Pushkaraj Wagh - Academia.edu (original) (raw)
Papers by Pushkaraj Wagh
Frontiers in Pharmacology, 2021
Celastrol (also called tripterine) is a quinone methide triterpene isolated from the root extract... more Celastrol (also called tripterine) is a quinone methide triterpene isolated from the root extract of Tripterygium wilfordii (thunder god vine in traditional Chinese medicine). Over the past two decades, celastrol has gained wide attention as a potent anti-inflammatory, anti-autoimmune, anti-cancer, anti-oxidant, and neuroprotective agent. However, its clinical translation is very challenging due to its lower aqueous solubility, poor oral bioavailability, and high organ toxicity. To deal with these issues, various formulation strategies have been investigated to augment the overall celastrol efficacy in vivo by attempting to increase the bioavailability and/or reduce the toxicity. Among these, nanotechnology-based celastrol formulations are most widely explored by pharmaceutical scientists worldwide. Based on the survey of literature over the past 15 years, this mini-review is aimed at summarizing a multitude of celastrol nanoformulations that have been developed and tested for vario...
Frontiers in Pharmacology, 2020
Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances ... more Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances in recent years. However, the incidence rate of cancer is still very high. Almost 40% of women and men are diagnosed with cancer during their lifetime. Such high incidence has not only resulted in high mortality but also severely compromised patient lifestyles, and added a great socioeconomic burden. In view of this, chemoprevention has gained wide attention as a method to reduce cancer incidence and its relapse after treatment. Among various stems of chemoprevention research, nanotechnology-based chemoprevention approaches have established their potential to offer better efficacy and safety. This review summarizes recent advances in nanotechnology-based chemoprevention strategies for various cancers with emphasis on lung and bronchial cancer, colorectal, pancreatic, and breast cancer and highlights the unmet needs in this developing field towards successful clinical translation.
Journal of Composites and Compounds, 2021
In recent years, various drug carrier nanomaterials have been investigated to improve drug delive... more In recent years, various drug carrier nanomaterials have been investigated to improve drug delivery systems in cancer treatment. However, an ongoing requirement exists for more beneficial therapeutic materials, yielding rapid clearance, high capacity for reducing systemic toxicity via specific-tumor targeting, and superior drug solubility. Given that, carbon allotropes, including Active Carbon (AC), carbon nanotubes (CNTs), graphene and graphene oxides (GOs), nanodiamonds (NDs), fullerenes, carbon nanohorns, soporous carbons, and carbon dots, have been studied owing to their high thermal conductivity, rigid structure, flexibility for modification and functionalization, adequate surface-to-volume ratio, and high biocompatibility. This review aims to overview recent advances in applying different carbon allotrope composites in drug delivery-based cancer therapy systems.
The intend of this study is to show the potential that nanotechnology has towards cancer diagnosi... more The intend of this study is to show the potential that nanotechnology has towards cancer diagnosis and targeted drug delivery. Various nanocarriers have been designed and manufactured to deliver the drug specifically and produce maximum therapeutic response. This shows the novel approach of nanocarriers by ruling out various disadvantages of conventional therapy. The study includes numerous nanocarriers such as liposomes, dendrimers, polymeric micelles etc. This study portrays the current scenario of nanocarriers around the globe. The review also explores the nanoparticles used in cancer diagnosis and imaging.
Dental caries is a dental biofilm-related disease associated with increased consumption of dietar... more Dental caries is a dental biofilm-related disease associated with increased consumption of dietary sugar and fermentable carbohydrates. This biofilm matures to become cariogenic and in some cases the bacteria present in the biofilm turns food starches into acid which erodes teeth. Streptococcus mutans (S. Mutans) was found to be the most dominant species in caries initiation having acidogenic and aciduric properties. Glucosyltransferases (Gtfs) have the main role in adhering S. Mutans on tooth enamel which eventually leads to a tooth decay. The adherence of S. Mutans to the surface of enamel or the physiological ability (acidogenity and aciduricity) in dental biofilms can be reduced, resulting in a decrease caries formation which may be achieved by using a nanostructured material. Nanostructured material are used in many fields, including biological sciences and medicine. Zerovalent bismuth nanoparticles were introduced to resist the resistance caused by microbes to various antibiot...
