RAGHAV MISHRA - Academia.edu (original) (raw)

Papers by RAGHAV MISHRA

Granular jamming is a popular soft robotics technology that has seen recent widespread applicatio... more Granular jamming is a popular soft robotics technology that has seen recent widespread applications including industrial gripping, surgical robotics and haptics. However, to date the field has not fully exploited the fundamental science of the jamming phase transition, which has been rigorously studied in the field of statistical and condensed matter physics. This work introduces vibration as a means to improve the properties of granular jamming grippers through vibratory fluidisation and the exploitation of resonant modes within the granular material. We show that vibration in soft jamming grippers can improve holding strength, reduce the downwards force needed for the gripping action, and lead to a simplified setup where the second air pump, generally used for unjamming, could be removed. In a series of studies, we show that frequency and amplitude of the waveforms are key determinants to performance, and that jamming performance is also dependent on temporal properties of the induced waveform. We hope to encourage further study in transitioning fundamental jamming mechanisms into a soft robotics context to improve performance and increase diversity of applications for granular jamming grippers.

Current Pharmaceutical Biotechnology

: By helping practitioners understand complicated and varied types of data, Artificial Intelligen... more : By helping practitioners understand complicated and varied types of data, Artificial Intelligence (AI) has influenced medical practice deeply. It is the use of a computer to mimic intelligent behaviour. Many medical professions, particularly those reliant on imaging or surgery, are progressively developing AI. While AI cognitive component outperforms human intellect, it lacks awareness, emotions, intuition, and adaptability. With minimum human participation, AI is quickly growing in healthcare, and numerous AI applications have been created to address current issues. This article explains AI, its various elements and how to utilize them in healthcare. It also offers practical suggestions for developing an AI strategy to assist the digital healthcare transition.

Letters in Drug Design & Discovery, 2022

Background: The role of retinoic acid receptor-related orphan receptors in cancer development has... more Background: The role of retinoic acid receptor-related orphan receptors in cancer development has raised the interest to develop multi-functional agents. Objective: The main purpose of this work was in silico design and synthesis of potential anticancer candidates with antioxidant effect. Methods: The compounds were designed based on their docking studies with respect to the RORγt receptor. Using the Gewald protocol, a series of new tetrahydrobenzothiophene derivatives was synthesized. The physicochemical and spectroanalytical findings, including FTIR, 1H-NMR, 13C-NMR, and mass spectroscopic techniques, verified the molecular structures of the synthesized derivatives. The anticancer and antioxidant potential of the synthesized compounds was assessed in vitro. The compounds were tested by the National Cancer Institute, USA for anticancer action towards different cell lines representing nine cancerous conditions. The antioxidant activity of compounds was assessed in vitro using the DP...

Pyrimidine nucleus is one of the most important heterocycles exhibiting remarkable pharmacologica... more Pyrimidine nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. The present review provides a broad view of the biological and medicinal activity possessed by compounds having pyrimidine nucleus. Available online on www.ijpsr.com 758International Journal of Pharmaceutical Sciences and Research ISSN: 0975-8232 INTRODUCTION: The practice of medicinal chemistry is devoted to the discovery and development of new agents for treating disease. The process of establishing a new drug is exceeding complex and involves talent of people from variety

Bioscience Biotechnology Research Communications, 2021

Due to the complexity of gastric emptying, as well as its considerable variability, the in vivo e... more Due to the complexity of gastric emptying, as well as its considerable variability, the in vivo efficacy of drug delivery devices cannot be predicted. When it pertains to drugs with an absorption window in the upper small intestine, a controlled drug delivery system with a longer residence period in the stomach may be of considerable practical significance. Recent developments have shown that floating microspheres are particularly well suited for mixing sustained and delayed releases to achieve a variety of release models with a minimal risk of dumping. The aim of present investigation is to develop and analyze the floating microspheres of amethopterin, which after oral administration could increase the gastric residence time and enhance the bioavailability of the drug by sustained release and minimize the dose dependent side effects as well as improves patient compliance. Floating microspheres of ethyl cellulose, Polyvinyl alcohol and polyvinyl pyrrolidone-K90 were formulated by em...

Oral prolonged release systems are manufactured to release the drug in-vivo with privies to enhan... more Oral prolonged release systems are manufactured to release the drug in-vivo with privies to enhance bioavailability, diminish untoward effects and enhance effectiveness of drugs. Microballoons or hollow microspheres are anticipated to persist buoyant in a permanent way upon the gastric ingredients. The various formulations comprise unfilled microspheres, powders, capsules, tablets and laminated films. Micro-balloons are distinctly attaining attention due to their immense significance in the drug targeting to the stomach. These floating micro-balloons have the convenience that they stay buoyant and circulate uniformly over the gastric ingredients to refrain the variations of gastric emptying and release the drug for extended period of time. Multiparticulate particles of low density can efficiently prolong the gastric retention time of drugs. This article provides an insight of fabrication and methods of evaluation of micro-balloons.

