Razieh Mirsafaei - Academia.edu (original) (raw)

Papers by Razieh Mirsafaei

International Journal of Environmental Science and Technology, 2016

A novel nanocatalyst silica-bonded sulfuric acid supported on KIT-5 as an organic-inorganic hybri... more A novel nanocatalyst silica-bonded sulfuric acid supported on KIT-5 as an organic-inorganic hybrid with high activity was prepared successfully. The KIT-5 with high surface area was reacted with chlorosulfonic acid via simple and rapid method. This efficient and reusable heterogeneous catalyst sulfuric acid nanocatalyst catalyzed one-pot synthesis of b-dicarbonyl compounds, aldehyde and ammonium acetate in the presence of 0.05 g of nanocatalyst at room temperature via solvent-free conditions to afford excellent yields of 1,4-dihydropyridines. This nanocatalyst was fully characterized by XRD, SEM-EDXS and Map analyses. The morphology of the catalyst surface by SEM images shows all porous of KIT-5 after the reaction was filled with the SO 3 H groups. The average size determines around 22-24 nm. This catalyst can be reused five times without any significant loss of activity, too. The ease of separation, high activity, high surface area and reaction under open air condition are the main advantages of this catalyst.

Applied organometallic chemistry, Jul 21, 2017

Metals corrosion and scales deposition are two serious problems of heavy burden in most industrie... more Metals corrosion and scales deposition are two serious problems of heavy burden in most industries. Both problems can be mitigated by adding special chemicals capable of being adsorbed on metallic surfaces as well as on scale growing crystal surfaces. Efficient materials should be rich in functional groups containing heteroatoms and/or π bonds for supporting their adsorbability on surfaces. In the present work, four novel pyrazole derivatives were synthesized and characterized for their structures using elemental analysis and spectroscopic tools. The tested compounds were fabricated by treating 2,3-diaryloxirane-2,3-dicarbonitriles with different nitrogen nucleophiles. The density functional theory (DFT) was then applied to explore the structural and electronic characteristics of these materials. Molecular dynamics simulation was also run to scrutinize the ability of the prepared compounds to act as corrosion inhibitors and antiscalant agents by adsorbing on Fe and CaSO 4 surfaces.

Poly (styrene-co-maleic anhydride) (SMA) was modified by reactionwith4-amino-2-methyl-10H-thiene ... more Poly (styrene-co-maleic anhydride) (SMA) was modified by reactionwith4-amino-2-methyl-10H-thiene [2,3-b][1,5]-benzodiazepine (ATD) hydrochloride, providing an imide with the appropriate sites for the coordination of Cu(I)ions. This modified SMA was reacted with CuI to obtain immobilized Cu(I) NPs. This Cu(I) NPs (CuI/SMI-TD) was fully characterized by conventional techniques such as FT-IR, NMR, SEM, TEM, EDAX and ICP-AES analysis. The SEM and TEM images clearly showed CuI NPs as spherical shapes and the size of particles is 30-60 nm. Moreover, a quantitative description for experimental features of CuI/SMI-TD was presented via computational assessment for the interactions between copper metal ions and coordination sites of SMI-TD ligand. The catalytic activity of this new catalyst was examined in the regioselective synthesis of 1,4-disubstituted-1,2,3 triazoles in a classical copper-catalyzed reaction a so-called click reaction. The catalyst showed highly efficient catalytic activit...

IET Nanobiotechnology

The aim of the present study was to synthesize a novel biopolymeric micelle based on punicic acid... more The aim of the present study was to synthesize a novel biopolymeric micelle based on punicic acid (PA) and polyacrylamide (PAM) for carrying chemotherapeutic drugs used in prostate cancer treatment. A polymer composite micelle was prepared by chemical conjugation between PAM and PA. The micelles were prepared by self-assembly via film casting followed by ultrasonication method. The successful production of PAMPA copolymeric micelles was confirmed using FTIR, 1H-NMR, and TEM. Then, flutamide was loaded in the designed nanomicelles and they were characterized. The cell cytotoxicity of the micelles was studied on PC3 cells of prostate cancer. The prepared nanomicelles showed the particle size of 88 nm, PDI of 0.246, zeta potential of -9 mV, drug loading efficiency of 94.5%, drug release of 85.6% until 10 hours in pH 7.4 and CMC of 74.13 μg/ml. The cell viability in blank nanocarriers was about 70% in PC3 cells at concentration of 25 μM. More significant cytotoxic effects were seen for flutamide loaded micelles at this concentration compared to the free drug. The results suggest that the PAMPA co-polymeric nanomicelles can be utilized as an effective carrier to enhance the cytotoxic effects of flutamide in prostate cancer.

