Pier Paolo Benetollo - Academia.edu (original) (raw)

Papers by Pier Paolo Benetollo

European urology open science, Oct 1, 2020

by 6 months after first symptoms, while 26% declare to have not received a correct diagnosis afte... more by 6 months after first symptoms, while 26% declare to have not received a correct diagnosis after 5 years. 48.76% of all diagnosis was made by gynecologists, 30.74% by dermatologists and 4.5% by andro-urologists. 81.96% of patients considers their diagnostic and therapeutic process complex (difficult, quite difficult, very difficult) vs 16.6% simply (simply, quite simply). 41.9% of patients have no sex because of LS, in 57.3% LS causes anxiety and discomfort in relationships. 71.72% was treated with topical therapy and 5 patients (1.7%) were directed to a specialist. 78.09% thinks doctors' knowledge about LS is inadequate and 63.9% hopes that a better doctors' preparation about LS is mandatory. Conclusions: Genital LS is a disease that significantly and negatively impact patients' quality of life. Genital LS causes anxiety, discomfort in sexual behaviors and impossibility to have sex. Late diagnosis is common and quite few patients are directed to specialists. Doctors' awareness and consciousness could lead to early diagnosis and improve genital LS treatment and management.

PubMed, Jan 26, 2022

Introduction: To evaluate the decline of antibodies induced by SARS-CoV-2 infection, the individu... more Introduction: To evaluate the decline of antibodies induced by SARS-CoV-2 infection, the individuals resident in 5 municipalities of the Autonomous Province of Trento, Northern Italy, who resulted IgG positive for anti-SARS-CoV-2 nucleocapsid (NC) in May 2020, were tested four months later. Methods: Anti-SARS-CoV-2 NC antibodies were detected using the Abbott SARS-CoV-2 IgG assay. Samples that gave a negative result were re-tested using the Liaison SARS-CoV-2 IgG assay to assess anti-spike (S) S1/S2 antibodies. The fifty-percent tissue culture infective dose (TCID50) neutralizing assay was performed on a subgroup of formerly positive sera. Statistical analysis was performed by STATA version 16.1 (STATA Corp., College Station, Texas, USA). Results: Overall, 480 out of 1159 participants became seronegative for anti-NC IgG antibodies. Age above 70 years and cough were associated with persistent anti-NC IgG levels. Most anti-NC IgG negative sera were positive for anti-S IgG (77.9%). The neutralization assay showed high concordance with anti-S antibodies positivity. Conclusion: In conclusion, a decline of anti-NC IgG values was recorded four months after the first evaluation. A high proportion of anti-NC seronegative individuals were positive for anti-spike IgG antibodies, which appear to persist longer and to better correlate with neutralization activity.

