Pushpendra Sharma - Academia.edu (original) (raw)

Papers by Pushpendra Sharma

Arabian Journal of Geosciences

Roadways are the lifeline for any city, especially in hilly regions. The increase in population a... more Roadways are the lifeline for any city, especially in hilly regions. The increase in population and road constructions has led to the destabilization of the slopes resulting in mass movement. Anisotropic rockmass, whose behaviour is largely dependent on the planes of weakness, was simulated using 3DEC . The three-dimensional discontinuum modelling technique provides the most rigorous analysis of the failure process and deformation in the anisotropic rock. However, due to the limited capacity of the software, it is impossible to include all the discontinuities implicitly in numerical simulation. This paper provides a methodology for the application of Ubiquitous-Joint models on a field scale to include the anisotropic behaviour of rockmass. After identifying the failure-prone area using rigorous 3DEC slope stability analysis, rockfall analysis was also carried out to identify the maximum run-out, bounce height and total kinetic energy of falling rock blocks in the same section of the slope. 3DEC results show the maximum total displacement of 2.6 cm with a maximum velocity of 0.25 m/s, which confirms the instability in the slope. The rockfall simulation reveals that the falling rock blocks can hit the vehicle on the roadway with the kinetic energy of 58.5 kJ that makes this roadway unsafe.

Research Journal of Pharmacy and Technology, 2017

A simple, rapid and precise reversed-phase high performance liquid chromatography method for simu... more A simple, rapid and precise reversed-phase high performance liquid chromatography method for simultaneous estimation of rosiglitazone maleate, glimepride and amlodipine besylate in a marketed tablet dosage form has been developed and validated. At optimum condition was performed on a C18 column by ratio of mobile phase Methanol: Water: Ortho Phosphoric Acid (75: 25: 0.2) with maintain of pH 4.5±0.01 at 1.0 mL/min. Selected wavelength at 230 nm and sample volume injected 20 μL at ambient temperature. Total run time was 10 min; rosiglitazone maleate, glimepride and amlodipine besylate were eluted with retention time of 1.75, 2.22 and 6.483 respectively. The developed method was validated as per ICH guideline. Validation revealed that method is specific, rapid, accurate, precise, reliable and reproducible.

ISRM Regional Symposium - EUROCK 2018, 2018

Springer, Feb 1, 2021

Mechanised depillaring (MD) has been proved to be a panacea for faster extraction of the develope... more Mechanised depillaring (MD) has been proved to be a panacea for faster extraction of the developed pillars which is blocking access to deeper deposits and locking more than 3200 Mt of coal, developed by Bord and Pillar mining method in Indian coalfields. Depillaring of these square/rectangular-shaped developed pillars by continuous miner creates irregular-shaped ribs/snooks. Stability assessment of such ribs/snooks becomes a challenging task due to various issues faced in estimation of load acting upon it and their strength. Area-based approach for the design of rib/snook is found to be the most suitable criteria during MD. Field investigations supported for parametric investigation for a competent size of rib/snook with varying nature of roof and depth of cover. Taking help from previous studies to design such ribs/snooks on numerical models using FLAC3D, a parametric study is carried out using 3DEC. Strength of such ribs/snooks and load acting upon them is calculated with the help of calibrated numerical models in order to estimate their factor of safety. This paper presents a review of the previous researches and a novel numerical simulation technique for estimation of a competent size of rib/snook in a given geo-mining condition

International Journal of Current Microbiology and Applied Sciences, 2020

Frontiers in Microbiology, 2022

Interactions among the plant microbiome and its host are dynamic, both spatially and temporally, ... more Interactions among the plant microbiome and its host are dynamic, both spatially and temporally, leading to beneficial or pathogenic relationships in the rhizosphere, phyllosphere, and endosphere. These interactions range from cellular to molecular and genomic levels, exemplified by many complementing and coevolutionary relationships. The host plants acquire many metabolic and developmental traits such as alteration in their exudation pattern, acquisition of systemic tolerance, and coordination of signaling metabolites to interact with the microbial partners including bacteria, fungi, archaea, protists, and viruses. The microbiome responds by gaining or losing its traits to various molecular signals from the host plants and the environment. Such adaptive traits in the host and microbial partners make way for their coexistence, living together on, around, or inside the plants. The beneficial plant microbiome interactions have been exploited using traditional culturable approaches by ...

