Pierre Croisille - Academia.edu (original) (raw)
Papers by Pierre Croisille
Frontiers in physiology, 2016
Background: Pioneer studies demonstrate the impact of extreme sport load on the human brain, lead... more Background: Pioneer studies demonstrate the impact of extreme sport load on the human brain, leading to threatening conditions for athlete's health such as cerebral edema. The investigation of brain water diffusivity, allowing the measurement of the intercellular water and the assessment of cerebral edema, can give a great contribution to the investigation of the effects of extreme sports on the brain. We therefore assessed the effect of supra-physiological effort (extreme distance and elevation changes) in mountain ultra-marathons (MUMs) athletes combining for the first time brain magnetic resonance imaging (MRI) and blood parameters. Methods:This longitudinal study included 19 volunteers (44.2 ± 9.5 years) finishing a MUM (330 km, elevation + 24000 m). Quantitative measurements of brain diffusion-weighted images (DWI) were performed at 3 time-points: Before the race, upon arrival and after 48 h. Multiple blood biomarkers were simultaneously investigated. Data analyses included...
PloS one, 2016
In sports medicine, there is increasing interest in quantifying the elastic properties of skeleta... more In sports medicine, there is increasing interest in quantifying the elastic properties of skeletal muscle, especially during extreme muscular stimulation, to improve our understanding of the impact of alterations in skeletal muscle stiffness on resulting pain or injuries, as well as the mechanisms underlying the relationships between these parameters. Our main objective was to determine whether real-time shear-wave elastography (SWE) can monitor changes in quadriceps muscle elasticity during an extreme mountain ultra-marathon, a powerful mechanical stress model. Our study involved 50 volunteers participating in an extreme mountain marathon (distance: 330 km, elevation: +24,000 m). Quantitative SWE velocity and shear modulus measurements were performed in most superficial quadriceps muscle heads at the following 4 time points: before the race, halfway through the race, upon finishing the race and after recovery (+48 h). Blood biomarker levels were also measured. A significant decreas...
Innovation Et Technologie En Biologie Et Medecine, 1998
The cardiac fiber architecture has an important role in electrophysiology, in mechanical function... more The cardiac fiber architecture has an important role in electrophysiology, in mechanical functions of the heart, and in remodeling processes. The variability of the fibers is the focus of various studies in different species. However, the variability of the laminar sheets is still not well known especially in humans. In this paper, we present preliminary results on a quantitative study on the variability of the human cardiac laminar structure. We show that the laminar structure has a complex variability and we show the possible presence of two populations of laminar sheets. Bimodal distributions of the intersection angle of the third eigenvector of the diffusion tensor have been observed in 10 ex vivo healthy human hearts. Additional hearts will complete the study and further characterize the different populations of cardiac laminar sheets.
Archives Des Maladies Du Coeur Et Des Vaisseaux Pratique, 2008
Journal De Radiologie, Oct 1, 1999
If cardiac MRI have been used for a long time to study cardiac morphology only, more recent devel... more If cardiac MRI have been used for a long time to study cardiac morphology only, more recent developments allow the assessment of flow, perfusion and contractile function. Breath-hold segmented and MR tagging sequences offer new capabilities to explore regional functional consequences, of particular interest to characterize post-ischemic injury after myocardial infarction, representing an alternative technique to echocardiography or nuclear medicine. Combined with pharmacologic stress test, MR cardiac imaging offer a more precise characterization of myocardial perfusion and contractile function. If MR coronary angiography requires further developments, cardiac MRI have the potential to represent in the future the only imaging modality allowing combined assessment of coronary vessels, myocardial perfusion and contractile function.
Circulation, Oct 1, 1995
Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonst... more Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regions of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast-enhanced fast MRI (Signa 1.5 T, General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for TTC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37 +/- 0.09 versus 0.88 +/- 0.10 mL/min per gram, respectively, P < .001) and with baseline (0.37 +/- 0.09 versus 0.87 +/- 0.15 mL/min per gram, P < .01). The spatial extent of hyperenhancement was smaller than the risk region (r = .64, slope = 0.48, P < .001) but highly correlated with TTC-negative regions and were, on average, 12% larger (r = .93, slope = 1.12, P = .035). In contrast-enhanced MR images of 2-day-old reperfused canine infarcts, myocardial regions of hypoenhancement are related to the no-reflow phenomenon. Approximately 90% of the myocardium within hyperenhanced regions is nonviable.