PubMed, Jan 11, 2022

Objectives: to analyse both direct and indirect impacts on surgical admissions, surgical rates, a... more Objectives: to analyse both direct and indirect impacts on surgical admissions, surgical rates, and clinical picture severity of the two COVID-19 pandemic waves in a hospital network covering an entire province (Trento, located in Trentino-Alto Adige Region, Northern Italy). Design: retrospective epidemiological study. Setting and participants: data regarding the patient load of the Surgical Urgencies/Emergencies flows (SUEs) of the Local Health Authority of the Autonomous Province of Trento derived from the Hospital Discharge Record (HDR) information flow. The population in study was that of patients hospitalized in the entire Province of Trento. This study compares the volume and characteristics of urgent/emergency surgery during the 2020 COVID-19 pandemic with the homologous period in 2019, subdividing the analysed pandemic period in 3 separated groups: • phase I (March-May 2020); • phase II (June-August 2020); • phase III (October-December 2020). The 3 groups represent, respectively: the 1st pandemic wave proclamation of national lockdown from 9 March to 18 May; the summer pandemic remission; the 2nd pandemic wave with partial restrictions on circulation and commercial activities. Clinical and surgical records of SUE population among these 3 periods (March-May; June-August; October-December) of both 2020 and 2019 were analyzed and compared. Main outcome measures: the overall number of admissions and surgical rates for SUEs in the study periods were chosen as primary outcomes. The same outcomes were analysed for the most represented diagnoses in the SUEs population: diverticulitis, intestinal obstruction, appendicitis, cholecystitis, gastrointestinal (GI) perforations, pancreatitis, traumas. To assess the degree of clinical picture severity, variables coming from the hospital discharging charts, commonly associated to worst outcomes in term of mortality and morbidity, such as age, length of hospital stay, DRG weight, and patients not discharged at home were extrapolated from the electronic database. A numerical weight was then assigned to each variable, obtaining a scoring system from 0 to 15 (severity index). Results: the number of admissions for SUEs in the studied period showed a sinusoidal trend, with a dramatic decrease in phase I and III (-46.6% and -31.6%, respectively). This trend was also observed even by stratifying admissions for the most frequent pathologies, except for gastrointestinal perforations and pancreatitis. The surgical rate among hospitalised patients for SUEs was 35.2% in phase, significantly higher than that of 2019 (25.6%). Considering the most frequent diagnoses individually, some had a progressive increase in the surgical rate in phases I and II (diverticulitis, bowel obstructions, cholecystitis), others showed an initial decrease and then settled on values not far from those of 2019 (GI perforations and appendicitis), others again had an initial significant increase and then gradually returned to values similar to those of 2019 in phase III (traumas). The mean patients age was significantly higher in phase I than in 2019 (p-value <0.001) and in phase II (p-value <0.05). Consistently with the trend of the number of urgent admissions, even the severity index calculated on the SUEs population showed a sinusoidal trend with and evident increase during the two pandemic waves. Conclusions: the effect of the COVID-19 pandemic on SUEs was mainly indirect, manifesting itself with a significant reduction in surgical admissions, particularly in phases I and III. Conversely, in the same phases, the surgical rate showed a significant increase compared to 2019. The stratified analysis confirmed these findings for the most frequent diagnoses except for GI perforations and pancreatitis. The clinical pictures were more severe in the two pandemic waves than in the reference period of 2019. Although with a slight numerical attenuation, in general, the second pandemic wave confirmed the first one findings.

IJC Heart & Vasculature, Oct 1, 2020

Introduction: During the recent COVID-19 outbreak, Italian health authorities mandated to replace... more Introduction: During the recent COVID-19 outbreak, Italian health authorities mandated to replace inperson outpatient evaluations with remote evaluations. Methods: From March 16th 2020 to April 22th 2020, all outpatients scheduled for in-person cardiac evaluations were instead evaluated by phone. We aimed to report the short-term follow-up of 345 patients evaluated remotely and to compare it with a cohort of patients evaluated in-person during the same period in 2019. Results: During a mean follow-up of 54 ± 11 days, a significantly higher proportion of patients evaluated in-person in 2019 visited the emergency department or died for any cause (39/391, 10% versus 13/345 3.7%, p = 0.001) and visited the emergency department for cardiovascular causes (19/391, 4.9% versus 7/345, 2.0%, p = 0.04) compared to 2020. No cardiovascular death was recorded in the two periods. To an evaluation with a satisfaction questionnaire 49% of patients would like to continue using remote controls in addition to traditional ones. Conclusion: These findings may have important implications for the management of patients during the current COVID-19 pandemic because they suggest that remote cardiovascular evaluations may replace in-hospital visits for a limited period.

