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Papers by Pontus Dunér

Research paper thumbnail of Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells

Circulation Research, Jun 19, 2009

Research paper thumbnail of Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion

Journal of Biological Chemistry, Nov 1, 2020

Research paper thumbnail of Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Research paper thumbnail of Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction

IJC Heart & Vasculature, Mar 1, 2015

Research paper thumbnail of An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

British Journal of Dermatology, Nov 1, 2019

Research paper thumbnail of Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice

Scientific Reports, Sep 8, 2015

Research paper thumbnail of Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

JACC: Basic to Translational Science, Dec 1, 2019

Research paper thumbnail of Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation

Embo Molecular Medicine, Apr 19, 2012

Research paper thumbnail of IL-25 expands innate lymphoid cells type 2 and inhibits atherosclerosis development in apoe deficient mice

Atherosclerosis, Aug 1, 2014

Research paper thumbnail of Endogenous production of osteopontin: A critical event in macrophage differentiation

Vascular Pharmacology, Sep 1, 2006

Research paper thumbnail of COVID-19 and Possible Pharmacological Preventive Options

Journal of Clinical Medicine Research, 2020

Research paper thumbnail of Interleukin-25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice

Journal of Biological Chemistry, May 1, 2018

Research paper thumbnail of The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent

Pflügers Archiv: European Journal of Physiology, Feb 15, 2019

Research paper thumbnail of Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Journal of the American Heart Association, Feb 4, 2020

Research paper thumbnail of IL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice

Research paper thumbnail of FcγRIIB Inhibits the Development of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

Journal of Immunology, Mar 1, 2010

Research paper thumbnail of Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE-/- mice

Scientific Reports, Apr 27, 2021

Research paper thumbnail of High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy

Cerebrovascular Diseases, 2016

Background: Galectin-3 (Gal-3) has been suggested to have both pro- and anti-atherogenic properti... more Background: Galectin-3 (Gal-3) has been suggested to have both pro- and anti-atherogenic properties. High plasma Gal-3 levels are associated with increased risk for cardiovascular (CV) death. However, it has so far not been investigated if plasma Gal-3 levels can predict the risk for future stroke in patients suffering from carotid atherosclerosis. The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA). Methods: Plasma samples were obtained from 558 CEA patients and Gal-3 levels were analyzed by the proximity extension assay technique. The Swedish national in-patient health register was used to identify postoperative cerebrovascular events during the follow-up period (42.6 ± 26.2 months). Results: Plasma Gal-3 was increased in patients treated for a symptomatic carotid stenosis (p = 0.013). Patients with Gal-3 levels above the median value had an increased incidence of stroke as shown by Kaplan-Meier curves of event-free survival (p = 0.007). Gal-3 was a predictor of postoperative stroke among women (hazard ratio 15.1, 95% CI 1.3-172.2; p = 0.028) even after correction for traditional CV risk factors. Conclusions: This study is the first to show that increased plasma levels of Gal-3 can help in predicting the occurrence of postoperative strokes among female subjects who undergo CEA, independently of traditional risk factors for cerebrovascular disease. This finding suggests that Gal-3 could be used as a marker to identify patients in need of intensified postoperative medical care.

Research paper thumbnail of ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Scientific Reports, Jun 16, 2017

Research paper thumbnail of Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe−/− mice

Atherosclerosis, Oct 1, 2010

Research paper thumbnail of Atheroprotective Effects of Alum Are Associated With Capture of Oxidized LDL Antigens and Activation of Regulatory T Cells

Circulation Research, Jun 19, 2009

Research paper thumbnail of Inhibitory effect of UDP-glucose on cAMP generation and insulin secretion

Journal of Biological Chemistry, Nov 1, 2020

Research paper thumbnail of Glucose-Dependent Insulinotropic Polypeptide Stimulates Osteopontin Expression in the Vasculature via Endothelin-1 and CREB

Research paper thumbnail of Autoantibodies against basement membrane collagen type IV are associated with myocardial infarction

IJC Heart & Vasculature, Mar 1, 2015

Research paper thumbnail of An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes

