Prof. Versha Parcha - Academia.edu (original) (raw)
Papers by Prof. Versha Parcha
Universities Journal of Phytochemistry and Ayurvedic Heights, Dec 29, 2023
Pharmacognosy …, 2009
... 6. 7. FM Al-Awaidi, MA Khattar and KA Gumaa. ON the mechanism of the hypoglycemic effect of a... more ... 6. 7. FM Al-Awaidi, MA Khattar and KA Gumaa. ON the mechanism of the hypoglycemic effect of a plant extract. Diabetologia. 28: 432-434 (1985). Back to cited text no. 7. 8. M. Rakesh, V. Wazir and R. Kapil. Biotheraupatic diterpene glucoside from Tinospora cordifolia. J. Indian. ...
Universities Journal of Phytochemistry and Ayurvedic Heights, Dec 6, 2021
Pharmaceutical and Biological Evaluations, Oct 2, 2017
Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by conden... more Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by condensing substituted acid hydrazides with various benzaldehydes and explore their antimicrobial potential. Methods: Present study synthesis of various derivatives of Schiffs bases was carried out by: firstly converting substituted acids to acid hydrazides and then to Schiff's bases after condensation with substituted benzaldehyde. Synthesized compounds were characterised on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect against Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus& Bacillus cereus. Results: From this study it could be observed that schiff's bases 2-[(aminophenylhydrazinyldene o,m,dinitrobenzoyl] aniline (H) and compound 2-[(aminophenylzinyldene) p amino benzoyl] aniline (I) showed very good zone of inhibition against almost all strains tested for. Conclusions: So further attempts could be made to extend the series and explore their antibacterial potential to achieve hopeful goal.
Journal of Natural Remedies, 2004
A review of phytoconstituents and biological activities of Dysoxylum species has been presented, ... more A review of phytoconstituents and biological activities of Dysoxylum species has been presented, considering the fact that there are about 110 species of this genus distributed all around the world and many of these species occur in India. In Ayurveda, Dysoxylum species are used either alone or as an important ingredient of several formulations for the cure of inflammation, cardio-disorder, CNS disorder and tumor etc. Several of the chemical compounds (alkaloids, flavonoids, steroids and terpenoids etc) were isolated. This review focuses on the detail of its chemical constituents and medicinal uses with emphasis on the pharmacological action.
ChemInform, Oct 28, 2008
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Indian Forester, Nov 1, 2003
Zenodo (CERN European Organization for Nuclear Research), Sep 30, 2004
A series of amides of naproxen and ibuprofen were synthesized by condensing different amino acid ... more A series of amides of naproxen and ibuprofen were synthesized by condensing different amino acid esters with 2-(6-methoxy-2'-napthyl) and 2-(4-isobutylphenyl)propionic acids. The synthesized compounds have been evaluated for anti-inflammatory activity and gastrointestinal toxicity which showed good anti-inflammatory activity and considerably reduced G.l. toxicity as compared to the parent drug. The structures of these compounds have been confirmed by physical and spectral analysis.
Pharmaceutical and Biological Evaluations, Dec 3, 2017
Objective: Chemical substances employed to treat various infections caused by various types of mi... more Objective: Chemical substances employed to treat various infections caused by various types of microorganism are termed as antimicrobials and natural chemical compounds produced by specific types of bacteria are termed as antibiotics. Unlimited use of antibiotics in humans and animals and in areas other than the treatment and prophylaxis of disease have resulted in a serious problem of drug resistance. Various attempts have been adopted to cope with the resistance problem and enhance the activity, or broaden the spectrum of drugs. Based on structure-activity relationship synthesis of new compounds has been one of the best approaches for better results. It has been demonstrated that Schiff base of some leading molecules and antibiotics possess good potential as more effective and safe drugs. Encouraged by reports on potential of Schiff's bases as antimicrobial agents and to cope up with the current requirements of developing newer, safer and broad spectrum agents attempts were made to synthesize new Schiff's bases. Methods: Our earlier in which structure activity relationship studies revealed that substitution by nitro and amino gp in Schiff's base moiety resulted in the enhancement of activity. So further attempts were made to extend the series with incorporation of nitro and amino moiety by condensing o,m dinitro substituted acid hydrazide with various nitro/amino substituted benzaldehydes for increasing their antimicrobial potential. Results: Synthesized compounds were characterized on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect. All the synthesized derivatives were screened further for their antibacterial effect. Conclusions: Highest activity was observed in the derivative with nitro substitution in both the aryl rings.