Clinical Infectious Diseases, Jun 16, 2021

We analyzed 221 coronavirus disease 2019 cases identified between June 2020 and January 2021 in 6... more We analyzed 221 coronavirus disease 2019 cases identified between June 2020 and January 2021 in 6074 individuals screened for immunoglobulin G antibodies in May 2020, representing 77% of residents of 5 Italian municipalities. The relative risk of developing symptomatic infection in seropositive participants was 0.055 (95% confidence interval, .014-.220).

medRxiv (Cold Spring Harbor Laboratory), Apr 20, 2021

To what extent infection with SARS-CoV-2 protects against subsequent reinfection or symptomatic r... more To what extent infection with SARS-CoV-2 protects against subsequent reinfection or symptomatic reinfection is still unclear. In this cohort study, we analyzed surveillance records of COVID-19 cases identified between June 2020 and January 2021 in five Italian municipalities, where 77.7% of the entire population was screened for IgG antibodies in May 2020. We compared the risk of observing symptomatic infections in two mutually exclusive groups defined by the initial serological response. We estimated that the cumulative incidence of identified symptomatic infections in the IgG negative and positive cohorts was 2.67% (95%CI: 2.12%-3.37%) and 0.14% (95%CI: 0.04%-0.58%), respectively. The adjusted odd ratio of developing symptomatic infection in individuals previously

La diffusione di tecnologie ampiamente guidate e controllate da sistemi basati sull'info... more La diffusione di tecnologie ampiamente guidate e controllate da sistemi basati sull'informatica ha consenti-to di introdurre sostanziali innovazioni nelle attività dei laboratori clinici (1-3). A quella che si presentava come una struttura squisitamente orientata alla tecnologia ana- ...

Research Square (Research Square), Feb 19, 2021

BACKGROUND: The aim of this retrospective comparative study was to assess the impact of the COVID... more BACKGROUND: The aim of this retrospective comparative study was to assess the impact of the COVID-19 related disease on emergency surgery, comparing clinical main outcomes in the period March-May 2019 (Group 1) with the same period in Covid-19 Italian lockdown (March-May 2020, Group 2). METHODS: A comparison (Group 1 versus 2) was performed between the demographic, anamnestic, surgical, clinical and management features. RESULTS: 246 patients were included, 137 in Group 1 and 109 in Group 2 (p=0.03). No signi cant differences in peri-operative characteristics were registered. A declared delay in access to hospital and SARS-CoV-2 preoperatively infection rates were 15.5% and 5.8% respectively in Group 2. The overall morbidity (OR=2.22, 95%CI=1.08-4.55, p=0.03) and 30-day mortality (OR=1.34, 95%CI=0.33-5.50, =0.68) increased signi cantly in Group 2. Delayed access cohort demonstrated a close correlation with increased morbidity (OR=3.19, 95%CI=0.89-11.44, p=0.07), blood transfusion (OR=5.13, 95%CI=1.05-25.15, p=0.04) and a 30-day mortality risk (OR=8.00, 95%CI=1.01-63.23, p=0.05). Positive SARS-CoV-2 patients had higher risk of blood transfusion (20% vs 7.8%, p= 0.37), ICU admissions (20% vs 2.6%, p= 0.17) and median LOS (9 days vs 4 days, p= 0.11). CONCLUSIONS: This article provides enhanced understanding of the effects of the COVID-19 pandemic on patients access to emergency surgical care. Our ndings suggest that COVID-19 changed the quality of surgical care with poorer prognosis and higher morbidity rates. A delayed Emergency Department access and a " lter effect" induced by a COVID-fear in the population resulted in only the most severe cases reaching the Emergency Department in time.

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Frontiers in Cardiovascular Medicine

IntroductionRemote monitoring (RM) technologies have the potential to improve patient care by inc... more IntroductionRemote monitoring (RM) technologies have the potential to improve patient care by increasing compliance, providing early indications of heart failure (HF), and potentially allowing for therapy optimization to prevent HF admissions. The aim of this retrospective study was to assess the clinical and economic consequences of RM vs. standard monitoring (SM) through in-office cardiology visits, in patients carrying a cardiac implantable electronic device (CIED).MethodsClinical and resource consumption data were extracted from the Electrophysiology Registry of the Trento Cardiology Unit, which has been systemically collecting patient information from January 2011 to February 2022. From a clinical standpoint, survival analysis was conducted, and incidence of cardiovascular (CV) related hospitalizations was measured. From an economic standpoint, direct costs of RM and SM were collected to compare the cost per treated patient over a 2-year time horizon. Propensity score matching ...

