentiation in Human Leukemia HL-60 Cells

Biochemical and Biophysical Research Communications, 1993

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Research paper thumbnail of Protein kinase C

Pharmacology & Therapeutics, 1991

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Research paper thumbnail of The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

bioRxiv (Cold Spring Harbor Laboratory), Jun 19, 2023

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Research paper thumbnail of Phosphatidylinositol(3,5)bisphosphate: a novel Inositol lipid linking stress responses to membrane trafficking in yeast

Biochemical Society Transactions, Jun 1, 1999

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Research paper thumbnail of Drug-resistant EGFR lung cancer mutations promote tumor growth by stabilizing interfaces in ligand-free signaling-competent EGFR oligomers

Research Square (Research Square), Jul 19, 2023

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Research paper thumbnail of Author response: Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

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Research paper thumbnail of Fluorescence Localisation Imaging with Photobleaching at 5 nm Resolution Reveals the Architecture of Basal EGFR Complexes and Mechanisms of Autoinhibition and Activation

Biophysical Journal, Feb 1, 2018

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Research paper thumbnail of Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study

Breast Cancer Research, Oct 13, 2017

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Research paper thumbnail of Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis

Molecular and Cellular Biology, Aug 15, 2002

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Research paper thumbnail of Clinical patterns of metastatic spread from formalin-fixed, paraffin-embedded (FFPE) expression profiles: A case-control study of 1,357 breast cancer patients

Annals of Oncology, May 1, 2015

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Research paper thumbnail of Protein Kinase C

Elsevier eBooks, 1993

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Research paper thumbnail of Michael D. Waterfield

Biochemical Journal

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Research paper thumbnail of Studies on the phosphorylation of protein kinase C-<i>α</i>

Biochemical Journal, Apr 15, 1992

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Research paper thumbnail of Supplementary Materials for The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

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Research paper thumbnail of Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts

Gastroenterology, 2021

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Research paper thumbnail of Protein Kinase C

Springer eBooks, 1986

Anoxic LTP is a long-lasting increase in synaptic effectiveness that follows a transient anoxic e... more Anoxic LTP is a long-lasting increase in synaptic effectiveness that follows a transient anoxic episode. Such postsynaptic persistent hyperexcitability is found particularly at the hippocampal Schaffer collateral/commissural–CA1 cell synapse.1–6 The mechanisms underlying anoxic LTP has been extensively investigated but not completely understood. With the use of extraand intracellular recording techniques in vitro, Ben-Ari and his colleagues have found that the induction of anoxic LTP is voltage, NMDA receptor and redox state dependent.1,2,7 Recently, we demonstrated that the induction of anoxic LTP is prevented by intracellular injection of the Ca2+ chelator BAPTA into the postsynaptic CA1 neurons.4 Thus a rise in intraneuronal Ca2+ seems to be responsible for a chain of events resulting in an anoxic LTP. However, which Ca2+-dependent processes are essential for the induction of anoxic LTP is still awaiting elucidation. Because the activation of Ca2+-dependent protein kinase (PKC) cascades is known to play an important role in the long-lasting use-dependent strengthening and reduction in synaptic efficacy, such as long-term potentiation (LTP) in the hippocampus and longterm depression (LTD) in the cerebellum,8,9 it is of particular interest to examine whether the induction of anoxic LTP also required the activation of PKC. The present study was undertaken to elucidate this possibility by examining the effect of specific PKC inhibitors on the induction of anoxic LTP in the CA1 neurons of rat hippocampal slices in vitro.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Autophosphorylation and protein kinase C phosphorylation of the epidermal growth factor receptor. Effect on tyrosine kinase activity and ligand binding affinity

Journal of Biological Chemistry, 1985

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Purification and Biochemical Characterization of a Mammalian Phosphatidylinositol 3,4,5-Trisphosphate 5-Phosphatase

