Piotr Modliborski - Academia.edu (original) (raw)
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Sanjay Gandhi Postgraduate Institute of Medician Sciences, Lucknow
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Papers by Piotr Modliborski
Biomolecules, 2021
Colorectal cancer (CRC) is one of the most common malignancies in Poland. Based on the findings o... more Colorectal cancer (CRC) is one of the most common malignancies in Poland. Based on the findings of clinical trials, it is safe to conclude that genetic predisposition and environmental factors are the main factors responsible for the formation of colorectal cancer.The NQO1 gene plays an important role in reducing endogenous and exogenous quinones as well as quinone compounds to hydroquinones. It is an enzyme which is a part of the body’s antioxidant defense system. The aim of the study was to evaluate the correlation between the 609C > T polymorphism of the NQO1 gene and colorectal cancer risk in the Polish population. A total of 512 people were recruited for the study, including 279 patients with colorectal cancer, diagnosed at the University Hospital, Pomeranian Medical University in Szczecin. Genomic DNA was isolated from peripheral blood and the analyzed polymorphism was determined by PCR-RFLP. In the present study, we analyzed the clinical valuesand frequency of NQO1 609C &g...
Pediatria Polska, 2021
Aim: Despite the known risk factors for the occurrence of DDH, such as the breech presentation, w... more Aim: Despite the known risk factors for the occurrence of DDH, such as the breech presentation, we still do not know all the factors that determine the more frequent incidence of dysplasia in female children. The aim of the study was compare anthropometric parameters of boys and girls in the first months of life, and to relate these measurements to cases of children diagnosed with developmental hip dysplasia (DDH). Material and methods: 502 children were enrolled in the study – 273 (54.4%) girls and 229 (45.6%) boys. The mean age at the time of the examination was: 1.8 ±0.9 months, boys; 1.98 ±1.4 months girls. The statistical analysis covered the birth weight, body weight at the time of the examination, length of pregnancy, type of delivery and pelvic measurements. Results: In the study, we observed a higher frequency of DDH in the group of girls: 15 cases in 13 (4.76%) girls. We observed relationship (p = 0.023322) between the week of pregnancy at time of delivery and the incidenc...
Biomolecules, 2021
Colorectal cancer (CRC) is one of the most common malignancies in Poland. Based on the findings o... more Colorectal cancer (CRC) is one of the most common malignancies in Poland. Based on the findings of clinical trials, it is safe to conclude that genetic predisposition and environmental factors are the main factors responsible for the formation of colorectal cancer.The NQO1 gene plays an important role in reducing endogenous and exogenous quinones as well as quinone compounds to hydroquinones. It is an enzyme which is a part of the body’s antioxidant defense system. The aim of the study was to evaluate the correlation between the 609C > T polymorphism of the NQO1 gene and colorectal cancer risk in the Polish population. A total of 512 people were recruited for the study, including 279 patients with colorectal cancer, diagnosed at the University Hospital, Pomeranian Medical University in Szczecin. Genomic DNA was isolated from peripheral blood and the analyzed polymorphism was determined by PCR-RFLP. In the present study, we analyzed the clinical valuesand frequency of NQO1 609C &g...
Pediatria Polska, 2021
Aim: Despite the known risk factors for the occurrence of DDH, such as the breech presentation, w... more Aim: Despite the known risk factors for the occurrence of DDH, such as the breech presentation, we still do not know all the factors that determine the more frequent incidence of dysplasia in female children. The aim of the study was compare anthropometric parameters of boys and girls in the first months of life, and to relate these measurements to cases of children diagnosed with developmental hip dysplasia (DDH). Material and methods: 502 children were enrolled in the study – 273 (54.4%) girls and 229 (45.6%) boys. The mean age at the time of the examination was: 1.8 ±0.9 months, boys; 1.98 ±1.4 months girls. The statistical analysis covered the birth weight, body weight at the time of the examination, length of pregnancy, type of delivery and pelvic measurements. Results: In the study, we observed a higher frequency of DDH in the group of girls: 15 cases in 13 (4.76%) girls. We observed relationship (p = 0.023322) between the week of pregnancy at time of delivery and the incidenc...