Advanced Science Letters, 2012

ABSTRACT Historically, scraping is the most significant manufacturing process in the industry of ... more ABSTRACT Historically, scraping is the most significant manufacturing process in the industry of machine tool. Since this skill is hard to program into a machine, it will be lost. In this paper, a scraping mechanism with the performance that is same as hand scraping techniques was developed. An automatic scraping mechanism emulate manual scraping operation is presented in this research. Firstly, the manual scraping operations were investigated, and the design requirements based on scraper's experience and engineering knowledge were integrated into the conceptual design, evaluation, and feasibility study. Through the use of CAD/CAM system, the geometric models and the assembly of the components of a designed scrapping mechanism were constructed. The motion programming and kinematic simulation were carried out using the mechanism simulation software. A scraping mechanism with three degrees of freedom was identified and a prototype was fabricated. The scarping patterns were compared with the ones that were made manually. The scraped marks under various cutting conditions were obtained. The designed automatic scraping mechanism is helpful to the intelligent automation of the scraping work.

Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2021

Minerva Urologica e Nefrologica, 2020

Epidemiologia e prevenzione, Jan 11, 2022

to analyse both direct and indirect impacts on surgical admissions, surgical rates, and clinical ... more to analyse both direct and indirect impacts on surgical admissions, surgical rates, and clinical picture severity of the two COVID-19 pandemic waves in a hospital network covering an entire province (Trento, located in Trentino-Alto Adige Region, Northern Italy). retrospective epidemiological study. data regarding the patient load of the Surgical Urgencies/Emergencies flows (SUEs) of the Local Health Authority of the Autonomous Province of Trento derived from the Hospital Discharge Record (HDR) information flow. The population in study was that of patients hospitalized in the entire Province of Trento. This study compares the volume and characteristics of urgent/emergency surgery during the 2020 COVID-19 pandemic with the homologous period in 2019, subdividing the analysed pandemic period in 3 separated groups: • phase I (March-May 2020); • phase II (June-August 2020); • phase III (October-December 2020). The 3 groups represent, respectively: the 1st pandemic wave proclamation of national lockdown from 9 March to 18 May; the summer pandemic remission; the 2nd pandemic wave with partial restrictions on circulation and commercial activities. Clinical and surgical records of SUE population among these 3 periods (March-May; June-August; October-December) of both 2020 and 2019 were analyzed and compared. the overall number of admissions and surgical rates for SUEs in the study periods were chosen as primary outcomes. The same outcomes were analysed for the most represented diagnoses in the SUEs population: diverticulitis, intestinal obstruction, appendicitis, cholecystitis, gastrointestinal (GI) perforations, pancreatitis, traumas. To assess the degree of clinical picture severity, variables coming from the hospital discharging charts, commonly associated to worst outcomes in term of mortality and morbidity, such as age, length of hospital stay, DRG weight, and patients not discharged at home were extrapolated from the electronic database. A numerical weight was then assigned to each variable, obtaining a scoring system from 0 to 15 (severity index). the number of admissions for SUEs in the studied period showed a sinusoidal trend, with a dramatic decrease in phase I and III (-46.6% and -31.6%, respectively). This trend was also observed even by stratifying admissions for the most frequent pathologies, except for gastrointestinal perforations and pancreatitis. The surgical rate among hospitalised patients for SUEs was 35.2% in phase, significantly higher than that of 2019 (25.6%). Considering the most frequent diagnoses individually, some had a progressive increase in the surgical rate in phases I and II (diverticulitis, bowel obstructions, cholecystitis), others showed an initial decrease and then settled on values not far from those of 2019 (GI perforations and appendicitis), others again had an initial significant increase and then gradually returned to values similar to those of 2019 in phase III (traumas). The mean patients age was significantly higher in phase I than in 2019 (p-value <0.001) and in phase II (p-value <0.05). Consistently with the trend of the number of urgent admissions, even the severity index calculated on the SUEs population showed a sinusoidal trend with and evident increase during the two pandemic waves. the effect of the COVID-19 pandemic on SUEs was mainly indirect, manifesting itself with a significant reduction in surgical admissions, particularly in phases I and III. Conversely, in the same phases, the surgical rate showed a significant increase compared to 2019. The stratified analysis confirmed these findings for the most frequent diagnoses except for GI perforations and pancreatitis. The clinical pictures were more severe in the two pandemic waves than in the reference period of 2019. Although with a slight numerical attenuation, in general, the second pandemic wave confirmed the first one findings.

