ROBERTO VALENTI - Academia.edu (original) (raw)
Papers by ROBERTO VALENTI
PubMed, 1992
To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven p... more To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven patients with Paget's disease of the bone entered the study. Eel calcitonin was administered via rectal mucosa at the dosage of 100 and 200 MRCU. Plasma calcium, plasma phosphate and plasma cAMP were measured at a baseline and after 10, 20, 30, 60, 90, 120, 180, 240 min. Rectal administration of 100 MRCU of eel calcitonin decreased plasma calcium and phosphate levels in normal subjects; the hypocalcaemic and hypophosphatemic effects were more marked and statistically significant in Paget's disease patients. Using 200 MRCU of eel calcitonin, statistically significant reductions in plasma calcium levels were observed in controls and in Paget's disease patients. Plasma phosphate decreased after rectal administration of the hormone, but not significantly. A slight but not significant increase in plasma cAMP was observed in normal subjects after the administration of 200 MRCU. These data demonstrate that eel calcitonin administered via rectal mucosa can exert some of the known biologic effects of the peptide.
PubMed, Oct 1, 1992
With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10... more With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10-20 minutes rather than the 60-80 minutes required by dual-photon absorptiometry (DPA). The DXA approach replace the Gd153 radionuclide source of DPA and provides substantially greater output intensity. The higher radiation flux achievable provides several advantages over conventional DPA: this makes total body scans routinely accessible. The measures of the entire skeleton and its major subregions cut down the problems of representativeness and relocation. The short term precision (coefficient of variation) was 0.5% for total body-bone mineral density (BMD) and about 1% for regional-BMD. We studied 885 women; study cohort consisted of 161 healthy postmenopausal women, 357 healthy postmenopausal women and 367 osteoporotic women with one or more vertebral crushes. The results indicate that bone mass begin decreasing during the last period of the premenopausal phase; the advent of menopause brings about a dramatic reduction of both total body and single area BMD: this phenomenon is particularly marked in subjects with osteoporosis. The single most important factor in determining BMD changes, is years since menopause. In order to assess the ability of DXA total body to distinguish women with postmenopausal osteoporosis of variable radiological degress from healthy postmenopausal women, we studied 330 postmenopausal females aged 42-85 years. There were 63 healthy women who were considered controls (Group 1).(ABSTRACT TRUNCATED AT 250 WORDS)
European Journal of Internal Medicine, Aug 1, 2010
Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk ... more Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial. To investigate whether or not plasma levels of total homocysteine (tHcy) and serum levels of folates and vitamin B12 are associated with bone mineral density (BMD), we carried out a cross-sectional study on 446 post-menopausal women (mean age: 65.1+/-9.4 years), consecutively seen at the Siena Unit (Tuscany region, Central Italy) for BMD evaluation over a two-year period. BMD of the total femur, femoral neck and lumbar spine was detected by dual-energy X-ray absorptiometry. The age-adjusted geometric mean of plasma tHcy levels (micromol/L) was 9.96+/-1.29 in women with normal BMD, 11.06+/-1.32 in those with osteopenia and 11.88+/-1.35 in those with osteoporosis (p<0.0001). On multiple linear regression analysis, adjusting for age, body mass index, folates, vitamin B12, creatinine clearance, smoking habit and alcohol intake, tHcy was negatively related to BMD of the total femur [beta estimate for log-homocysteine: -0.050 (95% CI: -0.100 to -0.001, p=0.048; R(2)=0.02)], but not of femoral neck or lumbar spine. There was no significant association between BMD and serum levels of folates and vitamin B12. tHcy is negatively associated with BMD of the total femur. The contribution of tHcy to explain the variance of BMD is small (2% of the total variance) but clinically relevant, considering the high prevalence of osteoporosis among post-menopausal women and the possibility to lower tHcy by vitamin supplementation.