From the past decade, researchers have seen the potential application of nanotechnology in the fi... more From the past decade, researchers have seen the potential application of nanotechnology in the field of cancer-targeted drug delivery. Nanoparticle-based chemical moieties such as polymeric based nanoparticles, dendrimers, polymersomes, liposomes, nano micelles, metal nanoparticles, carbon nanotubes (CNTs), etc. Due to their exclusive properties such as tunable surface chemistry, ability to penetrate cells, stimuli-sensitization they could be designed as per the targeted tissue or cells of the tumor. This review provides an insight into the development of nanomedicine with the help of different nanocarriers for cancer/tumor-targeted drug delivery. But apart from having desired flexibility in the development of nanocarrier based drug compound, it has some drawbacks/challenges. The review will also discuss
Frontiers in Pharmacology, 2021
Celastrol (also called tripterine) is a quinone methide triterpene isolated from the root extract... more Celastrol (also called tripterine) is a quinone methide triterpene isolated from the root extract of Tripterygium wilfordii (thunder god vine in traditional Chinese medicine). Over the past two decades, celastrol has gained wide attention as a potent anti-inflammatory, anti-autoimmune, anti-cancer, anti-oxidant, and neuroprotective agent. However, its clinical translation is very challenging due to its lower aqueous solubility, poor oral bioavailability, and high organ toxicity. To deal with these issues, various formulation strategies have been investigated to augment the overall celastrol efficacy in vivo by attempting to increase the bioavailability and/or reduce the toxicity. Among these, nanotechnology-based celastrol formulations are most widely explored by pharmaceutical scientists worldwide. Based on the survey of literature over the past 15 years, this mini-review is aimed at summarizing a multitude of celastrol nanoformulations that have been developed and tested for vario...
Frontiers in Pharmacology, 2020
Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances ... more Cancer research in pursuit of better diagnostic and treatment modalities has seen great advances in recent years. However, the incidence rate of cancer is still very high. Almost 40% of women and men are diagnosed with cancer during their lifetime. Such high incidence has not only resulted in high mortality but also severely compromised patient lifestyles, and added a great socioeconomic burden. In view of this, chemoprevention has gained wide attention as a method to reduce cancer incidence and its relapse after treatment. Among various stems of chemoprevention research, nanotechnology-based chemoprevention approaches have established their potential to offer better efficacy and safety. This review summarizes recent advances in nanotechnology-based chemoprevention strategies for various cancers with emphasis on lung and bronchial cancer, colorectal, pancreatic, and breast cancer and highlights the unmet needs in this developing field towards successful clinical translation.
Journal of Composites and Compounds, 2021
In recent years, various drug carrier nanomaterials have been investigated to improve drug delive... more In recent years, various drug carrier nanomaterials have been investigated to improve drug delivery systems in cancer treatment. However, an ongoing requirement exists for more beneficial therapeutic materials, yielding rapid clearance, high capacity for reducing systemic toxicity via specific-tumor targeting, and superior drug solubility. Given that, carbon allotropes, including Active Carbon (AC), carbon nanotubes (CNTs), graphene and graphene oxides (GOs), nanodiamonds (NDs), fullerenes, carbon nanohorns, soporous carbons, and carbon dots, have been studied owing to their high thermal conductivity, rigid structure, flexibility for modification and functionalization, adequate surface-to-volume ratio, and high biocompatibility. This review aims to overview recent advances in applying different carbon allotrope composites in drug delivery-based cancer therapy systems.
The intend of this study is to show the potential that nanotechnology has towards cancer diagnosi... more The intend of this study is to show the potential that nanotechnology has towards cancer diagnosis and targeted drug delivery. Various nanocarriers have been designed and manufactured to deliver the drug specifically and produce maximum therapeutic response. This shows the novel approach of nanocarriers by ruling out various disadvantages of conventional therapy. The study includes numerous nanocarriers such as liposomes, dendrimers, polymeric micelles etc. This study portrays the current scenario of nanocarriers around the globe. The review also explores the nanoparticles used in cancer diagnosis and imaging.
Dental caries is a dental biofilm-related disease associated with increased consumption of dietar... more Dental caries is a dental biofilm-related disease associated with increased consumption of dietary sugar and fermentable carbohydrates. This biofilm matures to become cariogenic and in some cases the bacteria present in the biofilm turns food starches into acid which erodes teeth. Streptococcus mutans (S. Mutans) was found to be the most dominant species in caries initiation having acidogenic and aciduric properties. Glucosyltransferases (Gtfs) have the main role in adhering S. Mutans on tooth enamel which eventually leads to a tooth decay. The adherence of S. Mutans to the surface of enamel or the physiological ability (acidogenity and aciduricity) in dental biofilms can be reduced, resulting in a decrease caries formation which may be achieved by using a nanostructured material. Nanostructured material are used in many fields, including biological sciences and medicine. Zerovalent bismuth nanoparticles were introduced to resist the resistance caused by microbes to various antibiot...
From the past decade, researchers have seen the potential application of nanotechnology in the fi... more From the past decade, researchers have seen the potential application of nanotechnology in the field of cancer-targeted drug delivery. Nanoparticle-based chemical moieties such as polymeric based nanoparticles, dendrimers, polymersomes, liposomes, nano micelles, metal nanoparticles, carbon nanotubes (CNTs), etc. Due to their exclusive properties such as tunable surface chemistry, ability to penetrate cells, stimuli-sensitization they could be designed as per the targeted tissue or cells of the tumor. This review provides an insight into the development of nanomedicine with the help of different nanocarriers for cancer/tumor-targeted drug delivery. But apart from having desired flexibility in the development of nanocarrier based drug compound, it has some drawbacks/challenges. The review will also discuss