Journal of Biological Chemistry, 1995

Bookmarks Related papers MentionsView impact

Research paper thumbnail of A comparison of demethoxyviridin and wortmannin as inhibitors of phosphatidylinositol 3‐kinase

FEBS Letters, 1994

The mammalian Ptdlns 3‐kinase is shown to be inhibited by low nanomolar concentrations of demetho... more The mammalian Ptdlns 3‐kinase is shown to be inhibited by low nanomolar concentrations of demethoxyviridin, an antifungal agent structurally related to wortmannin. The inhibitory potency of both compounds could be observed in purified Ptdlns 3‐kinase whether or not the regulatory subunit (p85α) was present, suggesting that the inhibitors bind to the catalytic subunit (p110) of the Ptdlns 3‐kinase. These inhibitors also show similar potency against the intrinsic p85‐phosphorylating activity of the p110‐kinase. However, the structurally related Ptdlns 3‐kinase from Saccharomyces cerevisae (Vps34p) is not inhibited by either compound. Both inhibitors target the mammalian Ptdlns 3‐kinase in vitro and in vivo, implying that these compounds should be useful in suppressing Ptdlns 3‐kinase in mammalian systems. The inhibitors did not affect the mammalian Ptdlns 4‐kinase, but they are able to inhibit a membrane‐associated Ptdlns 4‐kinase from Schizosacchromyces pombe.

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Branched chain 2‐oxo‐acid dehydrogenase complex of rat liver

FEBS Letters, 1978

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Differential Regulation of Protein Kinase C Isoenzymes during Sphinganine Potentiation of Retinoic Acid-Induced Granulocytic Differentiation in Human Leukemia HL-60 Cells

Biochemical and Biophysical Research Communications, 1993

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Protein kinase C

Pharmacology & Therapeutics, 1991

Bookmarks Related papers MentionsView impact

Research paper thumbnail of The T766M-EGFR lung cancer mutation promotes tumor growth by exploiting newfound assembly mechanisms in ligand-free EGFR oligomers

bioRxiv (Cold Spring Harbor Laboratory), Jun 19, 2023

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Phosphatidylinositol(3,5)bisphosphate: a novel Inositol lipid linking stress responses to membrane trafficking in yeast

Biochemical Society Transactions, Jun 1, 1999

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Drug-resistant EGFR lung cancer mutations promote tumor growth by stabilizing interfaces in ligand-free signaling-competent EGFR oligomers

Research Square (Research Square), Jul 19, 2023

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Author response: Inhibitor-induced HER2-HER3 heterodimerisation promotes proliferation through a novel dimer interface

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Fluorescence Localisation Imaging with Photobleaching at 5 nm Resolution Reveals the Architecture of Basal EGFR Complexes and Mechanisms of Autoinhibition and Activation

Biophysical Journal, Feb 1, 2018

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study

Breast Cancer Research, Oct 13, 2017

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Site-Directed Perturbation of Protein Kinase C- Integrin Interaction Blocks Carcinoma Cell Chemotaxis

Molecular and Cellular Biology, Aug 15, 2002

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Clinical patterns of metastatic spread from formalin-fixed, paraffin-embedded (FFPE) expression profiles: A case-control study of 1,357 breast cancer patients

Annals of Oncology, May 1, 2015

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Protein Kinase C

Elsevier eBooks, 1993

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Michael D. Waterfield

Biochemical Journal

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Studies on the phosphorylation of protein kinase C-<i>α</i>

Biochemical Journal, Apr 15, 1992

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Supplementary Materials for The ErbB4 CYT2 variant protects EGFR from ligand-induced degradation to enhance cancer cell motility

Bookmarks Related papers MentionsView impact

Research paper thumbnail of Immunogenomics of Colorectal Cancer Response to Checkpoint Blockade: Analysis of the KEYNOTE 177 Trial and Validation Cohorts

Gastroenterology, 2021

Bookmarks Related papers MentionsView impact

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