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Papers by Prof. Sunita Malhotra
In Block 2, we discussed in detail about the importance of various natural resources, their uses ... more In Block 2, we discussed in detail about the importance of various natural resources, their uses in socioeconomic development and the effect of developmental activities on the environment. More importantly, the need to properly manage the natural resources and environmental conservation have led to the concept of environmental quality management and use of eco-friendly technologies. This Block, discusses the threats to biodiversity and its conservation in Unit 8. Unit 9, describe about the pollution of the environment and how human health is being affected by it. This is followed by Unit 10 on 'Waste Management' where we focus our discussion on solid waste management. With a wide exposure to various aspects of the environment in the previous units, it is quite appropriate now to know about various environmental issues which are a matter of concern for people across the national boundaries. Hence, Unit 11 discusses about global environmental issues. Unit 8 Biodiversity: Threats and Conservation: This unit discusses the threats to biodiversity and its conservation and list various causes for biodiversity losses and their major impact on earth. This unit will also explain the need for biodiversity conservation for in-situ and ex-situ conservation of species. Unit 9 Environmental Pollution and Hazards: This unit describes the pollution of environment and how human health is being affected by the environmental pollution. This unit will enable you to identify and list major types of pollutants that contaminate our air, water and soil. In this unit we will also understand and trace the pathways of major pollutants in the ecosystem, explains the reasons for high noise levels in the urban areas, and discusses the hazardous effects of radiations and the need for safeguards to prevent accidental release of radioactivity.
In Block 2, we discussed in detail about the importance of various natural resources, their uses ... more In Block 2, we discussed in detail about the importance of various natural resources, their uses in socioeconomic development and the effect of developmental activities on the environment. More importantly, the need to properly manage the natural resources and environmental conservation have led to the concept of environmental quality management and use of eco-friendly technologies. This Block, discusses the threats to biodiversity and its conservation in Unit 8. Unit 9, describe about the pollution of the environment and how human health is being affected by it. This is followed by Unit 10 on 'Waste Management' where we focus our discussion on solid waste management. With a wide exposure to various aspects of the environment in the previous units, it is quite appropriate now to know about various environmental issues which are a matter of concern for people across the national boundaries. Hence, Unit 11 discusses about global environmental issues. Unit 8 Biodiversity: Threats and Conservation: This unit discusses the threats to biodiversity and its conservation and list various causes for biodiversity losses and their major impact on earth. This unit will also explain the need for biodiversity conservation for in-situ and ex-situ conservation of species. Unit 9 Environmental Pollution and Hazards: This unit describes the pollution of environment and how human health is being affected by the environmental pollution. This unit will enable you to identify and list major types of pollutants that contaminate our air, water and soil. In this unit we will also understand and trace the pathways of major pollutants in the ecosystem, explains the reasons for high noise levels in the urban areas, and discusses the hazardous effects of radiations and the need for safeguards to prevent accidental release of radioactivity.
Monatshefte für Chemie - Chemical Monthly, 2018
The present work describes the design, synthesis, molecular docking, biological evaluation, and a... more The present work describes the design, synthesis, molecular docking, biological evaluation, and assessment of structure-activity relationship of new derivatives based upon the molecular skeleton of the drug pioglitazone, a compound which is currently used for the management of type 2 diabetes mellitus. Pioglitazone has several side effects such as weight gain, edema, congestive heart failure, and bladder cancer. Therefore, there is a strong demand for identification of new lead candidates in the treatment of type 2 diabetes mellitus. A series of 24 compounds were prepared and evaluated for their peroxisome proliferator-activated receptor-c (PPARc) binding affinity assay and the IC 50 values were determined. Among these compounds, six compounds exhibited promising IC 50 values as compared to standard drugs pioglitazone and rosiglitazone. Furthermore, in order to confirm the target of these molecules, molecular docking study was carried out with peroxisome proliferator-activated receptor-c (PPARc) protein. Molecular modeling studies suggested that these compounds appropriately interact in the active sites of receptor.