Recent Patents on Nanotechnology

Background: Targeted nanocarriers can be used for reducing the un-wanted side effects of drugs in... more Background: Targeted nanocarriers can be used for reducing the un-wanted side effects of drugs in non-target organs. Punicic acid the polyunsaturated fatty acid of pomegranate seed oil has been shown to possess anti-cancer effects on prostate cancer. The objective of the current study was to synthesize a co-polymeric micelle for delivery of flutamide (FL) in prostate cancer using Polyacrylamide (PAM) and Punicic acid (PA). Methods: The copolymer of PAM and PA was synthesized and conjugated to folic acid. The successful conjugation was studied computationally by the density functional theory method and confirmed by FT-IR and 1HNMR. The folate-PAMPA micelles produced by film casting method were characterized physically. FL was loaded in the nanomicelles and its release test was done at different pH. The critical micelle concentration (CMC) was measured by pyrene as a fluorescent probe. Their cellular uptake and cytotoxicity were evaluated on PC3 prostate cancer cells. The molecular ge...

Current Organic Synthesis

Aim and Objective: KIT-5 nanoporous silica was functionalized with sulfonic acid and SO3H group h... more Aim and Objective: KIT-5 nanoporous silica was functionalized with sulfonic acid and SO3H group has been immobilized on nanoporous KIT-5 silica support via in situ method to produce novel nanocatalyst as “KIT-5-Pr-SO3H”. The catalyst was fully characterized by FT-IR, SEM, EDXs, TEM, BET and TGA techniques. The surface morphology images approved that the nanocatalyst particle sizes are around 7-15 nm. The prepared catalyst was efficiently used in the synthesis of benzimidazolo quinazolinones, imidazo[1,2- a]chromeno[4,3-d]pyrimidinone and imidazo[1,2-a]pyrimidine via a multicomponent reaction under green conditions. The easy synthesis condition, environmental compatibility, high specific surface area, reusability for 5 run without loses in any activity, high selectivity, availability of raw material, are the remarkable properties for this new catalyst. Materials and Methods: All reagents were purchased from Aldrich and Merck with high-grade quality and used as received. The structura...

Drug development and industrial pharmacy, 2018

The goal of the present work was to make novel co-polymeric micellar carriers for the delivery of... more The goal of the present work was to make novel co-polymeric micellar carriers for the delivery of docetaxel (DTX). Co-polymeric micelles can not only solubilize DTX and eliminate the need for toxic surfactants to dissolve it, but also cause passive targeting of the drug to the tumor and reduce its toxic side effects. Poly(styrene-maleic acid) (SMA) was conjugated to poly (amide-ether-ester-imide)-poly ethylene glycol (PAEEI-PEG). Copolymer synthesis was proven by Fourier transform infrared (FTIR) and H-nuclear magnetic resonance (H-NMR). The SMA-PAEEI-PEG micelles loaded with DTX were prepared and their critical micelle concentration (CMC), zeta potential, particle size, entrapment efficiency, and their release efficiency were studied. MCF-7 and MDA-MB231 breast cancer cells were used to evaluate the cellular uptake and cytotoxicity of the micelles. The antitumor activity of the DTX-loaded nanomicelles was measured in Balb/c mice. The FTIR and HNMR spectroscopy confirmed successful ...

Applied Organometallic Chemistry

Journal of Polymer Engineering, 2016

The novel poly (amide-ester-imide) (PAEI)/Na+-MMT (montmorillonite) nanocomposites were synthesiz... more The novel poly (amide-ester-imide) (PAEI)/Na+-MMT (montmorillonite) nanocomposites were synthesized by ultrasound-assisted technique successfully. PAEI/Na+-MMT nanocomposites with various content of Na+-MMT were applied to enhance the dispersion of the clay layers with polymer matrix. Water-soluble PAEI containing poly (ethylene glycol) (PEG-6000) was prepared, and nanocomposites with various content of Na+-MMT (5, 10, 15, and 20 mass %) were fabricated by ultrasonic method to produce nano-scale composites. The effects of Na+-MMT on the nanocomposites were investigated by Fourier transform infrared, X-ray diffraction (XRD), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) and for thermal properties. XRD approved the structure information of the synthesized nanomaterials, and it was shown that the interlayer spacing increased with clay loading. The magnitude of dispersion of the clay in the nanocomposite matrix was investigated by TEM and SEM images. The...

