Pooja Rawat - Academia.edu (original) (raw)

Papers by Pooja Rawat

Research paper thumbnail of Deciphering the potent application of nanobentonite and α-Fe2O3/bentonite nanocomposite in dye removal: revisiting the insights of adsorption mechanism

Applied Nanoscience

Clays are widely accepted for dye removal from wastewater. Here, in this work, nanobentonite was ... more Clays are widely accepted for dye removal from wastewater. Here, in this work, nanobentonite was synthesized by a simple, rapid, and cost-effective chemithermal method. Additionally, nanobentonite was coupled with hematite nanoparticles via thermal coupling to prepare a nanocomposite with enhanced surface absorption. Surface morphology, compositional and structural analysis of synthesized samples were done using various characterization techniques. Results suggested that nanobentonite and nanocomposite having an average diameter of 35.36 and 21.85 nm respectively were synthesized. Nanocomposite exhibited increased surface area. Additionally, the ability of all samples as an adsorbent for removal of methylene blue (MB) and Congo red (CR), from an aqueous solution was investigated under various optimization conditions. Adsorption kinetics revealed that Pseudo II order equation fits well for the adsorption process following intraparticular diffusion mechanism for both the dyes. The adsorption equilibrium data of MB and CR was fitted well by the Langmuir and Freundlich adsorption isotherm model, respectively. The thermodynamic parameters suggested adsorption process is endothermic and spontaneous in nature with increased entropy value.

Research paper thumbnail of Structural, thermal, and ion dynamics studies of PVA-CS-NaI-based biopolymer electrolyte films

Journal of Solid State Electrochemistry, 2021

A series of biopolymer blend electrolytes (BPBEs) based on ((100-x)PVA-xCS)-NaI, viz. BPBE-1 to B... more A series of biopolymer blend electrolytes (BPBEs) based on ((100-x)PVA-xCS)-NaI, viz. BPBE-1 to BPBE-5 (x = 10, 20, 30, 40, 50 in wt%), respectively, were prepared using solution cast technique. Prepared samples have been characterized using XRD, ATR-FTIR, TGA, and AC impedance spectroscopic techniques. ATR-FTIR results reveal the interactions between the constituents of PVA/CS with salt, NaI. XRD results show the semi-crystalline nature of PVA-CS polymer blend and %degree of crystallinity (Xc) was found to be minimum for sample BPBE-1. TGA and its 1st derivative (DTGA) results show that BPBE films decompose in multi-steps. The decomposition temperature peak (Td, peak) associated with CS-PVA polymer blend and the interactions between CS-PVA-NaI have been discussed using TGA analysis. Temperature-dependent dc conductivity (σdc) and relaxation frequency (fr) follow the Arrhenius type mechanism. The optimum σdc ~ 1.2 × 10−5 S/cm at 30 °C was received for sample, BPBE-1. The ac conductivity spectra for all samples follow the Jonscher’s power law (JPL). Dielectric permittivity and electric modulus studies have also been done for understanding the charge storage properties and conductivity relaxation. Ionic transference number (ITN) measurement has been carried out for knowing the ionic/electronic nature of charge species. Cyclic voltammetry (CV) measurement has been done to study the electrochemical behavior of the optimized sample.

Research paper thumbnail of Effect on Solar PV Panel Performance Due to Varying Latitude in Northern Hemisphere

Springer Proceedings in Energy, 2021

Research paper thumbnail of Managing Risk in Deepwater Frontiers - Key Learnings From Five Continents

Research paper thumbnail of A DNA quantitative analysis of lung cancer cells with different pathological types from bronchial brush specimens and its clinical significance

OBJECTIVE To explore the significance of a DNA quantitative analysis of lung cancer cells with di... more OBJECTIVE To explore the significance of a DNA quantitative analysis of lung cancer cells with different pathological types taken from bronchial brush specimens and its relationship with the clinicopathological features. METHODS 903 bronchial brush cytological specimens taken in the Cytology Department of the Fourth Hospital of Hebei Medical University were collected from March 2017 to December 2019 and divided into three groups: the squamous carcinoma (SC) group, the adenocarcinoma (AC) group, and the small-cell carcinoma (SCC) group. The maximum DNA index (DI) value, the percentage of cells with a DI larger than 2.5, the mean DI, and the peaks of the aneuploid cells of the three groups were compared. A single factor analysis was used to analyze the relationship between the DNA content, aneuploidy, and the clinico pathological features of the patients who had surgery. RESULTS The peaks of the aneuploid cells in the SC group, the AC group, and the SCC group had no significant differ...

