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Papers by Philip Sunshine

Research paper thumbnail of Late morbidity among survivors of necrotizing enterocolitis

Pediatrics, Dec 1, 1980

Of 40 survivors of necrotizing enterocolitis 19 were completely normal children at the time of fo... more Of 40 survivors of necrotizing enterocolitis 19 were completely normal children at the time of follow-up, one to three years later. Among the other 21 children, only six had moderate to severe neurologic impairment, representing 15% of all survivors. Despite the fact that intestinal injury is the main feature of the neonatal disease, only four children were symptomatic from gastrointestinal sequelae, and none of these suffered failure to thrive. Thus, 81% (17) of the children with late morbidity had problems unrelated to the gastrointestinal tract. The nongastrointestinal morbidity was associated with prematurity and the degree of perinatal stress.

Research paper thumbnail of Effects of Microwave Radiation on Anti-infective Factors in Human Milk

Pediatrics, 1992

In intensive care nurseries it has become common practice to use microwave thawing of frozen huma... more In intensive care nurseries it has become common practice to use microwave thawing of frozen human milk for more rapid accessibility. Twenty-two freshly frozen human milk samples were tested for lysozyme activity, total IgA, and specific secretory IgA to Escherichia coli serotypes 01, 04, and 06. The samples were heated by microwave for 30 seconds at a low- or high-power setting and then reanalyzed. One-mL aliquots of 10 additional human milk samples were micro-waved at low (20°C to 25°C), medium (60°C to 70°C), and high (≥98°C) setting before the addition to each of 1 mL of diluted E coli suspension. E coli growth was determined after 3½ hours of incubation at 37°C. Microwaving at high temperatures (72°C to 98°C) caused a marked decrease in activity of all the tested anti-infective factors. E coli growth at ≥98°C was 18 times that of control human milk. Microwaving at low temperatures(20°C to 53°C) had no significant effect on total IgA, specific IgA to E coli serotypes 01 and 04, ...

Research paper thumbnail of Maturational patterns of carbohydrases in the ileal remnant of rats after jejunectomy at infancy

The American Journal of Clinical Nutrition, 1988

Research paper thumbnail of Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors

Journal of perinatology : official journal of the California Perinatal Association, Jan 25, 2018

The risk of developing treatment-warranted Type 1 retinopathy of prematurity (ROP) might be reduc... more The risk of developing treatment-warranted Type 1 retinopathy of prematurity (ROP) might be reduced in preterm infants by modifying certain systemic factors. There are steps that can be taken both early and late in the course of retinal vascular maturation that may potentially reduce an infant's risk of developing Type 1 ROP. In prethreshold stage 2-3 ROP without plus disease, a combination of supplemental oxygen, correction of severe anemia, and light adaptation to reduce rod photoreceptor oxygen consumption helped us to reduce ROP severity, and encouraged a return to a more physiologic retinal vascular maturation pattern. Thus, it may be possible to reduce the risk of developing Type 1 ROP by making adjustments in certain systemic parameters aimed at reducing retinal hypoxia, thereby gently lowering pathologically elevated levels of vascular endothelial growth factor (VEGF) within the eye.

Research paper thumbnail of Perinatal aspiration syndrome: Its association with intrapartum events and anesthesia

American Journal of Obstetrics and Gynecology, 1974

Research paper thumbnail of Comprar Fetal and Neonatal Brain Injury 4Ed | Philip Sunshine | 9780521888592 | Cambridge University Press

Http Www Libreriasaulamedica Com, 2009

Tienda online donde Comprar Fetal and Neonatal Brain Injury 4Ed al precio 135,91 € de Philip Suns... more Tienda online donde Comprar Fetal and Neonatal Brain Injury 4Ed al precio 135,91 € de Philip Sunshine | William E. Benitz | David K. Stevenson, tienda de Libros de Medicina, Libros de Neurologia - Neurologia infantil

Research paper thumbnail of Correlations of clinical, laboratory, imaging, and placental findings as to the timing of asphyxial events

Fetal and Neonatal Brain Injury, 2009

Research paper thumbnail of Extended management

Mechanisms, Management and the Risks of Practice

Research paper thumbnail of 1339 Failure for Catch-Up Growth at 3 Years in Preterm Infants ≤ 1500 GM

Research paper thumbnail of Abnormalities of Carbamyl Phosphate Synthetase and Ornithine Transcarbamylase in Liver of Patients with Reye's Syndrome

Research paper thumbnail of Metabolic and Genetic Studies of a Family with Ornithine Transcarbamylase Deficiency

Research paper thumbnail of Preamble to: The Incubator and the Medical Discovery of the Premature Infant

Journal of Perinatology, 2000

Research paper thumbnail of Intestinal cytochrome response with repair of iron deficiency

