Pranjal Sharma - Academia.edu (original) (raw)
Papers by Pranjal Sharma
Asian Journal of Biological and Life Sciences
Proceedings of 5th International Electronic Conference on Entropy and Its Applications
In recent years geologists have put a lot of effort trying to study the evolution of earth using ... more In recent years geologists have put a lot of effort trying to study the evolution of earth using different techniques studying rocks, gases, and water at different channels like mantle, lithosphere and atmosphere. Some of the ways are Estimation of heat flux between the atmosphere and sea ice, Modelling global temperature changes, Groundwater monitoring networks, etc. But algorithms involving the study of earth's evolution have been a debated topic for decades. Also, there is distinct research on studying the mantle, lithosphere, and atmosphere using isotopic fractionation which this paper will take into consideration to form genes at the former stage. This factor of isotopic fractionation could be molded in QGA to study the earth's evolution. We combined these factors because the gases containing these isotopes move from mantle to lithosphere or atmosphere through gaps or volcanic eruptions contributing to it. We are likely to use the Rb/Sr and Sm/Nd ratios to study the evolution of these channels. This paper, in general, provides the idea on gathering some information of temperature changes by using isotopic ratios as chromosomes, in QGA the chromosomes depict the characteristic of a generation. Here these ratios depict the temperature characteristic and other steps of QGA would be molded to study these ratios in the form of temperature changes, which would further signify the evolution of earth based on the study that temperature changes with the change in isotopic ratios. This paper will collect these distinct studies and embed them into an upgraded quantum genetic algorithm called Quantum Genetic Terrain Algorithm or Quantum GTA.
Open Journal of Psychiatry & Allied Sciences, 2016
International journal of clinical pediatric dentistry
Need for the study: The most important procedure for a successful endodontic treatment is the cle... more Need for the study: The most important procedure for a successful endodontic treatment is the cleaning and shaping of the canal system. Understanding the internal anatomy of teeth provides valuable information to the clinician that would help him achieve higher clinical success during endodontic therapy. To evaluate by computed tomography-the internal anatomy of mandibular second primary molars with respect to the number of canals, cross-sectional shape of canals, cross-sectional area of canals and the root dentin thickness. A total of 31 mandibular second primary molars were subjected to computed-tomographic evaluation in the transverse plane, after mounting them in a prefabricated template. The images, thus, obtained were analyzed using De-winter Bio-wizard® software. All the samples demonstrated two canals in the mesial root, while majority of the samples (65.48%) demonstrated two canals in the distal root. The cross-sectional images of the mesial canals demonstrated a round shap...
D53. SEPSIS: MECHANISMS AND IMPLICATIONS FOR MANAGEMENT, 2010
Page 1. / Thematic Poster Session / Wednesday, May 19/8:15 D53 SEPSIS: MECHANISMS AND IMPLICATION... more Page 1. / Thematic Poster Session / Wednesday, May 19/8:15 D53 SEPSIS: MECHANISMS AND IMPLICATIONS FOR MANAGEMENT AM-4:00 PM / Area A, Hall G (First Level), Morial Convention Center Feasibility Study Of ...
A45. ICU MANAGEMENT AND OUTCOMES: PREDICTION, PROCEDURES AND POT POURRI, 2010
Division of Pulmonary and Critical Care Medicine, College of Medicine, Mayo Clinic, Rochester, MN... more Division of Pulmonary and Critical Care Medicine, College of Medicine, Mayo Clinic, Rochester, MN; (METRIC) Multidisciplinary 1 ... Epidemiology and Translational Research in Intensive Care, Rochester, MN, United States of America ... Corresponding author's ...
The Journal of Contemporary Dental Practice, 2011
The traumatized primary teeth have a great clinical significance because it not only have consequ... more The traumatized primary teeth have a great clinical significance because it not only have consequences on itself but also on its succedaneous developing permanent teeth due to its close anatomical relationship. The extent of severity is adjudged by the type of trauma and the age of the child at the time of trauma. For instance, avulsion and intrusive injuries present with high percentage of developmental disturbances in permanent teeth than subluxation and extrusive injuries. When considering the age of the child at the time of trauma, consequences are less severe in children over 4 years of age than in the younger age group. Clinical significance: It highlights the sequelae of trauma to primary teeth with the aim of aiding in detection of probable alterations in the traumatized primary teeth and its succedaneous permanent teeth.
