Peter Peters - Academia.edu (original) (raw)
Papers by Peter Peters
![Research paper thumbnail of Cerebral Blood Flow Measurements by Magnetic Resonance Imaging Bolus Tracking: Comparison With [15O]H2O Positron Emission Tomography in Humans](https://attachments.academia-assets.com/48744429/thumbnails/1.jpg)
](Journal of Cerebral Blood Flow and Metabolism, 1998
In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using mag... more In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using magnetic reso nance (MR) bolus tracking was compared with [,sO]H20 pos itron emission tomography (PET). The method yielded para metric CBF images with tissue contrast in good agreement with Abbreviations used: CJt), arterial input function; 0, convolution of R(t) with Ca(t); C,(t) , concentration of intravascular contrast agent within a given tissue element; EPI, echo planar imaging; Fe tissue flow; <PGd, common conversion factor; K/, unidirectional clearance for water; k2' K/Vd; MRI, magnetic resonance imaging; PET, positron emission tomography; R(t), vascular residue function (normalized input response function); !:J.R2, transverse relaxation rate; ROI, region of interest; S(O), signal intensity at baseline; S(t), signal intensity at time t; SVD, singUlar value decomposition; Vd, distribution volume of tracer; Vp, instantaneous vascular distribution volume of tissue.
British Journal of Anaesthesia, 1982
One hundred and eighty-four patients were studied to elucidate the contribution of intracuff pres... more One hundred and eighty-four patients were studied to elucidate the contribution of intracuff pressure and cuff type to the occurrence of sore throat and hoarseness after operation. The patients were allocated to one of the following groups: A = mask only; B = reusable Rüsch tube with intermittent cuff volume adjustment; C = reusable Rüsch tube without cuff volume adjustment; D = disposable Portex Blue Line tube with intermittent cuff volume adjustment; E = disposable Shiley Low Pressure tube with intermittent cuff volume adjustment. Nitrous oxide was a component of anaesthesia in all patients. Moderate or severe symptoms were recorded in 30-33% of the patients in groups C, D and E, contrasting with group B, in which these sequelae were seen in only 10% of patients (P less than 0.025). All sequelae occurred less frequently in group A than in any of the other groups (P less than 0.025). Women were more likely to develop sore throat after intubation than were men (P less than 0.01). A possible relationship between differences in cuff-trachea contact area is postulated.
IEEE Micro, 1994
Fault injection is an effective method for studying the effects of faults in computer systems and... more Fault injection is an effective method for studying the effects of faults in computer systems and for validating fault-handling mechanisms. Our approach involves injecting transient faults into integrated circuits by using heavy-ion radiation from a callfbtnhun-252 source. The proliferation of safety-critical and fault-tolerant systems us-VLSI technology makes such attempts to inject faults at internal locations in VLSI circuits increasingty important.
A simple and ready-to-go test based on a 5 nuclease (TaqMan) PCR technique was developed for iden... more A simple and ready-to-go test based on a 5 nuclease (TaqMan) PCR technique was developed for identification of presumptive Salmonella enterica isolates. The results were compared with those of conventional methods. The TaqMan assay was evaluated for its ability to accurately detect 210 S. enterica isolates, including 100 problematic "rough" isolates. An internal positive control was designed to use the same Salmonella primers for amplification of a spiked nonrelevant template (116 bp) in the sample tube. The PCR test correctly identified all the Salmonella strains by resulting in positive end-point fluorescence (FAM) signals for the samples and positive control (TET) signals (relative sensitivity [⌬Rn], >0.6). The diagnostic specificity of the method was assessed using 120 non-Salmonella strains, which all resulted in negative FAM signals (⌬Rn, <0.5). All 100 rough Salmonella strains tested resulted in positive FAM and TET signals. In addition, it was found that the complete PCR mixture, predispensed in microwell plates, could be stored for up to 3 months at ؊20°C. Thus, the diagnostic TaqMan assay developed can be a useful and simple alternative method for identification of Salmonella, particularly in large reference laboratories.
