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Papers by RIMARCS GOMES FERREIRA

Revista Brasileira de Educação Médica, 2022

Factor analysis of the performance at the medical residency exam, progress test and clerkship rot... more Factor analysis of the performance at the medical residency exam, progress test and clerkship rotations performance coefficient Análise fatorial do desempenho no exame de residência médica, teste de progresso e coeficiente de desempenho nos estágios do internato

BV UNIFESP: Teses e dissertaçõe

Jornal Brasileiro de Pneumologia, 2021

Objetivo: Biomarcadores associados à mucina-1, tais como Krebs von den Lungen-6 e carbohydrate an... more Objetivo: Biomarcadores associados à mucina-1, tais como Krebs von den Lungen-6 e carbohydrate antigen (CA, antígeno carboidrato) 15-3, encontram-se aumentados em diversas doenças pulmonares intersticiais. Nosso objetivo foi determinar se CA 15-3 poderia ser considerado um biomarcador de gravidade de doença em pacientes com pneumonite de hipersensibilidade crônica (PHc). Métodos: Estudo prospectivo observacional envolvendo pacientes adultos com PHc. Os níveis séricos de CA 15-3 foram medidos e correlacionados com variáveis relacionadas à gravidade e extensão da doença. As imagens de TCAR foram analisadas quantitativamente utilizando uma plataforma computacional e uma ferramenta de análise de imagem (Computer-Aided Lung Informatics for Pathology Evaluation and Rating). Os níveis de CA 15-3 foram normalizados por transformação logarítmica. Resultados: A amostra foi composta por 41 pacientes. A média de idade dos pacientes foi de 60,1 ± 11,6 anos. A média da CVF em % do previsto foi de 70,3% ± 17,3%, e a mediana do nível sérico de CA 15-3 foi de 48,1 U/ mL. Os níveis de CA 15-3 se correlacionaram inversamente com CVF em % do previsto (r = −0,30; p = 0,05), DLCO em % do previsto (r = −0,54; p < 0,01) e SpO 2 ao final de um teste de degrau de 4 minutos (r = −0,59; p < 0,01), mas se correlacionaram diretamente com a pontuação quantitativa total da TCAR (r = 0,47; p = 0,004), especialmente quanto a opacidades em vidro fosco (r = 0,58; p < 0,001). Conclusões: É provável que o CA 15-3 seja um biomarcador de gravidade de doença em pacientes com PHc, particularmente quanto a anormalidades nas trocas gasosas. Descritores: Antígenos glicosídicos associados a tumores; Alveolite alérgica extrínseca; Biomarcadores; Doenças pulmonares intersticiais.

The American Journal of Tropical Medicine and Hygiene, 1991

A 37-year-old hemophiliac patient with known, asymptomatic human immunodeficiency virus infection... more A 37-year-old hemophiliac patient with known, asymptomatic human immunodeficiency virus infection and chronic Chagas&amp;#39; disease was admitted to the hospital complaining of fever and headache. A computed tomographic scan revealed multiple ring-enhancing lesions in both cerebral hemispheres. No antibodies to Trypanosoma cruzi were found in the cerebrospinal fluid. Treatment for toxoplasmosis of the central nervous system, which was considered the most likely diagnosis, was instituted, but the patient died after progressive neurologic deterioration. An autopsy revealed severe meningoencephalitis caused by T. cruzi.

Phlebology: The Journal of Venous Disease, 2017

Background Sclerotherapy has been gaining increased acceptance and popularity as an effective the... more Background Sclerotherapy has been gaining increased acceptance and popularity as an effective therapy for the treatment of varicose veins. This attention has fed growing interest into the safety and potential complications of this procedure. There is no evidence of pulmonary complications from foam sclerotherapy in humans; however, animal studies have shown possible damage. The aim of this study is to show the changes in rat pulmonary parenchyma after the injection of 1% polidocanol Tessari foam into the peripheral vein using histological analysis of the inflammatory and fibrosis processes. Methods Twenty-four Wistar rats were divided into the following four groups: 24 h polidocanol, seven-day polidocanol, 28-day polidocanol, and control group. After the foam was injected into the lateral saphenous vein, the lungs of the rats were removed for histological analysis. Results Alveolar edema was observed in only the 24 h group (P

Jornal De Pneumologia, 2003

Rev Bras Cir, Dec 1, 1989

Jornal De Pneumologia, 2000

Objective: To evaluate the differences between surgical biopsies of distinct lung lobes in terms ... more Objective: To evaluate the differences between surgical biopsies of distinct lung lobes in terms of the histopathological features of usual interstitial pneumonia, using a semiquantitative score. Methods: We selected all of the patients diagnosed with idiopathic pulmonary fibrosis and submitted to surgical biopsy in two distinct lobes between 1995 and 2005 at the Hospital São Paulo and other hospitals operated