Journal of Clinical Pathology, 2000
Aim-To determine whether two recently described staining methods (the modified McMullen's and the... more Aim-To determine whether two recently described staining methods (the modified McMullen's and the Helicobacter pylori silver stain HpSS methods) used for the histological identification of H pylori organisms are superior to two established techniques (the modified Giemsa and anti-H pylori antibody immunostain) in terms of availability, reproducibility, rapidity, sensitivity, and cost. Methods-Histological sections from 63 paired gastric biopsies from adult patients previously investigated for dyspepsia were stained with the four methods and these were assessed blindly and independently by two observers. Of the 63 patients, 30 were originally negative in all tests for H pylori infection, 30 were positive, and the remaining three cases had discordant results using a combination of five tests (rapid biopsy urease test, urea breath test, culture, serology, and histology). Results-Interobserver agreement was best with the antibody method (98%), followed by the McMullen's (90%), Giemsa (87%), and HpSS (85%). Of the 60 "gold standard" positive and negative cases, 30 were positive by the modified Giemsa stain, 29 by the McMullen's method, 29 by HpSS, and 30 by the antibody stain. However, there were two false positives with the HpSS method. The modified Giemsa is the cheapest and easiest to perform technically. Conclusions-When H pylori are present, careful examination will almost always reveal them, whichever of these stains is used. However, the modified Giemsa stain is the method of choice because it is sensitive, cheap, easy to perform, and reproducible.
CHEST Journal, 2013
ABSTRACT
CHEST Journal, 2013
ABSTRACT Critical Care Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resid... more ABSTRACT Critical Care Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 29, 2013 at 01:30 PM - 02:30 PMINTRODUCTION: Staphylococcus aureus enterocolitis has been increasingly reported in recent times with an interesting sinusoidal trend over the last many decades. Given the paucity of literature on its role in the pathogenesis of shock, we herein report such a case.CASE PRESENTATION: Sixty-seven year old Caucasian female with hypertension and hyperlipidemia developed abdominal pain after eating at a local fast food restaurant. Over the next few hours, she developed worsening symptoms and became unresponsive. After extensive cardio-pulmonary resuscitation, the patient was transferred to our tertiary care center hypothermic, requiring mechanical ventilation and intravenous dobutamine. Her laboratory parameters showed WBC count 43,400/mm3, serum creatinine 2.5 mg/dL, AST 1853 IU/L and ALT 802 IU/L, lactate 11.2 mmol/L and arterial pH 7.05. The patient's abdominal CT revealed free peritoneal fluid without evidence of perforation, and paucity of colonic gas suggestive of ileus. In addition to aggressive volume resuscitation empirical antimicrobial therapy was started (vancomycin, ciprofloxacin and metronidazole). Stools cultures were positive for Staphylococcus aureus on two different occasions. Rectal erosions on colonoscopy showed inflammatory pathology. Patient responded to aggressive resuscitation over the next several days. Her leukocytosis improved and liver enzymes normalized. She was discharged home in a stable condition.DISCUSSION: In our patient, temporal relationship to her getting sick and eating at an outside facility, two sets of stool cultures growing Staphylococcal aureus and lack of another etiology for shock were important diagnostic clues. Increasing use of Metronidazole has been postulated as a cause for the re-emergence of Staphylococcal aureus enterocolitis. Mechanisms of shock are poorly understood; but bacteremia, toxin production and dehydration have been postulated. Varying mucosal appearances ranging from mild erythema (as in our case) to extensive necrosis have been reported. Although oral vancomycin is the preferred therapy, its utility in enterocolitis-induced shock has not been studied.CONCLUSIONS: Staphylococcus aureus enteritis should be considered as an etiology for shock in the setting of food borne illness when no other pathogen can be identified. Early recognition and aggressive supportive care is the cornerstone of management for this rare condition.Reference #1: Lin Z, Kotler DP, Schlievert PM, Sordillo EM. Staphylococcus Enterocolitis: Forgotten but not gone? Dig Dis Sci. 2010 May;55(5):1200-7.Reference #2: Kolter DP, Sordillo PM. Review: A case of Staphylococcal aureus Enterocolitis: A rare entity. Gastroenterol Hepatol (N Y). 2010 Feb;6(2):117-9.Reference #3: Kotler DP, Sandkovsky Y, Schlievert PM, Sordillo EM. Toxic Shock-like Syndrome associated with Staphylococcus Enterocolitis in an HIV-infected man. Clin Infect Dis. 2007 Jun 15;44(12):e121-3.DISCLOSURE: The following authors have nothing to disclose: Saraschandra Vallabhajosyula, Pranjal Sharma, Pranathi Sundaragiri, Pallavi Bellamkonda, Savio Reddymasu, Lee MorrowNo Product/Research Disclosure Information.
