Pujan Patel - Academia.edu (original) (raw)
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Papers by Pujan Patel
Recent investigation of the meninges, specifically the dura layer, has highlighted its importance... more Recent investigation of the meninges, specifically the dura layer, has highlighted its importance in CNS immune surveillance beyond a purely structural role. However, most of our understanding of the meninges stems from the use of pre-clinical models rather than human samples. In this study, we use single cell RNA-sequencing to perform the first characterization of both non-tumor-associated human dura and meningioma samples. First, we reveal a complex immune microenvironment in human dura that is transcriptionally distinct from that of meningioma. In addition, through T cell receptor sequencing, we show significant TCR overlap between matched dura and meningioma samples. We also identify a functionally heterogeneous population of non-immune cell types and report copy-number variant heterogeneity within our meningioma samples. Our comprehensive investigation of both the immune and non-immune cell landscapes of human dura and meningioma at a single cell resolution provide new insight ...
International Journal of Surgery Case Reports
INTRODUCTION: Transradial artery approach for cardiac catheterization was first introduced in the... more INTRODUCTION: Transradial artery approach for cardiac catheterization was first introduced in the late 1980s and has now become the approach of choice due to its anatomical advantage, reduction in complications, and overall improved patient experience. CASE PRESENTATION: We present a case of a 77 year-old female who presented with an extremely rare and late complication of radial artery pseudoaneurysm after transradial coronary intervention. The patient presented at a post-procedural follow-up with severe pain at the radial access site and was found to have a partially thrombosed pseudoaneurysm. Given the anatomical variance of the pseudoaneurysm, the patient underwent successful open surgical repair. CLINICAL DISCUSSION: Although radial artery access is a relatively safe approach in comparison to the transfemoral approach, the risk of adverse events still exists. Among the complications of the transradial approach, pseudoaneurysms are relatively rare, occurring in less than 0.1% of cases. Regardless, early identification of this complication is essential to timely intervention. CONCLUSION: Our case highlights the importance of post procedural monitoring and early identification and diagnosis of the complication to facilitate appropriate therapy.
Encyclopedia of Respiratory Medicine
Critical Care Medicine, 2015
Journal of the American College of Cardiology
Cangrelor is an intravenous P2Y12 receptor inhibitor with rapid onset and offset of action making... more Cangrelor is an intravenous P2Y12 receptor inhibitor with rapid onset and offset of action making it an attractive agent for bridging particularly in stented patients undergoing surgery who need to be on dual anti-platelet therapy (DAPT). However, to date there is limited real-world experience on
Recent investigation of the meninges, specifically the dura layer, has highlighted its importance... more Recent investigation of the meninges, specifically the dura layer, has highlighted its importance in CNS immune surveillance beyond a purely structural role. However, most of our understanding of the meninges stems from the use of pre-clinical models rather than human samples. In this study, we use single cell RNA-sequencing to perform the first characterization of both non-tumor-associated human dura and meningioma samples. First, we reveal a complex immune microenvironment in human dura that is transcriptionally distinct from that of meningioma. In addition, through T cell receptor sequencing, we show significant TCR overlap between matched dura and meningioma samples. We also identify a functionally heterogeneous population of non-immune cell types and report copy-number variant heterogeneity within our meningioma samples. Our comprehensive investigation of both the immune and non-immune cell landscapes of human dura and meningioma at a single cell resolution provide new insight ...
International Journal of Surgery Case Reports
INTRODUCTION: Transradial artery approach for cardiac catheterization was first introduced in the... more INTRODUCTION: Transradial artery approach for cardiac catheterization was first introduced in the late 1980s and has now become the approach of choice due to its anatomical advantage, reduction in complications, and overall improved patient experience. CASE PRESENTATION: We present a case of a 77 year-old female who presented with an extremely rare and late complication of radial artery pseudoaneurysm after transradial coronary intervention. The patient presented at a post-procedural follow-up with severe pain at the radial access site and was found to have a partially thrombosed pseudoaneurysm. Given the anatomical variance of the pseudoaneurysm, the patient underwent successful open surgical repair. CLINICAL DISCUSSION: Although radial artery access is a relatively safe approach in comparison to the transfemoral approach, the risk of adverse events still exists. Among the complications of the transradial approach, pseudoaneurysms are relatively rare, occurring in less than 0.1% of cases. Regardless, early identification of this complication is essential to timely intervention. CONCLUSION: Our case highlights the importance of post procedural monitoring and early identification and diagnosis of the complication to facilitate appropriate therapy.
Encyclopedia of Respiratory Medicine
Critical Care Medicine, 2015
Journal of the American College of Cardiology
Cangrelor is an intravenous P2Y12 receptor inhibitor with rapid onset and offset of action making... more Cangrelor is an intravenous P2Y12 receptor inhibitor with rapid onset and offset of action making it an attractive agent for bridging particularly in stented patients undergoing surgery who need to be on dual anti-platelet therapy (DAPT). However, to date there is limited real-world experience on