R. Aitken - Academia.edu (original) (raw)

Papers by R. Aitken

Research paper thumbnail of Who solves the variability problem?

Proceedings of the 47th Design Automation Conference on - DAC '10, 2010

... Jamil Kawa (Moderator) Synopsys Mountain View, CA, USA ... will bring the diverse views from ... more ... Jamil Kawa (Moderator) Synopsys Mountain View, CA, USA ... will bring the diverse views from academia, foundries, fabless and IDM communities to address various topics on next generation solutions for variability, with the main emphasis on design and architecture solutions. ...

Research paper thumbnail of Does Failure Analysis and Silicon Debug Research Need to be Redirected?

Research paper thumbnail of Working safely with nanomaterials in research & development

Research paper thumbnail of Assembly and Secretion of Oligomeric Toxins

Microbial Surface Components and Toxins in Relation to Pathogenesis, 1991

Research paper thumbnail of Test Roles in Diagnosis and Silicon Debug

16th Asian Test Symposium (ATS 2007), 2007

Abstract Test catches defective parts. Traditional DFT makes test-related activities more cost ef... more Abstract Test catches defective parts. Traditional DFT makes test-related activities more cost effective. Debug and diagnosis discovers why a design or part did not work. Yield relates to how many good parts can be shipped thus how many dollars can be received. As one ...

Research paper thumbnail of Modeling the impact of process variation on resistive bridge defects

2010 IEEE International Test Conference, 2010

Recent research has shown that tests generated without taking process variation into account may ... more Recent research has shown that tests generated without taking process variation into account may lead to loss of test quality. At present there is no efficient device-level modeling technique that models the effect of process variation on resistive bridges. This paper presents a fast and accurate technique to model the effect of process variation on resistive bridge defects. The proposed model is implemented in two stages: firstly, it employs an accurate transistor model (BSIM4) to calculate the critical resistance of a bridge; secondly, the effect of process variation is incorporated in this model by using three transistor parameters: gate length (L), threshold voltage (V ℎ ) and effective mobility ( ), where each follow Gaussian distribution. Experiments are conducted on a 65-nm gate library (for illustration purposes), and results show that on average the proposed modeling technique is more than 7 times faster and in the worst case, error in bridge critical resistance is 0.8% when compared with HSPICE.

Research paper thumbnail of Discussion. The Manora Breakwater, Kurrachee

Minutes of the Proceedings, 1876

Research paper thumbnail of Recombinant enterotoxins as vaccines against Escherichia coli-mediated diarrhoea

Vaccine, 1993

A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the pr... more A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability to bind to GM1 ganglioside. Native toxin epitopes are displayed and the molecule can be easily purified from periplasmic extracts of cells expressing the gene fusion. Although the protein carries the natural sequence of the heat-stable enterotoxin, it is greatly attenuated in toxicity. Systemic immunization of mice or oral administration of the fusion elicits antibody responses against both classes of E. coli enterotoxin.

Research paper thumbnail of The effect of timing of laparoscopic insemination in superovulated ewes, with or without sedation, on the recovery of embryos, their stage of develpoment and subsequent viability

Theriogenology, 1991

Twenty ewes were used as donors in a 2 x 2 factorial design experiment to investigate the effects... more Twenty ewes were used as donors in a 2 x 2 factorial design experiment to investigate the effects of two different insemination times (48 vs 60 h after pessary withdrawal), with or without sedation, on the ovum recovery rate 5 d after insemination, the proportion of transferable embryos recovered, and the subsequent survival rate of embryos transferred to recipients. The ovum recovery rate following intrauterine insemination at 48 h after progestagen pessary withdrawal was 63.8 and 53.4% for sedated and nonsedated control ewes, respectively. Following intrauterine insemination at 60 h the corresponding values for sedated and control ewes were 72.6 and 73.9%, respectively. The proportion of transferable quality embryos recovered was not affected by sedation but was improved by insemination at 48 h rather than 60 h after pessary withdrawal (100 vs 35.4%). Embryo survival following laparoscopic transfer to recipients from donor ewes inseminated at 48 h, with or without sedation was 38.8% (7/18) and 50% (7/14), respectively. Following intrauterine insemination of the donors at 60 h, the survival rate in recipients was reduced for embryos transferred from both the sedated and control ewes to 6.25% (1/16) and 36.3% (4/11). It is concluded that delaying the timing of intrauterine insemination relative to pessary withdrawal and the use of acepromazine maleate as a sedative at the time of insemination are deleterious to embryo development and subsequent viability.