Research paper thumbnail of Indagine sulla presenza di ipa del legno e nei vini trattati con il legno

Research paper thumbnail of Characterization of a novel lactoferrin receptor : Glyceraldehye 3-phosphate Dehydrogenase

Research paper thumbnail of Benchmarking Analysis of CNN Architectures for Artificial Intelligence Platforms

Proceedings of Emerging Trends and Technologies on Intelligent Systems, 2021

Research paper thumbnail of Analysis of Patents Filed for the Herbal Therapeutics Against Cancer

Anticancer plants: Properties and Application, 2018

Use of herbal medications for the treatment of various ailments is being practised since ancient ... more Use of herbal medications for the treatment of various ailments is being practised since ancient time. According to a recent report from the World Health Organization (WHO), cancer is the second leading cause of death worldwide and was responsible for 8.8 million deaths in 2015. Each year, more than 200,000 children are diagnosed with different cancer types. Modern science is witnessing an increased demand for natural medicines to treat cancer. The role of phytochemical compounds in modulation of immune systems and their mechanistic details is well investigated. Starting from the 1940s until the end of the year 2014, about 175 small molecules got approved as cancer therapeutics. Among these, 131 molecules (75%) were non-synthetic of which 85 (49%) were actual natural products or their direct derivatives. These effective natural products mainly originate from the plants, microbes, organism, cell lines, etc. The focus of the world has shifted towards the development of herb-based cancer therapeutics as evident from the increased number of patent applications filed and published in this area. China, the United States, Japan, Korea and Australia are among the top countries in filing the patents for inventions/innovations in the field of cancer drug discovery. These inventions encompass herbal formulations, plant extracts, processes, phyto-compounds or their derivatives, claimed against several types of cancers. The aim of this chapter is to focus on the analysis of patent literature of the herbal therapeutics for cancer, top players in the arena and the future of herbal drugs.

Research paper thumbnail of Lycopene-loaded nanostructured lipid carrier from carboxymethyl oil palm empty fruit bunch cellulose for topical administration

Carbohydrate Polymer Technologies and Applications, 2021

A novel lycopene loaded nanostructured lipid carriers (NLC) was prepared using carboxymethyl oil ... more A novel lycopene loaded nanostructured lipid carriers (NLC) was prepared using carboxymethyl oil palm empty fruit bunch cellulose (CM-OPEFBC), carnauba wax and palm oil. Presence of wax and oil in the lipid mixture aided in obtaining small uniform spherical particle size in the range of 16-22 nm having relatively small size distribution (polydispersity index < 0.5). The NLC provide a better drug loading capacity of an active substance to penetrate easily through the skin after applied topically. The entrapment efficiency of lycopene was found to be 98% for all the formulations. The particle size, size distribution, and zeta potential of lycopene-loaded NLC stored at room temperature for 8 weeks did not show any significant changes, proving an excellent colloidal stability of the formulations. The lycopene-loaded NLC are better and advanced systems for the stability and delivery of lycopene in pharmaceutical industry.

Research paper thumbnail of Nanotechnology and its application: a review

Nanotechnology in Cancer Management, 2021

Abstract Integration of functionalized nanoscale materials in various biomedical applications has... more Abstract Integration of functionalized nanoscale materials in various biomedical applications has introduced marked research interest in recent years. Nanotechnology operations in functionalized and altered biomedical is potent for use in drug delivery, bioimaging, diagnosis and treatment, genetic material sequencing, biosensors, active packaging, agriculture, and environment. Incorporation of nanostructures with functionalized biomaterial is a promising technology in biomedical application for the development of biosensor and drug delivery for point-of-care (P-O-C). The capsulation of a bioactive chip with biomaterial is an emerging technology for the development of miniaturized P-O-C technique in bioelectronic/biosensor industry. The use of nanoencapsules for the delivery of biofertilizers and nutrient to the plants and use of biosensors help in the controlled release of agrochemical to plant. Nanoparticles, nanoencapsule, nanotubes, nanospheres, and nanochip have a wide application in medical fields, water treatment, agriculture, health, and environmental safety. The harmful organic compound and pollutant from industries can be degradation using nanoparticles as photocatalyst and converted in harmless form. The capability and benefits of nanotechnology in medical technology, biosensors, cancer treatment, bioimaging, drug delivery, precision farming, water treatment, and environmental cleaning are discussed in this review chapter. The nanotechnology is a coming revolutionary technology and has the potential to solve various problems with advantages over conventional methods. In this chapter, the application of modern nanotechnology to the various biological systems are discussed.