Nudge Marketing is a strategy which is used by many companies and organization to influence a cus... more Nudge Marketing is a strategy which is used by many companies and organization to influence a customer’s decision indirectly without him knowing by providing the person with suggestions and reinforcements. In simple words, Nudge Marketing is planting of an idea in a person’s mind in order to encourage the customer to behave in a particular way without direct persuasion. Nudge Marketing is used in different sectors in different ways to persuade a customer’s decisions in the companies favour. Nudging helps the e-commerce sector in influencing a customer to buy a product. A fast growing sector like e-commerce needs to attract customers and therefore nudging forms an integral part of an e-commerce company to attract customers.

Summary The present study is done to evaluate antimicrobial activity of some novel thiazolidinone... more Summary The present study is done to evaluate antimicrobial activity of some novel thiazolidinones derivatives of 2-amino thiophene. All the synthesiz ed compounds were subjected to antimicrobial screening involving two bacterial str ains Escherichia coli and Streptococcus pneumoniae and two fungal strains Pseudomonas aeruginosa and Candida albicans using Ampicillin as standard at the same concentration. T he results were compared with that of standard drug. All the synthesized compounds have shown low to moderate activity against standard drugs.

Research Journal of Pharmacy and Technology, 2021

Thiazole nucleus has been established as the potential entity in the largely growing chemical wor... more Thiazole nucleus has been established as the potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics. A series of pyrazoline thiazole derivatives were synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material 2-amino-4-aryl thiazole (1) was synthesized via a multicomponent condensation between thiourea, acetophenone and bromine. The Compound 1 was reacted with p-chloroacetophenone and various substituted aldehydes to synthesize the intermediates (3a- 3d) which on cyclization with hydrazine hydrate yielded final products i.e. pyrazoline thiazole derivatives (4a- 4d). Synthesized compounds were purified, characterized and evaluated for their antimicrobial activity. Most of the compounds exhibited moderate to significant activities.

Journal of Pharmacognosy and Phytochemistry, 2016

Stroke is important cause of mortality and morbidity in the world. Prevention and effective treat... more Stroke is important cause of mortality and morbidity in the world. Prevention and effective treatment of stroke is of utmost importance. Stroke involves reduce blood supply in brain to fulfill metabolic demand. Limit in number of medicines and their conventional target approach of action in treating stroke, led us to the search for novel therapeutic approaches. Higher extent of research in field of drug discovery focus on the possible ability of natural compounds extracted from medicinal plants, to prevent ischemia. Natural compounds are promising in treating stroke involving cell process like oxidative phosphorylation, membrane functioning, neurotransmitter release, and free radical generation. Herbal compounds show preventive effect in following sequence calcium antagonism, anti-excitotoxicity, anti-oxidation, antiapoptosis and anti-inflammation on experimental induced ischemic brain injury. In this review, we discussed cascade pathway of stroke, role medicinal compounds and novel...

The multifaceted nature of Ebola sickness and its flare-ups has highlighted the need to enquire t... more The multifaceted nature of Ebola sickness and its flare-ups has highlighted the need to enquire the characteristics of Ebola virus Disease including ebb and flow comprehension of the transmission progression and the impact of control intercessions against its transmission. As indicated by the accessible information, boundaries to counteract and control the illness in influenced nations incorporate faltering and disordered wellbeing frameworks, substandard clean conditions, poor individual hygiene practices and false convictions and disgrace identified with Ebola Virus Disease. This review is correlative to past surveys and centers to review the episodes, method of transmission, clinical signs, treatment and aversion of Ebola Virus Disease.

Thiophene nucleus has been established as the potential entity in the largely growing chemical wo... more Thiophene nucleus has been established as the potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics. A series of tetrahydrobenzothiophene derivatives was synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material ethyl-2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate(1) was synthesized via a multicomponent condensation between sulphur, cyclohexanone and ethylcyanoacetate adopting Gewald Reaction. The Compound 1 was converted into respective Schiff bases (RBA1- RBA4) by refluxing it with various aromatic aldehydes in dioxane for 15 hours. The Schiff bases were further processed into the final compounds i.e. thiazolidinone derivatives (RSB1- RSB4) by treating them with thioglycollic acid in presence of anhydrous ZnCl2 in DMF and refluxing the reaction mixture for 4- 5 hours. Synthesized compounds were purified, characterized a...

European Chemical Bulletin, 2016

Thiophene, a five membered heterocycle is considered as biologically important dynamic scaffold t... more Thiophene, a five membered heterocycle is considered as biologically important dynamic scaffold that holds wide range of biological activities. The fruitful application of Cephoxitin as antimicrobial, Thenaldine as anti inflammatory, Ralitrexed as anticancer and Erdosteine as antioxidant proved the potential of thiophene moiety. Diverse biological response profile has pulled in consideration of many researchers to investigate this heterocycle to its multiple potential against several activities. This review is complementary to previous reviews and focuses to review the work reported on antimicrobial activities of thiophene derivatives.

