International Journal of Bone and Rheumatology Research (IJBRR) (original) (raw)

Volume 1 : Issue 1 by International Journal of Bone and Rheumatology Research (IJBRR)

Context: With increasing elderly population there is increasing prevalence of primary degenerativ... more Context: With increasing elderly population there is increasing prevalence of primary degenerative knee osteoarthritis (KOA),
but specific and sensitive tests to diagnose and ascertain the severity of such ailments are lacking. Bone and cartilage biomarkers,
like serum Cartilage Oligomeric Matrix Protein (sCOMP) level show changes much before than clinical or radiological changes. So far it has not been used in clinical practice as the diagnostic range of serum COMP levels have not been defined.
Aims: The aim of present study was to assess the efficacy of sCOMP levels in diagnosis of different grades of severity of primary knee osteoarthritis.
Settings and design: A hospital based prospective case control study recruiting 100 cases and 50 controls.
Methods and material: All subjects were examined clinically and further evaluated by plain radiography and serum COMP
values were estimated by enzyme linked immune-sorbent assay (ELISA). Multiple statistical tools were used to analyse the
results.
Results: The difference between sCOMP values among cases and controls was statistically significant (t=21.774; p<0.001).
The mean sCOMP also shows a gradual increase with increase in severity of knee osteoarthritis. [F=38.940; p<0.001 (ANOVA)].
Conclusions: The serum COMP levels can be used to diagnose normal and diseased individual and also assess different
grades of severity of knee osteoarthritis. We suggest cut off levels of sCOMP of 652.5 nano gram/deci litre (ng/dl) between
normal and diseased individual, of 801.5 ng/dl between mild and moderate grade of osteoarthritis, and of 1100.5 ng/dl between
moderate and severe grade of knee Osteoarthritis (KOA).

Volume 2: Issue 1 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2015

Multiple trauma usually results from RTAs or falls, affecting several systems. Treatment should b... more Multiple trauma usually results from RTAs or falls, affecting several systems. Treatment should be properly designated according to the type of injury, patient's assessment and health-care-serving status. Damage-control orthopaedics aims at improving the patient's physiological status as to delay any orthopaedic surgery that may worsen the patient's condition, meanwhile achieving provisional stability of the fractures. In this work, a patient with multiple fractures at once was managed using this approach. Advanced trauma life support (ATLS) was firstly applied, followed by reduction and fixation. The patient administered long- term prophylactic antibiotics and possessed physiotherapy sessions from the first week. On 3 and 6 months postoperatively, the patient showed progress and regained his ability to work and live normally.

Volume 2: Issue 2 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2015

Osteoarthritis (OA) is a chronic disease with a long silent period. The hallmarks of osteoarthrit... more Osteoarthritis (OA) is a chronic disease with a long silent period. The hallmarks of osteoarthritis (OA) include cartilage loss that leads to joint destruction and severe impairment of mobility. Involvement of subchondral bone and synovial tissue is well documentated. OA is the most prevalent cause of disability in the aging population of developing countries.The diagnosis is generally based on clinical symptoms and radiographic changes. However, X-ray has a poor sensitivity that does
not allow an early detection of OA or the monitoring of joint damage progression.

Volume 2: Issue 3 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2015

Subungual exostoses are bony projections which arise from the dorsal surface of the distal phalan... more Subungual exostoses are bony projections which arise from the dorsal surface of the distal phalanx, most commonly of the hallux, often disturbing the nail plate and causing pain. We report case of subungual exostosis in a female child of 10 years who presented since one year a fixed firm nodule of the great toe. Clinically, radiologic and histological finding were compatible with subungual exostosis. The treatment is surgical. Early diagnosis avoids nail dystrophy.

Volume 2: Issue 4 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2015

22 years old male patient was victim of severe trauma of the left upper Limb causing multiple fra... more 22 years old male patient was victim of severe trauma of the left upper Limb causing multiple fractures of the clavicle, humerus, radius with large bone defect of the ulna. Soft tissues damage was also significant with section of median and ulnar nerve, radial artery, flexor tendons of the hand and fingers. Treatment consisted initially to realize excision of devitalised and contaminated tissues from the wound, obtain skeletal stabilization with restoration of the upper limb length, and exceed
the cap of infection. Secondarily, the one bone forearm procedure was performed to recover maximum of function. One year and half after injury, the patient had full elbow flexion-extension with very satisfactory fingers mobility.