J Amer Coll Cardiol, 1998
Journal De Radiologie, 1999
Magn Reson Mater Phys Biol M, 2000
2014 12th International Conference on Signal Processing, Oct 1, 2014
Radiology, Jan 15, 2014
To determine whether extracellular volume fraction (ECV) quantification at cardiac magnetic reson... more To determine whether extracellular volume fraction (ECV) quantification at cardiac magnetic resonance (MR) imaging can demonstrate subclinical left ventricle (LV) abnormalities in a cohort of consecutive systemic sclerosis (SS) patients, and to investigate the relationship between ECV and diastolic and systolic LV function. All subjects gave their written informed consent. The protocol was approved by the ethics committee. ECV quantification with cardiac MR imaging was prospectively performed in 33 consecutive SS patients with normal echocardiography results and no late gadolinium chelate enhancement at MR imaging. Left ventricular and atrial volumes and peak circumferential strain were measured at cardiac MR imaging. Diastolic function was assessed at echocardiography. The results were compared with those of 16 age-matched healthy control subjects by using Mann-Whitney and Kruskal-Wallis tests. SS patients had significantly higher global ECV (P < .001) and higher local ECV for all basal and midventricular LV segments. Global ECV significantly correlated with left atrial volume (P = .002) and with the grade of diastolic dysfunction (P = .016). The majority of SS patients (63%; 21 of 33 patients) had a high global ECV and a low global systolic circumferential strain. ECV quantification can identify LV abnormalities at an early stage in SS patients. These abnormalities may reflect increase in diffuse myocardial fibrosis and are associated with diastolic LV dysfunction.
2014 12th International Conference on Signal Processing, Oct 1, 2014
Journal Belge De Radiologie, Jul 1, 1997
To date, most applications of cardiovascular MRI relate to the evaluation of major vessels. We re... more To date, most applications of cardiovascular MRI relate to the evaluation of major vessels. We review the currently established indications for thoracic vascular MRI and will touch on the advances that are likely to change the way we examine great thoracic vessels.
Data Revues 02210363 00915 C2 630, May 1, 2010
formation médicale continue le point sur… Comment je fais la différence en IRM entre une cardiomy... more formation médicale continue le point sur… Comment je fais la différence en IRM entre une cardiomyopathie restrictive et une péricardite constrictive en présence d'une adiastolie ? P Croisille Abstract Résumé Restrictive cardiomyopathy versus constrictive pericarditis in patients with diastolic dysfunction: MR imaging features J Radiol 2010;91:630-8
Journal De Radiologie, Oct 1, 2004
Cardiopathies ischémiques (perfusion myocardique et viabilité) : techniques et résultats P Croisi... more Cardiopathies ischémiques (perfusion myocardique et viabilité) : techniques et résultats P Croisille es maladies cardiovasculaires restent la première cause de mortalité en France, avec en 1999, 164 900 décès soit près de 31 % de l'ensemble des décès. Un tiers d'entre eux sont liés directement à la maladie coronarienne et près de la moitié des décès liés à une coronaropathie survient habituellement sans signes précurseurs (1). Au cours des deux dernières décennies, la compréhension physiopathologique, le diagnostic et la prise en charge des patients coronariens ont profondément évolué grâce au développement des techniques d'angioplastie coronarienne qui permettent de traiter les lésions coronariennes « significatives », mais aussi grâce au développement des techniques d'imagerie non-invasive permettant l'évaluation de la perfusion myocardique. À l'heure actuelle, d'une attitude initiale qui répondait à un pur réflexe « occulo-sténotique » négligeant l'état du myocarde sous-jacent, l'attitude est désormais plus raisonnée reposant sur une stratification du risque en fonction de l'existence d'une ischémie myocardique ou non dans les populations à risque, et une prise en compte non seulement des lésions les plus serrées mais aussi, voire surtout, celles présentant une sténose « à risque » de rupture (2). Désormais, il est clairement établi que le pronostic coronarien ultérieur dépend plus étroitement de la profondeur et de l'étendue de l'ischémie que du nombre et de l'aspect des lésions démontrées par la coronarographie. On peut schématiquement individualiser plusieurs situations cliniques où l'imagerie de perfusion joue dorénavant un rôle bien individualisé : 1. patients présentant une maladie coronarienne suspectée