Research paper thumbnail of Mark Aagaard

Springer

JOURNAL OF ELECTRONIC TESTING: Theory and Applications ... Mark Aagaard University of Waterloo M.... more JOURNAL OF ELECTRONIC TESTING: Theory and Applications ... Mark Aagaard University of Waterloo M. Abadir Motorola Rob Aitken Artisan Components H. Al-Asaad University of California Bashir Al-Hashimi University of Southhampton ME Amyeen Purdue University Lorena ...

Research paper thumbnail of Jaume Abella Barcelona Supercomputing Center ES El Mostapha Aboulhamid University of Montreal CA Antonio J Acosta-Jimenez University of Seville/IMSE ES Andrea Acquaviva Politecnico di Torino IT

Research paper thumbnail of Dennis Conti Bruce Cory Bernard Courtois Alfred Crouch Fa Dai

... Michael Hsiao Leendert M. Huisman Andé Ivanov Abhijit Jas Artur Jutman Seiji Kajihara Bozena ... more ... Michael Hsiao Leendert M. Huisman Andé Ivanov Abhijit Jas Artur Jutman Seiji Kajihara Bozena Kaminska Rohit Kapur David C ... TM Mak Rafic Makki Yiorgos Makris Sharad Malik Hans Manhaeve Erik Jan Marinissen Peter Maxwell Edward Mccluskey Cecilia Metra Linda Milor ...

Research paper thumbnail of The discrepancy between the uniform and variability aware atomistic TCAD simulations of decananometer bulk MOSFETs and FinFETs

2014 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD), 2014

Research paper thumbnail of Identification of exposed components on the surface of adult Schistosoma mansoni by lactoperoxidase-catalysed iodination

Molecular and biochemical parasitology, 1983

Adult schistosomes have been labelled with 125I using the lactoperoxidase-catalysed technique mod... more Adult schistosomes have been labelled with 125I using the lactoperoxidase-catalysed technique modified to cause minimal worm damage. After surface membrane removal and characterization, at least 13 labelled proteins were identified together with a large amount of labelled glycolipids, free fatty acids and phospholipids, especially phosphatidyl ethanolamine. Cationised ferritin has been used to stimulate surface membrane turnover of iodinated worms and the shedding of covalently bound 125I-counts used as an index of turnover. Finally worms have been iodinated before and after stimulation of membrane turnover in chemically defined media and the patterns of labelled proteins were compared.

Research paper thumbnail of Significance of reactive oxygen species and antioxidants in defining the efficacy of sperm preparation techniques

Journal of andrology

The mechanisms responsible for mediating the influence of sperm preparation protocols on human sp... more The mechanisms responsible for mediating the influence of sperm preparation protocols on human sperm function have been investigated. Techniques that involved the separation of motile spermatozoa prior to centrifugation were found to yield sperm suspensions of highest quality. If the spermatozoa were centrifuged prior to isolation of the motile cells, sperm function was impaired. The detrimental effects of centrifugation were associated with a sudden burst of reactive oxygen species production by a discrete subpopulation of cells (characterized by significantly diminished motility and fertilizing capacity) that could be separated from normal functional spermatozoa on Percoll gradients. If unfractionated sperm suspensions were subjected to centrifugation, the reactive oxygen species generated by this subpopulation impaired the functional competence of normal spermatozoa in the same suspension. Assessment of the ability of the antioxidants, butylated hydroxytoluene, and vitamin E, to ...

Research paper thumbnail of Device and technology implications of the Internet of Things

2014 Symposium on VLSI Technology (VLSI-Technology): Digest of Technical Papers, 2014

Research paper thumbnail of A scoping study into the manufacture and use of nanomaterials in the UK

Research paper thumbnail of Ttep 2004

Research paper thumbnail of Food Additives and Contaminants-Part A Chemistry

Research paper thumbnail of 2014 Index IEEE Journal on Emerging and Selected Topics in Circuits and Systems Vol. 4

Research paper thumbnail of Who solves the variability problem?

