RATNA ROY - Academia.edu (original) (raw)

Papers by RATNA ROY

International Journal of Pharmaceutical Sciences Review and Research, 2021

The infection that causes COVID-19 may be a pathogen referred to as severe acute respiratory synd... more The infection that causes COVID-19 may be a pathogen referred to as severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and is believed to possess originated from China's Wuhan Province. The rapid spread of coronavirus disease 2019 (COVID-19) has become a worldwide concern, with the planet Health Organization (WHO) declaring it an epidemic on March, 2020. To enter the cells, SARS-CoV-2 S requires angiotensin-converting enzyme 2 (ACE2). Many existing vaccines have drawbacks like insufficient system stimulation, in vivo instability, high toxicity, the need for a chilly chain, and multiple administration. A nanotechnology is an efficient tool for addressing these issues. A successful vaccine against SARS-CoV-2 infection is predicted to stimulate innate and adaptive immune responses and protects against severe sorts of coronavirus disease 2019 (COVID-19). Different strategies are introduced because the go after an efficient and safe vaccination has begun. Currently, the fore...

Structural Chemistry, 2022

The Ebola virus is a deadly pathogen that causes a highly lethal hemorrhagic fever illness in hum... more The Ebola virus is a deadly pathogen that causes a highly lethal hemorrhagic fever illness in humans, sometimes known as Ebola virus sickness (EVD). The Ebola virus polymerase cofactor VP35 acts by preventing the establishment of a cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor required for the induction of interferons alpha and beta, thus making it an appealing therapeutic target because there are currently not many available and effective therapeutic agents available against this virus. This study presented a molecular docking–based virtual screening (VS) of 10,829 compounds acquired from multiple databases against the VP35 receptor using Auto Dock Vina software to discover potential inhibitors. According to the results of the screening, the top two drugs, irinotecan and fexofenadine, exhibited a high affinity for the VP35 binding region. Their binding affinities were −8.2 and −8.0 kJ/mol, indicating that they were tightly bound to the target receptor. These results outperformed those obtained with the co-crystallized ligand, which exhibited a binding affinity of −6.8 kJ/mol. As a result of the VS and molecular docking techniques, novel VP35 inhibitors from diverse databases were discovered using the Lipinski rule of five and functional molecular interactions with the target protein, as proven by the findings of this work. The findings suggest that the compounds discovered may offer viable avenues for the development of Ebola virus VP35 inhibitors and that they need further evaluation and investigation.

In the realm of global business environment and particularly in the sphere of corporate finance, ... more In the realm of global business environment and particularly in the sphere of corporate finance, India has entered a new phase in which Indian corporate sectors are playing pivotal role both domestically as well as internationally. In order to keep pace with the rhythm of global finance the need for adopting dynamic financial policies and corporate practices have emerged. The introduction of Mergers and Acquisitions (M&A) in India has got due importance as a mechanism of financial restructuring which is an important part of corporate restructuring. Corporate restructuring involves the reorganization and rearrangement of corporate affairs by the will of corporate executives to make the competition benign and to reduce business risk under fierce competitive environment. One of the modes of expanding size is merger In the present paper an attempt has been made to analyze the financial performance of selected Indian company through traditional and modern financial methods to determine w...

In the realm of global business environment and particularly in the sphere of corporate finance, ... more In the realm of global business environment and particularly in the sphere of corporate finance, India has entered a new phase in which Indian corporate sectors are playing pivotal role both domestically as well as internationally. In order to keep pace with the rhythm of global finance the need for adopting dynamic financial policies and corporate practices has been emerged. The introduction of Mergers and Acquisitions (M&A) in India has got due importance as a mechanism of financial restructuring which is an important part of corporate restructuring. Corporate restructuring involves the reorganization and rearrangement of corporate affairs by the will of corporate executives, eliminate the competition and to reduce business risk under fierce competitive environment. One of the modes of expanding size is merger. In the present paper an attempt has been made to analyze the financial performance of select Indian companies through traditional and modern financial methods to determine ...

