Roger Guillard - Academia.edu (original) (raw)
Papers by Roger Guillard
Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe
International Journal of Peptide and Protein Research, 2009
The properties related to non-radiative energy transfer of a number of enkephalin analogues with ... more The properties related to non-radiative energy transfer of a number of enkephalin analogues with tryptophan substituted for phenylalanine in position 4 and n.m.r. 3JNH-C alpha H coupling constants of corresponding [Phe4]-enkephalin analogues are being derived from semi-empirical conformational energy. The molecules considered contain a glycyl, a D-alanyl or an L-alanyl as second residue; two of the compounds are N-methylated at position 4 or 5. The [Trp4]-enkephalin analogues and the corresponding [Phe4]-enkephalin analogues display nearly parallel affinities in the opiate receptor binding assay (Schiller et al. (1). The comparison of computed and experimental properties shows that an ensemble of conformers is a satisfactory representation of the state of these molecules in water.
Archives internationales de physiologie et de biochimie, 1974
Archives internationales de physiologie et de biochimie, 1979
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Polymer Photochemistry, 1984
The use of photosensitive initiators of the polymerization of composite materials used in restora... more The use of photosensitive initiators of the polymerization of composite materials used in restorative dentistry has become widespread. Experimental and theoretical studies of hardening mechanisms as a function of chemical reactions leading to reticulation and of the light dispersion due to mineral fillers have been performed. Experimental profiles derived from our study deviate significantly from the classical Beer-Lambert absorption law. They demonstrated the difIiculty of obtaining an homogeneous hardness of this material in the cured tooth cavity. At the same time, measurements of the distribution of light intensity at the irradiation surface of commercial sources have been performed. Observed heterogeneities can be explained using a computer assisted simulation taking into account the geometrical characteristics of optical fibers. This effect is reduced by the diffusion of light in the reaction vessel.
Macromolecules, 1975
Macromolecules mixture of chloroform and glacial acetic acid (for the swellable resins) or pure g... more Macromolecules mixture of chloroform and glacial acetic acid (for the swellable resins) or pure glacial acetic acid (for the macroreticular resins) and an excess of 50% potassium iodide solution was added. After stirring under nitrogen for 10-30 min, the iodine liberated was titrated with 0.1 N sodium thiosulfate, Blank titrations were carried out on the corresponding 0-COOH resins and corrections were made when required. Epoxidation of Cyclohexene. A suspension of 3 g (2.9 mmol) of macroreticular @-COOOH in 10 ml of purified dioxane containing 0.2 ml (2 mmol) of cyclohexene was stirred at 40' for 6 hr. Analysis of the product was effected by gas chromatography on a column packed with 5% SE-30 liquid phase on Chromosorb W. The absence of a-glycol by-product was shown by titration with sodium metaperiodate. Results of the epoxidation reactions are shown in Table 11.
International Journal of Chemical Kinetics, 1984
The general effect of back energy transfer is to reduce the apparent quenching constant which is ... more The general effect of back energy transfer is to reduce the apparent quenching constant which is an important parameter in the interpretation of energy transfer data. However, this interpretation may be erroneous when possible diffusion effects and the existence of nonuniform configurational distributions are not taken into account. Copyright © 1984 John Wiley & Sons, Inc.
FEBS Letters, 1983
In order to obtain a better understanding of the possible influence of the primary sequence of a ... more In order to obtain a better understanding of the possible influence of the primary sequence of a protein on its folding pathway, renaturation of reduced human milk lysozyme was compared to that of reduced hen egg white lysozyme. Following disulfide bond formation, under identical conditions, similar products were found during the folding of both lysozymes, but the kinetics of appearance and disappearance of these intermediates as well as the appearance of the native conformation were different. Folding Disulfide Kinetic intermediate Human lysozyme Renaturation Hen egg white lysozyme
Dental Materials Journal, 1984
The use of photosensitive initiators of the polymerization of composite materials used in restora... more The use of photosensitive initiators of the polymerization of composite materials used in restorative dentistry has become widespread. Experimental and theoretical studies of hardening mechanisms as a function of chemical reactions leading to polymerization and of the light dispersion due to mineral filler have been performed. Experimental profiles derived from our study deviate significantly from the classical Beer-Lambert absorption law. They demonstrated the difficulty of obtaining an homogeneous hardness of this material in the cured tooth cavity.
Biopolymers, 1976
The properties relevant to nonradiative energy transfer have been computed in the unperturbed cha... more The properties relevant to nonradiative energy transfer have been computed in the unperturbed chain model for oligopeptides composed of from 4 to 21 residues of the formula Tyr-(Ala),,-Tyr and Trp-(X),,-Tyr, X being either Ala o r Gly. A Monte Carlo method has been used for the generation of the chains. The relation between the distribution functions of the distances between the luminophores and the various properties in energy transfer has been examined for chains of different lengths and compositions. The average of the orientation factor K') has been computed as a function of chain length both for molecules in a randomly coiled state and for molecules with backbones in a welldefined three-dimensional structure. The various averaging regimes of energy-transfer efficiency and of fluorescence decay are compared. Theoretical curves relating experimental efficiencies to the mean distance between the luminophores are proposed.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1983
Emission spectroscopy of intramolecular excimer probes allows the determination of 'equivalent vi... more Emission spectroscopy of intramolecular excimer probes allows the determination of 'equivalent viscosity' of membranes. While increasing the pressure on artificial membrane suspensions, variations in viscosityessentially related to an increase in the order parameter in the membranes-are observed. In the case of mixed phospholipids, the effect of pressure is amplified, probably due to the existence of holes on the molecular scale between the two lipidic layers.
Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
SCOPUS: NotDefined.jinfo:eu-repo/semantics/publishe
International Journal of Peptide and Protein Research, 2009
The properties related to non-radiative energy transfer of a number of enkephalin analogues with ... more The properties related to non-radiative energy transfer of a number of enkephalin analogues with tryptophan substituted for phenylalanine in position 4 and n.m.r. 3JNH-C alpha H coupling constants of corresponding [Phe4]-enkephalin analogues are being derived from semi-empirical conformational energy. The molecules considered contain a glycyl, a D-alanyl or an L-alanyl as second residue; two of the compounds are N-methylated at position 4 or 5. The [Trp4]-enkephalin analogues and the corresponding [Phe4]-enkephalin analogues display nearly parallel affinities in the opiate receptor binding assay (Schiller et al. (1). The comparison of computed and experimental properties shows that an ensemble of conformers is a satisfactory representation of the state of these molecules in water.
Archives internationales de physiologie et de biochimie, 1974
Archives internationales de physiologie et de biochimie, 1979
SCOPUS: ar.jinfo:eu-repo/semantics/publishe
Polymer Photochemistry, 1984
The use of photosensitive initiators of the polymerization of composite materials used in restora... more The use of photosensitive initiators of the polymerization of composite materials used in restorative dentistry has become widespread. Experimental and theoretical studies of hardening mechanisms as a function of chemical reactions leading to reticulation and of the light dispersion due to mineral fillers have been performed. Experimental profiles derived from our study deviate significantly from the classical Beer-Lambert absorption law. They demonstrated the difIiculty of obtaining an homogeneous hardness of this material in the cured tooth cavity. At the same time, measurements of the distribution of light intensity at the irradiation surface of commercial sources have been performed. Observed heterogeneities can be explained using a computer assisted simulation taking into account the geometrical characteristics of optical fibers. This effect is reduced by the diffusion of light in the reaction vessel.
Macromolecules, 1975
Macromolecules mixture of chloroform and glacial acetic acid (for the swellable resins) or pure g... more Macromolecules mixture of chloroform and glacial acetic acid (for the swellable resins) or pure glacial acetic acid (for the macroreticular resins) and an excess of 50% potassium iodide solution was added. After stirring under nitrogen for 10-30 min, the iodine liberated was titrated with 0.1 N sodium thiosulfate, Blank titrations were carried out on the corresponding 0-COOH resins and corrections were made when required. Epoxidation of Cyclohexene. A suspension of 3 g (2.9 mmol) of macroreticular @-COOOH in 10 ml of purified dioxane containing 0.2 ml (2 mmol) of cyclohexene was stirred at 40' for 6 hr. Analysis of the product was effected by gas chromatography on a column packed with 5% SE-30 liquid phase on Chromosorb W. The absence of a-glycol by-product was shown by titration with sodium metaperiodate. Results of the epoxidation reactions are shown in Table 11.
International Journal of Chemical Kinetics, 1984
The general effect of back energy transfer is to reduce the apparent quenching constant which is ... more The general effect of back energy transfer is to reduce the apparent quenching constant which is an important parameter in the interpretation of energy transfer data. However, this interpretation may be erroneous when possible diffusion effects and the existence of nonuniform configurational distributions are not taken into account. Copyright © 1984 John Wiley & Sons, Inc.
FEBS Letters, 1983
In order to obtain a better understanding of the possible influence of the primary sequence of a ... more In order to obtain a better understanding of the possible influence of the primary sequence of a protein on its folding pathway, renaturation of reduced human milk lysozyme was compared to that of reduced hen egg white lysozyme. Following disulfide bond formation, under identical conditions, similar products were found during the folding of both lysozymes, but the kinetics of appearance and disappearance of these intermediates as well as the appearance of the native conformation were different. Folding Disulfide Kinetic intermediate Human lysozyme Renaturation Hen egg white lysozyme
Dental Materials Journal, 1984
The use of photosensitive initiators of the polymerization of composite materials used in restora... more The use of photosensitive initiators of the polymerization of composite materials used in restorative dentistry has become widespread. Experimental and theoretical studies of hardening mechanisms as a function of chemical reactions leading to polymerization and of the light dispersion due to mineral filler have been performed. Experimental profiles derived from our study deviate significantly from the classical Beer-Lambert absorption law. They demonstrated the difficulty of obtaining an homogeneous hardness of this material in the cured tooth cavity.
Biopolymers, 1976
The properties relevant to nonradiative energy transfer have been computed in the unperturbed cha... more The properties relevant to nonradiative energy transfer have been computed in the unperturbed chain model for oligopeptides composed of from 4 to 21 residues of the formula Tyr-(Ala),,-Tyr and Trp-(X),,-Tyr, X being either Ala o r Gly. A Monte Carlo method has been used for the generation of the chains. The relation between the distribution functions of the distances between the luminophores and the various properties in energy transfer has been examined for chains of different lengths and compositions. The average of the orientation factor K') has been computed as a function of chain length both for molecules in a randomly coiled state and for molecules with backbones in a welldefined three-dimensional structure. The various averaging regimes of energy-transfer efficiency and of fluorescence decay are compared. Theoretical curves relating experimental efficiencies to the mean distance between the luminophores are proposed.
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1983
Emission spectroscopy of intramolecular excimer probes allows the determination of 'equivalent vi... more Emission spectroscopy of intramolecular excimer probes allows the determination of 'equivalent viscosity' of membranes. While increasing the pressure on artificial membrane suspensions, variations in viscosityessentially related to an increase in the order parameter in the membranes-are observed. In the case of mixed phospholipids, the effect of pressure is amplified, probably due to the existence of holes on the molecular scale between the two lipidic layers.