CHEST Journal, 2012
ABSTRACT SESSION TYPE: Non Pulmonary Critical Care PostersPRESENTED ON: Wednesday, October 24, 20... more ABSTRACT SESSION TYPE: Non Pulmonary Critical Care PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Renal insufficiency (RI) is common in the ICU and is associated with worse clinical outcomes. However, little is known about its epidemiology in ventilator-associated pneumonia (VAP) patients. Given the implications for dosing many ICU medications, including antibiotics, this study was undertaken to describe changes in renal function after the onset of VAP.METHODS: We retrospectively collected data from 472 consecutive adults with clinically-diagnosed VAP diagnosed between 1/1/02 and 12/31/09 in a single academic hospital ICU. Patients with end-stage renal disease at ICU admission were excluded. Demographics, comorbid illness, daily laboratory values, antibiotic prescription, and length of stay measures were abstracted. Creatinine clearance (CrCl) was calculated daily using the Cockroft-Gault equation. Patients were classified as having no RI (CrCl >90 mL/min), mild RI (CrCl 51-90 mL/min), moderate RI (CrCl 10-50 mL/min), or severe RI (CrCl <10 mL/min). Subset analyses were repeated for geriatric (age ≥65 yrs) and non-geriatric patients.RESULTS: The cohort was 64% male, had an average age of 54.3 years and an average APACHE II score of 23.6. At diagnosis of VAP 13% of patients merited consideration of renal dosage adjustment (CrCl ≤50 mL/min). This increased to 23% over the next 14 days. Compared to non-geriatric patients, significantly more geriatric patients had RI severe enough to merit consideration of renal dosage adjustment at enrollment (29% vs. 10%, p<0.001) and over the ensuing 14 days (51% vs. 16%, p<0.001).CONCLUSIONS: RI is common in patients with VAP and is more likely to occur in geriatric patients.CLINICAL IMPLICATIONS: This study reinforces the importance of monitoring renal function in patients with VAP in order to optimize drug dosing regimens.DISCLOSURE: The following authors have nothing to disclose: Lee Morrow, Pranjal Sharma, Rugmini Warrier, Mark MaleskerNo Product/Research Disclosure InformationCreighton University, Omaha, NE.
ChemMedChem, 2012
A new series of 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles (3 a-h) were synthesized by C-... more A new series of 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles (3 a-h) were synthesized by C-arylation of 2-arylimidazo[2,1-b]benzothiazoles using palladium acetate as catalyst, and the resulting compounds were evaluated for their anticancer activity. Compounds 3 a, 3 e, and 3 h exhibited good antiproliferative activity, with GI50 values in the range of 0.19-83.1 μM. Compound 3 h showed potent anticancer efficacy against 60 human cancer cell lines, with a mean GI50 value of 0.88 μM. This compound also induced cell-cycle arrest in the G2/M phase and inhibited tubulin polymerization followed by activation of caspase-3 and apoptosis. A high-throughput tubulin polymerization assay showed that the level of inhibition for compound 3 h is similar to that of combretastatin A-4. Molecular modeling studies provided a molecular basis for the favorable binding of compounds 3 a, 3 e, and 3 h to the colchicine binding pocket of tubulin.