mais non certaine ; 2. patients présentant une maladie coronarienne déjà documentée (coronarographie) et 3. patients au décours d'un infarctus myocardique. Dans toutes ces circonstances, l'imagerie de perfusion a un rôle fondamental en apportant des informations à la fois en terme de marqueur de l'ischémie myocardique (territoires à risque de survenue d'une nécrose), mais aussi en identifiant les dégâts myocardiques irréversibles (régions non viables). À l'heure actuelle, la scintigraphie myocardique de perfusion au thallium (201Tl) ou sestamibi (99mTc-MIBI) constitue la méthode de référence en routine clinique pour l'exploration de la perfusion myocardique. Ses limites sont bien connues (résolution spatiale limitée, artéfacts d'atténuation, irradiation) et son rôle a été clairement établi sur de larges cohortes de patients ayant défini sa valeur diagnostique et pronostique dans le spectre des situations cliniques de la maladie coronaire. Dans ce contexte, l'IRM de perfusion apparaît donc comme une technique alternative, en devenir qui a bénéficié au cours des quelques dernières années d'améliorations significatives qui permettent à la fois l'étude de la perfusion au cours du premier passage après injection de gadolinium, mais aussi de rechercher les lésions myocardiques irréversibles (rehaussement tardif).
Medecine Et Hygiene, 1993
Journal de Radiologie, 2006
Frontiers in physiology, 2016
Background: Pioneer studies demonstrate the impact of extreme sport load on the human brain, lead... more Background: Pioneer studies demonstrate the impact of extreme sport load on the human brain, leading to threatening conditions for athlete's health such as cerebral edema. The investigation of brain water diffusivity, allowing the measurement of the intercellular water and the assessment of cerebral edema, can give a great contribution to the investigation of the effects of extreme sports on the brain. We therefore assessed the effect of supra-physiological effort (extreme distance and elevation changes) in mountain ultra-marathons (MUMs) athletes combining for the first time brain magnetic resonance imaging (MRI) and blood parameters. Methods:This longitudinal study included 19 volunteers (44.2 ± 9.5 years) finishing a MUM (330 km, elevation + 24000 m). Quantitative measurements of brain diffusion-weighted images (DWI) were performed at 3 time-points: Before the race, upon arrival and after 48 h. Multiple blood biomarkers were simultaneously investigated. Data analyses included...
PloS one, 2016
In sports medicine, there is increasing interest in quantifying the elastic properties of skeleta... more In sports medicine, there is increasing interest in quantifying the elastic properties of skeletal muscle, especially during extreme muscular stimulation, to improve our understanding of the impact of alterations in skeletal muscle stiffness on resulting pain or injuries, as well as the mechanisms underlying the relationships between these parameters. Our main objective was to determine whether real-time shear-wave elastography (SWE) can monitor changes in quadriceps muscle elasticity during an extreme mountain ultra-marathon, a powerful mechanical stress model. Our study involved 50 volunteers participating in an extreme mountain marathon (distance: 330 km, elevation: +24,000 m). Quantitative SWE velocity and shear modulus measurements were performed in most superficial quadriceps muscle heads at the following 4 time points: before the race, halfway through the race, upon finishing the race and after recovery (+48 h). Blood biomarker levels were also measured. A significant decreas...
Innovation Et Technologie En Biologie Et Medecine, 1998
The cardiac fiber architecture has an important role in electrophysiology, in mechanical function... more The cardiac fiber architecture has an important role in electrophysiology, in mechanical functions of the heart, and in remodeling processes. The variability of the fibers is the focus of various studies in different species. However, the variability of the laminar sheets is still not well known especially in humans. In this paper, we present preliminary results on a quantitative study on the variability of the human cardiac laminar structure. We show that the laminar structure has a complex variability and we show the possible presence of two populations of laminar sheets. Bimodal distributions of the intersection angle of the third eigenvector of the diffusion tensor have been observed in 10 ex vivo healthy human hearts. Additional hearts will complete the study and further characterize the different populations of cardiac laminar sheets.