The Journal of Pediatrics, 1966

Research paper thumbnail of Macrosomia: Causes and consequences

The Journal of Pediatrics, 1982

Research paper thumbnail of Prognosis of children surviving with the aid of mechanical ventilation in the newborn period

The Journal of Pediatrics, 1974

Research paper thumbnail of Neonatal hypoxia and pulmonary vasospasm: Response to tolazoline

The Journal of Pediatrics, 1976

Research paper thumbnail of Evidence for the Possible Relationship of Neonatal Skinfold Thickness to Maternal Glucose Metabolism During the Third Trimester

Journal of Pediatric Gastroenterology and Nutrition, 1982

Research paper thumbnail of Sugar hydrolases and their arrangement on the rat intestinal microvillus membrane

The Journal of Membrane Biology, 1979

The arrangement of the sugar hydrolases, sucrase-isomaltase, maltase, and lactase on the microvil... more The arrangement of the sugar hydrolases, sucrase-isomaltase, maltase, and lactase on the microvillus membrane of rat intestine was investigated by immunological technique. The enzymes were purified essentially free of each other to near homogeneity and antisera of high specificity were obtained against each. Microvillus membranes were prepared routinely in high purity from rat intestine and contained an average 61% protein, 20% lipid, and 19% carbohydrate, with the sugar hydrolases comprising an estimated 20--25% of the membrane protein. The immunoreactivity of membrane-bound sucrase-isomaltase, maltase, and lactase was investigated with antisera demostrating specific reactivity to each, when tested in the presence of other membrane extractives. The membrane-bound enzymes were found in each case to combine with antibody in amounts equivalent to that required to effect precipitation of comparable units of the free enzymes from solution. Preloading membrane vesicles with antibodies to any two of the enzymes did not affect either the immunoreactivity or extractability (by papain or Triton X-100) of the third. The antibody-binding studies indicated an arrangement of these enzymes independent of each other on the membrane surface, in a manner allowing each to maintain a high degree of molecular freedom.

Research paper thumbnail of Effect of carbohydrate and corticosteroids on activity of α-glucosidases in intestine of the infant rat

Journal of Clinical Investigation, 1972

Research paper thumbnail of Effect of colchicine on intestinal disaccharidases: correlation with biochemical aspects of cellular renewal

Journal of Clinical Investigation, 1970

Research paper thumbnail of Late morbidity among survivors of necrotizing enterocolitis

Pediatrics, Dec 1, 1980

Of 40 survivors of necrotizing enterocolitis 19 were completely normal children at the time of fo... more Of 40 survivors of necrotizing enterocolitis 19 were completely normal children at the time of follow-up, one to three years later. Among the other 21 children, only six had moderate to severe neurologic impairment, representing 15% of all survivors. Despite the fact that intestinal injury is the main feature of the neonatal disease, only four children were symptomatic from gastrointestinal sequelae, and none of these suffered failure to thrive. Thus, 81% (17) of the children with late morbidity had problems unrelated to the gastrointestinal tract. The nongastrointestinal morbidity was associated with prematurity and the degree of perinatal stress.

Research paper thumbnail of Effects of Microwave Radiation on Anti-infective Factors in Human Milk

Pediatrics, 1992

In intensive care nurseries it has become common practice to use microwave thawing of frozen huma... more In intensive care nurseries it has become common practice to use microwave thawing of frozen human milk for more rapid accessibility. Twenty-two freshly frozen human milk samples were tested for lysozyme activity, total IgA, and specific secretory IgA to Escherichia coli serotypes 01, 04, and 06. The samples were heated by microwave for 30 seconds at a low- or high-power setting and then reanalyzed. One-mL aliquots of 10 additional human milk samples were micro-waved at low (20°C to 25°C), medium (60°C to 70°C), and high (≥98°C) setting before the addition to each of 1 mL of diluted E coli suspension. E coli growth was determined after 3½ hours of incubation at 37°C. Microwaving at high temperatures (72°C to 98°C) caused a marked decrease in activity of all the tested anti-infective factors. E coli growth at ≥98°C was 18 times that of control human milk. Microwaving at low temperatures(20°C to 53°C) had no significant effect on total IgA, specific IgA to E coli serotypes 01 and 04, ...