International Journal of Applied Pharmaceutics, 2022

Objective: This study was aimed to analyze the inhibitory effect of the drugs used in nanocarrier... more Objective: This study was aimed to analyze the inhibitory effect of the drugs used in nanocarrier as well as nanoparticles formulation based drug delivery system selected from PubChem database literature against 3CLpro (3C-like protease) receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by implementing several in silico analysis techniques. Methods: This paper detailed a molecular docking-based virtual screening of 5240 compounds previously utilized in nanoparticle and nanocarrier drug delivery systems utilizing AutoDock Vina software on 3CL protease to discover potential inhibitors using a molecular docking technique. Results: According to the results of the screening, the top two compounds, PubChem Id 58823276 and PubChem Id 60838 exhibited a high affinity for the 3CL protease binding region. Their binding affinities were-9.6 and-8.5 kJ/mol, indicating that they were tightly bound to the target receptor, respectively. These results outperformed those obtaine...

Water is an essential commodity of life. Low rainfall in consecutive years results in scarcity of... more Water is an essential commodity of life. Low rainfall in consecutive years results in scarcity of water.As the surface water source is limited, we have to depend on ground water for everyday need. With the increasing need for water the number of tubewells and borewells are also increasing. Although the external pollution in groundwater is less than surfacewater, but the chances of fluoride concentration is more.Ground water usually contain fluoride ion dissolved from geological formation.

Fresh Water bodies constitute a very small total area of earth or even of land surface and an ext... more Fresh Water bodies constitute a very small total area of earth or even of land surface and an external small fraction of the total water but from the view point of human use these are among the most important natural water resources. Man uses water for many purposes. For domestic purpose, we prefer to use soft water. However several statistical studies have demonstrated a highly significant inverse relationship between cardiovascular disease mortality and water hardness even when other environmental and socioeconomic factors are taken into account. Pure water is poor conductor of electricity but when electrolytes in form of mineral dissolves, it imparts conductivity. Higher the concentration of ions, more is its electrical conductance (i.e. lesser the resistance) The total hardness of water is the sum of the concentration of alkaline earth metal cations present in it. Calcium and magnesium is found in all natural water and its source lies in the rocks from which it is leached. Its c...

Water found in nature is not pure in the chemical sense, but natural water are not regarded as po... more Water found in nature is not pure in the chemical sense, but natural water are not regarded as polluted. Impurities in traces are universal for water. We get concerned only when its physical, chemical or biological characteristic deteriorate and becomes harmful to man. The causes of chemical pollution are of numerous types one of which is toxic metal ion. Under present investigation the cause, analysis, and impact of Arsenic pollution on human life is being observed. In traces Arsenic is found everywhere and it enters the environment from natural and manmade sources. There is continuous cycling of Arsenic through the air, oceans and land all the time. Arsenic enters the living world in the body of plants and animals from the soil and water, and is released through combustion, decomposition and volatilisation. It is used in alloys, pesticides, wood preservatives and some medical preparations. It was formerly used in paint pigments but this use discontinued, when it was found that und...

The first evidence of dance in Orissa dates to the 2nd century BC, in the iconographical represen... more The first evidence of dance in Orissa dates to the 2nd century BC, in the iconographical representation of a female dancer with four female musicians. The panels are situated in the Rani Gumpha cave in Bhubaneswar, in what scholar and theatre director, Sri Dhiren Dash, proved was a Sanskrit theatre venue. Since the 10th century AD, the dance has been performed by female temple dancers (Maharis) in Orissa, particularly in the temple of Lord Jagannatha. Around the 15th century AD, the gotipua tradition was born, with young boys impersonating females. Both traditions of dance continued in Orissa during Muslim rule in India, although the former went underground several times due to Muslim attacks on the temple. During British colonial rule, both styles debilitated due to lack of patronage, attack on the Mahari institution by nationalists and Brahmin patriarchy, and proselytizing by Christian missionaries. The dance style was reconstructed in the 50’s and 60’s of the 20thcentury by a gro...