The question to what extent particle induced transients in combinational parts of a circuit propa... more The question to what extent particle induced transients in combinational parts of a circuit propagate into memory elements is addressed in this paper An experimental method is presented in which the proportion of bit flips originating from heavy-ion hits in combinational logic is determined. It is proposed that a voltage pulse may only propagate through a limited number of transistor stages and still be latched. The proportion of all transients in combinational logic that were latched into registers was experimentally, estimated to be between 0.7/spl middot/10/sup -3/ and 2/spl middot/10/sup -3/ for a custom designed CMOS circuit. Very few multiple bit flips were observed during the experiments which indicates that the single bit flip model used in many high-level simulations is reasonable accurate.>
Diabetologia, 1991
The prevalence of micro- and macroalbuminuria was determined in Type 2 (non-insulin-dependent) di... more The prevalence of micro- and macroalbuminuria was determined in Type 2 (non-insulin-dependent) diabetic patients, less than 76 years of age, attending a diabetic clinic during 1987. All eligible patients (n=557) were asked to collect a 24-h urine sample for quantitative albumin analysis. Urine collections were obtained in 296 males and 253 females (96%). Normoalbuminuria were defined as urinary albumin excretion≤30 mg/24 h (n=323), microalbuminuria as 31–299 mg/24 h (n=151), and macroalbuminuria as ≥300 mg/ 24 h (n=75). The prevalence of macroalbuminuria was significantly higher in males (20%) than in females (6%), while the prevalence of microalbuminuria was almost identical in males (26%) and females (29%). The prevalence of arterial hypertension increased with increased albuminuria, being 48%, 68%, and 85% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of proliferative retinopathy rose with increasing albuminuria, being 2%, 5% and 12% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of coronary heart disease, based on Minnesota coded electrocardiograms, was more frequent in patients with macroalbuminuria (46%) compared to patients with microalbuminuria (26%) and patients with normoalbuminuria (22%). Foot ulcers were more frequent in micro- and macroalbuminuric patients, being 13% and 25%, respectively, compared to 5% in patients with normoalbuminuria. This cross-sectional study has revealed a high prevalence of microalbuminuria (27%) and macroalbuminuria (14%) in Type 2 diabetic patients. Patients with raised urinary albumin excretion are characterized by obesity, elevated haemoglobin Alc, increased frequency of arterial hypertension, proliferative retinopathy, coronary heart disease and foot ulcers. Thus, these findings suggest that urinary excretion of albumin should be monitored routinely in patients with Type 2 diabetes.
Journal of Mass Spectrometry, 1993
During the last decade new ionization techniques have made it possible to measure the molecular w... more During the last decade new ionization techniques have made it possible to measure the molecular weight of many intact proteins by mass spectrometry, and they have made it much easier to obtain a mass spectrometric peptide map of a protein. At the same time advances in protein and DNA sequencing technology are resulting in an exponential increase in the number of sequences deposited in databases. Here we investigate the possibility to use mass spectrometric data to identify proteins in databases. Searching a database by total molecular weight is found to be an easy and sometimes sufficient approach. For more specificity and for error tolerance in both the mass spectrometric data and the database information we search by partial mass spectrometric peptide map of the protein. In general, just four to six proteolytic peptides measured with a mass accuracy between 0.1 and 0.01% allow a useful search of databases such as the Protein Identification Resource (PIR). As the size of DNA and protein sequence databases grows, protein identification by partial mass spectrometric peptide maps should become increasingly powerful and may become a general method to identify and characterize proteins.
Reviews of Modern Physics, 1998
Kidney International, 2000
may contribute to the high incidence of CVD in maintenance dialysis patients .
Journal of Cerebral Blood Flow and Metabolism, 1998
In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using mag... more In six young, healthy volunteers, a novel method to determine cerebral blood flow (CBF) using magnetic reso nance (MR) bolus tracking was compared with [,sO]H20 pos itron emission tomography (PET). The method yielded para metric CBF images with tissue contrast in good agreement with Abbreviations used: CJt), arterial input function; 0, convolution of R(t) with Ca(t); C,(t) , concentration of intravascular contrast agent within a given tissue element; EPI, echo planar imaging; Fe tissue flow; <PGd, common conversion factor; K/, unidirectional clearance for water; k2' K/Vd; MRI, magnetic resonance imaging; PET, positron emission tomography; R(t), vascular residue function (normalized input response function); !:J.R2, transverse relaxation rate; ROI, region of interest; S(O), signal intensity at baseline; S(t), signal intensity at time t; SVD, singUlar value decomposition; Vd, distribution volume of tracer; Vp, instantaneous vascular distribution volume of tissue.
British Journal of Anaesthesia, 1982
One hundred and eighty-four patients were studied to elucidate the contribution of intracuff pres... more One hundred and eighty-four patients were studied to elucidate the contribution of intracuff pressure and cuff type to the occurrence of sore throat and hoarseness after operation. The patients were allocated to one of the following groups: A = mask only; B = reusable Rüsch tube with intermittent cuff volume adjustment; C = reusable Rüsch tube without cuff volume adjustment; D = disposable Portex Blue Line tube with intermittent cuff volume adjustment; E = disposable Shiley Low Pressure tube with intermittent cuff volume adjustment. Nitrous oxide was a component of anaesthesia in all patients. Moderate or severe symptoms were recorded in 30-33% of the patients in groups C, D and E, contrasting with group B, in which these sequelae were seen in only 10% of patients (P less than 0.025). All sequelae occurred less frequently in group A than in any of the other groups (P less than 0.025). Women were more likely to develop sore throat after intubation than were men (P less than 0.01). A possible relationship between differences in cuff-trachea contact area is postulated.
IEEE Micro, 1994
Fault injection is an effective method for studying the effects of faults in computer systems and... more Fault injection is an effective method for studying the effects of faults in computer systems and for validating fault-handling mechanisms. Our approach involves injecting transient faults into integrated circuits by using heavy-ion radiation from a callfbtnhun-252 source. The proliferation of safety-critical and fault-tolerant systems us-VLSI technology makes such attempts to inject faults at internal locations in VLSI circuits increasingty important.