Asian Journal of Pharmaceutics, 2015
ABSTRACT This study aimed to apply the simultaneous optimization method incorporating artificial ... more ABSTRACT This study aimed to apply the simultaneous optimization method incorporating artificial neural network (ANN) using multi-layer perceptron (MLP) model to develop buccoadhesive pharmaceutical wafers containing loratadine with an optimized physicochemical property and drug release. The amount of sodium carboxymethyl cellulose and lactose monohydrate at three levels (−1, 0, +1) for each was selected as casual factors. Bioadhesive strength, disintegration time, percent swelling index and t 70% as wafer properties were selected as output variables. Nine buccoadhesive wafers were prepared according to a 3 2 factorial design and their physicochemical property and dissolution tests were performed. Commercially available Statistica Neural Network Software (Stat Soft, Inc., Tulsa, OK, USA) was used throughout the study. The training process of MLP was completed until a satisfactory value of root mean square for the test data was obtained using back propagation, conjugate gradient descent method. This work exemplifies the probability for an ANN with MLP, to support in development of buccoadhesive wafers with enviable characteristics.
Journal of Pharmacy Research, 2011
Abstract: Antihyperglycemic activity of total methanolic extract of Tinospora cordifolia (Willd.)... more Abstract: Antihyperglycemic activity of total methanolic extract of Tinospora cordifolia (Willd.) stem was evaluated against increased blood glucose level in alloxan and streptozotocin induced hyperglycemic rats. The total methanolic extract showed antihyperglycemic ...
Pharmacognosy Magazine, 2012
Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieti... more Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieties of synthetic drugs are used in the treatment, still the searches are on for better medicaments especially from the plant kingdom. Many medicinal plants have been studied in this context but most of them are seasonal or have restricted availability. One such weed, available throughout the year is Salvadora oleoides (decne.). Materials and Methods: Column chromatographic fractionation of the butanol fraction of leaves of Salvadora oleoides (decne.) yielded four fractions (fraction AD). All sub-fractions were tested for their anti-hyperlipidemic activity. Fractions were administered at a dose of 65 mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Results: Sub-fraction D showed maximum significant reduction (P<0.05) among four sub-fractions in comparison with standard drug fenofibrate. Conclusion: Further studies on the isolated fractions and constituents are needed to isolate compound responsible for activity and elucidate the mechanism by which Salvadora oleoides (decne.) exerts protective effects against hyperlipidemia.
Universities Journal of Phytochemistry and Ayurvedic Heights, Dec 24, 2022
Biochar is a pyrogenic black carbon produced from thermal degradation of carbon-rich biomass (<70... more Biochar is a pyrogenic black carbon produced from thermal degradation of carbon-rich biomass (<700°C) in an oxygen-limited environment, and usually has a porous structure, a surface rich in oxygenated functional groups, strong adsorption capacity, and a certain degree of surface area and stability. Biochar has multiple uses, including agricultural applications for soil remediation and pollution control in water and soil. Biochar has several significant socioeconomic and environmental benefits such as carbon sequestration, pollutant removal, and soil improvement. Pyrolysis temperature affects biochar properties, which in turn determines its application potential. The collected Crofton weed (except for the roots) was washed, air-dried at room temperature, and crushed for passage through a 10-mesh sieve. Here, we examined the properties of Crofton weed biochar (C-BC) produced at different pyrolysis temperatures of 300°C, 400°C, 500°C, and 600°C. We measured the yield, ash content, pH, iodine sorption value (ISV), and elemental composition of C-BC. We also characterized C-BC using scanning electron microscopy (SEM), as well as its ability to remove Pb 2+ and Cd 2+ contaminantsfrom an aqueous solution. C-BC yield decreased with increasing pyrolysis temperature, whereas ash content and pH increased. ISV first increased at 300-400°C and decreased at 500-600°C. For C-BC produced at pyrolysis temperatures 300-600°C (C-BC300 to C-BC600, respectively), H, N, and O content decreased, but C, Ca, Mg, P, and K content increased with increasing temperature. All C-BCs had a certain number of pore structures. Increasing pyrolysis temperatures decreased the amount of-OH,-COOH, aliphatic C-H, and polar CO on the C-BC surface. The percentage of Pb 2+ and Cd 2+ removed increased with increasing pyrolysis temperatures. Overall, for C-BC, a low pyrolysis temperature was beneficial for producing a more porous biochar and increased content of water-soluble calcium, magnesium, nitrogen, and phosphorus, whereas high pyrolysis temperatures yield biochar that had high alkalinity, aromaticity, and stability, as well as heavy metal removal activity
Asian Pacific Journal of Tropical Disease, 2012
Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieti... more Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieties of synthetic drugs are used in the treatment, still the searches are on for better medicaments especially from the plant kingdom. Many medicinal plants have been studied in this context but most of them are seasonal or have restricted availability. One such weed, available throughout the year is Salvadora oleoides (decne.). Materials and Methods: Column chromatographic fractionation of the butanol fraction of leaves of Salvadora oleoides (decne.) yielded four fractions (fraction AD). All sub-fractions were tested for their anti-hyperlipidemic activity. Fractions were administered at a dose of 65 mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Results: Sub-fraction D showed maximum significant reduction (P<0.05) among four sub-fractions in comparison with standard drug fenofibrate. Conclusion: Further studies on the isolated fractions and constituents are needed to isolate compound responsible for activity and elucidate the mechanism by which Salvadora oleoides (decne.) exerts protective effects against hyperlipidemia.