 Abstract-An indirect forced convection solar dryer is designed and fabricated to investigate it... more  Abstract-An indirect forced convection solar dryer is designed and fabricated to investigate its performance under the hot and dry climatic condition of Jaipur, India. The system consists of flat plate collector and drying chamber with two shelves and a chimney. Dimensions of collector and drying chamber are 1.21 m x 0.87 m and 0.5 x 0.5 x 0.5 m respectively. There are four baffles of dimension 40cmx3cmx7cm fitted between absorber and back plate. The distance between back plate and absorber plate is 8cm. The experiments were performed on green chilies. The drying time is 10 hours. Collector is inclined at 45° with horizontal and oriented in the South-North direction. During experimentation 11 temperatures, relative humidity, air velocity and solar intensity were measured hourly in the month of May and July, 2010 for drying of green chilies and potato chips. Solar intensity varied between 550-890 W/m 2 and maximum temperature rise was 20.6 o C. Hot air at 61 o C from the collector ...

Environmental Technology & Innovation, 2021

Abstract Microbial conversion of agro-residues into valuable products such as GABA and lactic aci... more Abstract Microbial conversion of agro-residues into valuable products such as GABA and lactic acid is of considerable environmental and biotechnological significance. In this study, twenty-nine lactic acid bacteria were isolated from traditional fermented milk and screened for lactic acid and GABA production. Among these, one strain LP-9, identified as Lactobacillus plantarum demonstrated co-production of GABA (0.86 g/L) and lactic acid (19.81 g/L) in De Man, Rogosa and Sharpe (MRS) broth supplemented with 1% monosodium glutamate (MSG). Under RSM optimized conditions, cumulative effect of factors influencing microbial product formation led to a two-fold increase in production of GABA (1.53 g/L) as compared to unoptimized conditions along with substantial production of lactic acid (21.87 g/L). Further, to develop an economical bioprocess on these lines, L. plantarum LP-9 was tested for its capability to utilize agro residues (wheat bran, rice bran and corn bran) and cassava (starchy food crop as control) in form of carbon source for GABA and lactic acid production using conditions optimized in RSM. The substrates were saccharified with enzyme cocktail containing α -amylase, amyloglucosidase, and cellulase followed by fermentation with L. plantarum LP-9 in MRS medium supplemented with 1% MSG but without sugar. The results showed that the saccharified agroresidues tested gave significant and comparable production of GABA (1.14–1.30 g/L) and lactic acid (22.83–29.82 g/L) as that obtained with cassava (1.39 g/L GABA and 31.76 g/L LA). This study illustrated the potential of isolate L. plantarum LP-9 to co-produce GABA and lactic acid from agro residues via biorefinery approach. The developed bioprocess will also help in safe, efficient and ecofriendly disposal of agriwastes.

Archives of Microbiology, 2021

Gamma amino butyric acid (GABA) is a chemical messenger that plays a significant role in muscle r... more Gamma amino butyric acid (GABA) is a chemical messenger that plays a significant role in muscle relaxation and brain health. Certain lactic acid bacteria (LAB) produce significant levels of GABA and thus act as potential psychobiotic cultures. In the present study, LAB were isolated from non-rhizospheric soil sample of Syzygium cumini (Black plum). A total of 57 LAB were isolated on the basis of their morphological and acid producing characteristic on de Man Rogosa Sharpe (MRS) agar. Only seven isolates were found to produce GABA (0.09-1.13 gL-1) in MRS broth and were identified as Lactococcus. However, L. lactis LP-68 produced highest amount of GABA and was selected for further optimization of culture conditions (pH, temperature and MSG) by response surface methodology (RSM). The optimization resulted in approximately four-fold increase in GABA production (4.11 gL-1). The results indicate that the L. lactis LP-68 can be used as starter culture for production of GABA-enriched functional foods.

Global journal of computer science and technology, 2018

A totally distinctive MIMO sharp band-notched antenna with high isolation for UWB applications is... more A totally distinctive MIMO sharp band-notched antenna with high isolation for UWB applications is given. The antenna consists of two antenna elements with an overall space. A shaped stub is extruded among the bottom plane to enhance isolation associated with a shaped stub to introduce band-notched. The designed antenna possesses an occasional mutual coupling over the operative band. The performance of this antenna is studied in terms of isolation between the 2 ports, pattern, efficiency, realized gain, and envelope correlation coefficient.

The Pharma Innovation Journal, 2017

Diagnosis of Diabetes in its very early stage will become very important in the days to come to p... more Diagnosis of Diabetes in its very early stage will become very important in the days to come to prevent the morbidity and mortality of the patients. From this study a relationship between amino acid losses in urine of diabetic patients and their glycaemic control has been established. The observations of this study indicate that analysis of acidic, branched chain, aromatic amino acids and in particular, the measurement of His, Glu, Met, in the urine of diabetic patients under treatment holds significance, as it can be used as an index of hyperglycaemia and effectiveness of treatment. Since urine samples can be easily obtained from patients and Chromatographic method of amino acid estimation is cheap and convenient, it can be easily used for semi quantitative estimation of certain amino acids.