A simple and ready-to-go test based on a 5 nuclease (TaqMan) PCR technique was developed for iden... more A simple and ready-to-go test based on a 5 nuclease (TaqMan) PCR technique was developed for identification of presumptive Salmonella enterica isolates. The results were compared with those of conventional methods. The TaqMan assay was evaluated for its ability to accurately detect 210 S. enterica isolates, including 100 problematic "rough" isolates. An internal positive control was designed to use the same Salmonella primers for amplification of a spiked nonrelevant template (116 bp) in the sample tube. The PCR test correctly identified all the Salmonella strains by resulting in positive end-point fluorescence (FAM) signals for the samples and positive control (TET) signals (relative sensitivity [⌬Rn], >0.6). The diagnostic specificity of the method was assessed using 120 non-Salmonella strains, which all resulted in negative FAM signals (⌬Rn, <0.5). All 100 rough Salmonella strains tested resulted in positive FAM and TET signals. In addition, it was found that the complete PCR mixture, predispensed in microwell plates, could be stored for up to 3 months at ؊20°C. Thus, the diagnostic TaqMan assay developed can be a useful and simple alternative method for identification of Salmonella, particularly in large reference laboratories.
The question to what extent particle induced transients in combinational parts of a circuit propa... more The question to what extent particle induced transients in combinational parts of a circuit propagate into memory elements is addressed in this paper An experimental method is presented in which the proportion of bit flips originating from heavy-ion hits in combinational logic is determined. It is proposed that a voltage pulse may only propagate through a limited number of transistor stages and still be latched. The proportion of all transients in combinational logic that were latched into registers was experimentally, estimated to be between 0.7/spl middot/10/sup -3/ and 2/spl middot/10/sup -3/ for a custom designed CMOS circuit. Very few multiple bit flips were observed during the experiments which indicates that the single bit flip model used in many high-level simulations is reasonable accurate.>
Diabetologia, 1991
The prevalence of micro- and macroalbuminuria was determined in Type 2 (non-insulin-dependent) di... more The prevalence of micro- and macroalbuminuria was determined in Type 2 (non-insulin-dependent) diabetic patients, less than 76 years of age, attending a diabetic clinic during 1987. All eligible patients (n=557) were asked to collect a 24-h urine sample for quantitative albumin analysis. Urine collections were obtained in 296 males and 253 females (96%). Normoalbuminuria were defined as urinary albumin excretion≤30 mg/24 h (n=323), microalbuminuria as 31–299 mg/24 h (n=151), and macroalbuminuria as ≥300 mg/ 24 h (n=75). The prevalence of macroalbuminuria was significantly higher in males (20%) than in females (6%), while the prevalence of microalbuminuria was almost identical in males (26%) and females (29%). The prevalence of arterial hypertension increased with increased albuminuria, being 48%, 68%, and 85% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of proliferative retinopathy rose with increasing albuminuria, being 2%, 5% and 12% in patients with normoalbuminuria, microalbuminuria, and macroalbuminuria respectively. Prevalence of coronary heart disease, based on Minnesota coded electrocardiograms, was more frequent in patients with macroalbuminuria (46%) compared to patients with microalbuminuria (26%) and patients with normoalbuminuria (22%). Foot ulcers were more frequent in micro- and macroalbuminuric patients, being 13% and 25%, respectively, compared to 5% in patients with normoalbuminuria. This cross-sectional study has revealed a high prevalence of microalbuminuria (27%) and macroalbuminuria (14%) in Type 2 diabetic patients. Patients with raised urinary albumin excretion are characterized by obesity, elevated haemoglobin Alc, increased frequency of arterial hypertension, proliferative retinopathy, coronary heart disease and foot ulcers. Thus, these findings suggest that urinary excretion of albumin should be monitored routinely in patients with Type 2 diabetes.
Journal of Mass Spectrometry, 1993
During the last decade new ionization techniques have made it possible to measure the molecular w... more During the last decade new ionization techniques have made it possible to measure the molecular weight of many intact proteins by mass spectrometry, and they have made it much easier to obtain a mass spectrometric peptide map of a protein. At the same time advances in protein and DNA sequencing technology are resulting in an exponential increase in the number of sequences deposited in databases. Here we investigate the possibility to use mass spectrometric data to identify proteins in databases. Searching a database by total molecular weight is found to be an easy and sometimes sufficient approach. For more specificity and for error tolerance in both the mass spectrometric data and the database information we search by partial mass spectrometric peptide map of the protein. In general, just four to six proteolytic peptides measured with a mass accuracy between 0.1 and 0.01% allow a useful search of databases such as the Protein Identification Resource (PIR). As the size of DNA and protein sequence databases grows, protein identification by partial mass spectrometric peptide maps should become increasingly powerful and may become a general method to identify and characterize proteins.
Reviews of Modern Physics, 1998
Kidney International, 2000
may contribute to the high incidence of CVD in maintenance dialysis patients .