RACHANA VIJAYA GOPAL - Academia.edu (original) (raw)
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Papers by RACHANA VIJAYA GOPAL
Indian Journal Of Pharmaceutical Education And Research, 2014
A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationa... more A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1 H NMR, 13 C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative.
Indian Journal Of Pharmaceutical Education And Research, 2014
A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationa... more A series of monosubstituted chalcones with potential anti-inflammatory activity have been rationally designed leading to a focused library of ligands 4a-j with ring-A substitution. Subsequent to drug-likeness and druggability assessments, the library members were synthesized in optimal yields and their structures were confirmed by IR, 1 H NMR, 13 C NMR and mass spectral analysis. Screening for anti-inflammatory activity revealed that most of the compounds were quite effective in containing inflammation with compound 4b being the most promising derivative.