Research paper thumbnail of Ammonium fluoride mediated mechano chemical synthesis of A2PdF6 (A = K, Rb) along with their catalytic role in environmental remediation

Journal of Environmental Chemical Engineering, 2017

To highlight the power of mechanochemistry to oxidize metal ions leading to the discovery of newe... more To highlight the power of mechanochemistry to oxidize metal ions leading to the discovery of newer phases, ammonium fluoride mediated synthesis of A 2 PdF 6 (A = Rb, K) has been carried out. Grinding reactions of ammonium fluoride with palladium (II) acetate and further cation exchange with AF (A = Rb, K) were closely monitored ex-situ characterizations such as high resolution powder X-ray diffraction (PXRD), fourier transform infrared (FT-IR) and Raman spectroscopy measurements. For the reaction involving RbF, Rb 2 PdF 6 possessing K 2 PtCl 6 type structure was confirmed from the Rietveld refinement of PXRD pattern, high resolution transmission emission microscopy (HR-TEM) and selected area electron diffraction (SAED) measurements. Elemental composition and oxidation state of palladium in Rb 2 PdF 6 were examined using X-ray photoelectron spectroscopy (XPS) analysis. Ligand to metal charge transfer and d-d transitions of Pd (IV) were present in the UV-vis diffuse reflectance spectrum of Rb 2 PdF 6 with a band gap of 2.67 eV estimated using the Kubelka-Munk function. Its role as a catalyst to degrade the aqueous dye solutions (Methylene Blue, Malachite Green, Rhodamine-6G and Rhodamine-B) under UV-vis radiation has been evaluated along with their kinetics. The catalyst was active after four cycles of use. The reduction of Pd 4+ to Pd 0 by NaBH 4 has been favourably used for the efficient and rapid conversion of highly carcinogenic, toxic, mutagenic Cr 6+ to less toxic Cr 3+. K 2 PdF 6 possessing cubic K 2 PtCl 6type structure has also been synthesized for the first time by this method which presented yet another example for the alteration of reaction landscapes by mechanical forces.

Research paper thumbnail of Capping agent-induced variation of physicochemical and biological properties of α-Fe2O3 nanoparticles

Materials Chemistry and Physics, 2021

Abstract Capping agents play a vital role in controlling the size, morphology, and monodispersity... more Abstract Capping agents play a vital role in controlling the size, morphology, and monodispersity of nanoparticles. To understand a comprehensive overview of the influence of capping on the structure and properties of hematite nanoparticles (HNPs), we have synthesized hematite nanoparticles (HNPs) with narrow size distribution by an economic co-precipitation method using capping agents like sodium citrate, Polyvinyl Pyrrolidone (PVP) and starch. A comparative in-depth study of structure, morphology, and surface analysis along with thermal, optical, magnetic and electrochemical properties of synthesized capped and uncapped HNPs has been performed. The effect of capping agents on photocatalytic and antioxidant activities along with cytotoxicity of all fabricated nanoparticles was studied against MDA-MB-231 cell line causing breast cancer along with flow cytometry. Results revealed a definite improvement in grain size, crystallinity, optical, thermal and magnetic properties of HNPs is due to efficient capping. PVP has reduced the maximum of crystalline size up to 23% of HNPs and removed 98.80% of dye from wastewater among all capping agents. Our findings also suggest that PVP capped HNPs proved to be cytotoxic to the cancer cell line. Taken together, our studies will be helpful to understand the role of capping agents in determining properties of HNPs that can further help in designing engineer HNPs.

Research paper thumbnail of Green synthesis of copper and copper sulfide nanoparticles

3RD INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC-2019), 2020

Research paper thumbnail of Clinical outcomes of intramedullary femoral nailing system to treat femoral fracture

International Journal of Research in Orthopaedics, 2020

Background: Femoral fractures are bone fracture involve femur, common injuries in adults. Intrame... more Background: Femoral fractures are bone fracture involve femur, common injuries in adults. Intramedullary femoral nailing system is the recommended solution or treatment for fractures due to its high union rates.Methods: In this clinical inspection 30 patients were selected with bone fracture of femur, and treated by using intramedullary femoral nailing system (universal intramedullary cannulated femoral nail, expert femoral nail, gamma nail and retrograde femoral nail) manufactured by Auxein Medical Private Limited, Sonepat, Haryana, India. There are two types of patients used in this study, one is male (n=18) and another female (n=12). Patients physical fitness was also observed through American Society of Anesthesiologist.Results: Outcomes record from the patients using visual analog scale. Follow up of the patients were taken on 1st month, 6th month, and 12 months. Post-operative outcomes were good with none of the patients showing non-union of fracture site. There were no compli...

Research paper thumbnail of A Novel Synthesis of the Graphene Oxide-Silver (GO-Ag) Nanocomposite for Unique Physiochemical Applications

ACS Omega, 2020

Graphene oxide-silver nanocomposite (GO-Ag) was fabricated via the sonochemical method, which sho... more Graphene oxide-silver nanocomposite (GO-Ag) was fabricated via the sonochemical method, which shows unique physiochemical properties. Graphene oxide (GO) and silver nanoparticles (AgNPs) were synthesized by modified Hummer's and Chemical reduction methods, respectively. The synthesized nanocomposite was characterized using powder X-ray diffraction, Raman spectroscopy, and Fourier-transform infrared spectroscopy. The surface morphology of synthesized nanoparticles was studied using scanning electron microscopy and transmission electron microscopy. The thermoluminescence property of the nanocomposite was analyzed by irradiating the samples in gamma radiation at 1 kGy. Electrochemical reversibility of the GO-Ag nanocomposite was examined by cyclic voltammetry. The photocatalytic application of the nanocomposite was studied using degradation of methylene blue dye. Results reveal that doping of AgNPs on the GO surface not only improves its dye degradation property but also enhances its thermoluminescence property. This knowledge will be helpful in determining the antibacterial property of the GO-Ag nanocomposite in the future.

