Peymaneh Taheri - Academia.edu (original) (raw)

Papers by Peymaneh Taheri

$Research paper thumbnail of New Insights in the Management of Refractory Neonatal Gerd$

EPRA international journal of multidisciplinary research, Jul 13, 2023

Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates. The main g... more Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates. The main goals of infantile GERD treatment are maintaining clinical recovery, sufficient growth, and preventing the recurrence rate and related problems. Acidsuppressive therapy including H2RAs and PPIs are the basic pharmacologic therapy for adult and pediatric GERD. PPIs are more effective than H2RAs in GERD treatment. Neonatal GERD remains a difficult entity to define and manage, and additional studies to aid in the clinical diagnosis and management are needed. Neonatal GERD refractory to conservative and monotherapy is a dilemma and performing trials to evaluate the effect of a PPI or a H2RA plus prokinetics in the management of these neonates is necessary to prevent considering invasive diagnostic procedures and early surgical treatment. we performed three different clinical trials to survey the efficacy and safety of combined therapy including an H2RA plus a prokinetic or a PPI plus a prokinetic in neonatal GERD refractory to conservative and monotherapy.

International journal of multidisciplinary research and analysis, Jan 9, 2023

Background: Recent evidence emphasizes the positive effect of probiotics and synbiotics in the tr... more Background: Recent evidence emphasizes the positive effect of probiotics and synbiotics in the treatment of functional constipation in childhood, but no study has surveyed the effectiveness of synbiotics in improving the clinical conditions in infants ≤6 months suffering from functional constipation, so we performed this study. Aims: Comparing the efficacy and safety of two types of synbiotics including PediLact® (Zist-Takhmir Co., Tehran, Iran) drop containing Bifidobacterium infantis, Lactobacillus reuteri, Lactobacillus rhamnosus plus fructooligosaccharides with BBCare® (Zist-Takhmir Co., Tehran, Iran) drop containing Bifidobacterium lactis BB-12 plus fructooligosaccharides in the treatment of infantile functional constipation. Study Design: This trial was performed on infants less than 6 months of age who met the ROME IV criteria for infantile functional constipation. The patients were randomly assigned to receive PediLact drop (n = 44) or BB-Care drop (n = 45) for one month and were evaluated on the seventh day and at the end of the first month. Results: A significant downward trend was revealed in the responsive rate of every clinical symptom in both intervention groups but BB-Care was more effective than PediLact in improving the frequency of weekly defecation. Both synbiotics also improved significantly all symptoms of constipation in all types of feeding methods after one week and one month of intervention (primary outcomes). There was no side effect of synbiotics through intervention (secondary outcome). Conclusions: This study shows that both synbiotics improved significantly all symptoms of functional constipation after one week and one month of intervention apart from type of feeding method in infants less than 6 months of age. Due to the greater effectiveness of BB-care in increasing stool frequency, B. lactis may play a more prominent role in this age group. This study has been registered at the Iranian Registry of Clinical Trails (IRCT20160827029535N7).

INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH AND ANALYSIS

Gastroesophageal reflux (GER) is a common physiologic process in infants that often resolves with... more Gastroesophageal reflux (GER) is a common physiologic process in infants that often resolves with growth and maturation, while gastroesophageal reflux disease (GERD) is a serious and common referral disease in infants and neonates. The first-line treatment for both GER and GERD is conservative therapy. H2RAs and PPIs are the two basic pharmacologic agents in the treatment of GERD in pediatrics and adults. The efficacy of PPIs is higher than that of H2RAs in GERD treatment. There are controversies in the pharmacologic treatment of neonatal GERD, and performing more clinical trials to survey the effect of PPIs and H2RAs and compare them with each other is necessary in this age group. We conducted three different clinical trials to compare the efficacy and safety of ranitidine with omeprazole or lansoprazole in refractory neonatal GERD.