Research paper thumbnail of Maturational patterns of carbohydrases in the ileal remnant of rats after jejunectomy at infancy

The American Journal of Clinical Nutrition, 1988

Research paper thumbnail of Prethreshold retinopathy of prematurity: VEGF inhibition without VEGF inhibitors

Journal of perinatology : official journal of the California Perinatal Association, Jan 25, 2018

The risk of developing treatment-warranted Type 1 retinopathy of prematurity (ROP) might be reduc... more The risk of developing treatment-warranted Type 1 retinopathy of prematurity (ROP) might be reduced in preterm infants by modifying certain systemic factors. There are steps that can be taken both early and late in the course of retinal vascular maturation that may potentially reduce an infant's risk of developing Type 1 ROP. In prethreshold stage 2-3 ROP without plus disease, a combination of supplemental oxygen, correction of severe anemia, and light adaptation to reduce rod photoreceptor oxygen consumption helped us to reduce ROP severity, and encouraged a return to a more physiologic retinal vascular maturation pattern. Thus, it may be possible to reduce the risk of developing Type 1 ROP by making adjustments in certain systemic parameters aimed at reducing retinal hypoxia, thereby gently lowering pathologically elevated levels of vascular endothelial growth factor (VEGF) within the eye.

Research paper thumbnail of Perinatal aspiration syndrome: Its association with intrapartum events and anesthesia

American Journal of Obstetrics and Gynecology, 1974

Research paper thumbnail of Comprar Fetal and Neonatal Brain Injury 4Ed | Philip Sunshine | 9780521888592 | Cambridge University Press

Http Www Libreriasaulamedica Com, 2009

Tienda online donde Comprar Fetal and Neonatal Brain Injury 4Ed al precio 135,91 € de Philip Suns... more Tienda online donde Comprar Fetal and Neonatal Brain Injury 4Ed al precio 135,91 € de Philip Sunshine | William E. Benitz | David K. Stevenson, tienda de Libros de Medicina, Libros de Neurologia - Neurologia infantil

Research paper thumbnail of Correlations of clinical, laboratory, imaging, and placental findings as to the timing of asphyxial events

Fetal and Neonatal Brain Injury, 2009

Research paper thumbnail of Extended management

Mechanisms, Management and the Risks of Practice

Research paper thumbnail of 1339 Failure for Catch-Up Growth at 3 Years in Preterm Infants ≤ 1500 GM

Research paper thumbnail of Abnormalities of Carbamyl Phosphate Synthetase and Ornithine Transcarbamylase in Liver of Patients with Reye's Syndrome

Research paper thumbnail of Metabolic and Genetic Studies of a Family with Ornithine Transcarbamylase Deficiency

Research paper thumbnail of Preamble to: The Incubator and the Medical Discovery of the Premature Infant

Journal of Perinatology, 2000

Research paper thumbnail of Intestinal cytochrome response with repair of iron deficiency

The Journal of Pediatrics, 1966

Research paper thumbnail of Macrosomia: Causes and consequences

The Journal of Pediatrics, 1982

Research paper thumbnail of Prognosis of children surviving with the aid of mechanical ventilation in the newborn period

The Journal of Pediatrics, 1974

Research paper thumbnail of Neonatal hypoxia and pulmonary vasospasm: Response to tolazoline

The Journal of Pediatrics, 1976

Research paper thumbnail of Evidence for the Possible Relationship of Neonatal Skinfold Thickness to Maternal Glucose Metabolism During the Third Trimester

Journal of Pediatric Gastroenterology and Nutrition, 1982

Research paper thumbnail of Sugar hydrolases and their arrangement on the rat intestinal microvillus membrane

The Journal of Membrane Biology, 1979

The arrangement of the sugar hydrolases, sucrase-isomaltase, maltase, and lactase on the microvil... more The arrangement of the sugar hydrolases, sucrase-isomaltase, maltase, and lactase on the microvillus membrane of rat intestine was investigated by immunological technique. The enzymes were purified essentially free of each other to near homogeneity and antisera of high specificity were obtained against each. Microvillus membranes were prepared routinely in high purity from rat intestine and contained an average 61% protein, 20% lipid, and 19% carbohydrate, with the sugar hydrolases comprising an estimated 20--25% of the membrane protein. The immunoreactivity of membrane-bound sucrase-isomaltase, maltase, and lactase was investigated with antisera demostrating specific reactivity to each, when tested in the presence of other membrane extractives. The membrane-bound enzymes were found in each case to combine with antibody in amounts equivalent to that required to effect precipitation of comparable units of the free enzymes from solution. Preloading membrane vesicles with antibodies to any two of the enzymes did not affect either the immunoreactivity or extractability (by papain or Triton X-100) of the third. The antibody-binding studies indicated an arrangement of these enzymes independent of each other on the membrane surface, in a manner allowing each to maintain a high degree of molecular freedom.

Research paper thumbnail of Effect of carbohydrate and corticosteroids on activity of α-glucosidases in intestine of the infant rat

Journal of Clinical Investigation, 1972

Research paper thumbnail of Effect of colchicine on intestinal disaccharidases: correlation with biochemical aspects of cellular renewal

Journal of Clinical Investigation, 1970