Universities' Journal of Phytochemistry and Ayurvedic Heights
Essential oils are important plant products that often have a complicated composition made up of ... more Essential oils are important plant products that often have a complicated composition made up of the volatile plant components. Numerous biological actions are reportedly connected to essential oils, and a new class of aromaceuticals is being developed. The market for essential oils has increased since they are used to cure these types of ailments as a result of the emergence of various mental issues due to changing living standards, such as depression, anxiety, sleeplessness, and stress. Studies on animal models have shown that the mode of action of essential oils, which cause physiological changes in the brain, involves a number of neurotransmitter systems. Despite mounting proof that essential oils have quantifiable effects on animal behavior. Therefore the current study is proposed to investigate the physical and chemical characteristics of the essential oil obtained from the rhizome of Cyperus scariosus and assess its anxiolytic effects on the central nervous system in rodent m...
South African Journal of Botany
Archives of Microbiology, 2022
Universities Journal of Phytochemistry and Ayurvedic Heights, Dec 29, 2023
Pharmacognosy …, 2009
... 6. 7. FM Al-Awaidi, MA Khattar and KA Gumaa. ON the mechanism of the hypoglycemic effect of a... more ... 6. 7. FM Al-Awaidi, MA Khattar and KA Gumaa. ON the mechanism of the hypoglycemic effect of a plant extract. Diabetologia. 28: 432-434 (1985). Back to cited text no. 7. 8. M. Rakesh, V. Wazir and R. Kapil. Biotheraupatic diterpene glucoside from Tinospora cordifolia. J. Indian. ...
Universities Journal of Phytochemistry and Ayurvedic Heights, Dec 6, 2021
Pharmaceutical and Biological Evaluations, Oct 2, 2017
Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by conden... more Objective: To design, synthesize and screen biologically newer Substituted Schiff bases by condensing substituted acid hydrazides with various benzaldehydes and explore their antimicrobial potential. Methods: Present study synthesis of various derivatives of Schiffs bases was carried out by: firstly converting substituted acids to acid hydrazides and then to Schiff's bases after condensation with substituted benzaldehyde. Synthesized compounds were characterised on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect against Salmonella typhimurium, Shigella sonnei, Staphylococcus aureus& Bacillus cereus. Results: From this study it could be observed that schiff's bases 2-[(aminophenylhydrazinyldene o,m,dinitrobenzoyl] aniline (H) and compound 2-[(aminophenylzinyldene) p amino benzoyl] aniline (I) showed very good zone of inhibition against almost all strains tested for. Conclusions: So further attempts could be made to extend the series and explore their antibacterial potential to achieve hopeful goal.
Journal of Natural Remedies, 2004
A review of phytoconstituents and biological activities of Dysoxylum species has been presented, ... more A review of phytoconstituents and biological activities of Dysoxylum species has been presented, considering the fact that there are about 110 species of this genus distributed all around the world and many of these species occur in India. In Ayurveda, Dysoxylum species are used either alone or as an important ingredient of several formulations for the cure of inflammation, cardio-disorder, CNS disorder and tumor etc. Several of the chemical compounds (alkaloids, flavonoids, steroids and terpenoids etc) were isolated. This review focuses on the detail of its chemical constituents and medicinal uses with emphasis on the pharmacological action.