Proceedings of the 47th Design Automation Conference on - DAC '10, 2010

... Jamil Kawa (Moderator) Synopsys Mountain View, CA, USA ... will bring the diverse views from ... more ... Jamil Kawa (Moderator) Synopsys Mountain View, CA, USA ... will bring the diverse views from academia, foundries, fabless and IDM communities to address various topics on next generation solutions for variability, with the main emphasis on design and architecture solutions. ...

Research paper thumbnail of Does Failure Analysis and Silicon Debug Research Need to be Redirected?

Research paper thumbnail of Working safely with nanomaterials in research & development

Research paper thumbnail of Assembly and Secretion of Oligomeric Toxins

Microbial Surface Components and Toxins in Relation to Pathogenesis, 1991

Research paper thumbnail of Test Roles in Diagnosis and Silicon Debug

16th Asian Test Symposium (ATS 2007), 2007

Abstract Test catches defective parts. Traditional DFT makes test-related activities more cost ef... more Abstract Test catches defective parts. Traditional DFT makes test-related activities more cost effective. Debug and diagnosis discovers why a design or part did not work. Yield relates to how many good parts can be shipped thus how many dollars can be received. As one ...

Research paper thumbnail of Modeling the impact of process variation on resistive bridge defects

2010 IEEE International Test Conference, 2010

Recent research has shown that tests generated without taking process variation into account may ... more Recent research has shown that tests generated without taking process variation into account may lead to loss of test quality. At present there is no efficient device-level modeling technique that models the effect of process variation on resistive bridges. This paper presents a fast and accurate technique to model the effect of process variation on resistive bridge defects. The proposed model is implemented in two stages: firstly, it employs an accurate transistor model (BSIM4) to calculate the critical resistance of a bridge; secondly, the effect of process variation is incorporated in this model by using three transistor parameters: gate length (L), threshold voltage (V ℎ ) and effective mobility ( ), where each follow Gaussian distribution. Experiments are conducted on a 65-nm gate library (for illustration purposes), and results show that on average the proposed modeling technique is more than 7 times faster and in the worst case, error in bridge critical resistance is 0.8% when compared with HSPICE.

Research paper thumbnail of Discussion. The Manora Breakwater, Kurrachee

Minutes of the Proceedings, 1876

Research paper thumbnail of Recombinant enterotoxins as vaccines against Escherichia coli-mediated diarrhoea

Vaccine, 1993

A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the pr... more A fusion protein, comprising the B subunit of the heat-labile enterotoxin and a portion of the precursor to the heat-stable enterotoxin of Escherichia coli, has been created by recombinant genetic techniques. It is exported successfully to the bacterial periplasm and assembles into pentamers which retain the ability to bind to GM1 ganglioside. Native toxin epitopes are displayed and the molecule can be easily purified from periplasmic extracts of cells expressing the gene fusion. Although the protein carries the natural sequence of the heat-stable enterotoxin, it is greatly attenuated in toxicity. Systemic immunization of mice or oral administration of the fusion elicits antibody responses against both classes of E. coli enterotoxin.

Research paper thumbnail of The effect of timing of laparoscopic insemination in superovulated ewes, with or without sedation, on the recovery of embryos, their stage of develpoment and subsequent viability

Theriogenology, 1991

Twenty ewes were used as donors in a 2 x 2 factorial design experiment to investigate the effects... more Twenty ewes were used as donors in a 2 x 2 factorial design experiment to investigate the effects of two different insemination times (48 vs 60 h after pessary withdrawal), with or without sedation, on the ovum recovery rate 5 d after insemination, the proportion of transferable embryos recovered, and the subsequent survival rate of embryos transferred to recipients. The ovum recovery rate following intrauterine insemination at 48 h after progestagen pessary withdrawal was 63.8 and 53.4% for sedated and nonsedated control ewes, respectively. Following intrauterine insemination at 60 h the corresponding values for sedated and control ewes were 72.6 and 73.9%, respectively. The proportion of transferable quality embryos recovered was not affected by sedation but was improved by insemination at 48 h rather than 60 h after pessary withdrawal (100 vs 35.4%). Embryo survival following laparoscopic transfer to recipients from donor ewes inseminated at 48 h, with or without sedation was 38.8% (7/18) and 50% (7/14), respectively. Following intrauterine insemination of the donors at 60 h, the survival rate in recipients was reduced for embryos transferred from both the sedated and control ewes to 6.25% (1/16) and 36.3% (4/11). It is concluded that delaying the timing of intrauterine insemination relative to pessary withdrawal and the use of acepromazine maleate as a sedative at the time of insemination are deleterious to embryo development and subsequent viability.