American-Eurasian Journal of Toxicological Sciences, 2015

Myocardial infarction is the leading cause of congestive heart failure and death in most develope... more Myocardial infarction is the leading cause of congestive heart failure and death in most developed and developing countries. This review focuses on novel treatment methods like stem cell therapy and nutritional factors projecting towards treatment of acute myocardial infarction. Stem cell therapy for conditions characterized by myocyte loss in myocardial infarction and heart failure is intuitively appealing. Stem cell therapy, initially introduced as a novel approach to regenerate injured cardiac myocytes, has now been widely gaining popularity as a feasible strategy for repairing injured myocardial muscle tissue. In certain cases inefficient cellular metabolism and blood borne nutrients is important factor in determining whether cardiac pathology will develop or not. Metabolic dysfunction could result from intracellular deficiencies of magnesium, coenzyme Q 10 , carnitine and certain B vitamins, nutrients which play a role in synthesis of ATP. Nutritional treatment is potentially e...

Current Materials Science, 2022

Background: Localized drug delivery to the respiratory system has become an increasingly successf... more Background: Localized drug delivery to the respiratory system has become an increasingly successful and essential treatment strategy for several pulmonary diseases, including asthma, chronic abstractive disease, pneumonia, bronchitis, and cystic fibrosis. The rising incidence of respiratory diseases is a significant factor driving the worldwide market for respiratory inhaler devices. Objective: The objective of this article is to present various aspects of pharmaceutical aerosols, including their types, components, fundamentals, in-process and finished product quality control tests based on pharmacopeial standards and specifications, and commercial utility considering the pharmaceutical aerosol dosage forms that have been patented from 2000 to 2020, along with a list of marketed pharmaceutical products. Method: Aerosol, collectively referred to as a pressurized device, operates by triggering an appropriate valve system with a continuous or metered dosage of tiny mist spray. It is us...

Mini-Reviews in Medicinal Chemistry, 2021

: The field of Free Radical Chemistry has gained considerable interest in the current scenario. T... more : The field of Free Radical Chemistry has gained considerable interest in the current scenario. The formation of free radicals is attributable to different physiochemical factors, radiation exposure, pathological conditions, environmental contaminants, and as by-products of metabolized drugs. The concentration of free radicals is regulated strongly under normal conditions by physiological antioxidants. Free radicals may cause oxidative damage to proteins, lipids, sugars, and DNA when abundantly produced or when antioxidants are depleted. This imbalance of reduction-oxidation, referred to as oxidative stress, can change the body's physiological conditions and ultimately lead to tissue injury, further contributing to various disease pathologies. A proper balance between free radicals and antioxidants is required for an effective physiological process. The oxidation mechanism is chemically hindered by antioxidants; these are often called free radical scavengers. The application of an external antioxidant source is crucial in addressing the issue of oxidative stress. Plenty of naturally occurring, semi-synthetic, and synthetic antioxidants are used, and the search for an efficient, non-toxic, and safe antioxidant is stepped up over time. As an influential scaffold, thiophene and its derivatives have become a significant source of interest for researchers due to its substantial variety of biological activities. The versatility of thiophene moiety has been identified by an affluent unveiling of its derivatives with anti-inflammatory, antioxidant, anti-cancer, and antimicrobial behaviors. Thiophene activity has been influenced greatly by the nature and orientation of the substitutions. The current study aims at addressing various synthetic compounds with thiophene or condensed thiophene as a fundamental moiety or substituent as radical scavengers.

Journal of Heterocyclic Chemistry, 2020

Due to its appreciable diversity in biological actions, thiazole and its substituted components, ... more Due to its appreciable diversity in biological actions, thiazole and its substituted components, a significant class of heterocyclic compounds has developed as an influential scaffold in the field of chemical sciences. The variability of thiazole core has been expressed through the effective instigation of its anticancer (Dasatinib, Tiazofurin), antiretroviral (Ritonavir, Brecanavir), antimicrobial (Sulfathiazole, Ravuconazole) and anti-inflammatory (Fenclozic acid, Meloxicam) derivatives. This reasonable diversity in the physiological reaction pattern led many scientists to refine and develop new structural alternatives with much more efficient pharmacological action. This review is crucial for previous studies and projects to survey the antimicrobial activity of thiazole and thiazole related compounds to the mid of 2019.

Mini-Reviews in Medicinal Chemistry, 2020

Cancer is the world's second-largest cause of mortality and one of the biggest global health ... more Cancer is the world's second-largest cause of mortality and one of the biggest global health concerns. The prevalence and mortality rates of cancer remain high despite significant progress in cancer therapy. The search for more effective, as well as less toxic treatment methods for cancer, is at the focus of current studies. Thiophene and its derivatives have surged as an influential scaffold, which, because of their appreciable diversity in biological activities, has drawn the concerned interest of the researchers in the field of medicinal chemistry. By the affluent introduction of its derivatives, which have antioxidant, anti-inflammatory, antimicrobial, and anticancer activities, the adaptability of the thiophene moiety has been displayed. The nature and positioning of the substitutions significantly impacted thiophene moiety activity. This decent array in the living response account about this moiety has picked plentiful researcher’s consideration to inquire about it to its ...