Groundwater is the water that exists below the land surface and fills the spaces between sediment... more Groundwater is the water that exists below the land surface and fills the spaces between sediment grains and fractures in rocks. A geologic formation saturated with ground water is considered to be an aquifer if it is sufficiently permeable as to allow the groundwater to be economically extracted. It is replenished naturally through the infiltration of rainfall and artificially through the irrigation of crops. Soluble chemicals in rain water (like NO in acid rain or at the land surface like pesticides) can be transported downward with percolating water to reach ground water. Any addition of undesirable substance is to groundwater caused by human activities is considered to be contamination. Groundwater contaminants come from two categories of sources, point sources and distributed or non point sources. Landfills, leaking gasoline storage tanks, leaking septic tank and accidental spills are examples of point sources. Infiltration from farm land treated with pesticides and fertilizers...

International Journal of Advanced Research in Chemical Science, 2015

Ground water is the water located beneath the ground, or surface, in soil pore spaces and in the ... more Ground water is the water located beneath the ground, or surface, in soil pore spaces and in the fractures of rock formation, constitute about 95% of the fresh water on our planet 1 . It is a replenishable but finite resources. It often provides water supply that is more reliable in quantity and more stable in quality than the surface water 3 and thus it has economic and operational advantages due to reduced treatment requirement. But nowadays due to over exploitation of ground water led to decline of these resources, the water table is going down deeper & deeper. More over excessive use of fertilizers and pesticides in agriculture added by improper disposal of urban / industrial waste can cause contamination of ground water resources. Inorganic contaminant including salinity chloride, fluoride, nitrate, iron and some other metals are important in determining the suitability of ground water for drinking purposes. High incidence of the constituents such as fluoride, Manganese, and ir...

Groundwater is a fundamental segment of the Earth’s water resources, about 25% of the planet’... more Groundwater is a fundamental segment of the Earth’s water resources, about 25% of the planet’s overall fresh water supply, while surface water stored in rivers, lakes and soil moisture accounts for less than 1%. Groundwater and surface water are often closely interconnected, so when surface water becomes polluted, groundwater can become contaminated as well. Water is the basis of the life of all living beings. With the development of modern human civilization, the problem of water pollution has become a serious issue. There is a growing trend of industrialization and urbanization. The villages are fast being transformed into cities and urban clusters with the establishment of various industries in and around, leading to over-exploitation and contamination of water resources. Initially, when various technologies were not developed, the people used to live in the lap of the nature, but with the fast paced development and emergence of industrialization, water pollution has assumed ...

International Journal of Pharmaceutical Sciences Review and Research, 2021

The infection that causes COVID-19 may be a pathogen referred to as severe acute respiratory synd... more The infection that causes COVID-19 may be a pathogen referred to as severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and is believed to possess originated from China's Wuhan Province. The rapid spread of coronavirus disease 2019 (COVID-19) has become a worldwide concern, with the planet Health Organization (WHO) declaring it an epidemic on March, 2020. To enter the cells, SARS-CoV-2 S requires angiotensin-converting enzyme 2 (ACE2). Many existing vaccines have drawbacks like insufficient system stimulation, in vivo instability, high toxicity, the need for a chilly chain, and multiple administration. A nanotechnology is an efficient tool for addressing these issues. A successful vaccine against SARS-CoV-2 infection is predicted to stimulate innate and adaptive immune responses and protects against severe sorts of coronavirus disease 2019 (COVID-19). Different strategies are introduced because the go after an efficient and safe vaccination has begun. Currently, the fore...

Structural Chemistry, 2022

The Ebola virus is a deadly pathogen that causes a highly lethal hemorrhagic fever illness in hum... more The Ebola virus is a deadly pathogen that causes a highly lethal hemorrhagic fever illness in humans, sometimes known as Ebola virus sickness (EVD). The Ebola virus polymerase cofactor VP35 acts by preventing the establishment of a cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor required for the induction of interferons alpha and beta, thus making it an appealing therapeutic target because there are currently not many available and effective therapeutic agents available against this virus. This study presented a molecular docking–based virtual screening (VS) of 10,829 compounds acquired from multiple databases against the VP35 receptor using Auto Dock Vina software to discover potential inhibitors. According to the results of the screening, the top two drugs, irinotecan and fexofenadine, exhibited a high affinity for the VP35 binding region. Their binding affinities were −8.2 and −8.0 kJ/mol, indicating that they were tightly bound to the target receptor. These results outperformed those obtained with the co-crystallized ligand, which exhibited a binding affinity of −6.8 kJ/mol. As a result of the VS and molecular docking techniques, novel VP35 inhibitors from diverse databases were discovered using the Lipinski rule of five and functional molecular interactions with the target protein, as proven by the findings of this work. The findings suggest that the compounds discovered may offer viable avenues for the development of Ebola virus VP35 inhibitors and that they need further evaluation and investigation.