Volume 2: Editorial 1 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2015

Despite high prevalence and social impact, osteoarthritis (OA) is far behind other skeletal disea... more Despite high prevalence and social impact, osteoarthritis (OA)
is far behind other skeletal diseases like osteoporosis in the evelopment of disease-modifying treatments. This is mainly because little is known about the underlying molecular mechanism that could be the therapeutic target. Since OA is a multifactorial disease caused by complex interplay between environmental and genetic factors with estimates of around 50% heritability depending on the site [1], numerous efforts and great expense have been spent on human genetic studies on OA worldwide. Although linkage studies have shown large areas of chromosomes associated with the disease, they have failed to detect the susceptible genes. Candidate gene studies have proposed over 100 genes as being responsible; however, most of them have not later been reproduced
in larger meta-analysis studies. Recently, while genome-wide association studies (GWAS) have led to the discovery of over 600 gene loci in over 50 common multifactorial diseases, most of the gene variants are of only minimal individual effect.

Volume 3: Issue 1 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

This report presents a very aggressive and unusual case of a rare musculoskeletal neoplastic proc... more This report presents a very aggressive and unusual case of a rare musculoskeletal neoplastic process, which ultimately resulted in the death of a patient. It is of utmost importance to present this case, in order to display the abnormal nature of this disease process, improve future treatment, and reduce morbidity and mortality. The abnormal pathological variant presented in this case and the lack of literature on the malignancy, highlights the lack of studies into the orthopedic sequela of these tumors. Further research regarding this entity, will decrease the complications, including; pathological fractures,
subsequent debility and death.

Volume 3: Issue 2 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Deep vein thrombosis (DVT) is a serious complication of total knee replacement (TKA). While the n... more Deep vein thrombosis (DVT) is a serious complication of total knee replacement (TKA). While the need for post op prophylaxis is accepted, controversy exists as to which regimen(s) to use. ASA use has seen resurgence due to its efficacy, safety profile, and easy administration. To date no study has evaluated patient satisfaction and compliance with ASA chemoprophylaxis after TKA. Ninety-six TKA patients were surveyed after randomization to receive either oral ASA or injected low molecular weight heparin. Satisfaction was significantly greater in the ASA group. Confidence in treatment was equivalent between the groups. Patient satisfaction withanticoagulation after TKA should not be overlooked. We have demonstrated increased satisfaction with ASA treatment without affecting perceptions of efficacy. Our findings should be considered when prescribing postoperative prophylaxis

Volume 3: Issue 3 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Patients and Methods This retrospective study was done on the patients undergoing total knee repl... more Patients and Methods This retrospective study was done on the patients undergoing total knee replacement collected for this analysis was part of a Abstract Objective: Osteoarthritis of the knee is one of the leading causes of pain and disability. The primary goal of the total knee arthroplasty is to relief the pain and to improve the patient's quality of life. The aim of the study is find any correlation between the preoperative radiographic degree of osteoarthritis and the results in primary total knee arthroplasty. Study Methods: It is a retrospective study. 160 patients, 203 knees were included in the study. Patients were between the ages of 31 to 90 years of age (69.4). 62% were females and 38% were male. An x-ray was taken for all patients in order to grade the damage of each knee according to the radiographic grading system of Kellgren and Lawrence. After the operation each patient was assessed after 1, 5 and 10 years. Results: In general the benefit of surgery was obvious among all x-ray Osteoarthritic grades, which was obvious by the improvement in the post-op scores among all four groups in the first year after surgery, although early stages grades (I&II) showed better improvement in function scores than the late two stages within the same period. In 5 and 10 years, however, all grades' outcomes went down in both knee and function scores. Conclusion: These results prove delaying surgery in symptomatic early stages is of no benefit. It has also showed that the outcome of the surgery is of high benefit to all patients regardless their pre-op x-ray grades.