Research paper thumbnail of Post Market Surveillance of VERTAUX Pedicle Screws System to Treat Spondylolisthesis Related Problems

Acta Scientific Orthopaedics, 2019

Methods: This is a prospective study of 25 patients with one year follow up. The Spondylolisthesi... more Methods: This is a prospective study of 25 patients with one year follow up. The Spondylolisthesis related problems were treated with Spinal System-VERTAUX Pedicle Screws System manufactured by Auxein Medical Private Limited, India. X-ray was used to check the pre and post clinical conditions. Functional outcomes were assessed with Average VAS score. Results: X-ray was showing good results. Before surgery Average VAS score was 7.44 and at the end of one year Average VAS score was 0.4 only. After 1 month, 3 months, 6 months and 9 months Average VAS score were calculated as 5.25, 4.18, 2.84 and 1.6 respectively. Conclusion: Treatment of Spondylolisthesis with VERTAUX Pedicle Screws System shows good outcomes with less complications.

Research paper thumbnail of Open reduction and internal fixation treatment of distal tibia fracture with Wise lock plate followed by two year follow up

International Journal of Research in Orthopaedics, 2019

Background: Distal tibial fractures are high energy injuries with high complication rate. The obj... more Background: Distal tibial fractures are high energy injuries with high complication rate. The objective of this study was to reduce the postoperative complications of distal tibial fracture by using indigenously manufactured implants (plates and screws).Methods: This was a prospective study of 10 patients (6 patients had 43-B1 fracture, 4 patients had 43-B2 fracture) with two year follow up period followed by physical exercises after one month of the surgery. The fractures were treated with 3.5 mm Wise lock medial distal tibia plate. X-ray was used to check the union, non-union. Functional outcomes were assessed with visual analog scale (VAS) score.Results: X-ray was showing good results. Average VAS score was 1.5 (90%) 9 patients and 2.5 (10%) in 1 patient. At the end of the first year VAS score is 2 for one patient with 9 others having 1 and at the end of the second year the VAS score is 0 for 9 patients and 1 for one patient.Conclusions: Treatment of distal tibial fracture with 3...

Research paper thumbnail of Treatment of humerus fracture with wise-lock implants

International Journal of Research in Orthopaedics, 2019

Background: Humerus fracture is a common fracture in aging population mainly occurring due to fal... more Background: Humerus fracture is a common fracture in aging population mainly occurring due to fall, high energy trauma and sports injury. Locking plate treatment is showing good results in stabilization of the fracture. The purpose of this study is to showcase the surgical treatment and results by using Auxein locking implants for the treatment of proximal humeral fracture.Methods: Prospectively 13 patients were treated with ORIF treatment (6 males, 7 females with an average age of 43.6years). Fracture type is classified as per the Muller AO classification of fracture, 6 patients had type 11-A1 and 7 patients had type 11-A2. 1 patient were felt under American Society of Anesthesiologists grade 2 have mild systemic disease. Clinical outcomes were assessed at 1year follow-up with visual analogue scale score at 4 week, 16 week, 24 week and 1 year.Results: The follow-up of patients was taken at 4th, 16th, 24th and 1 year bearing good clinical results. 2 patients were encountered with pa...

Research paper thumbnail of Facile Synthesis of CuFe2O4 Doped Polyacrylic Acid Hydrogel Nanocomposite and its Application in Dye Degradation

Materials Letters, 2019

Abstract Polyacrylic acid hydrogel doped with copper ferrite nanoparticles has been prepared and ... more Abstract Polyacrylic acid hydrogel doped with copper ferrite nanoparticles has been prepared and studied for the removal and degradation of organic dye (methylene blue) from wastewater. Phase purity of nanoparticles was confirmed by powder X-ray diffraction and EDX analysis. Raman spectra showed three bands at Eg, F2g and A1g, attributing the formation of spinel phase with a band gap of 2.12 eV. Hydrogel composite showed an increase in weight by 1771% when soaked in water. Degradation and absorption studies of methylene blue dye solution with copper ferrite nanoparticles as well as hydrogel nanocomposite suggest absorption of dye by hydrogel and degradation with copper ferrite nanoparticles. Such hydrogel nanocomposites could be a promising material for mitigation of water pollution caused by organic dyes discharged by small and medium scale industries.