In the realm of global business environment and particularly in the sphere of corporate finance, ... more In the realm of global business environment and particularly in the sphere of corporate finance, India has entered a new phase in which Indian corporate sectors are playing pivotal role both domestically as well as internationally. In order to keep pace with the rhythm of global finance the need for adopting dynamic financial policies and corporate practices have emerged. The introduction of Mergers and Acquisitions (M&A) in India has got due importance as a mechanism of financial restructuring which is an important part of corporate restructuring. Corporate restructuring involves the reorganization and rearrangement of corporate affairs by the will of corporate executives to make the competition benign and to reduce business risk under fierce competitive environment. One of the modes of expanding size is merger In the present paper an attempt has been made to analyze the financial performance of selected Indian company through traditional and modern financial methods to determine w...

In the realm of global business environment and particularly in the sphere of corporate finance, ... more In the realm of global business environment and particularly in the sphere of corporate finance, India has entered a new phase in which Indian corporate sectors are playing pivotal role both domestically as well as internationally. In order to keep pace with the rhythm of global finance the need for adopting dynamic financial policies and corporate practices has been emerged. The introduction of Mergers and Acquisitions (M&A) in India has got due importance as a mechanism of financial restructuring which is an important part of corporate restructuring. Corporate restructuring involves the reorganization and rearrangement of corporate affairs by the will of corporate executives, eliminate the competition and to reduce business risk under fierce competitive environment. One of the modes of expanding size is merger. In the present paper an attempt has been made to analyze the financial performance of select Indian companies through traditional and modern financial methods to determine ...

International Journal of Applied Pharmaceutics, 2022

Objective: This study was aimed to analyze the inhibitory effect of the drugs used in nanocarrier... more Objective: This study was aimed to analyze the inhibitory effect of the drugs used in nanocarrier as well as nanoparticles formulation based drug delivery system selected from PubChem database literature against 3CLpro (3C-like protease) receptor of SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) by implementing several in silico analysis techniques. Methods: This paper detailed a molecular docking-based virtual screening of 5240 compounds previously utilized in nanoparticle and nanocarrier drug delivery systems utilizing AutoDock Vina software on 3CL protease to discover potential inhibitors using a molecular docking technique. Results: According to the results of the screening, the top two compounds, PubChem Id 58823276 and PubChem Id 60838 exhibited a high affinity for the 3CL protease binding region. Their binding affinities were-9.6 and-8.5 kJ/mol, indicating that they were tightly bound to the target receptor, respectively. These results outperformed those obtaine...

Water is an essential commodity of life. Low rainfall in consecutive years results in scarcity of... more Water is an essential commodity of life. Low rainfall in consecutive years results in scarcity of water.As the surface water source is limited, we have to depend on ground water for everyday need. With the increasing need for water the number of tubewells and borewells are also increasing. Although the external pollution in groundwater is less than surfacewater, but the chances of fluoride concentration is more.Ground water usually contain fluoride ion dissolved from geological formation.

Fresh Water bodies constitute a very small total area of earth or even of land surface and an ext... more Fresh Water bodies constitute a very small total area of earth or even of land surface and an external small fraction of the total water but from the view point of human use these are among the most important natural water resources. Man uses water for many purposes. For domestic purpose, we prefer to use soft water. However several statistical studies have demonstrated a highly significant inverse relationship between cardiovascular disease mortality and water hardness even when other environmental and socioeconomic factors are taken into account. Pure water is poor conductor of electricity but when electrolytes in form of mineral dissolves, it imparts conductivity. Higher the concentration of ions, more is its electrical conductance (i.e. lesser the resistance) The total hardness of water is the sum of the concentration of alkaline earth metal cations present in it. Calcium and magnesium is found in all natural water and its source lies in the rocks from which it is leached. Its c...