Innovations in Cyber Physical Systems
Materials Research Express
Materials Research Express
Open Journal of Psychiatry & Allied Sciences, 2016
Asian Journal of Biological and Life Sciences
Proceedings of 5th International Electronic Conference on Entropy and Its Applications
In recent years geologists have put a lot of effort trying to study the evolution of earth using ... more In recent years geologists have put a lot of effort trying to study the evolution of earth using different techniques studying rocks, gases, and water at different channels like mantle, lithosphere and atmosphere. Some of the ways are Estimation of heat flux between the atmosphere and sea ice, Modelling global temperature changes, Groundwater monitoring networks, etc. But algorithms involving the study of earth's evolution have been a debated topic for decades. Also, there is distinct research on studying the mantle, lithosphere, and atmosphere using isotopic fractionation which this paper will take into consideration to form genes at the former stage. This factor of isotopic fractionation could be molded in QGA to study the earth's evolution. We combined these factors because the gases containing these isotopes move from mantle to lithosphere or atmosphere through gaps or volcanic eruptions contributing to it. We are likely to use the Rb/Sr and Sm/Nd ratios to study the evolution of these channels. This paper, in general, provides the idea on gathering some information of temperature changes by using isotopic ratios as chromosomes, in QGA the chromosomes depict the characteristic of a generation. Here these ratios depict the temperature characteristic and other steps of QGA would be molded to study these ratios in the form of temperature changes, which would further signify the evolution of earth based on the study that temperature changes with the change in isotopic ratios. This paper will collect these distinct studies and embed them into an upgraded quantum genetic algorithm called Quantum Genetic Terrain Algorithm or Quantum GTA.
Open Journal of Psychiatry & Allied Sciences, 2016
International journal of clinical pediatric dentistry
Need for the study: The most important procedure for a successful endodontic treatment is the cle... more Need for the study: The most important procedure for a successful endodontic treatment is the cleaning and shaping of the canal system. Understanding the internal anatomy of teeth provides valuable information to the clinician that would help him achieve higher clinical success during endodontic therapy. To evaluate by computed tomography-the internal anatomy of mandibular second primary molars with respect to the number of canals, cross-sectional shape of canals, cross-sectional area of canals and the root dentin thickness. A total of 31 mandibular second primary molars were subjected to computed-tomographic evaluation in the transverse plane, after mounting them in a prefabricated template. The images, thus, obtained were analyzed using De-winter Bio-wizard® software. All the samples demonstrated two canals in the mesial root, while majority of the samples (65.48%) demonstrated two canals in the distal root. The cross-sectional images of the mesial canals demonstrated a round shap...
D53. SEPSIS: MECHANISMS AND IMPLICATIONS FOR MANAGEMENT, 2010
Page 1. / Thematic Poster Session / Wednesday, May 19/8:15 D53 SEPSIS: MECHANISMS AND IMPLICATION... more Page 1. / Thematic Poster Session / Wednesday, May 19/8:15 D53 SEPSIS: MECHANISMS AND IMPLICATIONS FOR MANAGEMENT AM-4:00 PM / Area A, Hall G (First Level), Morial Convention Center Feasibility Study Of ...
A45. ICU MANAGEMENT AND OUTCOMES: PREDICTION, PROCEDURES AND POT POURRI, 2010
Division of Pulmonary and Critical Care Medicine, College of Medicine, Mayo Clinic, Rochester, MN... more Division of Pulmonary and Critical Care Medicine, College of Medicine, Mayo Clinic, Rochester, MN; (METRIC) Multidisciplinary 1 ... Epidemiology and Translational Research in Intensive Care, Rochester, MN, United States of America ... Corresponding author's ...
The Journal of Contemporary Dental Practice, 2011
The traumatized primary teeth have a great clinical significance because it not only have consequ... more The traumatized primary teeth have a great clinical significance because it not only have consequences on itself but also on its succedaneous developing permanent teeth due to its close anatomical relationship. The extent of severity is adjudged by the type of trauma and the age of the child at the time of trauma. For instance, avulsion and intrusive injuries present with high percentage of developmental disturbances in permanent teeth than subluxation and extrusive injuries. When considering the age of the child at the time of trauma, consequences are less severe in children over 4 years of age than in the younger age group. Clinical significance: It highlights the sequelae of trauma to primary teeth with the aim of aiding in detection of probable alterations in the traumatized primary teeth and its succedaneous permanent teeth.