The present study describes a simple and stability-indicating reverse phase high-performance liqu... more The present study describes a simple and stability-indicating reverse phase high-performance liquid chromatography (RPHPLC) method for the quantification of the related substances of Iguratimod drug substance. Successful separations of the possible impurities were achieved on a Inertsil ODS-3 (150 × 4.6 mm, 5μm) and UV detector at 257nm, 0.8mL/min as a flow rate, and 20μL as an injection volume. For mobile phase-A preparation, 5.44gm potassium dihydrogen orthophosphate dissolved in 2 liter water and adjusted pH 4.00±0.05 with dilute orthophosphoric acid and filter through 0.45μ membrane filter. Use HPLC grade Acetonitrile as mobile phaseB. Use gradient flow program with column temperature 40°C. Percentage recovery obtained in the range of 80-120% and the method is linear for all possible impurities and Iguratimod for specified concentration range with coefficient of variation (r) not less than 0.99. Acid, base, peroxide and thermal degradation were carried in drug substance. The pro...

Suspension system is the necessary part in the automobile vehicle. Suspension system provide comf... more Suspension system is the necessary part in the automobile vehicle. Suspension system provide comfort ride to the passengers. Suspension system absorbs the unnecessary vibration which applied on the upward from road irregularities. Here in this paper we will find deflection of existing car with the existing suspension system and going to modified suspension system and find deflection for modified design. Also, we are going to compare deflection for existing and modified design.

Suspension system is essential part of the vehicle. Passenger cars commonly use front suspension ... more Suspension system is essential part of the vehicle. Passenger cars commonly use front suspension as Macpherson suspension system to absorb road shocks and provide comfort to passengers. Even freshly paved roads are not smooth roads have irregularities and it cause bumpy ride if suspension system are not used. Most of the work carried out on the coil spring of the suspension system. For more comfort of the passengers modification of the existing suspension is necessary when irregularities are present in road. Here we have taken Mcpherson suspension system of existing car. We have done analysis with kerb weight of the car. After modifying design we are going to do analysis again with the kerb weight.

Journal of Drug Delivery and Therapeutics, 2018

The essential oil and chloroform extract of air-dried leaves of Otostegia integrifolia Benth. wer... more The essential oil and chloroform extract of air-dried leaves of Otostegia integrifolia Benth. were investigated for the first time using analytical and preparative gas chromatography (GC), GC-mass spectrometry (MS) and NMR techniques. A total of 40 constituents including monoterpenes, sesquiterpenes, diterpenes and their derivatives were identified. A prenylbisabolane type diterpene, 1-methyl-4-(5, 9-dimethyl-1-methylene-deca-4, 8- dienyl) cyclohexene was identified as a major component. The chloroform extract of the leaves yielded two new labdane type diterpenoids, 15, 16-epoxy-3a, 9a-dihydroxy-labda- 13(16), 14-diene and 9(13), 15(16)-diepoxy-3a-hydroxy-16-dihydrolabda-14-ene, a saturated hydrocarbon, pentatriacontane, and stigmasterol. The structures of the isolated compounds were established by spectroscopic methods. Keywords: Otostegia integrifolia Benth.; Lamiaceae; Essential oil, Furanolabdane diterpenes, Otostegindiol, Preotostegindiol, (+)-Axinyssene, Pentatriacontane, Stig...

Asian Journal of Research in Chemistry, 2020

Journal of Pharmacognosy and Phytochemistry, 2018

Pinus roxburghii commonly used as timber plant along with medicinal properties is used in present... more Pinus roxburghii commonly used as timber plant along with medicinal properties is used in present study as a sustainable approach for utilizing bio-resources. Plant-associated endophytic Actinobacteria were objected and explored for their therapeutic potential properties. The results indicated that a total of two hundred eighty-three endophytes were isolated from different tissues and belonged to predominating genus Streptomyces followed by Kitastaosporia, Actinomadura, Micromonospora, Streptosporangium, Microbiospora and Nocardia. During preliminary screening, 47.7% and 14.8% were active against bacterial and fungal pathogens respectively. Isolate GBTPR-137 having maximum zone of inhibition against Micrococcus luteus (27.3±0.5 mm) followed by Pseudomonas aeruginosa (18.3±0.5 mm), Neisseria cinerea (18.7±0.5 mm) and Klebsiella pneumonia (18.3±0.5 mm) While GBTPR-281 was having antibacterial as well as antifungal activity against multicellular fungi Aspergillus fumigates (16.7±0.5 mm...