Archives Des Maladies Du Coeur Et Des Vaisseaux Pratique, 2008
Journal De Radiologie, Oct 1, 1999
If cardiac MRI have been used for a long time to study cardiac morphology only, more recent devel... more If cardiac MRI have been used for a long time to study cardiac morphology only, more recent developments allow the assessment of flow, perfusion and contractile function. Breath-hold segmented and MR tagging sequences offer new capabilities to explore regional functional consequences, of particular interest to characterize post-ischemic injury after myocardial infarction, representing an alternative technique to echocardiography or nuclear medicine. Combined with pharmacologic stress test, MR cardiac imaging offer a more precise characterization of myocardial perfusion and contractile function. If MR coronary angiography requires further developments, cardiac MRI have the potential to represent in the future the only imaging modality allowing combined assessment of coronary vessels, myocardial perfusion and contractile function.
Circulation, Oct 1, 1995
Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonst... more Contrast-enhanced fast magnetic resonance (MR) images of acute, reperfused human infarcts demonstrate regions of hypoenhancement and hyperenhancement. The relations between the spatial extent and time course of these enhancement patterns to myocardial risk, infarct, and no-reflow regions have not been well characterized. The proximal left anterior descending coronary artery was occluded in 11 closed-chest dogs for 90 minutes followed by 2 days of reperfusion. Regional blood flow was determined by use of radioactive microspheres. The animals were studied at the 2-day time point with contrast-enhanced fast MRI (Signa 1.5 T, General Electric). Thioflavin-S was administered to demarcate no-reflow regions. The hearts were then excised, sectioned into five base-to-apex slices, stained with 2,3,5-triphenyltetrazolium chloride (TTC), and photographed under room light (for TTC) and ultraviolet light (for thioflavin). The spatial extents of thioflavin-negative, TTC-negative, and risk regions were compared planimetrically with MRI hypoenhanced and hyperenhanced regions. The spatial locations of subendocardial hypoenhancement in MR images correlated closely with those of thioflavin-negative regions. Microsphere blood flow in these regions was significantly reduced compared with remote regions (0.37 +/- 0.09 versus 0.88 +/- 0.10 mL/min per gram, respectively, P < .001) and with baseline (0.37 +/- 0.09 versus 0.87 +/- 0.15 mL/min per gram, P < .01). The spatial extent of hyperenhancement was smaller than the risk region (r = .64, slope = 0.48, P < .001) but highly correlated with TTC-negative regions and were, on average, 12% larger (r = .93, slope = 1.12, P = .035). In contrast-enhanced MR images of 2-day-old reperfused canine infarcts, myocardial regions of hypoenhancement are related to the no-reflow phenomenon. Approximately 90% of the myocardium within hyperenhanced regions is nonviable.
J Amer Coll Cardiol, 1998
Journal De Radiologie, 1999
Magn Reson Mater Phys Biol M, 2000
2014 12th International Conference on Signal Processing, Oct 1, 2014
Radiology, Jan 15, 2014
To determine whether extracellular volume fraction (ECV) quantification at cardiac magnetic reson... more To determine whether extracellular volume fraction (ECV) quantification at cardiac magnetic resonance (MR) imaging can demonstrate subclinical left ventricle (LV) abnormalities in a cohort of consecutive systemic sclerosis (SS) patients, and to investigate the relationship between ECV and diastolic and systolic LV function. All subjects gave their written informed consent. The protocol was approved by the ethics committee. ECV quantification with cardiac MR imaging was prospectively performed in 33 consecutive SS patients with normal echocardiography results and no late gadolinium chelate enhancement at MR imaging. Left ventricular and atrial volumes and peak circumferential strain were measured at cardiac MR imaging. Diastolic function was assessed at echocardiography. The results were compared with those of 16 age-matched healthy control subjects by using Mann-Whitney and Kruskal-Wallis tests. SS patients had significantly higher global ECV (P < .001) and higher local ECV for all basal and midventricular LV segments. Global ECV significantly correlated with left atrial volume (P = .002) and with the grade of diastolic dysfunction (P = .016). The majority of SS patients (63%; 21 of 33 patients) had a high global ECV and a low global systolic circumferential strain. ECV quantification can identify LV abnormalities at an early stage in SS patients. These abnormalities may reflect increase in diffuse myocardial fibrosis and are associated with diastolic LV dysfunction.