Volume 3: Issue 4 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Objectives: Although historical studies frequently classify posterior malleolus fractures (PMFs) ... more Objectives: Although historical studies frequently classify posterior malleolus fractures (PMFs) according to fragment size, our hypothesis is that PMFs have more complex patterns than is widely recognized. None of the studies so far have provided a comprehensive picture of the complexity of PMFs or guidelines for surgical decision making. The optimal management of PMFs is still unclear. This study aims to look at the typology of PMFs using a combination of initial injury radiographs, preoperative computed tomographic (CT) scans, and intra-operative image intensifier (II) screening, as well as fixation technique and a surgery fixation approach, in order to gain insight into PMFs. Methods: Between 2013 and 2015, 56 consecutive patients, all with bi-or tri-malleolar fracture or dislocation of ankle joints, with one or more posterior fragments, who were treated at our institute, were identified. We retrospectively analysed the patients' preoperative initial injury radiographs, CT scans, and II data to see the stability of the ankle joints in coronal and sagittal planes, and look at the typology in relation to fracture fixation technique and surgery fixation approach. Conclusions: Bi-or tri-malleolar fractures of the ankle with associated posterior malleolar fractures appear to be highly variable. We identified certain types of PMFs which we can categorise. Ankle stability in the coronal and sagittal planes on initial injury radiographs, intra-operative II and preoperative CT scans are critical in order to identify different PMFs patterns. PMFs have highly variable typology regardless of fragment size and this must take into consideration when deciding treatment plans.

Volume 3: Issue 5 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. When this malignancy is dia... more Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. When this malignancy is diagnosed, often there are distant metastases (usually liver and/or bone). Brown tumor is a localized form of osteitis fibrosa cystica; classic manifestation in bone of excess parathyroid hormone and this is a bening pathology. We encountered an unusual case of parathyroid carcinoma with images that mimicked metastatic bone tumors, whose differential diagnosis with brown tumor may be complicated. Positron emission tomography/computed tomography (PET/CT) scan was requested for the evaluation of fluorodeoxyglucosa uptake of these lesions. PET/CT images showed multiple hypermetabolic images that mimicked multiple skeletal metastasis but brown tumors could not be dismissed.

Volume 3: Issue 6 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Ankylosing Spondylitis (AS) is a chronic disease with inflammation at the enthesis of the spine a... more Ankylosing Spondylitis (AS) is a chronic disease with inflammation at the enthesis of the spine and peripheral skeleton, which leads to bony erosion or juxtain sertional osteoporosis in the early stages. However, in later stages, new bone formation, syndesmophytes and ankylosis can occur. Generalized as well as regional osteopaenia is common in AS [1] with a frequency ranging from 50-92% [2-4]. It ranges from 41–62% in spine and 46–86% in femur.

Volume 3: Issue 7 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Background: Vitamin D deficiency was reported to be common in rheumatoid arthritis patients and a... more Background: Vitamin D deficiency was reported to be common in rheumatoid arthritis patients and an association with female sex, disease severity, higher disease activity and worse quality of life was suggested. Objectives: To estimate the prevalence of different levels of vitamin D and disability among female patients with rheumatoid arthritis, and to investigate its possible impact on the degree of disability in rheumatoid arthritis. Subjects & Methods: A cross sectional hospital-based survey conducted during the year 2015-2016. Total number of patients included in the study was 160, with a mean age of 44.80 ± 3.69 years. The data was collected through an interview questionnaire from all participants over a period of one month (November 2015). Results: The prevalence of low levels of vitamin D and disability among rheumatoid arthritis patients was 54.4% and 63.7% respectively. There was no statistically significant difference between different levels of vitamin D regarding age and duration of rheumatoid arthritis (P > 0.05). Class IV and III of disability was commonly reported among rheumatoid arthritis patients with a disease duration of more than 5 years and represented 27.3% and 24.5% respectively, and there was statistically significant difference (P < 0.05). There was a significant association between different classes of disability and different levels of vitamin D (χ 2 = 15.28, P < 0.05). Conclusion: It appears that low vitamin D is highly prevalent in patients with rheumatoid arthritis and that vitamin D insufficiency and deficiency may be linked to disease impact on functional ability and disability.