Assistenza Infermieristica E Ricerca, Apr 1, 2021
Bone, 2001
This study examines the influence of circulating insulin-like growth factor-1 (IGF-1) and serum l... more This study examines the influence of circulating insulin-like growth factor-1 (IGF-1) and serum leptin on bone mass as well as modulation of bone mass during skeletal development. Moreover, an inverse relationship between IGF-1 and leptin is reported. To evaluate the effects of serum IGF-1 and serum leptin on bone mass in healthy postmenopausal women, and the possible role of IGF-1 in leptin production, we studied a population of 123 women, aged 39-82 years. Bone mineral density (BMD) was determined by whole-body dual-energy X ray absorptiometry, which also enables measurement of body composition. Bone metabolism was assessed by measuring serum total alkaline phosphatase (TAP) and urinary hydroxyproline/creatinine (HP/Cr) excretion. IGF-1 correlated significantly with age (r = -0.28, p < 0.01) and years since menopause (r = -0.24, p < 0.01). A negative correlation was also found with weight and body mass index (r = -0.15, p < 0.05 and r = -0.19, p < 0.05, respectively). Leptin values were strongly correlated with weight (r = 0.7, p < 0.01), BMI (r = 0.7, p < 0.01), fat mass (r = 0.77, p < 0.01), and lean mass (r = 0.39, p < 0.01); a significant correlation was found with total body BMD (r = 0.29, p < 0.01), TAP (r = 0.15, p < 0.05), and HP/Cr (r = 0.18, p < 0.05). After adjustment for BMI, the significance of these relationships disappeared, demonstrating the lack of effect of serum leptin on BMD and bone turnover independent of body weight. On the other hand, the relationship between BMD and fat mass remained statistically significant after adjusting for serum leptin (r = 0.15, p < 0.05). Controlling for BMI eliminated the significant inverse correlation between IGF-1 and leptin; significant differences in leptin levels were found among women in the lower and higher quartile of IGF-1, suggesting that leptin production may be inhibited only at high values of serum IGF-1. We conclude that serum IGF-1 and serum leptin have no direct effect on bone mass and bone turnover.
Journal of Internal Medicine, Oct 13, 2001
Clinical Oral Implants Research, Apr 5, 2010
Frontiers in Endocrinology
In these recent years many people are adopting a vegetarian type diet due to the numerous positiv... more In these recent years many people are adopting a vegetarian type diet due to the numerous positive health effects of this regimen such as the reduction of the incidence of many chronic disorders like diabetes, hypertension, obesity and cancer. However this diet is quite restrictive and so it could be possible to have a deficiency in some specific nutrients, increasing the risk of osteoporosis and fractures. Although there are conflicting results on the effects of the vegetarian diet on bone health and fracture incidence, it is always recommendable in vegetarian people to have an adequate intake of calcium and vitamin D, through an increased intake of supplements, natural and fortified foods, an adequate intake of protein, fruit, vegetables, as well as vitamin B12. The aim of this literature review is to revise the actual knowledge of the effect of some nutrients and vegetarian diets on bone health.
In vitro studies indicate that parathyroid hormone (PTH) decrease osteoprotegerin (OPG) secretion... more In vitro studies indicate that parathyroid hormone (PTH) decrease osteoprotegerin (OPG) secretion by the osteoblasts and increase RANKL production. Studies in healthy men have shown a negative correlation between endogenus PTH and serum OPG; moreover a decrease of serum OPG with an increase of serum RANKL have been reported by an interventional study where postmenopausal women with glucocorticoid osteoporosis were treated with intermittent injections of PTH. The aim of this study is to evaluate the behaviour of serum OPG and RANKL in women with established postmenopausal osteoporosis treated for six months with teriparatide (20 μg/die). We enroled 21 women (aged 71.5±7.8 years) with one or more vertebral fractures and a T-score at densitometric examination of lumbar spine or proximal femur lower than –2.5. Patients on treatment were included in the study after a three months wash-out period. As control group, we studied 15 age-matched women. A blood sample was drawn from each patien...
The aim of our study was to evaluate the reproducibility and the diagnostic accuracy of a new dev... more The aim of our study was to evaluate the reproducibility and the diagnostic accuracy of a new device for the assessment of bone mineral density (BMD) of the heel, called dual X-ray and laser (DXL Calscan). This technique associates X-ray absorptiometry to the measure of heel thickness with a laser beam. The calcaneus BMD, calcaneus quantitative sonography (QUS), and lumbar spine and total-body BMD, were evaluated in 40 postmenopausal women. On the basis of the BMD T-score measured by dual-energy X-ray absorptiometry (DXA) of L2‐L4, 20 women were classified as osteoporotic and 20 women were considered nonosteoporotic according to the WHO classification. The short-term coefficient of variation of the DXL was 2.4% and 1.7% in osteoporotic and nonosteoporotic women, respectively. The calcaneus BMD was lower in osteoporotic than in nonosteoporotic women. Among osteoporotic patients, 14 patients had a T-score lower than ‐2.5 at Calscan, whereas only 4 patients classified as nonosteoporoti...