Research paper thumbnail of Deciphering the potent application of nanobentonite and α-Fe2O3/bentonite nanocomposite in dye removal: revisiting the insights of adsorption mechanism

Applied Nanoscience

Clays are widely accepted for dye removal from wastewater. Here, in this work, nanobentonite was ... more Clays are widely accepted for dye removal from wastewater. Here, in this work, nanobentonite was synthesized by a simple, rapid, and cost-effective chemithermal method. Additionally, nanobentonite was coupled with hematite nanoparticles via thermal coupling to prepare a nanocomposite with enhanced surface absorption. Surface morphology, compositional and structural analysis of synthesized samples were done using various characterization techniques. Results suggested that nanobentonite and nanocomposite having an average diameter of 35.36 and 21.85 nm respectively were synthesized. Nanocomposite exhibited increased surface area. Additionally, the ability of all samples as an adsorbent for removal of methylene blue (MB) and Congo red (CR), from an aqueous solution was investigated under various optimization conditions. Adsorption kinetics revealed that Pseudo II order equation fits well for the adsorption process following intraparticular diffusion mechanism for both the dyes. The adsorption equilibrium data of MB and CR was fitted well by the Langmuir and Freundlich adsorption isotherm model, respectively. The thermodynamic parameters suggested adsorption process is endothermic and spontaneous in nature with increased entropy value.

Research paper thumbnail of Structural, thermal, and ion dynamics studies of PVA-CS-NaI-based biopolymer electrolyte films

Journal of Solid State Electrochemistry, 2021

A series of biopolymer blend electrolytes (BPBEs) based on ((100-x)PVA-xCS)-NaI, viz. BPBE-1 to B... more A series of biopolymer blend electrolytes (BPBEs) based on ((100-x)PVA-xCS)-NaI, viz. BPBE-1 to BPBE-5 (x = 10, 20, 30, 40, 50 in wt%), respectively, were prepared using solution cast technique. Prepared samples have been characterized using XRD, ATR-FTIR, TGA, and AC impedance spectroscopic techniques. ATR-FTIR results reveal the interactions between the constituents of PVA/CS with salt, NaI. XRD results show the semi-crystalline nature of PVA-CS polymer blend and %degree of crystallinity (Xc) was found to be minimum for sample BPBE-1. TGA and its 1st derivative (DTGA) results show that BPBE films decompose in multi-steps. The decomposition temperature peak (Td, peak) associated with CS-PVA polymer blend and the interactions between CS-PVA-NaI have been discussed using TGA analysis. Temperature-dependent dc conductivity (σdc) and relaxation frequency (fr) follow the Arrhenius type mechanism. The optimum σdc ~ 1.2 × 10−5 S/cm at 30 °C was received for sample, BPBE-1. The ac conductivity spectra for all samples follow the Jonscher’s power law (JPL). Dielectric permittivity and electric modulus studies have also been done for understanding the charge storage properties and conductivity relaxation. Ionic transference number (ITN) measurement has been carried out for knowing the ionic/electronic nature of charge species. Cyclic voltammetry (CV) measurement has been done to study the electrochemical behavior of the optimized sample.

Research paper thumbnail of Effect on Solar PV Panel Performance Due to Varying Latitude in Northern Hemisphere

Springer Proceedings in Energy, 2021

Research paper thumbnail of Managing Risk in Deepwater Frontiers - Key Learnings From Five Continents

Research paper thumbnail of A DNA quantitative analysis of lung cancer cells with different pathological types from bronchial brush specimens and its clinical significance

OBJECTIVE To explore the significance of a DNA quantitative analysis of lung cancer cells with di... more OBJECTIVE To explore the significance of a DNA quantitative analysis of lung cancer cells with different pathological types taken from bronchial brush specimens and its relationship with the clinicopathological features. METHODS 903 bronchial brush cytological specimens taken in the Cytology Department of the Fourth Hospital of Hebei Medical University were collected from March 2017 to December 2019 and divided into three groups: the squamous carcinoma (SC) group, the adenocarcinoma (AC) group, and the small-cell carcinoma (SCC) group. The maximum DNA index (DI) value, the percentage of cells with a DI larger than 2.5, the mean DI, and the peaks of the aneuploid cells of the three groups were compared. A single factor analysis was used to analyze the relationship between the DNA content, aneuploidy, and the clinico pathological features of the patients who had surgery. RESULTS The peaks of the aneuploid cells in the SC group, the AC group, and the SCC group had no significant differ...