Volume 3: Issue 8 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2016

Arthritis is the leading cause of disability in the US workforce, leading to debilitating limitat... more Arthritis is the leading cause of disability in the US workforce, leading to debilitating limitations with mobility and function in an otherwise healthy adult. In 2005, 21.6% of US adults (46.4 million) were formally diagnosed with arthritis, and by 2030 is projected to reach 40% (~67 million) [1-3]. A high correlation exists between age and the presence of rotator cuff disease and glenohumeral arthritis. The average age of individuals with unilateral cuff tears is 58.7, 67.8 years for those with bilateral, and 50% likelihood of a bilateral tear after age 60. It is estimated 13% of patients in their fifties suffer from a cuff tears and 54% of patients 60 years
or older, with more than half of asymptomatic rotator cuff tears progressing in size and becoming symptomatic within 3 years.

Volume 4: Issue 1 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2017

Floating dislocated elbow is an extremely rare injury, only a few cases were reported. We present... more Floating dislocated elbow is an extremely rare injury, only a few cases were reported. We present here a case of the constellation of skeletal trauma which associates a proximal humerus fracture, distal radius fracture and elbow dislocation. Through the literature review we will include clinical, radiological, therapeutic and functional results of this injury.

Volume 4: Issue 2 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2017

Background: Osteoarthritis (OA) is a chronic, degenerative and inflammatory disease. It is charac... more Background: Osteoarthritis (OA) is a chronic, degenerative and inflammatory disease. It is characterized by progressive deterioration of articular cartilage. It is the most common disabling rheumatic pathology in adults older than 45 years, and there is no specific treatment. Objectives: Based on the rationale that in vitro polymerized-type I collagen induces chondrocytes proliferation, up-regulates the cartilage extracellular matrix proteins and down-regulates proinflammatory cytokines, we decided to evaluate its effect on cartilage repair in a rat model of OA. Methods: Thirty Wistar male rats with partial meniscectomy were subjected to daily high impact exercise during 3 weeks. Rats were randomly allocated into 5 groups a) training control, b)sham/operated control, c) toxicity control, d) OA treated with 4 intraarticular (IA) injections of placebo, and e) OA treated with 4 IA injections of polymerized-type I collagen. Weight, temperature and thickness of the knee were measured. Histological and radiological analysis was also performed. Type I and II collagen as well as, MMP13 expression was determined by immunofluorescence. Results: Clinimorphometric analysis showed a higher temperature and thickness of the knee in OA/placebo vs. OA/polymerized-type I collagen treated rats. Radiological and histological analysis demonstrated that polymerized-type I collagen but not placebo preserved joint cavity structure and proteoglycans content and induced an increase of 2 to 4 fold type II collagenexpressing chondrocytes whereas it inhibited type I collagen and MMP13 producing chondrocytes. Conclusion: The results suggest that polymerized-type I collagen is safe and effective chondroprotective biodrug with disease modifying effects. It induces high quality cartilage repair.

Volume 5: Issue 1 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2020

Osteoporosis is a skeletal disease-causing bone fragility by disturbing micro architecture of the... more Osteoporosis is a skeletal disease-causing bone fragility by disturbing micro architecture of the bone leading to osteoclasts mediated bone loss. Inhibition of the Farnesyl Pyrophosphate Synthase (FPPS) of mevalonate pathway and Receptor Activator of Nuclear factor kappa-Β ligand (RANKL/OPG) complex by using anti resorptive drugs like Nitrogen containing Bisphosphonates aid in the effective treatment of osteoporosis. The in-silico docking analysis of newly synthesized Ibandronatehydroxyapatite conjugate has shown as a most powerful binary to HMG-COA Reductase, Farnesyl pyrophosphate synthase (FPPS), Human Geranyl Geranyl pyrophosphate synthase (GPPS) & RANKL/OPG in contrast to pure Ibandronate. The docking score of Ibandronate hydroxyapatite (IBA-HAP) was found to be-6.12,-6.75,-5.33 and-6.49 as against standard pure Ibandronate of-1.28,-2.07,-1.97 and-3.23 kcal/mol. Also, ΔG binding energy and pIC 50 values showed promising potential anti-osteoporotic effect for Ibandronate-hydroxyapatite conjugate.