Introduction. To evaluate the decline of antibodies induced by SARS-CoV-2 infection, the individu... more Introduction. To evaluate the decline of antibodies induced by SARS-CoV-2 infection, the individuals resident in 5 municipalities of the Autonomous Province of Trento, Northern Italy, who resulted IgG positive for anti-SARS-CoV-2 nucleocapsid (NC) in May 2020, were tested four months later. Methods. Anti-SARS-CoV-2 NC antibodies were detected using the Abbott SARS-CoV-2 IgG assay. Samples that gave a negative result were re-tested using the Liaison SARS-CoV-2 IgG assay to assess anti-spike (S) S1/S2 antibodies. The fifty-percent tissue culture infective dose (TCID 50) neutralizing assay was performed on a subgroup of formerly positive sera. Statistical analysis was performed by STATA version 16.1 (STATA Corp., College Station, Texas, USA). Results. Overall, 480 out of 1159 participants became seronegative for anti-NC IgG antibodies. Age above 70 years and cough were associated with persistent anti-NC IgG levels. Most anti-NC IgG negative sera were positive for anti-S IgG (77.9%). The neutralization assay showed high concordance with anti-S antibodies positivity. Conclusion. In conclusion, a decline of anti-NC IgG values was recorded four months after the first evaluation. A high proportion of anti-NC seronegative individuals were positive for anti-spike IgG antibodies, which appear to persist longer and to better correlate with neutralization activity.

International Journal of Environmental Research and Public Health, 2021

The authors would like to make the following corrections to this paper [...]

UNLABELLED: Identifying a measure of community nurses' workload is complicated due to the dif... more UNLABELLED: Identifying a measure of community nurses' workload is complicated due to the difficulty of capturing and standardizing the nature of community nursing across health care settings. AIM: Aim of this paper is to validate a workload/caseload nursing score for home care patients. METHODS: Patients of health care districts of Veneto region with at least two home care visits per month and a multi-dimensional and professional assessment were assesses with instruments used in routine care, adapted to the scope (a multidimensional assessment scale for frail elderly, that includes assessment of cognitive function, social support, mobility, functional status, health care needs); a list of patients needs. Time required for home care visits (excluded travelling time) was voluntarily registered in 5/8 districts. Uni and multivariate analyses were performed and a robust logistic regression accounting for skewed values. A tree regression analysis with CART Package model to identify ...

World Journal of Emergency Surgery, 2021

Background The aim of this retrospective comparative study was to assess the impact of COVID-19 a... more Background The aim of this retrospective comparative study was to assess the impact of COVID-19 and delayed emergency department access on emergency surgery outcomes, by comparing the main clinical outcomes in the period March–May 2019 (group 1) with the same period during the national COVID-19 lockdown in Italy (March–May 2020, group 2). Methods A comparison (groups 1 versus 2) and subgroup analysis were performed between patients’ demographic, medical history, surgical, clinical and management characteristics. Results Two-hundred forty-six patients were included, 137 in group 1 and 109 in group 2 (p = 0.03). No significant differences were observed in the peri-operative characteristics of the two groups. A declared delay in access to hospital and preoperative SARS-CoV-2 infection rates were 15.5% and 5.8%, respectively in group 2. The overall morbidity (OR = 2.22, 95% CI 1.08–4.55, p = 0.03) and 30-day mortality (OR = 1.34, 95% CI 0.33–5.50, =0.68) were significantly higher in gro...