Preethi V Reddy - Academia.edu (original) (raw)

Papers by Preethi V Reddy

Indian Journal of Psychological Medicine, Aug 19, 2021

On post-hoc analysis, HR subjects exhibited a significant deficit in the labeling accuracy of FA ... more On post-hoc analysis, HR subjects exhibited a significant deficit in the labeling accuracy of FA facial emotions (P < 0.001) compared to HC. The BD group was found to have significant differences in all FA (P = 0.004) and SD (P = 0.003) emotion matching as well as FA (P = 0.001) and SD (P < 0.001) emotion labeling accuracy scores. Conclusions: BD in remission exhibits FERD in general, whereas specific labeling deficits of fear and anger emotions, indicating impaired directive higher order aspect of emotion processing, were demonstrated in HR subjects. This appears to be a potential endophenotype. These deficits could underlie the pathogenesis in BD, with possible frontolimbic circuitry impairment. They may have potential implications in functional recovery and prognosis of BD.

Bipolar Disorders, Mar 10, 2023

Asian Journal of Psychiatry, Dec 1, 2020

Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on ... more Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

Journal of Affective Disorders, Nov 1, 2018

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service... more This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights  The early course of Bipolar Disorder-I after first manic episode, based on treatment seeking data collected from a tertiary care centre, is mania-predominant in the Indian population.  Predictors of recurrence in course include hypothyroidism and early discontinuation of treatment.  Previous history of depression is associated with inter-episodic residual mood symptoms.

Clinical Psychopharmacology and Neuroscience

Objective: Exacerbated inflammatory pathway has emerged as a predominant etiological construct of... more Objective: Exacerbated inflammatory pathway has emerged as a predominant etiological construct of major depressive disorder (MDD). Innate immune molecules like complement proteins induce inflammatory responses and also regulate key neurobiological processes. However, there is a dearth of literature on the impact of critical complement proteins in MDD. Herein, plasma profiling of seven complement proteins was carried out to obtain a better insight into the role of the complement pathway in MDD. Methods: Plasma levels of C1q, C3, C3b/iC3b, C4, Factor B, Factor H, and properdin were assayed in 22 patients with MDD and 27 healthy controls by multiplex suspension assay. The patients with MDD were diagnosed as per DSM IV-TR. Hamilton Depression Rating Scale (HAM-D), Montgomery Depression Rating Scale and Clinical Global Improvement were used for clinical assessments of the patients. The plasma levels of these complement proteins were also correlated with various clinical scores and phenotypes of MDD. Results: The patients with MDD and healthy controls did not differ in terms of age and gender (p ＞ 0.1). The patients with MDD had a mean duration of illness of around 3 years, with average number of depressive episodes being 6 and the mean HAM-D score was 19. Of the seven complement components, the plasma levels of C1q, Factor B, and Factor H (p ≤ 0.05) were significantly elevated in MDD patients compared to healthy controls. However, the plasma levels of these complement proteins were not found to correlate with the clinical profile of MDD patients. Conclusion: Both Factor B and Factor H are crucial in the induction and regulation of the alternative pathway of complement activation. The alternative pathway also plays a critical role in inflammation. These findings suggest an important role of the alternative complement pathway in immuno-inflammation in MDD.

Indian Journal of Psychological Medicine, 2021

Background: Emotion processing deficits have been described in patients with bipolar disorder (BD... more Background: Emotion processing deficits have been described in patients with bipolar disorder (BD) and are considered one of the core cognitive abnormalities in BD with endophenotype potential. However, the literature on specific impairments in emotion processing cognitive strategies (directive/cortical/higher versus intuitive/limbic/lower) in euthymic adult BD patients and healthy first-degree relatives/high-risk (HR) subjects in comparison with healthy controls (HCs) is sparse. Methods: We examined facial emotion recognition deficits (FERD) in BD ( N = 30), HR ( N = 21), and HC ( N = 30) matched for age (years), years of education, and sex using computer-administered face emotions–Matching And Labeling Task (eMALT). Results: The three groups were significantly different based on labeling accuracy scores for fear and anger (FA) (P < 0.001) and sad and disgust (SD) (P < 0.001). On post-hoc analysis, HR subjects exhibited a significant deficit in the labeling accuracy of FA fac...