International journal of pediatrics, Jun 2, 2022

Background. Advantages of caffeine for the treatment of apnea of prematurity (AOP) have prompted ... more Background. Advantages of caffeine for the treatment of apnea of prematurity (AOP) have prompted clinicians to use it as a preventive drug even before the occurrence of apnea. Objective. To compare the effect of early preventive caffeine therapy with routine late preventive caffeine on the occurrence rate of apnea of prematurity, bronchopulmonary dysplasia (BPD) and related radiographic changes, necrotizing enterocolitis (NEC), intraventricular hemorrhage (IVH), and patent ductus arteriosus (PDA), the need for mechanical ventilation, the length of mechanical ventilation, and the length of hospitalization. Materials and Methods. In this open randomized clinical trial study, 90 preterm neonates with the gestational age of 25-35 weeks were divided into 2 groups: group A received caffeine during the first two days of life (early preventive caffeine), while group B received caffeine during the third to the tenth day of life (late preventive caffeine). The occurrence rate of AOP and other outcomes were the primary outcomes. The adverse effects of caffeine in each group were the secondary outcomes. Results. The total occurrence rate of AOP was significantly higher (32.6%) in the late group versus (6.8%) in the early group (p = 0:002). The total occurrence rate of BPD was also significantly higher (37%) in the late group versus (18.2%) in the early group (p = 0:047). On the other hand, we found a lower need for mechanical ventilation, shorter length of mechanical ventilation, shorter length of hospitalization, and a lower occurrence rate of PDA, NEC, and IVH in the early group that was not significant. No adverse effect of caffeine was observed in each group. Conclusions. Early preventive caffeine administration was associated with a significantly lower occurrence rate of AOP, BPD, and BPD radiologic changes. As other outcomes occurred lesser in the early group that were not significant, future studies with more participants are recommended. This study has been registered at the Iranian Registry of Clinical Trials (IRCT20160827029535N8).

Japanese Journal of Gastroenterology Research

Introduction: Gastroesophageal reflux disease (GERD) is present in pediatric patients when reflux... more Introduction: Gastroesophageal reflux disease (GERD) is present in pediatric patients when reflux of gastric contents causes troublesome symptoms

Case Reports in Perinatal Medicine, 2017

Acute mastoiditis (AM) is rarely seen in newborns. It is characterized by retroauricular pain, sw... more Acute mastoiditis (AM) is rarely seen in newborns. It is characterized by retroauricular pain, swelling, tenderness and protrusion of the auricle. This is the first report of the neonatal mastoiditis in a 17-day-old term neonate with no obvious clinical manifestation of mastoiditis and no associated malformation of the ears and mastoids. A computed tomography (CT) scan of the temporal bones revealed right mastoiditis without osteitis, destruction of the mastoid bone or abscess formation. Discharge culture revealed streptococcus A colonies sensitive to ampicillin, ceftriaxone, vancomycin and chloramphenicol. She was successfully treated with intravenous ampicillin and ceftizoxime. No complication or recurrence was reported.

Background: Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates... more Background: Gastroesophageal reflux disease (GERD) is one of the most common problems in neonates. The main clinical manifestations of GERD are frequent regurgitation or vomiting associated with irritability, anorexia or feeding refusal, failure to thrive, Sandifer posturing, apnea, bradycardia and stridor in infants. Since the clinical manifestations of GERD are often non-specific in preterm infants, it has been described as the clinical syndrome responding to anti-reflux treatment. Aims: To our knowledge, no clinical trial has compared the efficacy of histamine-2 receptor antagonists (H2RAs) and proton pump inhibitors (PPIs) in preterm infants, nor has any study assessed the effect of adding a prokinetic agent to an acid suppressant and compared them together in these infants, so the present study was conducted. Study design: This study was performed on 58 preterm newborns (mean age, 9.72 ± 6.78 days, 43.2% boys and birth weight of 1,571.9 ± 596.59 grams) with GERD resistant to co...