Research paper thumbnail of Indagine sulla presenza di ipa del legno e nei vini trattati con il legno

Research paper thumbnail of Characterization of a novel lactoferrin receptor : Glyceraldehye 3-phosphate Dehydrogenase

Research paper thumbnail of Benchmarking Analysis of CNN Architectures for Artificial Intelligence Platforms

Proceedings of Emerging Trends and Technologies on Intelligent Systems, 2021

Research paper thumbnail of Analysis of Patents Filed for the Herbal Therapeutics Against Cancer

Anticancer plants: Properties and Application, 2018

Use of herbal medications for the treatment of various ailments is being practised since ancient ... more Use of herbal medications for the treatment of various ailments is being practised since ancient time. According to a recent report from the World Health Organization (WHO), cancer is the second leading cause of death worldwide and was responsible for 8.8 million deaths in 2015. Each year, more than 200,000 children are diagnosed with different cancer types. Modern science is witnessing an increased demand for natural medicines to treat cancer. The role of phytochemical compounds in modulation of immune systems and their mechanistic details is well investigated. Starting from the 1940s until the end of the year 2014, about 175 small molecules got approved as cancer therapeutics. Among these, 131 molecules (75%) were non-synthetic of which 85 (49%) were actual natural products or their direct derivatives. These effective natural products mainly originate from the plants, microbes, organism, cell lines, etc. The focus of the world has shifted towards the development of herb-based cancer therapeutics as evident from the increased number of patent applications filed and published in this area. China, the United States, Japan, Korea and Australia are among the top countries in filing the patents for inventions/innovations in the field of cancer drug discovery. These inventions encompass herbal formulations, plant extracts, processes, phyto-compounds or their derivatives, claimed against several types of cancers. The aim of this chapter is to focus on the analysis of patent literature of the herbal therapeutics for cancer, top players in the arena and the future of herbal drugs.

Research paper thumbnail of Lycopene-loaded nanostructured lipid carrier from carboxymethyl oil palm empty fruit bunch cellulose for topical administration

Carbohydrate Polymer Technologies and Applications, 2021

A novel lycopene loaded nanostructured lipid carriers (NLC) was prepared using carboxymethyl oil ... more A novel lycopene loaded nanostructured lipid carriers (NLC) was prepared using carboxymethyl oil palm empty fruit bunch cellulose (CM-OPEFBC), carnauba wax and palm oil. Presence of wax and oil in the lipid mixture aided in obtaining small uniform spherical particle size in the range of 16-22 nm having relatively small size distribution (polydispersity index < 0.5). The NLC provide a better drug loading capacity of an active substance to penetrate easily through the skin after applied topically. The entrapment efficiency of lycopene was found to be 98% for all the formulations. The particle size, size distribution, and zeta potential of lycopene-loaded NLC stored at room temperature for 8 weeks did not show any significant changes, proving an excellent colloidal stability of the formulations. The lycopene-loaded NLC are better and advanced systems for the stability and delivery of lycopene in pharmaceutical industry.

Research paper thumbnail of Nanotechnology and its application: a review

Nanotechnology in Cancer Management, 2021

Abstract Integration of functionalized nanoscale materials in various biomedical applications has... more Abstract Integration of functionalized nanoscale materials in various biomedical applications has introduced marked research interest in recent years. Nanotechnology operations in functionalized and altered biomedical is potent for use in drug delivery, bioimaging, diagnosis and treatment, genetic material sequencing, biosensors, active packaging, agriculture, and environment. Incorporation of nanostructures with functionalized biomaterial is a promising technology in biomedical application for the development of biosensor and drug delivery for point-of-care (P-O-C). The capsulation of a bioactive chip with biomaterial is an emerging technology for the development of miniaturized P-O-C technique in bioelectronic/biosensor industry. The use of nanoencapsules for the delivery of biofertilizers and nutrient to the plants and use of biosensors help in the controlled release of agrochemical to plant. Nanoparticles, nanoencapsule, nanotubes, nanospheres, and nanochip have a wide application in medical fields, water treatment, agriculture, health, and environmental safety. The harmful organic compound and pollutant from industries can be degradation using nanoparticles as photocatalyst and converted in harmless form. The capability and benefits of nanotechnology in medical technology, biosensors, cancer treatment, bioimaging, drug delivery, precision farming, water treatment, and environmental cleaning are discussed in this review chapter. The nanotechnology is a coming revolutionary technology and has the potential to solve various problems with advantages over conventional methods. In this chapter, the application of modern nanotechnology to the various biological systems are discussed.

