Piero Quintiliani - Academia.edu (original) (raw)
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Papers by Piero Quintiliani
Pharmacology & Therapeutics, 1988
Free-radical-mediated oxidative damage, formerly considered to be a typical pathogenetic event in... more Free-radical-mediated oxidative damage, formerly considered to be a typical pathogenetic event in the development of the biological effects of ionizing radiation, has been recognized during the last 15 to 20 years to occur in a variety of other pathological conditions . These include aging, inflammation, carcinogenesis and toxicity of drugs and chemicals. As with ionizing radiation where its role in the lethal response of cells has long been established, the hydroxyl radical has been suggested to be mainly responsible for reactions leading to oxidative damage in critical bio-molecules. Investigations of free-radical reactivities with appropriate model compounds are therefore relevant to understanding the molecular mechanism in the development of both radiation injury and the above mentioned noxious conditions. By the same token, studies on possible interactions of oxygen-free radicals with antiagents, such as radioprotectors, antioxidants, and anti-inflammatory drugs, may be informative as to the mechanisms available to prevent or minimize harmful biological consequences. Particular attention has been paid to the reaction of the thiyl radical RS. with oxygen . The most prominent sulfur-centered radical intermediate resulting from defensive processes involving thiols against free-radical attack in cell systems, i.e. RS., adds oxygen with a second order rate constant of approximately 109dm 3.mol-l.s-l for glutathione, cysteine and penicillamine.
Pharmacology & Therapeutics, 1988
Free-radical-mediated oxidative damage, formerly considered to be a typical pathogenetic event in... more Free-radical-mediated oxidative damage, formerly considered to be a typical pathogenetic event in the development of the biological effects of ionizing radiation, has been recognized during the last 15 to 20 years to occur in a variety of other pathological conditions . These include aging, inflammation, carcinogenesis and toxicity of drugs and chemicals. As with ionizing radiation where its role in the lethal response of cells has long been established, the hydroxyl radical has been suggested to be mainly responsible for reactions leading to oxidative damage in critical bio-molecules. Investigations of free-radical reactivities with appropriate model compounds are therefore relevant to understanding the molecular mechanism in the development of both radiation injury and the above mentioned noxious conditions. By the same token, studies on possible interactions of oxygen-free radicals with antiagents, such as radioprotectors, antioxidants, and anti-inflammatory drugs, may be informative as to the mechanisms available to prevent or minimize harmful biological consequences. Particular attention has been paid to the reaction of the thiyl radical RS. with oxygen . The most prominent sulfur-centered radical intermediate resulting from defensive processes involving thiols against free-radical attack in cell systems, i.e. RS., adds oxygen with a second order rate constant of approximately 109dm 3.mol-l.s-l for glutathione, cysteine and penicillamine.