Water found in nature is not pure in the chemical sense, but natural water are not regarded as po... more Water found in nature is not pure in the chemical sense, but natural water are not regarded as polluted. Impurities in traces are universal for water. We get concerned only when its physical, chemical or biological characteristic deteriorate and becomes harmful to man. The causes of chemical pollution are of numerous types one of which is toxic metal ion. Under present investigation the cause, analysis, and impact of Arsenic pollution on human life is being observed. In traces Arsenic is found everywhere and it enters the environment from natural and manmade sources. There is continuous cycling of Arsenic through the air, oceans and land all the time. Arsenic enters the living world in the body of plants and animals from the soil and water, and is released through combustion, decomposition and volatilisation. It is used in alloys, pesticides, wood preservatives and some medical preparations. It was formerly used in paint pigments but this use discontinued, when it was found that und...

The first evidence of dance in Orissa dates to the 2nd century BC, in the iconographical represen... more The first evidence of dance in Orissa dates to the 2nd century BC, in the iconographical representation of a female dancer with four female musicians. The panels are situated in the Rani Gumpha cave in Bhubaneswar, in what scholar and theatre director, Sri Dhiren Dash, proved was a Sanskrit theatre venue. Since the 10th century AD, the dance has been performed by female temple dancers (Maharis) in Orissa, particularly in the temple of Lord Jagannatha. Around the 15th century AD, the gotipua tradition was born, with young boys impersonating females. Both traditions of dance continued in Orissa during Muslim rule in India, although the former went underground several times due to Muslim attacks on the temple. During British colonial rule, both styles debilitated due to lack of patronage, attack on the Mahari institution by nationalists and Brahmin patriarchy, and proselytizing by Christian missionaries. The dance style was reconstructed in the 50’s and 60’s of the 20thcentury by a gro...

Groundwater is the water that exists below the land surface and fills the spaces between sediment... more Groundwater is the water that exists below the land surface and fills the spaces between sediment grains and fractures in rocks. A geologic formation saturated with ground water is considered to be an aquifer if it is sufficiently permeable as to allow the groundwater to be economically extracted. It is replenished naturally through the infiltration of rainfall and artificially through the irrigation of crops. Soluble chemicals in rain water (like NO in acid rain or at the land surface like pesticides) can be transported downward with percolating water to reach ground water. Any addition of undesirable substance is to groundwater caused by human activities is considered to be contamination. Groundwater contaminants come from two categories of sources, point sources and distributed or non point sources. Landfills, leaking gasoline storage tanks, leaking septic tank and accidental spills are examples of point sources. Infiltration from farm land treated with pesticides and fertilizers...

International Journal of Advanced Research in Chemical Science, 2015

Ground water is the water located beneath the ground, or surface, in soil pore spaces and in the ... more Ground water is the water located beneath the ground, or surface, in soil pore spaces and in the fractures of rock formation, constitute about 95% of the fresh water on our planet 1 . It is a replenishable but finite resources. It often provides water supply that is more reliable in quantity and more stable in quality than the surface water 3 and thus it has economic and operational advantages due to reduced treatment requirement. But nowadays due to over exploitation of ground water led to decline of these resources, the water table is going down deeper & deeper. More over excessive use of fertilizers and pesticides in agriculture added by improper disposal of urban / industrial waste can cause contamination of ground water resources. Inorganic contaminant including salinity chloride, fluoride, nitrate, iron and some other metals are important in determining the suitability of ground water for drinking purposes. High incidence of the constituents such as fluoride, Manganese, and ir...

Groundwater is a fundamental segment of the Earth’s water resources, about 25% of the planet’... more Groundwater is a fundamental segment of the Earth’s water resources, about 25% of the planet’s overall fresh water supply, while surface water stored in rivers, lakes and soil moisture accounts for less than 1%. Groundwater and surface water are often closely interconnected, so when surface water becomes polluted, groundwater can become contaminated as well. Water is the basis of the life of all living beings. With the development of modern human civilization, the problem of water pollution has become a serious issue. There is a growing trend of industrialization and urbanization. The villages are fast being transformed into cities and urban clusters with the establishment of various industries in and around, leading to over-exploitation and contamination of water resources. Initially, when various technologies were not developed, the people used to live in the lap of the nature, but with the fast paced development and emergence of industrialization, water pollution has assumed ...