A45. NON-IDIOPATHIC PULMONARY FIBROSIS INTERSTITIAL LUNG DISEASES, 2012

C41. OUTCOMES IN INTERSTITIAL LUNG DISEASE, 2012

The American Journal of the Medical Sciences, 2000

Diffuse panbronchiolitis (DPB) is a unusual form of bronchiolar disease that has been reported al... more Diffuse panbronchiolitis (DPB) is a unusual form of bronchiolar disease that has been reported almost exclusively in Asians. We describe DPB in a non-Asian Brazilian citizen who has never traveled outside the country. The clinical, radiographic, and histologic features of this case resemble those described in Japanese patients. The present case shows that DPB, al

American Journal of Industrial Medicine, 2007

Data on prevalence of lung diseases due to inhalation of carbonaceous materials other than minera... more Data on prevalence of lung diseases due to inhalation of carbonaceous materials other than mineral coal is very limited. We present three cases of wood charcoal pneumoconiosis, two due to activated carbon, and one from wood charcoal artisan handling. To our knowledge, no clinical cases of wood charcoal pneumoconiosis, from artisan handling has been published so far. The three cases had their X rays classified by two B-readers as p/q round opacities with profusion ranging from 2/2 to 3/3. HRCT of two of them showed a diffuse centrilobular ground glass nodular pattern with subpleural small areas of consolidations. Transbronchial biopsies showed deposition of black pigment in the bronchiolar interstice similar to the histological appearance of simple coal workers pneumoconiosis, with no signs of fibrosis. Spirometry showed no abnormalities in the three cases. The authors point out to a probably underestimated respiratory occupational risk related to wood charcoal manipulation, which must be addressed mostly in developing countries, where deficient workplace conditions can lead to exposure above limit levels.

Additional file 1: Fig. S1. Inclusion criteria diagram. Fig. S2. Probable usual interstitial pneu... more Additional file 1: Fig. S1. Inclusion criteria diagram. Fig. S2. Probable usual interstitial pneumonia pattern on high resolution chest tomography. Fig. S3. Fibrotic hypersensitivity pneumonitis. Fig. S4. Idiopathic pulmonary fibrosis. Fig. S5. Interstitial lung disease ascribed to gastroesophageal reflux disease. Fig. S6. Survival in patients with a probable UP pattern on HRCT was analysed according to the main diagnostic groups. Table S1. Clinical characteristics, functional characteristics, and HRCT findings of 50 patients with fibrotic chronic hypersensitivity pneumonia, IPF, and other diagnoses and a probable UIP HRCT pattern.

The genetic diversity of C. arabica in Ethiopia, its region of origin, was explored. Its use for ... more The genetic diversity of C. arabica in Ethiopia, its region of origin, was explored. Its use for C. arabica breeding, though limited to a few F1 crosses with cultivars, proved to be efficient in terms of genetic gain regarding important coffee agronomic characteristics such as vigor, adaptability and quality. A collection derived from the 1964-65 FAO survey in Ethiopia was established at IAPAR in Londrina, PR, Brazil in 1976. Genotyping was undertaken using SSR markers that were polymorphic within these accessions. Preliminary results regarding the relation between genetic and phenotypic diversity are presented. Self pollinated progenies of 179 plants representing 115 Ethiopian accessions were established at IAPAR, from 2009 to 2012. 47 of them were also established at CPAC, DF. Various growth parameters were measured. (Resume d'auteur)

Background: Usual interstitial pneumonia (UIP) can present with a probable pattern on high-resolu... more Background: Usual interstitial pneumonia (UIP) can present with a probable pattern on high-resolution computed tomography (HRCT), but the probability of UIP by surgical lung biopsy in such cases remains controversial. We aimed to determine the final clinical diagnosis in patients with a probable UIP pattern on HRCT subjected to surgical lung biopsy.Methods: HRCT images were assessed and categorized by three radiologists, and tissue slides were evaluated by two pathologists, all of whom were blinded to the clinical findings. The final clinical diagnosis was accomplished via a multidisciplinary discussion. Patients with a single layer of honeycombing located outside of the lower lobes on HRCT were not excluded.Results: A total of 50 patients were evaluated. The most common final clinical diagnosis was fibrotic hypersensitivity pneumonitis (38.0%; 95% CI: 24.7% to 52.8%), followed by idiopathic pulmonary fibrosis (24.0%; 95% CI: 13.1% to 38.2%) and interstitial lung disease ascribed to...