Research paper thumbnail of Mark Aagaard

Springer

JOURNAL OF ELECTRONIC TESTING: Theory and Applications ... Mark Aagaard University of Waterloo M.... more JOURNAL OF ELECTRONIC TESTING: Theory and Applications ... Mark Aagaard University of Waterloo M. Abadir Motorola Rob Aitken Artisan Components H. Al-Asaad University of California Bashir Al-Hashimi University of Southhampton ME Amyeen Purdue University Lorena ...

Research paper thumbnail of Jaume Abella Barcelona Supercomputing Center ES El Mostapha Aboulhamid University of Montreal CA Antonio J Acosta-Jimenez University of Seville/IMSE ES Andrea Acquaviva Politecnico di Torino IT

Research paper thumbnail of Dennis Conti Bruce Cory Bernard Courtois Alfred Crouch Fa Dai

... Michael Hsiao Leendert M. Huisman Andé Ivanov Abhijit Jas Artur Jutman Seiji Kajihara Bozena ... more ... Michael Hsiao Leendert M. Huisman Andé Ivanov Abhijit Jas Artur Jutman Seiji Kajihara Bozena Kaminska Rohit Kapur David C ... TM Mak Rafic Makki Yiorgos Makris Sharad Malik Hans Manhaeve Erik Jan Marinissen Peter Maxwell Edward Mccluskey Cecilia Metra Linda Milor ...

Research paper thumbnail of The discrepancy between the uniform and variability aware atomistic TCAD simulations of decananometer bulk MOSFETs and FinFETs

2014 International Conference on Simulation of Semiconductor Processes and Devices (SISPAD), 2014

Research paper thumbnail of Identification of exposed components on the surface of adult Schistosoma mansoni by lactoperoxidase-catalysed iodination

Molecular and biochemical parasitology, 1983

Adult schistosomes have been labelled with 125I using the lactoperoxidase-catalysed technique mod... more Adult schistosomes have been labelled with 125I using the lactoperoxidase-catalysed technique modified to cause minimal worm damage. After surface membrane removal and characterization, at least 13 labelled proteins were identified together with a large amount of labelled glycolipids, free fatty acids and phospholipids, especially phosphatidyl ethanolamine. Cationised ferritin has been used to stimulate surface membrane turnover of iodinated worms and the shedding of covalently bound 125I-counts used as an index of turnover. Finally worms have been iodinated before and after stimulation of membrane turnover in chemically defined media and the patterns of labelled proteins were compared.

Research paper thumbnail of Significance of reactive oxygen species and antioxidants in defining the efficacy of sperm preparation techniques

Journal of andrology

The mechanisms responsible for mediating the influence of sperm preparation protocols on human sp... more The mechanisms responsible for mediating the influence of sperm preparation protocols on human sperm function have been investigated. Techniques that involved the separation of motile spermatozoa prior to centrifugation were found to yield sperm suspensions of highest quality. If the spermatozoa were centrifuged prior to isolation of the motile cells, sperm function was impaired. The detrimental effects of centrifugation were associated with a sudden burst of reactive oxygen species production by a discrete subpopulation of cells (characterized by significantly diminished motility and fertilizing capacity) that could be separated from normal functional spermatozoa on Percoll gradients. If unfractionated sperm suspensions were subjected to centrifugation, the reactive oxygen species generated by this subpopulation impaired the functional competence of normal spermatozoa in the same suspension. Assessment of the ability of the antioxidants, butylated hydroxytoluene, and vitamin E, to ...

Research paper thumbnail of Device and technology implications of the Internet of Things

2014 Symposium on VLSI Technology (VLSI-Technology): Digest of Technical Papers, 2014

Research paper thumbnail of A scoping study into the manufacture and use of nanomaterials in the UK

Research paper thumbnail of Ttep 2004

Research paper thumbnail of Food Additives and Contaminants-Part A Chemistry

Research paper thumbnail of 2014 Index IEEE Journal on Emerging and Selected Topics in Circuits and Systems Vol. 4