Internal and Emergency Medicine, 2018
Drugs under experimental and clinical research, 1992
To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven p... more To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven patients with Paget's disease of the bone entered the study. Eel calcitonin was administered via rectal mucosa at the dosage of 100 and 200 MRCU. Plasma calcium, plasma phosphate and plasma cAMP were measured at a baseline and after 10, 20, 30, 60, 90, 120, 180, 240 min. Rectal administration of 100 MRCU of eel calcitonin decreased plasma calcium and phosphate levels in normal subjects; the hypocalcaemic and hypophosphatemic effects were more marked and statistically significant in Paget's disease patients. Using 200 MRCU of eel calcitonin, statistically significant reductions in plasma calcium levels were observed in controls and in Paget's disease patients. Plasma phosphate decreased after rectal administration of the hormone, but not significantly. A slight but not significant increase in plasma cAMP was observed in normal subjects after the administration of 200 MRCU. Thes...
Minerva endocrinologica
With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10... more With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10-20 minutes rather than the 60-80 minutes required by dual-photon absorptiometry (DPA). The DXA approach replace the Gd153 radionuclide source of DPA and provides substantially greater output intensity. The higher radiation flux achievable provides several advantages over conventional DPA: this makes total body scans routinely accessible. The measures of the entire skeleton and its major subregions cut down the problems of representativeness and relocation. The short term precision (coefficient of variation) was 0.5% for total body-bone mineral density (BMD) and about 1% for regional-BMD. We studied 885 women; study cohort consisted of 161 healthy postmenopausal women, 357 healthy postmenopausal women and 367 osteoporotic women with one or more vertebral crushes. The results indicate that bone mass begin decreasing during the last period of the premenopausal phase; the advent of menopaus...
Journal of Internal Medicine, 2008
Current Therapeutic Research, 1996
... INTRODUCTION Postmenopausal osteoporosis is a metabolic bone disease characterized by Address... more ... INTRODUCTION Postmenopausal osteoporosis is a metabolic bone disease characterized by Address correspondence to: Prof. Angelo Caniggia, Metabolic Bone Disease Center, University of Siena, P. zza dells Selva, 7, 53100 Siena, Italy. ... In: Christiansen C, Riis B, eds. ...
Clinical Oral Implants Research, 2010
Objectives: This study investigated the correlation of quantitative ultrasound with bone quality ... more Objectives: This study investigated the correlation of quantitative ultrasound with bone quality as evaluable from implant final insertion torque.Material and methods: Implants were planned at diaphyses (group 1) and epiphyses (group 2) of 16 rabbit femurs where amplitude‐dependent speed of sound (Ad‐SOS) was measured. The insertion torque from 7‐mm‐long implants placed at planned sites was recorded. The correlation between cutting torque and Ad‐SOS was evaluated using Spearman's coefficient.Results: Statistics were based on data from 15 diaphyses and 13 epiphyses. The mean insertion torque was 8.8 N cm while the mean Ad‐SOS was 1710.9 m/s. A negative correlation resulted between insertion torque and Ad‐SOS.Conclusions: In the rabbit bone model investigated, quantitative ultrasound correlates inversely with implant insertion torque. Although this correlation remains to be verified in humans because rabbit femur does not convincingly represents different human bone qualities, it ...
PubMed, 1992
To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven p... more To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven patients with Paget's disease of the bone entered the study. Eel calcitonin was administered via rectal mucosa at the dosage of 100 and 200 MRCU. Plasma calcium, plasma phosphate and plasma cAMP were measured at a baseline and after 10, 20, 30, 60, 90, 120, 180, 240 min. Rectal administration of 100 MRCU of eel calcitonin decreased plasma calcium and phosphate levels in normal subjects; the hypocalcaemic and hypophosphatemic effects were more marked and statistically significant in Paget's disease patients. Using 200 MRCU of eel calcitonin, statistically significant reductions in plasma calcium levels were observed in controls and in Paget's disease patients. Plasma phosphate decreased after rectal administration of the hormone, but not significantly. A slight but not significant increase in plasma cAMP was observed in normal subjects after the administration of 200 MRCU. These data demonstrate that eel calcitonin administered via rectal mucosa can exert some of the known biologic effects of the peptide.