Journal of Clinical Pathology, 2000
Aim-To determine whether two recently described staining methods (the modified McMullen's and the... more Aim-To determine whether two recently described staining methods (the modified McMullen's and the Helicobacter pylori silver stain HpSS methods) used for the histological identification of H pylori organisms are superior to two established techniques (the modified Giemsa and anti-H pylori antibody immunostain) in terms of availability, reproducibility, rapidity, sensitivity, and cost. Methods-Histological sections from 63 paired gastric biopsies from adult patients previously investigated for dyspepsia were stained with the four methods and these were assessed blindly and independently by two observers. Of the 63 patients, 30 were originally negative in all tests for H pylori infection, 30 were positive, and the remaining three cases had discordant results using a combination of five tests (rapid biopsy urease test, urea breath test, culture, serology, and histology). Results-Interobserver agreement was best with the antibody method (98%), followed by the McMullen's (90%), Giemsa (87%), and HpSS (85%). Of the 60 "gold standard" positive and negative cases, 30 were positive by the modified Giemsa stain, 29 by the McMullen's method, 29 by HpSS, and 30 by the antibody stain. However, there were two false positives with the HpSS method. The modified Giemsa is the cheapest and easiest to perform technically. Conclusions-When H pylori are present, careful examination will almost always reveal them, whichever of these stains is used. However, the modified Giemsa stain is the method of choice because it is sensitive, cheap, easy to perform, and reproducible.
CHEST Journal, 2013
ABSTRACT
CHEST Journal, 2013
ABSTRACT Critical Care Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resid... more ABSTRACT Critical Care Student/Resident Case Report Posters IISESSION TYPE: Medical Student/Resident Case ReportPRESENTED ON: Tuesday, October 29, 2013 at 01:30 PM - 02:30 PMINTRODUCTION: Staphylococcus aureus enterocolitis has been increasingly reported in recent times with an interesting sinusoidal trend over the last many decades. Given the paucity of literature on its role in the pathogenesis of shock, we herein report such a case.CASE PRESENTATION: Sixty-seven year old Caucasian female with hypertension and hyperlipidemia developed abdominal pain after eating at a local fast food restaurant. Over the next few hours, she developed worsening symptoms and became unresponsive. After extensive cardio-pulmonary resuscitation, the patient was transferred to our tertiary care center hypothermic, requiring mechanical ventilation and intravenous dobutamine. Her laboratory parameters showed WBC count 43,400/mm3, serum creatinine 2.5 mg/dL, AST 1853 IU/L and ALT 802 IU/L, lactate 11.2 mmol/L and arterial pH 7.05. The patient's abdominal CT revealed free peritoneal fluid without evidence of perforation, and paucity of colonic gas suggestive of ileus. In addition to aggressive volume resuscitation empirical antimicrobial therapy was started (vancomycin, ciprofloxacin and metronidazole). Stools cultures were positive for Staphylococcus aureus on two different occasions. Rectal erosions on colonoscopy showed inflammatory pathology. Patient responded to aggressive resuscitation over the next several days. Her leukocytosis improved and liver enzymes normalized. She was discharged home in a stable condition.DISCUSSION: In our patient, temporal relationship to her getting sick and eating at an outside facility, two sets of stool cultures growing Staphylococcal aureus and lack of another etiology for shock were important diagnostic clues. Increasing use of Metronidazole has been postulated as a cause for the re-emergence of Staphylococcal aureus enterocolitis. Mechanisms of shock are poorly understood; but bacteremia, toxin production and dehydration have been postulated. Varying mucosal appearances ranging from mild erythema (as in our case) to extensive necrosis have been reported. Although oral vancomycin is the preferred therapy, its utility in enterocolitis-induced shock has not been studied.CONCLUSIONS: Staphylococcus aureus enteritis should be considered as an etiology for shock in the setting of food borne illness when no other pathogen can be identified. Early recognition and aggressive supportive care is the cornerstone of management for this rare condition.Reference #1: Lin Z, Kotler DP, Schlievert PM, Sordillo EM. Staphylococcus Enterocolitis: Forgotten but not gone? Dig Dis Sci. 2010 May;55(5):1200-7.Reference #2: Kolter DP, Sordillo PM. Review: A case of Staphylococcal aureus Enterocolitis: A rare entity. Gastroenterol Hepatol (N Y). 2010 Feb;6(2):117-9.Reference #3: Kotler DP, Sandkovsky Y, Schlievert PM, Sordillo EM. Toxic Shock-like Syndrome associated with Staphylococcus Enterocolitis in an HIV-infected man. Clin Infect Dis. 2007 Jun 15;44(12):e121-3.DISCLOSURE: The following authors have nothing to disclose: Saraschandra Vallabhajosyula, Pranjal Sharma, Pranathi Sundaragiri, Pallavi Bellamkonda, Savio Reddymasu, Lee MorrowNo Product/Research Disclosure Information.