Supplemental Material, Consort_chart for Impact of a Course of Add-on Supervised Yoga on Cortical... more Supplemental Material, Consort_chart for Impact of a Course of Add-on Supervised Yoga on Cortical Inhibition in Major Depressive Disorder: A Randomized Controlled Trial by Praerna H. Bhargav, Preethi V. Reddy, Ramajayam Govindaraj, Kankan Gulati, Arya Ravindran, D. Gayathri, Sneha J. Karmani, Kaviraja Udupa, Ganesan Venkatasubramanian, Mariamma Philip, Monojit Debnath, Rose Dawn Bharath, T. N. Sathyaprabha, Bangalore N. Gangadhar and Kesavan Muralidharan in The Canadian Journal of Psychiatry

Supplemental material, Supp_table_1 for Adverse childhood experiences in families with multiple m... more Supplemental material, Supp_table_1 for Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses by Amala Someshwar, Bharath Holla, Preeti Pansari Agarwal, Anza Thomas, Anand Jose, Boban Joseph, Birudu Raju, Hariprasad Karle, M Muthukumaran, Prabhath G Kodancha, Pramod Kumar, Preethi V Reddy, Ravi Kumar Nadella, Sanjay T Naik, Sayantanava Mitra, Sreenivasulu Mallappagiri, Vanteemar S Sreeraj, Srinivas Balachander, Suhas Ganesh, Pratima Murthy, Vivek Benegal, Janardhan YC Reddy, Sanjeev Jain, Jayant Mahadevan and Biju Viswanath in Australian & New Zealand Journal of Psychiatry

Supplemental material, Description_of_Total_ACE_Exposure_Score for Adverse childhood experiences ... more Supplemental material, Description_of_Total_ACE_Exposure_Score for Adverse childhood experiences in families with multiple members diagnosed to have psychiatric illnesses by Amala Someshwar, Bharath Holla, Preeti Pansari Agarwal, Anza Thomas, Anand Jose, Boban Joseph, Birudu Raju, Hariprasad Karle, M Muthukumaran, Prabhath G Kodancha, Pramod Kumar, Preethi V Reddy, Ravi Kumar Nadella, Sanjay T Naik, Sayantanava Mitra, Sreenivasulu Mallappagiri, Vanteemar S Sreeraj, Srinivas Balachander, Suhas Ganesh, Pratima Murthy, Vivek Benegal, Janardhan YC Reddy, Sanjeev Jain, Jayant Mahadevan and Biju Viswanath in Australian & New Zealand Journal of Psychiatry

Asian Journal of Psychiatry, 2021

HRV is inversely proportional to severity of depression. Effect of 12-weeks adjunct yoga therapy ... more HRV is inversely proportional to severity of depression. Effect of 12-weeks adjunct yoga therapy on HRV in patients with MDD was assessed through a randomized controlled trial. Sixty-eight subjects (40 females) with mean age 31.58 ± 8.79 years, scoring ≥ 18 on HDRS were randomized to either (YG; n = 35) or (WG; n = 33). Linear mixed model analysis showed no significant difference between groups. On comparing change in mean percentage, substantial more decrease could be elicited only for LF/HF ratio in YG compared to WG, while being comparable for other variables across the groups. Findings suggest Yoga therapy may help in bringing parasympathetic dominance in patients with MDD.

Asian Journal of Psychiatry, 2020

ObjectiveAdverse Childhood Experiences (ACEs) are linked to the development of a number of psychi... more ObjectiveAdverse Childhood Experiences (ACEs) are linked to the development of a number of psychiatric illnesses in adulthood. Our study examined the pattern of ACEs and their relation to the age of onset (AAO) of major psychiatric conditions in individuals from families that had ≥ 2 first degree relatives with major psychiatric conditions (multiplex families) identified as part of an ongoing longitudinal study.MethodsOur sample consisted of 509 individuals from 215 families. Of these, 268 were affected i.e diagnosed with bipolar disorder (BPAD) (n=61), obsessive-compulsive disorder (OCD) (n=58), schizophrenia (n=52), substance dependence (SUD) (n=59), or co-occurring diagnoses (n=38); while 241 were at-risk first degree relatives (FDRs) who were either unaffected (n=210) or had other depressive or anxiety disorders (n=31). All individuals were evaluated using the Adverse Childhood Experiences – International Questionnaire (ACE-IQ) and ACE binary and frequency scores were calculated...