2014 12th International Conference on Signal Processing, Oct 1, 2014
Journal Belge De Radiologie, Jul 1, 1997
To date, most applications of cardiovascular MRI relate to the evaluation of major vessels. We re... more To date, most applications of cardiovascular MRI relate to the evaluation of major vessels. We review the currently established indications for thoracic vascular MRI and will touch on the advances that are likely to change the way we examine great thoracic vessels.
Data Revues 02210363 00915 C2 630, May 1, 2010
formation médicale continue le point sur… Comment je fais la différence en IRM entre une cardiomy... more formation médicale continue le point sur… Comment je fais la différence en IRM entre une cardiomyopathie restrictive et une péricardite constrictive en présence d'une adiastolie ? P Croisille Abstract Résumé Restrictive cardiomyopathy versus constrictive pericarditis in patients with diastolic dysfunction: MR imaging features J Radiol 2010;91:630-8
Journal De Radiologie, Oct 1, 2004
Cardiopathies ischémiques (perfusion myocardique et viabilité) : techniques et résultats P Croisi... more Cardiopathies ischémiques (perfusion myocardique et viabilité) : techniques et résultats P Croisille es maladies cardiovasculaires restent la première cause de mortalité en France, avec en 1999, 164 900 décès soit près de 31 % de l'ensemble des décès. Un tiers d'entre eux sont liés directement à la maladie coronarienne et près de la moitié des décès liés à une coronaropathie survient habituellement sans signes précurseurs (1). Au cours des deux dernières décennies, la compréhension physiopathologique, le diagnostic et la prise en charge des patients coronariens ont profondément évolué grâce au développement des techniques d'angioplastie coronarienne qui permettent de traiter les lésions coronariennes « significatives », mais aussi grâce au développement des techniques d'imagerie non-invasive permettant l'évaluation de la perfusion myocardique. À l'heure actuelle, d'une attitude initiale qui répondait à un pur réflexe « occulo-sténotique » négligeant l'état du myocarde sous-jacent, l'attitude est désormais plus raisonnée reposant sur une stratification du risque en fonction de l'existence d'une ischémie myocardique ou non dans les populations à risque, et une prise en compte non seulement des lésions les plus serrées mais aussi, voire surtout, celles présentant une sténose « à risque » de rupture (2). Désormais, il est clairement établi que le pronostic coronarien ultérieur dépend plus étroitement de la profondeur et de l'étendue de l'ischémie que du nombre et de l'aspect des lésions démontrées par la coronarographie. On peut schématiquement individualiser plusieurs situations cliniques où l'imagerie de perfusion joue dorénavant un rôle bien individualisé : 1. patients présentant une maladie coronarienne suspectée mais non certaine ; 2. patients présentant une maladie coronarienne déjà documentée (coronarographie) et 3. patients au décours d'un infarctus myocardique. Dans toutes ces circonstances, l'imagerie de perfusion a un rôle fondamental en apportant des informations à la fois en terme de marqueur de l'ischémie myocardique (territoires à risque de survenue d'une nécrose), mais aussi en identifiant les dégâts myocardiques irréversibles (régions non viables). À l'heure actuelle, la scintigraphie myocardique de perfusion au thallium (201Tl) ou sestamibi (99mTc-MIBI) constitue la méthode de référence en routine clinique pour l'exploration de la perfusion myocardique. Ses limites sont bien connues (résolution spatiale limitée, artéfacts d'atténuation, irradiation) et son rôle a été clairement établi sur de larges cohortes de patients ayant défini sa valeur diagnostique et pronostique dans le spectre des situations cliniques de la maladie coronaire. Dans ce contexte, l'IRM de perfusion apparaît donc comme une technique alternative, en devenir qui a bénéficié au cours des quelques dernières années d'améliorations significatives qui permettent à la fois l'étude de la perfusion au cours du premier passage après injection de gadolinium, mais aussi de rechercher les lésions myocardiques irréversibles (rehaussement tardif).
Medecine Et Hygiene, 1993
Journal de Radiologie, 2006