Research paper thumbnail of Ammonium fluoride mediated mechano chemical synthesis of A2PdF6 (A = K, Rb) along with their catalytic role in environmental remediation

Journal of Environmental Chemical Engineering, 2017

To highlight the power of mechanochemistry to oxidize metal ions leading to the discovery of newe... more To highlight the power of mechanochemistry to oxidize metal ions leading to the discovery of newer phases, ammonium fluoride mediated synthesis of A 2 PdF 6 (A = Rb, K) has been carried out. Grinding reactions of ammonium fluoride with palladium (II) acetate and further cation exchange with AF (A = Rb, K) were closely monitored ex-situ characterizations such as high resolution powder X-ray diffraction (PXRD), fourier transform infrared (FT-IR) and Raman spectroscopy measurements. For the reaction involving RbF, Rb 2 PdF 6 possessing K 2 PtCl 6 type structure was confirmed from the Rietveld refinement of PXRD pattern, high resolution transmission emission microscopy (HR-TEM) and selected area electron diffraction (SAED) measurements. Elemental composition and oxidation state of palladium in Rb 2 PdF 6 were examined using X-ray photoelectron spectroscopy (XPS) analysis. Ligand to metal charge transfer and d-d transitions of Pd (IV) were present in the UV-vis diffuse reflectance spectrum of Rb 2 PdF 6 with a band gap of 2.67 eV estimated using the Kubelka-Munk function. Its role as a catalyst to degrade the aqueous dye solutions (Methylene Blue, Malachite Green, Rhodamine-6G and Rhodamine-B) under UV-vis radiation has been evaluated along with their kinetics. The catalyst was active after four cycles of use. The reduction of Pd 4+ to Pd 0 by NaBH 4 has been favourably used for the efficient and rapid conversion of highly carcinogenic, toxic, mutagenic Cr 6+ to less toxic Cr 3+. K 2 PdF 6 possessing cubic K 2 PtCl 6type structure has also been synthesized for the first time by this method which presented yet another example for the alteration of reaction landscapes by mechanical forces.

Research paper thumbnail of Capping agent-induced variation of physicochemical and biological properties of α-Fe2O3 nanoparticles

Materials Chemistry and Physics, 2021

Abstract Capping agents play a vital role in controlling the size, morphology, and monodispersity... more Abstract Capping agents play a vital role in controlling the size, morphology, and monodispersity of nanoparticles. To understand a comprehensive overview of the influence of capping on the structure and properties of hematite nanoparticles (HNPs), we have synthesized hematite nanoparticles (HNPs) with narrow size distribution by an economic co-precipitation method using capping agents like sodium citrate, Polyvinyl Pyrrolidone (PVP) and starch. A comparative in-depth study of structure, morphology, and surface analysis along with thermal, optical, magnetic and electrochemical properties of synthesized capped and uncapped HNPs has been performed. The effect of capping agents on photocatalytic and antioxidant activities along with cytotoxicity of all fabricated nanoparticles was studied against MDA-MB-231 cell line causing breast cancer along with flow cytometry. Results revealed a definite improvement in grain size, crystallinity, optical, thermal and magnetic properties of HNPs is due to efficient capping. PVP has reduced the maximum of crystalline size up to 23% of HNPs and removed 98.80% of dye from wastewater among all capping agents. Our findings also suggest that PVP capped HNPs proved to be cytotoxic to the cancer cell line. Taken together, our studies will be helpful to understand the role of capping agents in determining properties of HNPs that can further help in designing engineer HNPs.

Research paper thumbnail of Green synthesis of copper and copper sulfide nanoparticles

3RD INTERNATIONAL CONFERENCE ON CONDENSED MATTER AND APPLIED PHYSICS (ICC-2019), 2020

Research paper thumbnail of Clinical outcomes of intramedullary femoral nailing system to treat femoral fracture

International Journal of Research in Orthopaedics, 2020

Background: Femoral fractures are bone fracture involve femur, common injuries in adults. Intrame... more Background: Femoral fractures are bone fracture involve femur, common injuries in adults. Intramedullary femoral nailing system is the recommended solution or treatment for fractures due to its high union rates.Methods: In this clinical inspection 30 patients were selected with bone fracture of femur, and treated by using intramedullary femoral nailing system (universal intramedullary cannulated femoral nail, expert femoral nail, gamma nail and retrograde femoral nail) manufactured by Auxein Medical Private Limited, Sonepat, Haryana, India. There are two types of patients used in this study, one is male (n=18) and another female (n=12). Patients physical fitness was also observed through American Society of Anesthesiologist.Results: Outcomes record from the patients using visual analog scale. Follow up of the patients were taken on 1st month, 6th month, and 12 months. Post-operative outcomes were good with none of the patients showing non-union of fracture site. There were no compli...

Research paper thumbnail of A Novel Synthesis of the Graphene Oxide-Silver (GO-Ag) Nanocomposite for Unique Physiochemical Applications

ACS Omega, 2020

Graphene oxide-silver nanocomposite (GO-Ag) was fabricated via the sonochemical method, which sho... more Graphene oxide-silver nanocomposite (GO-Ag) was fabricated via the sonochemical method, which shows unique physiochemical properties. Graphene oxide (GO) and silver nanoparticles (AgNPs) were synthesized by modified Hummer's and Chemical reduction methods, respectively. The synthesized nanocomposite was characterized using powder X-ray diffraction, Raman spectroscopy, and Fourier-transform infrared spectroscopy. The surface morphology of synthesized nanoparticles was studied using scanning electron microscopy and transmission electron microscopy. The thermoluminescence property of the nanocomposite was analyzed by irradiating the samples in gamma radiation at 1 kGy. Electrochemical reversibility of the GO-Ag nanocomposite was examined by cyclic voltammetry. The photocatalytic application of the nanocomposite was studied using degradation of methylene blue dye. Results reveal that doping of AgNPs on the GO surface not only improves its dye degradation property but also enhances its thermoluminescence property. This knowledge will be helpful in determining the antibacterial property of the GO-Ag nanocomposite in the future.