Journal of affective disorders, 2018

An understanding of the early course of Bipolar Disorder (BD) can contribute towards developing t... more An understanding of the early course of Bipolar Disorder (BD) can contribute towards developing timely interventions. First episode mania (FEM) determines a diagnosis of bipolarity, and therefore, onset of BD-I. We investigated the course of BD-I over a five-year period after FEM by retrospective chart review. Charts of patients diagnosed with FEM in 2008 (n = 108) were reviewed. Data was extracted about FEM and subsequent course up to 5 years, for those who came for follow-up during this period. The factors influencing course were evaluated with statistical analyses including logistic regression and survival analysis. The mean age at onset of BD was 26 ± 9.2 years and mean age at FEM was 27.1 ± 9 years. 41 (38%) patients had previous depression. Patients who returned for at least one follow-up were 60/108 (55.6%), with 54 (90%) of them experiencing another mood episode following FEM. Most recurrences occurred between 6 months to 1 year after FEM, with manic episodes occurring two-t...

Asian Journal of Psychiatry, 2014

DIGITAL HEALTH

Objective To examine feasibility and acceptability of smartphone mental health app use for sympto... more Objective To examine feasibility and acceptability of smartphone mental health app use for symptom, cognitive, and digital phenotyping monitoring among people with schizophrenia in India and the United States. Methods Participants in Boston, USA and Bhopal and Bangalore, India used a smartphone app to monitor symptoms, play cognitive games, access relaxation and psychoeducation resources and for one month, with an initial clinical and cognitive assessment and a one-month follow-up clinical assessment. Engagement with the app was compared between study sites, by clinical symptom severity and by cognitive functioning. Digital phenotyping data collection was also compared between three sites. Results By Kruskal-Wallis rank-sum test, we found no difference between app activities completed or digital phenotyping data collected across the three study sites. App use also did not correlate to clinical or cognitive assessment scores. When using the app for symptom monitoring, preliminary fin...

Journal of Psychiatric Research, 2021

Multiple lines of investigations suggest the presence of cortical inhibition aberrations as centr... more Multiple lines of investigations suggest the presence of cortical inhibition aberrations as central to the phenotypic manifestations of severe mental disorders. Transcranial Magnetic Stimulation (TMS) combined with electromyography can characterize these inhibitory processes in the motor cortex with satisfactory temporal precision. We examined TMS-evoked short- (SICI) and long-interval intracortical inhibition (LICI) and cortical silent period (CSP) as markers of GABAA- (SICI) and GABAB-mediated (LICI and CSP) cortical neurotransmission in symptomatic individuals with mania (n = 40), schizophrenia (n = 76), unipolar depression (n = 86), and OCD (n = 43), and compared them against similar recordings in healthy subjects (n = 125). We hypothesized transdiagnostic GABAA deficits across all the clinical groups and diagnosis-specific GABAB alterations in mania (increased) and OCD (decreased). After controlling for potential confounder variables (gender, education, benzodiazepine prescription, and motor threshold) using the ANCOVA, we observed no significant group difference in SICI (F = 1.04, P = 0.38), but a significant group effect in LICI (F = 16.29, P < 0.001) and CSP (F = 3.02, P = 0.018). Post-hoc analyses revealed that LICI was significantly reduced in OCD but increased in mania and schizophrenia with reference to the healthy group. Similarly, CSP was significantly reduced in OCD and depression groups as compared to the reference group. We observed that LICI and CSP, both followed similar descending gradients from mania through schizophrenia and depression to OCD; with significant elevation in mania, and reduction in depression and OCD, as compared to the healthy group. This pattern of GABAB-mediated cortical inhibition aberrations needs independent validation as potential state-markers of distinct clinical categories.

The Canadian Journal of Psychiatry, 2020

Indian Journal of Psychiatry, 2019