British Journal of Dermatology, Nov 1, 2019

Research paper thumbnail of Dystrophin deficiency reduces atherosclerotic plaque development in ApoE-null mice

Scientific Reports, Sep 8, 2015

Research paper thumbnail of Associations of Interleukin-5 With Plaque Development and Cardiovascular Events

JACC: Basic to Translational Science, Dec 1, 2019

Research paper thumbnail of Plasma fibronectin deficiency impedes atherosclerosis progression and fibrous cap formation

Embo Molecular Medicine, Apr 19, 2012

Research paper thumbnail of IL-25 expands innate lymphoid cells type 2 and inhibits atherosclerosis development in apoe deficient mice

Atherosclerosis, Aug 1, 2014

Research paper thumbnail of Endogenous production of osteopontin: A critical event in macrophage differentiation

Vascular Pharmacology, Sep 1, 2006

Research paper thumbnail of COVID-19 and Possible Pharmacological Preventive Options

Journal of Clinical Medicine Research, 2020

Research paper thumbnail of Interleukin-25 (IL-25) has a protective role in atherosclerosis development in the aortic arch in mice

Journal of Biological Chemistry, May 1, 2018

Research paper thumbnail of The functional impact of G protein-coupled receptor 142 (Gpr142) on pancreatic β-cell in rodent

Pflügers Archiv: European Journal of Physiology, Feb 15, 2019

Research paper thumbnail of Syndecan‐4 Protects the Heart From the Profibrotic Effects of Thrombin‐Cleaved Osteopontin

Journal of the American Heart Association, Feb 4, 2020

Research paper thumbnail of IL-25 Inhibits Atherosclerosis Development in Apolipoprotein E Deficient Mice

Research paper thumbnail of FcγRIIB Inhibits the Development of Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient Mice

Journal of Immunology, Mar 1, 2010

Research paper thumbnail of Antibodies against apoB100 peptide 210 inhibit atherosclerosis in apoE-/- mice

Scientific Reports, Apr 27, 2021

Research paper thumbnail of High Plasma Levels of Galectin-3 Are Associated with Increased Risk for Stroke after Carotid Endarterectomy

Cerebrovascular Diseases, 2016

Background: Galectin-3 (Gal-3) has been suggested to have both pro- and anti-atherogenic properti... more Background: Galectin-3 (Gal-3) has been suggested to have both pro- and anti-atherogenic properties. High plasma Gal-3 levels are associated with increased risk for cardiovascular (CV) death. However, it has so far not been investigated if plasma Gal-3 levels can predict the risk for future stroke in patients suffering from carotid atherosclerosis. The aim of this study was to investigate whether Gal-3 could be used as a marker to predict postoperative cerebrovascular ischemic events among patients who underwent carotid endarterectomy (CEA). Methods: Plasma samples were obtained from 558 CEA patients and Gal-3 levels were analyzed by the proximity extension assay technique. The Swedish national in-patient health register was used to identify postoperative cerebrovascular events during the follow-up period (42.6 ± 26.2 months). Results: Plasma Gal-3 was increased in patients treated for a symptomatic carotid stenosis (p = 0.013). Patients with Gal-3 levels above the median value had an increased incidence of stroke as shown by Kaplan-Meier curves of event-free survival (p = 0.007). Gal-3 was a predictor of postoperative stroke among women (hazard ratio 15.1, 95% CI 1.3-172.2; p = 0.028) even after correction for traditional CV risk factors. Conclusions: This study is the first to show that increased plasma levels of Gal-3 can help in predicting the occurrence of postoperative strokes among female subjects who undergo CEA, independently of traditional risk factors for cerebrovascular disease. This finding suggests that Gal-3 could be used as a marker to identify patients in need of intensified postoperative medical care.

Research paper thumbnail of ADAMTS-7 is associated with a high-risk plaque phenotype in human atherosclerosis

Scientific Reports, Jun 16, 2017

Research paper thumbnail of Immune responses against aldehyde-modified laminin accelerate atherosclerosis in Apoe−/− mice

Atherosclerosis, Oct 1, 2010

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