Neonatal sepsis, a life-threatening condition, presents with non-specific clinical manifestations... more Neonatal sepsis, a life-threatening condition, presents with non-specific clinical manifestations and needs immediate empirical antimicrobial therapy. Choosing an appropriate antibiotic regimen covering the most probable pathogens is an important issue. In this study we compared the effectiveness of ceftizoxime and amikacin in the treatment of neonatal sepsis both in combination with ampicillin. In a randomized clinical trial, all term neonates with suspected sepsis referred to Bahrami hospital during March 2008 to March 2010 were evaluated. Patients were randomly recruited into two groups; one group receiving ampicillin and amikacin and the other ampicillin and ceftizoxime. Blood, urine and cerebrospinal fluid cultures, leukocyte count and C-reactive protein level were measured in all neonates. A total of 135 neonates were evaluated, 65 in amikacin group and 70 in ceftizoxime group. 60 neonates (85.7%) in ceftizoxime group and 54 neonates (83.1%) in amikacin group responded to the ...

Iranian journal of pediatrics, 2013

Acta Medica Iranica, 2011

Iranian journal of public health, 2013

Susceptibility pattern of organisms causing urinary tract infection (UTI) in neonate would potent... more Susceptibility pattern of organisms causing urinary tract infection (UTI) in neonate would potentially improve the clinical management by enabling clinicians to choose most reasonable first line empirical antibiotics. This study aimed to this end by studying isolated organisms from neonates with UTI in an inpatient setting. Current retrospective study has recruited all cases of neonatal UTI diagnosed through a suprapubic/catheterized sample, admitted to Neonatal Division of Bahrami Children's Hospital, Tehran, Iran, from June 2004 to June 2012. Escherichia coli was the dominant (64.4%) bacteria among a total of 73 cases (69.9% boys and 30.1% girls; aged 14.14 ± 7.68 days; birth weight of 3055.85 ± 623.00 g) and Enterobacter (19.2%), Klebsiella (12.3%), and Staphylococcus epidermdisis (4.1%) were less frequent isolated bacteria. E. coli was mostly resistant to ampicillin (93.6%), cefixime (85.7%) and cephalexin (77.3%), and sensitive to cefotaxime (63.6%). Enterobacter found to b...

Infant Behavior and Development, 2017

To evaluate the effect of low intensity recorded maternal voice on the physiologic reactions of h... more To evaluate the effect of low intensity recorded maternal voice on the physiologic reactions of healthy premature infants in the neonatal intensive care unit (NICU). Physiologic responses of 20 healthy preterm infants in the NICU of Shariati Hospital, Tehran, were obtained during a 15min intervention including three 5min periods (no-sound control, audio recorded playback of mother's voice, no-sound post-voice). The intervention was presented three times a day for three consecutive days. During each intervention, oxygen saturation (%, OSPR), heart rate (HR), and respiratory rate (RR) were recorded at 1min intervals over the 15min and then averaged over each 5min period, resulting in 3 averages for each variable for each intervention. Repeated Measures Analysis of Variance were employed to examine each variable separately. Over the three days, comparison of oxygen saturation over each of the three periods (before, during voice, after) revealed an increase in oxygen saturation during the voice period, compared to the pre-voice period, which persisted over the post-voice period; there were no differences between the voice and post-voice periods. Analyses of the HR and RR data showed a decrease in both variables during the voice period compared to the pre-voice period which persisted over the post-voice period. Again, there were no differences between the voice and post-voice periods. Exposure to low intensity recorded maternal voice has positive effects on the preterm infants 'physiologic responses.

Journal of Perinatal Medicine, 2016

Breast feeding alone does not provide adequate nutrition for growth in preterm infants; therefore... more Breast feeding alone does not provide adequate nutrition for growth in preterm infants; therefore, fortifiers are added when over 70-80 cc/kg/day of breast milk is tolerated. As there are few studies comparing early and late breast milk fortification, the following study was conducted. This double-blind clinical trial was performed on 80 preterm infants (gestational age of 28-34 weeks, birth weight <2 kg). The newborns were randomly divided into two groups to receive either early or late fortification. The primary and secondary outcomes were the difference in growth indices and complications (including feeding intolerance, necrotizing enterocolitis (NEC), and septicemia) between the two groups, respectively. Both groups showed increases in growth indices; however, there was no statistically significant difference in increments of growth indices and complications between the two groups. Our findings suggest that early fortification from the first feeding in neonates with exclusive breast feeding did not improve growth in the first 4 weeks in preterm neonates in comparison with late fortification; so early fortification may not be cost effective.