International Research Journal of Pharmacy, 2016
Traditionally, the extraction of oil from the Seabuckthorn pulp was done by first separating out ... more Traditionally, the extraction of oil from the Seabuckthorn pulp was done by first separating out the juice by mechanically pressing the berries followed by centrifugal separation of oil from the juice by density difference. But the pressed pulp cake still contained both the oil and the juice to some extent. Thus, a complete separation of the lipophilic (oil) and hydrophilic (juice) fractions of the pulp was not achieved. The process that we present in this work separates both the oil and juice fractions very discretely by directly processing the pulp as a whole in an alcoholic medium to separate the lipophilic and the vitamin-rich hydrophilic fractions embedded in the pulp. Moreover, we achieve this separation without employing expensive machines like mechanical presses and high-speed centrifuges. Further, the extraction of the oil from lipophilic part has been done by both the solvent and supercritical extraction methods followed by a comparative study using HPLC analysis of the bio-actives obtained from both the methods. We found that the carotenoids extracted better with the solvent extraction, while sterols extracted better with the supercritical extraction. The overall yield of the oil and the bio-actives was comparable to that of the earlier methods. The aqueous alcohol soluble fraction was evaluated for vitamin C, total acids and reducing sugars. We conclude that our process is convenient, cost-effective and good in terms of yield and recovery of the bio-actives, which makes it industrially applicable. This was endorsed by a successful pilot study trial of a 10 kg batch conducted at
Magnetic Resonance in Chemistry, 1990
HOTRA, VK SHARMA and SUDDHAM SINGH Department of Chemistry, University of Delhi, Delhi-110 007, I... more HOTRA, VK SHARMA and SUDDHAM SINGH Department of Chemistry, University of Delhi, Delhi-110 007, India P. M. BOLL Department of Chemistry, Odense University, DK-5230 Odense M, Denmark ... The 13C NMR spectra of 48 differently substituted chalcones (1.3-...
In Block 2, we discussed in detail about the importance of various natural resources, their uses ... more In Block 2, we discussed in detail about the importance of various natural resources, their uses in socioeconomic development and the effect of developmental activities on the environment. More importantly, the need to properly manage the natural resources and environmental conservation have led to the concept of environmental quality management and use of eco-friendly technologies. This Block, discusses the threats to biodiversity and its conservation in Unit 8. Unit 9, describe about the pollution of the environment and how human health is being affected by it. This is followed by Unit 10 on 'Waste Management' where we focus our discussion on solid waste management. With a wide exposure to various aspects of the environment in the previous units, it is quite appropriate now to know about various environmental issues which are a matter of concern for people across the national boundaries. Hence, Unit 11 discusses about global environmental issues. Unit 8 Biodiversity: Threats and Conservation: This unit discusses the threats to biodiversity and its conservation and list various causes for biodiversity losses and their major impact on earth. This unit will also explain the need for biodiversity conservation for in-situ and ex-situ conservation of species. Unit 9 Environmental Pollution and Hazards: This unit describes the pollution of environment and how human health is being affected by the environmental pollution. This unit will enable you to identify and list major types of pollutants that contaminate our air, water and soil. In this unit we will also understand and trace the pathways of major pollutants in the ecosystem, explains the reasons for high noise levels in the urban areas, and discusses the hazardous effects of radiations and the need for safeguards to prevent accidental release of radioactivity.