Volume 5: Issue 2 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2020

Soft tissue chondroma is a benign and rare tumor. We report a specific case of this type of tumor... more Soft tissue chondroma is a benign and rare tumor. We report a specific case of this type of tumor, and we discuss it through a review of the literature.

Volume 5: Issue 3 by International Journal of Bone and Rheumatology Research (IJBRR)

SciDoc Publishers, 2020

Reconstruction for malignant tumors around the knee after wide resection constitutes a real surgi... more Reconstruction for malignant tumors around the knee after wide resection constitutes a real surgical challenge. We evaluated by referring to literature data, the 3 year results of tumoral resection and joint reconstruction using rotating-hinge knee. There were 12 distal femoral and tibial proximal replacements. Clinical and functional outcomes obtained were comparable to those of the literature. Our prosthetic survival was 75%.

SciDoc Publishers, 2020

We report the results of 12 patients followed for post traumatic feet equinus deformity treated b... more We report the results of 12 patients followed for post traumatic feet equinus deformity treated by percutaneous Achilles tendon lengthening by triple hemisection. Thanks to its multiple advantages, this procedure allowed 11 patients to recover near complete foot neutral position in standing and walking.

SciDoc Publishers, 2015

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SciDoc Publishers, 2020

SciDoc Publishers, 2021

Although sacral perineural cysts are mostly seen as incidental findings on computed tomography (C... more Although sacral perineural cysts are mostly seen as incidental findings on computed tomography (CT) or magnetic resonance imaging (MRI), occasionaly they may become symptomatic. Generally only follow-up is recommended in asymptomatic cases. However, there are various non-surgical or invasive interventions for the treatment of symptomatic cases, but optimal treatment strategy is not clear yet. Debates continue regarding the etiology, pathogenesis and treatment of these cysts.

SciDoc Publishers, 2021

The aim of this study was to measure the levels of trace elements (TEs) in serum, bone and disc t... more The aim of this study was to measure the levels of trace elements (TEs) in serum, bone and disc tissue of patients with lumbar spinal stenosis (LSS) and lumbar disc herniation(LDH) and so to evaluate the role TEs in the physiopathogenesis of in these pathologies. Material and method: In this study, serum, bone, and disc tissue levels of 10 TEs including phosphorus (P), calcium (Ca), magnesium (Mg), manganese (Mn), vanadium (V), zinc (Zn), chromium (Cr), copper (Cu), selenium (Se), cobalt (Co) levels were measured in 20 patients with LDH and 30 patients with LSS by the way of Inductively Coupled Plasma-Mass Spectrometer (ICP-MS). Results: While there was no significant difference in the serum levels of the two groups, statistically significant differences were observed in the amount of Ca, Co, P, and V elements in bone and disc tissues. In the LSS group, the Ca element was found to be higher in the bone tissues, whereas in the LDH group, the Co element was found to be higher in the bone tissue. In disc tissue, Ca, P and Co elements were found to be higher in LSS group. Conclusion: The differences in trace element levels seen in these pathologies are discussed in terms of possible causes in the light of current literature. Although it is known that high doses of trace elements have toxic effects, it supports the hypothesis that these trace elements may have beneficial biological effects at pharmacological levels in accordance with the results obtained in our study.

SciDOc Publishers, 2021

SciDoc Publishers, 2021

The histiocytofibroma is a mesenchymal tumor of distal cutaneous localization in most cases, bone... more The histiocytofibroma is a mesenchymal tumor of distal cutaneous localization in most cases, bone location is unusual and especially in the long bones. She usually sits in epiphyseal or metaphyseal location. The location of the tibial shaft is very rare. Few studies have described the clinical, pathological and prognostic of bone histiocytofibroma, it is difficult to differentiate them from other rare lesions such as giant cell tumor (GCT) and non-ossifying fibroma. In this article, we will describe this very rare bone lesion and describe the clinical, therapeutic and prognostic characteristics from a case.