Pediatric Dimensions, 2016

Case Reports in Infectious Diseases, 2016

Acute otitis externa (AOE) is an infection of the external auditory canal, the auricle, and the o... more Acute otitis externa (AOE) is an infection of the external auditory canal, the auricle, and the outer surface of the tympanic membrane. Although AOE is one of the most common otologic conditions encountered in pediatric population, it is known to primarily affect children older than 2 years. We report a case of AOE caused by Staphylococcus aureus in a 23-day-old neonate. A 23-day-old female infant presented to our neonatology clinic with irritability and discharge from the right ear. There were yellow otorrhea, mild erythema, and edema of right external ear canal. There was no sign of otitis media on otoscopy. The results of laboratory tests were insignificant. The discharge culture grew colonies of methicillin-sensitive Staphylococcus aureus. After 48 hours of treatment with intravenous cloxacillin, significant improvement was observed. The present case highlights an unusual presentation of staphylococcal infection in a neonate. This is the first case of methicillin-sensitive Staphylococcus aureus otitis externa in an immunocompetent newborn.

International Journal of Pediatric Otorhinolaryngology Extra, 2016

‫ﺗﻬﺮان،‬ ‫ﭘﺰﺷﻜﻲ‬ ‫ﻋﻠﻮم‬ ‫داﻧﺸﮕﺎه‬ ‫ﭘﺰﺷﻜﻲ،‬ ‫داﻧﺸﻜﺪه‬ ‫ﻣﺠﻠﻪ‬ ‫اﺳﻔﻨﺪ‬ 1391 ‫دوره‬ ، 70 ‫ﺷﻤﺎره‬ ، 12... more ‫ﺗﻬﺮان،‬ ‫ﭘﺰﺷﻜﻲ‬ ‫ﻋﻠﻮم‬ ‫داﻧﺸﮕﺎه‬ ‫ﭘﺰﺷﻜﻲ،‬ ‫داﻧﺸﻜﺪه‬ ‫ﻣﺠﻠﻪ‬ ‫اﺳﻔﻨﺪ‬ 1391 ‫دوره‬ ، 70 ‫ﺷﻤﺎره‬ ، 12 ، 788 ‫ﺗﺎ‬ 792 ‫ﺑﺮرﺳ‬ ‫ﻲ‬ ‫ﻣ‬ ‫راﺑﻄﻪ‬ ‫ﻴ‬ ‫ﺰان‬ ‫اﻓﺰا‬ ‫ﻳ‬ ‫ﺶ‬ ‫ﺑ‬ ‫ﻴ‬ ‫ﻠ‬ ‫ﻲ‬ ‫روﺑ‬ ‫ﻴ‬ ‫ﻦ‬ ‫در‬ 48 -24 ‫ﺗﻮﻟﺪ‬ ‫ﻓﺼﻞ‬ ‫ﺑﺎ‬ ‫ﺗﻮﻟﺪ‬ ‫اول‬ ‫ﺳﺎﻋﺖ‬ ‫ﺳﺠﺎدﻳﺎن‬ ‫ﻧﮕﺎر‬ 1 * ‫ﺷﺠﺮي‬ ‫ﺣﻤﻴﺪه‬ 1 ، ‫ﻣﻔﻴﺪ‬ ‫روزا‬ 2 ‫ﺟﻬﺎدي‬ ‫راﻣﻴﻦ‬ 3 ، ‫ﻃﺎﻫﺮي‬ ‫ﻋﻠﻴﺰاده‬ ‫ﭘﻴﻤﺎﻧﻪ‬ 4 5 -3 ‫ﺑﻴﻠﻲ‬ ‫ﻣﺘﺎﺑﻮﻟﻴﺴﻢ‬ ‫ﻣﺮﺣﻠ‬ ‫در‬ ‫ﺷﺪه‬ ‫ﻣﺘﻮﻟﺪ‬ ‫ﺗﺎزه‬ ‫ﻧﻮزاد‬ ‫در‬ ‫روﺑﻴﻦ‬ ‫دوره‬ ‫از‬ ‫ﮔـﺬر‬ ‫ﻪ‬ ‫ﺑﺰرگ‬ ‫ﻣﺮﺣﻠﻪ‬ ‫ﺑﻪ‬ ‫ﺟﻨﻴﻨﻲ‬ ‫ﺗﻮﻟـﺪ‬ ‫از‬ ‫ﺑﻌـﺪ‬ ‫ﻛـﻪ‬ ‫ﻣﻬﻤـﻲ‬ ‫اﺗﻔـﺎق‬ ‫و‬ ‫اﺳـﺖ‬ ‫ﺳﺎﻟﻲ‬ ‫ﻣﻲ‬ ‫ﺑﻴﻠﻲ‬ ‫ﺛﺎﺑﺖ‬ ‫اﻓﺰاﻳﺶ‬ ‫اﻓﺘﺪ‬ ‫اﺳﺖ‬ ‫ﺳﺮم‬ ‫روﺑﻴﻦ‬ . ‫ﺑﻴﻠﻲ‬ ‫ﺑـﺪن‬ ‫در‬ ‫روﺑﻴﻦ‬ ‫ﻧﻘـﺶ‬ ‫ﻣﺤﺎﻓﻈﺘﻲ‬ ‫اﻛﺴﻴﺪان‬ ‫ﺑﺮاﺑﺮ‬ ‫در‬ ‫ﻫﺎ‬ ‫ﻣﻲ‬ ‫اﻳﻔﺎ‬ ‫ﻛﻨﺪ‬ . ‫آن‬ ‫از‬ ‫ﻛـﻪ‬ ‫ﺟـﺎﻳﻲ‬ ‫ﺑـﻪ‬ ‫ﻧـﻮزادان‬ ‫اﻛﺴﻴﺪاﺗﻴﻮ‬ ‫ﺻﺪﻣﺎت‬ ‫ﺑﺴﻴﺎر‬ ‫ﻫﺴﺘﻨﺪ‬ ‫ﺣﺴﺎس‬ ، 6 ‫ﺗﻔـﺎوت‬ ‫اﺳـﺖ‬ ‫ﻣﻤﻜـﻦ‬ ‫ﻫـﺎي‬ ‫ﻓﺼﻠ‬ ‫ﺑﻴﻠﻲ‬ ‫ﺳﻄﺢ‬ ‫ﻲ‬ ‫آن‬ ‫ﻧﻤـﻮ‬ ‫در‬ ‫ﻋﻤـﺮ‬ ‫اول‬ ‫روز‬ ‫ﭼﻨﺪ‬ ‫در‬ ‫ﺧﻮن‬ ‫روﺑﻴﻦ‬ ‫و‬ ‫ﻫـﺎ‬ ‫ﺑﻴﻤﺎري‬ ‫ﺑﻪ‬ ‫اﺑﺘﻼ‬ ‫اﺳﺘﻌﺪاد‬ ‫ﺑﺎﺷـﺪ‬ ‫ﻣـﺆﺛﺮ‬ ‫ﺑﻌـﺪي‬ ‫ﭘﺎﺗﻮﻟﻮژﻳﻜﻲ‬ ‫ﺗﻈﺎﻫﺮات‬ ‫و‬ ‫ﻫﺎ‬ . ‫ﻣﻘﺪﻣﻪ‬ ‫اﺻﻴﻞ‬ ‫ﻣﻘﺎﻟﻪ‬ ‫ﺗﻬﺮان،‬ ‫ﭘﺰﺷﻜﻲ‬ ‫ﻋﻠﻮم‬ ‫داﻧﺸﮕﺎه‬ ‫ﭘﺰﺷﻜﻲ،‬ ‫داﻧﺸﻜﺪه‬ ‫ﻣﺠﻠﻪ‬ ‫اﺳﻔﻨﺪ‬ 1391 ، ‫دوره‬ 70 ، ‫ﺷﻤﺎره‬ 