In Block 2, we discussed in detail about the importance of various natural resources, their uses ... more In Block 2, we discussed in detail about the importance of various natural resources, their uses in socioeconomic development and the effect of developmental activities on the environment. More importantly, the need to properly manage the natural resources and environmental conservation have led to the concept of environmental quality management and use of eco-friendly technologies. This Block, discusses the threats to biodiversity and its conservation in Unit 8. Unit 9, describe about the pollution of the environment and how human health is being affected by it. This is followed by Unit 10 on 'Waste Management' where we focus our discussion on solid waste management. With a wide exposure to various aspects of the environment in the previous units, it is quite appropriate now to know about various environmental issues which are a matter of concern for people across the national boundaries. Hence, Unit 11 discusses about global environmental issues. Unit 8 Biodiversity: Threats and Conservation: This unit discusses the threats to biodiversity and its conservation and list various causes for biodiversity losses and their major impact on earth. This unit will also explain the need for biodiversity conservation for in-situ and ex-situ conservation of species. Unit 9 Environmental Pollution and Hazards: This unit describes the pollution of environment and how human health is being affected by the environmental pollution. This unit will enable you to identify and list major types of pollutants that contaminate our air, water and soil. In this unit we will also understand and trace the pathways of major pollutants in the ecosystem, explains the reasons for high noise levels in the urban areas, and discusses the hazardous effects of radiations and the need for safeguards to prevent accidental release of radioactivity.
Monatshefte für Chemie - Chemical Monthly, 2018
The present work describes the design, synthesis, molecular docking, biological evaluation, and a... more The present work describes the design, synthesis, molecular docking, biological evaluation, and assessment of structure-activity relationship of new derivatives based upon the molecular skeleton of the drug pioglitazone, a compound which is currently used for the management of type 2 diabetes mellitus. Pioglitazone has several side effects such as weight gain, edema, congestive heart failure, and bladder cancer. Therefore, there is a strong demand for identification of new lead candidates in the treatment of type 2 diabetes mellitus. A series of 24 compounds were prepared and evaluated for their peroxisome proliferator-activated receptor-c (PPARc) binding affinity assay and the IC 50 values were determined. Among these compounds, six compounds exhibited promising IC 50 values as compared to standard drugs pioglitazone and rosiglitazone. Furthermore, in order to confirm the target of these molecules, molecular docking study was carried out with peroxisome proliferator-activated receptor-c (PPARc) protein. Molecular modeling studies suggested that these compounds appropriately interact in the active sites of receptor.
International Research Journal of Pharmacy, 2016
Traditionally, the extraction of oil from the Seabuckthorn pulp was done by first separating out ... more Traditionally, the extraction of oil from the Seabuckthorn pulp was done by first separating out the juice by mechanically pressing the berries followed by centrifugal separation of oil from the juice by density difference. But the pressed pulp cake still contained both the oil and the juice to some extent. Thus, a complete separation of the lipophilic (oil) and hydrophilic (juice) fractions of the pulp was not achieved. The process that we present in this work separates both the oil and juice fractions very discretely by directly processing the pulp as a whole in an alcoholic medium to separate the lipophilic and the vitamin-rich hydrophilic fractions embedded in the pulp. Moreover, we achieve this separation without employing expensive machines like mechanical presses and high-speed centrifuges. Further, the extraction of the oil from lipophilic part has been done by both the solvent and supercritical extraction methods followed by a comparative study using HPLC analysis of the bio-actives obtained from both the methods. We found that the carotenoids extracted better with the solvent extraction, while sterols extracted better with the supercritical extraction. The overall yield of the oil and the bio-actives was comparable to that of the earlier methods. The aqueous alcohol soluble fraction was evaluated for vitamin C, total acids and reducing sugars. We conclude that our process is convenient, cost-effective and good in terms of yield and recovery of the bio-actives, which makes it industrially applicable. This was endorsed by a successful pilot study trial of a 10 kg batch conducted at
Magnetic Resonance in Chemistry, 1990
HOTRA, VK SHARMA and SUDDHAM SINGH Department of Chemistry, University of Delhi, Delhi-110 007, I... more HOTRA, VK SHARMA and SUDDHAM SINGH Department of Chemistry, University of Delhi, Delhi-110 007, India P. M. BOLL Department of Chemistry, Odense University, DK-5230 Odense M, Denmark ... The 13C NMR spectra of 48 differently substituted chalcones (1.3-...