Applied Organometallic Chemistry, 2016

Chemical Papers, 2015

A novel silica-bonded propyl-

Poly (ethylene glycol) (PEG) is often introduced to the polymer’s chain for its hydrophilicity, n... more Poly (ethylene glycol) (PEG) is often introduced to the polymer’s chain for its hydrophilicity, nontoxcity, biocompatibilituy and nonimmunogenicity [1, 2]. So, copolymers containing PEG as hydrophilic and soft segment have been widely studied. In addition copolymers such as poly(amide-imide)s containing PEG show high solubility [3]. But, polymers restrain PEG fragment do not show good mechanical and thermal properties. There has been extensive interest in the development of polymer-clay nanocomposite [4]. In this paper, the novel biodegradable poly(amide-ester-imide)s (PAEI)s with different molecular weight of PEG (M.W= 2000 and 6000) as hydrophilic and soft segment were prepared and intercalated into the gallery of modified montmorillonite (MMT). Poly(ethylene glycol)-bis-(N-trimellitylimido-4-phenyl carboxylic acid) (3) as a novel diacid monomer was synthesized via two step. The reaction of PEG with trimellitic anhydride yield poly(ethylene glycol)-bis-trimellitic anhydride (1). T...

Poly(ethylene glycol)-bis-(N-trimellitylimido-4-phenyl carboxylic acid) (3) as a novel diacid mon... more Poly(ethylene glycol)-bis-(N-trimellitylimido-4-phenyl carboxylic acid) (3) as a novel diacid monomer was synthesized via two step. The reaction of PEG (600 or 6000) with trimellitic anhydride chloride yield poly(ethylene glycol)-bis-trimellitic anhydride (1). The reaction of dianhydride 1 with p-aminobenzoic acid produces novel diacid monomer 3. The direct polycondensation technique was used for the polyamidation of diacid 3 with several aromatic diamines using pyridine(Py)/ N-methyl-2-pyrrolidone(NMP)/ triphenylphosphite(TPP) / CaCl2 as condensing agent.

A novel heterogeneous copper nano catalyst supported on modified silica mesopore KIT-5 was succes... more A novel heterogeneous copper nano catalyst supported on modified silica mesopore KIT-5 was success-fully prepared. The 3-aminopropyltriethoxysilane (APTES) on KIT-5 was coordinated with copper(I) andaccurately characterized. In addition a comparative survey on the metal-ligand interactions in the syn-theses of catalyst in two different solvents via density functional theory calculations was performed.A one-pot procedure for syntheses of 1,4-disubstituted 1,2,3-triazole derivatives via a three-componentreaction between terminal alkynes, alkyl halides, and sodium azide, namely click reaction in the presencesof 3 mol% nanoparticles copper/APTES-KIT-5 (Cu/AK) as a catalyst was developed to give the productsin good to excellent yields. This catalyst showed high catalytic activity in water as a “green” solvent.This reaction was performed under open air conditions and required no special reaction conditions andchromatographic separation for purification.

ABSTRACT Poly(ethylene glycol)-bis-(N-trimellitylimido-4-phenyl carboxylic acid) (3) as a novel d... more ABSTRACT Poly(ethylene glycol)-bis-(N-trimellitylimido-4-phenyl carboxylic acid) (3) as a novel diacid monomer was synthesized via two step. The reaction of PEG (600 or 6000) with trimellitic anhydride chloride yield poly(ethylene glycol)-bis-trimellitic anhydride (1). The reaction of dianhydride 1 with p-aminobenzoic acid produces novel diacid monomer 3. The direct polycondensation technique was used for the polyamidation of diacid 3 with several aromatic diamines using pyridine(Py)/ N-methyl-2-pyrrolidone(NMP)/ triphenylphosphite(TPP) / CaCl2 as condensing agent.

Journal of Molecular Catalysis A: Chemical, 2015

ABSTRACT A novel heterogeneous copper nano catalyst supported on modified silica mesopoure KIT-5 ... more ABSTRACT A novel heterogeneous copper nano catalyst supported on modified silica mesopoure KIT-5 was successfully prepared. The 3-aminopropyltriethoxysilane (APTES) on KIT-5 was coordinated with copper (I) and accurately characterized. In addition a comparative survey on the metal-ligand interactions in the syntheses of catalyst in two different solvents via density functional theory calculations was performed. A one-pot procedure for syntheses of 1,4-disubstituted 1,2,3-triazole derivatives via a three-componen reaction between terminal alkynes, alkyl halides, and sodium azide, namely click reaction in the presences of 3 mol% nanoparticles copper/APTES-KIT-5 (Cu/AK) as a catalyst was developed to give the products in good to excellent yields. This catalyst showed high catalytic activity in water as a “green” solvent. This reaction was performed under open air conditions and required no special reaction conditions and chromatographic separation for purification.