CHEST Journal, 2012
ABSTRACT SESSION TYPE: Non Pulmonary Critical Care PostersPRESENTED ON: Wednesday, October 24, 20... more ABSTRACT SESSION TYPE: Non Pulmonary Critical Care PostersPRESENTED ON: Wednesday, October 24, 2012 at 01:30 PM - 02:30 PMPURPOSE: Renal insufficiency (RI) is common in the ICU and is associated with worse clinical outcomes. However, little is known about its epidemiology in ventilator-associated pneumonia (VAP) patients. Given the implications for dosing many ICU medications, including antibiotics, this study was undertaken to describe changes in renal function after the onset of VAP.METHODS: We retrospectively collected data from 472 consecutive adults with clinically-diagnosed VAP diagnosed between 1/1/02 and 12/31/09 in a single academic hospital ICU. Patients with end-stage renal disease at ICU admission were excluded. Demographics, comorbid illness, daily laboratory values, antibiotic prescription, and length of stay measures were abstracted. Creatinine clearance (CrCl) was calculated daily using the Cockroft-Gault equation. Patients were classified as having no RI (CrCl >90 mL/min), mild RI (CrCl 51-90 mL/min), moderate RI (CrCl 10-50 mL/min), or severe RI (CrCl <10 mL/min). Subset analyses were repeated for geriatric (age ≥65 yrs) and non-geriatric patients.RESULTS: The cohort was 64% male, had an average age of 54.3 years and an average APACHE II score of 23.6. At diagnosis of VAP 13% of patients merited consideration of renal dosage adjustment (CrCl ≤50 mL/min). This increased to 23% over the next 14 days. Compared to non-geriatric patients, significantly more geriatric patients had RI severe enough to merit consideration of renal dosage adjustment at enrollment (29% vs. 10%, p<0.001) and over the ensuing 14 days (51% vs. 16%, p<0.001).CONCLUSIONS: RI is common in patients with VAP and is more likely to occur in geriatric patients.CLINICAL IMPLICATIONS: This study reinforces the importance of monitoring renal function in patients with VAP in order to optimize drug dosing regimens.DISCLOSURE: The following authors have nothing to disclose: Lee Morrow, Pranjal Sharma, Rugmini Warrier, Mark MaleskerNo Product/Research Disclosure InformationCreighton University, Omaha, NE.
ChemMedChem, 2012
A new series of 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles (3 a-h) were synthesized by C-... more A new series of 3-substituted 2-phenylimidazo[2,1-b]benzothiazoles (3 a-h) were synthesized by C-arylation of 2-arylimidazo[2,1-b]benzothiazoles using palladium acetate as catalyst, and the resulting compounds were evaluated for their anticancer activity. Compounds 3 a, 3 e, and 3 h exhibited good antiproliferative activity, with GI50 values in the range of 0.19-83.1 μM. Compound 3 h showed potent anticancer efficacy against 60 human cancer cell lines, with a mean GI50 value of 0.88 μM. This compound also induced cell-cycle arrest in the G2/M phase and inhibited tubulin polymerization followed by activation of caspase-3 and apoptosis. A high-throughput tubulin polymerization assay showed that the level of inhibition for compound 3 h is similar to that of combretastatin A-4. Molecular modeling studies provided a molecular basis for the favorable binding of compounds 3 a, 3 e, and 3 h to the colchicine binding pocket of tubulin.
Innovations in Cyber Physical Systems
Materials Research Express
Materials Research Express
Open Journal of Psychiatry & Allied Sciences, 2016