Research paper thumbnail of Post Market Surveillance of VERTAUX Pedicle Screws System to Treat Spondylolisthesis Related Problems

Acta Scientific Orthopaedics, 2019

Methods: This is a prospective study of 25 patients with one year follow up. The Spondylolisthesi... more Methods: This is a prospective study of 25 patients with one year follow up. The Spondylolisthesis related problems were treated with Spinal System-VERTAUX Pedicle Screws System manufactured by Auxein Medical Private Limited, India. X-ray was used to check the pre and post clinical conditions. Functional outcomes were assessed with Average VAS score. Results: X-ray was showing good results. Before surgery Average VAS score was 7.44 and at the end of one year Average VAS score was 0.4 only. After 1 month, 3 months, 6 months and 9 months Average VAS score were calculated as 5.25, 4.18, 2.84 and 1.6 respectively. Conclusion: Treatment of Spondylolisthesis with VERTAUX Pedicle Screws System shows good outcomes with less complications.

Research paper thumbnail of Open reduction and internal fixation treatment of distal tibia fracture with Wise lock plate followed by two year follow up

International Journal of Research in Orthopaedics, 2019

Background: Distal tibial fractures are high energy injuries with high complication rate. The obj... more Background: Distal tibial fractures are high energy injuries with high complication rate. The objective of this study was to reduce the postoperative complications of distal tibial fracture by using indigenously manufactured implants (plates and screws).Methods: This was a prospective study of 10 patients (6 patients had 43-B1 fracture, 4 patients had 43-B2 fracture) with two year follow up period followed by physical exercises after one month of the surgery. The fractures were treated with 3.5 mm Wise lock medial distal tibia plate. X-ray was used to check the union, non-union. Functional outcomes were assessed with visual analog scale (VAS) score.Results: X-ray was showing good results. Average VAS score was 1.5 (90%) 9 patients and 2.5 (10%) in 1 patient. At the end of the first year VAS score is 2 for one patient with 9 others having 1 and at the end of the second year the VAS score is 0 for 9 patients and 1 for one patient.Conclusions: Treatment of distal tibial fracture with 3...

Research paper thumbnail of Treatment of humerus fracture with wise-lock implants

International Journal of Research in Orthopaedics, 2019

Background: Humerus fracture is a common fracture in aging population mainly occurring due to fal... more Background: Humerus fracture is a common fracture in aging population mainly occurring due to fall, high energy trauma and sports injury. Locking plate treatment is showing good results in stabilization of the fracture. The purpose of this study is to showcase the surgical treatment and results by using Auxein locking implants for the treatment of proximal humeral fracture.Methods: Prospectively 13 patients were treated with ORIF treatment (6 males, 7 females with an average age of 43.6years). Fracture type is classified as per the Muller AO classification of fracture, 6 patients had type 11-A1 and 7 patients had type 11-A2. 1 patient were felt under American Society of Anesthesiologists grade 2 have mild systemic disease. Clinical outcomes were assessed at 1year follow-up with visual analogue scale score at 4 week, 16 week, 24 week and 1 year.Results: The follow-up of patients was taken at 4th, 16th, 24th and 1 year bearing good clinical results. 2 patients were encountered with pa...

Research paper thumbnail of Facile Synthesis of CuFe2O4 Doped Polyacrylic Acid Hydrogel Nanocomposite and its Application in Dye Degradation

Materials Letters, 2019

Abstract Polyacrylic acid hydrogel doped with copper ferrite nanoparticles has been prepared and ... more Abstract Polyacrylic acid hydrogel doped with copper ferrite nanoparticles has been prepared and studied for the removal and degradation of organic dye (methylene blue) from wastewater. Phase purity of nanoparticles was confirmed by powder X-ray diffraction and EDX analysis. Raman spectra showed three bands at Eg, F2g and A1g, attributing the formation of spinel phase with a band gap of 2.12 eV. Hydrogel composite showed an increase in weight by 1771% when soaked in water. Degradation and absorption studies of methylene blue dye solution with copper ferrite nanoparticles as well as hydrogel nanocomposite suggest absorption of dye by hydrogel and degradation with copper ferrite nanoparticles. Such hydrogel nanocomposites could be a promising material for mitigation of water pollution caused by organic dyes discharged by small and medium scale industries.