Pinal Patel - Academia.edu (original) (raw)
Uploads
Papers by Pinal Patel
![Research paper thumbnail of C—H...O hydrogen-bonding and C—H...π interactions in 3-(4-fluorophenyl)-1,5,7-trimethyl-1,2,3,4-tetrahydropyrido[2,3- d ]pyrimidine-2,4-dione](https://attachments.academia-assets.com/46661566/thumbnails/1.jpg)
](Acta Crystallographica Section C Crystal Structure Communications, 2007
Acta Crystallographica Section E Structure Reports Online, 2007
Genome medicine, 2013
A fully automated, high-throughput method was developed to profile the fatty acids of phospholipi... more A fully automated, high-throughput method was developed to profile the fatty acids of phospholipids from human plasma samples for application to a large epidemiological sample set (n > 25,000). We report here on the data obtained for the quality-control materials used with the first 860 batches, and the validation process used. The method consists of two robotic systems combined with gas chromatography, performing lipid extraction, phospholipid isolation, hydrolysis and derivatization to fatty-acid methyl esters, and on-line analysis. This is the first report showing that fatty-acid profiling is an achievable strategy for metabolic phenotyping in very large epidemiological and genetic studies.
The American journal of clinical nutrition, 2014
Background: Stable-isotope ratios of carbon ( 13 C/ 12 C, expressed as d 13 C) and nitrogen ( 15 ... more Background: Stable-isotope ratios of carbon ( 13 C/ 12 C, expressed as d 13 C) and nitrogen ( 15 N/ 14 N, or d 15 N) have been proposed as potential nutritional biomarkers to distinguish between meat, fish, and plant-based foods. Objective: The objective was to investigate dietary correlates of d 13 C and d 15 N and examine the association of these biomarkers with incident type 2 diabetes in a prospective study. Design: Serum d 13 C and d 15 N (&) were measured by using isotope ratio mass spectrometry in a case-cohort study (n = 476 diabetes cases; n = 718 subcohort) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk populationbased cohort. We examined dietary (food-frequency questionnaire) correlates of d 13 C and d 15 N in the subcohort. HRs and 95% CIs were estimated by using Prentice-weighted Cox regression. Results: Mean (6SD) d 13 C and d 15 N were 222.8 6 0.4& and 10.2 6 0.4&, respectively, and d 13 C (r = 0.22) and d 15 N (r = 0.20) were positively correlated (P , 0.001) with fish protein intake. Animal protein was not correlated with d 13 C but was significantly correlated with d 15 N (dairy protein: r = 0.11; meat protein: r = 0.09; terrestrial animal protein: r = 0.12, P # 0.013). d 13 C was inversely associated with diabetes in adjusted analyses (HR per tertile: 0.74; 95% CI: 0.65, 0.83; P-trend , 0.001], whereas d 15 N was positively associated (HR: 1.23; 95% CI: 1.09, 1.38; P-trend = 0.001). Conclusions: The isotope ratios d 13 C and d 15 N may both serve as potential biomarkers of fish protein intake, whereas only d 15 N may reflect broader animal-source protein intake in a European population. The inverse association of d 13 C but a positive association of d 15 N with incident diabetes should be interpreted in the light of knowledge of dietary intake and may assist in identifying dietary components that are associated with health risks and benefits. Am J Clin Nutr
Acta Crystallographica Section C Crystal Structure Communications, 2007
Acta Crystallographica Section E Structure Reports Online, 2007
Genome medicine, 2013
A fully automated, high-throughput method was developed to profile the fatty acids of phospholipi... more A fully automated, high-throughput method was developed to profile the fatty acids of phospholipids from human plasma samples for application to a large epidemiological sample set (n > 25,000). We report here on the data obtained for the quality-control materials used with the first 860 batches, and the validation process used. The method consists of two robotic systems combined with gas chromatography, performing lipid extraction, phospholipid isolation, hydrolysis and derivatization to fatty-acid methyl esters, and on-line analysis. This is the first report showing that fatty-acid profiling is an achievable strategy for metabolic phenotyping in very large epidemiological and genetic studies.
The American journal of clinical nutrition, 2014
Background: Stable-isotope ratios of carbon ( 13 C/ 12 C, expressed as d 13 C) and nitrogen ( 15 ... more Background: Stable-isotope ratios of carbon ( 13 C/ 12 C, expressed as d 13 C) and nitrogen ( 15 N/ 14 N, or d 15 N) have been proposed as potential nutritional biomarkers to distinguish between meat, fish, and plant-based foods. Objective: The objective was to investigate dietary correlates of d 13 C and d 15 N and examine the association of these biomarkers with incident type 2 diabetes in a prospective study. Design: Serum d 13 C and d 15 N (&) were measured by using isotope ratio mass spectrometry in a case-cohort study (n = 476 diabetes cases; n = 718 subcohort) nested within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk populationbased cohort. We examined dietary (food-frequency questionnaire) correlates of d 13 C and d 15 N in the subcohort. HRs and 95% CIs were estimated by using Prentice-weighted Cox regression. Results: Mean (6SD) d 13 C and d 15 N were 222.8 6 0.4& and 10.2 6 0.4&, respectively, and d 13 C (r = 0.22) and d 15 N (r = 0.20) were positively correlated (P , 0.001) with fish protein intake. Animal protein was not correlated with d 13 C but was significantly correlated with d 15 N (dairy protein: r = 0.11; meat protein: r = 0.09; terrestrial animal protein: r = 0.12, P # 0.013). d 13 C was inversely associated with diabetes in adjusted analyses (HR per tertile: 0.74; 95% CI: 0.65, 0.83; P-trend , 0.001], whereas d 15 N was positively associated (HR: 1.23; 95% CI: 1.09, 1.38; P-trend = 0.001). Conclusions: The isotope ratios d 13 C and d 15 N may both serve as potential biomarkers of fish protein intake, whereas only d 15 N may reflect broader animal-source protein intake in a European population. The inverse association of d 13 C but a positive association of d 15 N with incident diabetes should be interpreted in the light of knowledge of dietary intake and may assist in identifying dietary components that are associated with health risks and benefits. Am J Clin Nutr