ChemInform, Oct 28, 2008
ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was e... more ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Indian Forester, Nov 1, 2003
Zenodo (CERN European Organization for Nuclear Research), Sep 30, 2004
A series of amides of naproxen and ibuprofen were synthesized by condensing different amino acid ... more A series of amides of naproxen and ibuprofen were synthesized by condensing different amino acid esters with 2-(6-methoxy-2'-napthyl) and 2-(4-isobutylphenyl)propionic acids. The synthesized compounds have been evaluated for anti-inflammatory activity and gastrointestinal toxicity which showed good anti-inflammatory activity and considerably reduced G.l. toxicity as compared to the parent drug. The structures of these compounds have been confirmed by physical and spectral analysis.
Pharmaceutical and Biological Evaluations, Dec 3, 2017
Objective: Chemical substances employed to treat various infections caused by various types of mi... more Objective: Chemical substances employed to treat various infections caused by various types of microorganism are termed as antimicrobials and natural chemical compounds produced by specific types of bacteria are termed as antibiotics. Unlimited use of antibiotics in humans and animals and in areas other than the treatment and prophylaxis of disease have resulted in a serious problem of drug resistance. Various attempts have been adopted to cope with the resistance problem and enhance the activity, or broaden the spectrum of drugs. Based on structure-activity relationship synthesis of new compounds has been one of the best approaches for better results. It has been demonstrated that Schiff base of some leading molecules and antibiotics possess good potential as more effective and safe drugs. Encouraged by reports on potential of Schiff's bases as antimicrobial agents and to cope up with the current requirements of developing newer, safer and broad spectrum agents attempts were made to synthesize new Schiff's bases. Methods: Our earlier in which structure activity relationship studies revealed that substitution by nitro and amino gp in Schiff's base moiety resulted in the enhancement of activity. So further attempts were made to extend the series with incorporation of nitro and amino moiety by condensing o,m dinitro substituted acid hydrazide with various nitro/amino substituted benzaldehydes for increasing their antimicrobial potential. Results: Synthesized compounds were characterized on the basis of spectral studies (like UV, IR, and NMR). All the synthesized derivatives were screened further for their antibacterial effect. All the synthesized derivatives were screened further for their antibacterial effect. Conclusions: Highest activity was observed in the derivative with nitro substitution in both the aryl rings.
Asian Journal of Pharmaceutics, 2015
ABSTRACT This study aimed to apply the simultaneous optimization method incorporating artificial ... more ABSTRACT This study aimed to apply the simultaneous optimization method incorporating artificial neural network (ANN) using multi-layer perceptron (MLP) model to develop buccoadhesive pharmaceutical wafers containing loratadine with an optimized physicochemical property and drug release. The amount of sodium carboxymethyl cellulose and lactose monohydrate at three levels (−1, 0, +1) for each was selected as casual factors. Bioadhesive strength, disintegration time, percent swelling index and t 70% as wafer properties were selected as output variables. Nine buccoadhesive wafers were prepared according to a 3 2 factorial design and their physicochemical property and dissolution tests were performed. Commercially available Statistica Neural Network Software (Stat Soft, Inc., Tulsa, OK, USA) was used throughout the study. The training process of MLP was completed until a satisfactory value of root mean square for the test data was obtained using back propagation, conjugate gradient descent method. This work exemplifies the probability for an ANN with MLP, to support in development of buccoadhesive wafers with enviable characteristics.
Journal of Pharmacy Research, 2011
Abstract: Antihyperglycemic activity of total methanolic extract of Tinospora cordifolia (Willd.)... more Abstract: Antihyperglycemic activity of total methanolic extract of Tinospora cordifolia (Willd.) stem was evaluated against increased blood glucose level in alloxan and streptozotocin induced hyperglycemic rats. The total methanolic extract showed antihyperglycemic ...
Pharmacognosy Magazine, 2012
Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieti... more Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieties of synthetic drugs are used in the treatment, still the searches are on for better medicaments especially from the plant kingdom. Many medicinal plants have been studied in this context but most of them are seasonal or have restricted availability. One such weed, available throughout the year is Salvadora oleoides (decne.). Materials and Methods: Column chromatographic fractionation of the butanol fraction of leaves of Salvadora oleoides (decne.) yielded four fractions (fraction AD). All sub-fractions were tested for their anti-hyperlipidemic activity. Fractions were administered at a dose of 65 mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Results: Sub-fraction D showed maximum significant reduction (P<0.05) among four sub-fractions in comparison with standard drug fenofibrate. Conclusion: Further studies on the isolated fractions and constituents are needed to isolate compound responsible for activity and elucidate the mechanism by which Salvadora oleoides (decne.) exerts protective effects against hyperlipidemia.