12 ‫ﺻﻔﺤﻪ‬ ، ‫ﻫﺎي‬ 788 ‫ﺗﺎ‬ 792 ‫ﺟﺪول‬ 1 : ‫اﻓﺰاﻳ‬ ‫ﻣﻴﺰان‬ ‫ﺑﻴﻦ‬ ‫ارﺗﺒﺎط‬ ‫ﺑﻴﻠﻲ‬ ‫ﺶ‬ ‫ﺳﺎل‬ ‫ﻣﺨﺘﻠﻒ‬ ‫ﻓﺼﻮل‬ ‫در‬ ‫روﺑﻴﻦ‬ ‫ﻓﺼﻞ‬ ‫ﺑﻴﻠﻲ‬ ‫اﻓﺰاﻳﺶ‬ ‫ﻣﻴﺎﻧﮕﻴﻦ‬ ‫روﺑﻴﻦ‬ ± ‫اﻧﺤﺮاف‬ ‫ﻣﻌﻴﺎر‬ ‫ﺑﻬﺎر‬ ( ‫آﻣﺎري‬ ‫آزﻣﻮن‬ ANOVA ، ‫ﻣﻌﻨﻲ‬ ‫ﻣﻘﺎدﻳﺮ‬ ‫دار‬ 05 / 0 P< . ‫ﻳﺎﻓﺘﻪ‬ ‫ﻫﺎ‬ ‫روش‬ ‫ﺑﺮرﺳﻲ‬ Downloaded from http://journals.tums.ac.ir/ at 11:47 IRDT on Tuesday August 13th 2013 10 ‫در‬ ‫ﻣﻄﺎﻟﻌﻪ‬ Bottini ‫ﺳﺎل‬ ‫در‬ 2010 ‫راﺑﻄﻪ‬ ‫ي‬ ‫ﺑﻴﻠﻲ‬ ‫ﺳﻄﺢ‬ ‫و‬ ‫ﻓﺼﻞ‬ ‫ﺑﻴﻦ‬ ‫را‬ ‫روﺑﻴﻦ‬ ‫در‬ ‫ﻓﺘﻮﺗﺮاﭘﻲ‬ ‫ﻣﻴﺰان‬ ‫آﻧﺎﻟﻴﺰ‬ ‫ﺑﺎ‬ ‫ﻧﻮزادي‬ ‫دوره‬ ‫در‬ 5540 ‫ﻛـﺮد‬ ‫ﺑﺮرﺳـﻲ‬ ‫ﻧﻮزاد‬ . ‫ﺑﻴﺶ‬ ‫ﻛﻪ‬ ‫داد‬ ‫ﻧﺸﺎن‬ ‫وي‬ ‫ﺗﺮﻳﻦ‬ ‫و‬ ‫ﻣـﻲ‬ ‫ﻣﺎه‬ ‫ﺑﻴﻦ‬ ‫در‬ ‫ﻓﺘﻮﺗﺮاﭘﻲ‬ ‫از‬ ‫اﺳﺘﻔﺎده‬ ‫ﻣﻴﺰان‬ ‫ﻣﻲ‬ ‫دﻳﺪه‬ ‫آﮔﻮﺳﺖ‬ ‫و‬ ‫ﻓﺘـﻮﺗﺮاﭘﻲ‬ ‫از‬ ‫اﺳﺘﻔﺎده‬ ‫ﻣﻴﺰان‬ ‫و‬ ‫ﺗﻮﻟﺪ‬ ‫ﻓﺼﻞ‬ ‫ﺑﻴﻦ‬ ‫و‬ ‫ﺷﻮد‬ ‫ﻣﻌﻨﻲ‬ ‫راﺑﻄﻪ‬ ‫زردي‬ ‫وﻗﻮع‬ ‫اﺣﺘﻤﺎل‬ ‫دارد‬ ‫وﺟﻮد‬ ‫دار‬ . 11 ‫ﻣﻄﺎﻟﻌﻪ‬ ‫در‬ Cerna ‫ﻛﻪ‬ ‫ﺑﻴﻠﻲ‬ ‫اﻓﺰاﻳﺶ‬ ‫ﻣﻴﺰان‬ ‫ﻧـﻮزادان‬ ‫در‬ ‫ﺗﺎﺑـﺴﺘﺎن‬ ‫و‬ ‫زﻣـﺴﺘﺎن‬ ‫ﻓﺼﻞ‬ ‫دو‬ ‫در‬ ‫روﺑﻴﻦ‬ ‫ﺑـﻮد‬ ‫ﺷـﺪه‬ ‫ﻣﻘﺎﻳﺴﻪ‬ ‫ﺳﺎﻟﻢ‬ ‫و‬ ‫ﺗﺮم‬ ‫ﺑﻴﻠـﻲ‬ ‫اﻓـﺰاﻳﺶ‬ ‫ﻣﻴـﺰان‬ ، ‫ﻓـﺼﻞ‬ ‫در‬ ‫روﺑـﻴﻦ‬ ‫ﺑﻴﺶ‬ ‫زﻣﺴﺘﺎن‬ ‫ﺗﺎﺑـﺴﺘﺎن‬ ‫در‬ ‫ﻧﻴـﺰ‬ ‫ﻓﺘﻮﺗﺮاﭘﻲ‬ ‫از‬ ‫اﺳﺘﻔﺎده‬ ‫ﻣﻴﺰان‬ ‫و‬ ‫ﺗﺎﺑﺴﺘﺎن‬ ‫از‬ ‫ﺗﺮ‬ ‫ﺑﺤﺚ‬ Downloaded from http://journals.tums.ac.ir/ at 11:47 IRDT on Tuesday August 13th 2013 ‫ﻣ‬ ‫راﺑﻄﻪ‬ ‫ﻴ‬ ‫ﺰان‬ ‫اﻓﺰا‬ ‫ﻳ‬ ‫ﺶ‬ ‫ﺑ‬ ‫ﻴ‬ ‫ﻠ‬ ‫ﻲ‬ ‫روﺑ‬ ‫ﻴ‬ ‫ﻦ‬ ‫در‬ 48 -24 ‫ﺗﻮﻟﺪ‬ ‫ﻓﺼﻞ‬ ‫ﺑﺎ‬ ‫ﺗﻮﻟﺪ‬ ‫اول‬ ‫ﺳﺎﻋﺖ‬ 791 http://tumj.tums.ac.ir Tehran Univ Med J (TUMJ) 2013 March;70(12):788-92

Acta medica Iranica, 2012

Urinary tract infection (UTI) is a neonatal life threatening infection which is usually treated w... more Urinary tract infection (UTI) is a neonatal life threatening infection which is usually treated with ampicillin plus an aminoglycoside or a third-generation cephalosporin. Recently, growing number of Escherchia coli species resistant to ampicillin and aminoglycosides have raised concerns regarding the necessity to change the empirical therapy. This motivates us to determine neonatal UTI clinical response to the used empirical antibiotics. This study was designed as a Case Series. All neonates admitted to Bahrami Children Hospital, Tehran, Iran, during 2001- 2010 with a diagnosis of UTI surveyed by simple non-random sampling. Totally, 97 cases (including 83 (85.6%) term, 8 (8.2%) post-term and 6 (6.2%) preterm neonates) with a mean age of 15.85 ± 7.05 days at admission ,average weight of 3195.57 ± 553g at birth and 3276.29 ± 599.182 g at admission were studied. Ampicillin resistance in 93 cases (95.9%), gentamicin resistance in 51 cases (52.6%) and trimethoprim- sulfamethoxazole resi...