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Papers by Alexander Potapov

Research paper thumbnail of Spontaneous polarization in dilute polar-nonpolar solutions in the dielectric relaxation region

Soviet Journal of Experimental and Theoretical Physics, 1993

Research paper thumbnail of Neurosurgery in Russia and USSR

International Neuroscience Journal, 2015

Research paper thumbnail of Therapeutic hypothermia for out-of-hospital cardiac arrest: an update for neurosurgeons

World neurosurgery, 2010

Neurosurgeons have been familiar with the idea that hypothermia is protective against various typ... more Neurosurgeons have been familiar with the idea that hypothermia is protective against various types of brain injuries, including traumatic brain injury (TBI). Recent randomized controlled trials, however, have failed to demonstrate the efficacy of therapeutic hypothermia (TH) in patients with TBI. On the other hand, TH becomes popular in the treatment of out-of-hospital cardiac arrest (OHCA) survivors, after randomized controlled trials have shown that survival rate and functional outcome is improved with the use of TH in selected patients. We believe that knowledge on the recent progress in TH for OHCA is useful for neurosurgeons, because feedback of information obtained in the treatment of OHCA may revitalize the interest in TH for neurosurgical disorders, particularly TBI. A review of the literature was conducted with the use of PubMed. Various cooling techniques and devices have been developed and trialed in the treatment of OHCA survivors, including prehospital cooling with bol...

Research paper thumbnail of Applying Cerebral Hypothermia and Brain Oxygen Monitoring in Treating Severe Traumatic Brain Injury

Research paper thumbnail of Madjid Samii – Neurosurgeon of the year

Research paper thumbnail of Analysis of expression of microRNAs and genes involved in the control of key signaling mechanisms that support or inhibit development of brain tumors of different grades

Clinica Chimica Acta, 2014

Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regu... more Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regulation of key biological processes. Different miRNAs with pro-oncogenic and anti-oncogenic properties have been identified in glioblastomas. We decided to analyze expression profiles of 10 mature miRNAs (miR-7-1, miR-10а, miR-17, miR-20а, miR-21, miR-23а, miR-26а, miR-137, and miR-222) in post-surgery glioma specimens of different grades in order to find whether the expression level correlates with tumor grades. We also measured expression of six key genes such as PTEN, p21/CDKN1A, MDR1, ABCG2, BAX, and BCL-2 involved in the regulation of critical glioma signaling pathways to establish the effect of miRNAs on these signaling mechanisms. Methods: Using RT-PCR, we performed expression analysis of 25 tumor fresh samples (grades II-IV). Results: We found gradual increase in miR-21 and miR-23a levels in all tumor grades whereas miR-7 and miR-137 were significantly down-regulated depending on the glioma grade. MDR, ABCG2, and p21/CDKN1A levels were significantly up-regulated while expression of PTEN was down-regulated in tumor samples compared to the normal brain tissue. Conclusions: These observations provide new insights into molecular pathogenic mechanisms of glioma progression and suggest about a potential value of miRNAs as a putative diagnostic marker of brain tumors.

Research paper thumbnail of Updike, John - Brazil (Knopf, 1994)

Research paper thumbnail of Spontaneous polarization in dilute polar-nonpolar solutions in the dielectric relaxation region

Soviet Journal of Experimental and Theoretical Physics, 1993

Research paper thumbnail of Neurosurgery in Russia and USSR

International Neuroscience Journal, 2015

Research paper thumbnail of Therapeutic hypothermia for out-of-hospital cardiac arrest: an update for neurosurgeons

World neurosurgery, 2010

Neurosurgeons have been familiar with the idea that hypothermia is protective against various typ... more Neurosurgeons have been familiar with the idea that hypothermia is protective against various types of brain injuries, including traumatic brain injury (TBI). Recent randomized controlled trials, however, have failed to demonstrate the efficacy of therapeutic hypothermia (TH) in patients with TBI. On the other hand, TH becomes popular in the treatment of out-of-hospital cardiac arrest (OHCA) survivors, after randomized controlled trials have shown that survival rate and functional outcome is improved with the use of TH in selected patients. We believe that knowledge on the recent progress in TH for OHCA is useful for neurosurgeons, because feedback of information obtained in the treatment of OHCA may revitalize the interest in TH for neurosurgical disorders, particularly TBI. A review of the literature was conducted with the use of PubMed. Various cooling techniques and devices have been developed and trialed in the treatment of OHCA survivors, including prehospital cooling with bol...

Research paper thumbnail of Applying Cerebral Hypothermia and Brain Oxygen Monitoring in Treating Severe Traumatic Brain Injury

Research paper thumbnail of Madjid Samii – Neurosurgeon of the year

Research paper thumbnail of Analysis of expression of microRNAs and genes involved in the control of key signaling mechanisms that support or inhibit development of brain tumors of different grades

Clinica Chimica Acta, 2014

Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regu... more Background: MicroRNAs (miRNAs) are a class of small non-coding RNA molecules involved in the regulation of key biological processes. Different miRNAs with pro-oncogenic and anti-oncogenic properties have been identified in glioblastomas. We decided to analyze expression profiles of 10 mature miRNAs (miR-7-1, miR-10а, miR-17, miR-20а, miR-21, miR-23а, miR-26а, miR-137, and miR-222) in post-surgery glioma specimens of different grades in order to find whether the expression level correlates with tumor grades. We also measured expression of six key genes such as PTEN, p21/CDKN1A, MDR1, ABCG2, BAX, and BCL-2 involved in the regulation of critical glioma signaling pathways to establish the effect of miRNAs on these signaling mechanisms. Methods: Using RT-PCR, we performed expression analysis of 25 tumor fresh samples (grades II-IV). Results: We found gradual increase in miR-21 and miR-23a levels in all tumor grades whereas miR-7 and miR-137 were significantly down-regulated depending on the glioma grade. MDR, ABCG2, and p21/CDKN1A levels were significantly up-regulated while expression of PTEN was down-regulated in tumor samples compared to the normal brain tissue. Conclusions: These observations provide new insights into molecular pathogenic mechanisms of glioma progression and suggest about a potential value of miRNAs as a putative diagnostic marker of brain tumors.

Research paper thumbnail of Updike, John - Brazil (Knopf, 1994)