Universities Journal of Phytochemistry and Ayurvedic Heights, Dec 24, 2022
Biochar is a pyrogenic black carbon produced from thermal degradation of carbon-rich biomass (<70... more Biochar is a pyrogenic black carbon produced from thermal degradation of carbon-rich biomass (<700°C) in an oxygen-limited environment, and usually has a porous structure, a surface rich in oxygenated functional groups, strong adsorption capacity, and a certain degree of surface area and stability. Biochar has multiple uses, including agricultural applications for soil remediation and pollution control in water and soil. Biochar has several significant socioeconomic and environmental benefits such as carbon sequestration, pollutant removal, and soil improvement. Pyrolysis temperature affects biochar properties, which in turn determines its application potential. The collected Crofton weed (except for the roots) was washed, air-dried at room temperature, and crushed for passage through a 10-mesh sieve. Here, we examined the properties of Crofton weed biochar (C-BC) produced at different pyrolysis temperatures of 300°C, 400°C, 500°C, and 600°C. We measured the yield, ash content, pH, iodine sorption value (ISV), and elemental composition of C-BC. We also characterized C-BC using scanning electron microscopy (SEM), as well as its ability to remove Pb 2+ and Cd 2+ contaminantsfrom an aqueous solution. C-BC yield decreased with increasing pyrolysis temperature, whereas ash content and pH increased. ISV first increased at 300-400°C and decreased at 500-600°C. For C-BC produced at pyrolysis temperatures 300-600°C (C-BC300 to C-BC600, respectively), H, N, and O content decreased, but C, Ca, Mg, P, and K content increased with increasing temperature. All C-BCs had a certain number of pore structures. Increasing pyrolysis temperatures decreased the amount of-OH,-COOH, aliphatic C-H, and polar CO on the C-BC surface. The percentage of Pb 2+ and Cd 2+ removed increased with increasing pyrolysis temperatures. Overall, for C-BC, a low pyrolysis temperature was beneficial for producing a more porous biochar and increased content of water-soluble calcium, magnesium, nitrogen, and phosphorus, whereas high pyrolysis temperatures yield biochar that had high alkalinity, aromaticity, and stability, as well as heavy metal removal activity
Asian Pacific Journal of Tropical Disease, 2012
Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieti... more Background: Hyperlipidemia is implicated as the cause for coronary heart diseases. Though varieties of synthetic drugs are used in the treatment, still the searches are on for better medicaments especially from the plant kingdom. Many medicinal plants have been studied in this context but most of them are seasonal or have restricted availability. One such weed, available throughout the year is Salvadora oleoides (decne.). Materials and Methods: Column chromatographic fractionation of the butanol fraction of leaves of Salvadora oleoides (decne.) yielded four fractions (fraction AD). All sub-fractions were tested for their anti-hyperlipidemic activity. Fractions were administered at a dose of 65 mg/kg (oral) to the Triton WR-1339 induced hyperlipidemic rats. Results: Sub-fraction D showed maximum significant reduction (P<0.05) among four sub-fractions in comparison with standard drug fenofibrate. Conclusion: Further studies on the isolated fractions and constituents are needed to isolate compound responsible for activity and elucidate the mechanism by which Salvadora oleoides (decne.) exerts protective effects against hyperlipidemia.
Universities' Journal of Phytochemistry and Ayurvedic Heights
Essential oils are important plant products that often have a complicated composition made up of ... more Essential oils are important plant products that often have a complicated composition made up of the volatile plant components. Numerous biological actions are reportedly connected to essential oils, and a new class of aromaceuticals is being developed. The market for essential oils has increased since they are used to cure these types of ailments as a result of the emergence of various mental issues due to changing living standards, such as depression, anxiety, sleeplessness, and stress. Studies on animal models have shown that the mode of action of essential oils, which cause physiological changes in the brain, involves a number of neurotransmitter systems. Despite mounting proof that essential oils have quantifiable effects on animal behavior. Therefore the current study is proposed to investigate the physical and chemical characteristics of the essential oil obtained from the rhizome of Cyperus scariosus and assess its anxiolytic effects on the central nervous system in rodent m...
South African Journal of Botany
Archives of Microbiology, 2022