PubMed, Oct 1, 1992
With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10... more With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10-20 minutes rather than the 60-80 minutes required by dual-photon absorptiometry (DPA). The DXA approach replace the Gd153 radionuclide source of DPA and provides substantially greater output intensity. The higher radiation flux achievable provides several advantages over conventional DPA: this makes total body scans routinely accessible. The measures of the entire skeleton and its major subregions cut down the problems of representativeness and relocation. The short term precision (coefficient of variation) was 0.5% for total body-bone mineral density (BMD) and about 1% for regional-BMD. We studied 885 women; study cohort consisted of 161 healthy postmenopausal women, 357 healthy postmenopausal women and 367 osteoporotic women with one or more vertebral crushes. The results indicate that bone mass begin decreasing during the last period of the premenopausal phase; the advent of menopause brings about a dramatic reduction of both total body and single area BMD: this phenomenon is particularly marked in subjects with osteoporosis. The single most important factor in determining BMD changes, is years since menopause. In order to assess the ability of DXA total body to distinguish women with postmenopausal osteoporosis of variable radiological degress from healthy postmenopausal women, we studied 330 postmenopausal females aged 42-85 years. There were 63 healthy women who were considered controls (Group 1).(ABSTRACT TRUNCATED AT 250 WORDS)
European Journal of Internal Medicine, Aug 1, 2010
Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk ... more Whether or not mild hyperhomocysteinemia and low serum levels of folates or vitamin B12 are risk factors for osteoporosis in the elderly is controversial. To investigate whether or not plasma levels of total homocysteine (tHcy) and serum levels of folates and vitamin B12 are associated with bone mineral density (BMD), we carried out a cross-sectional study on 446 post-menopausal women (mean age: 65.1+/-9.4 years), consecutively seen at the Siena Unit (Tuscany region, Central Italy) for BMD evaluation over a two-year period. BMD of the total femur, femoral neck and lumbar spine was detected by dual-energy X-ray absorptiometry. The age-adjusted geometric mean of plasma tHcy levels (micromol/L) was 9.96+/-1.29 in women with normal BMD, 11.06+/-1.32 in those with osteopenia and 11.88+/-1.35 in those with osteoporosis (p<0.0001). On multiple linear regression analysis, adjusting for age, body mass index, folates, vitamin B12, creatinine clearance, smoking habit and alcohol intake, tHcy was negatively related to BMD of the total femur [beta estimate for log-homocysteine: -0.050 (95% CI: -0.100 to -0.001, p=0.048; R(2)=0.02)], but not of femoral neck or lumbar spine. There was no significant association between BMD and serum levels of folates and vitamin B12. tHcy is negatively associated with BMD of the total femur. The contribution of tHcy to explain the variance of BMD is small (2% of the total variance) but clinically relevant, considering the high prevalence of osteoporosis among post-menopausal women and the possibility to lower tHcy by vitamin supplementation.
Assistenza Infermieristica E Ricerca, Apr 1, 2021
Bone, 2001
This study examines the influence of circulating insulin-like growth factor-1 (IGF-1) and serum l... more This study examines the influence of circulating insulin-like growth factor-1 (IGF-1) and serum leptin on bone mass as well as modulation of bone mass during skeletal development. Moreover, an inverse relationship between IGF-1 and leptin is reported. To evaluate the effects of serum IGF-1 and serum leptin on bone mass in healthy postmenopausal women, and the possible role of IGF-1 in leptin production, we studied a population of 123 women, aged 39-82 years. Bone mineral density (BMD) was determined by whole-body dual-energy X ray absorptiometry, which also enables measurement of body composition. Bone metabolism was assessed by measuring serum total alkaline phosphatase (TAP) and urinary hydroxyproline/creatinine (HP/Cr) excretion. IGF-1 correlated significantly with age (r = -0.28, p < 0.01) and years since menopause (r = -0.24, p < 0.01). A negative correlation was also found with weight and body mass index (r = -0.15, p < 0.05 and r = -0.19, p < 0.05, respectively). Leptin values were strongly correlated with weight (r = 0.7, p < 0.01), BMI (r = 0.7, p < 0.01), fat mass (r = 0.77, p < 0.01), and lean mass (r = 0.39, p < 0.01); a significant correlation was found with total body BMD (r = 0.29, p < 0.01), TAP (r = 0.15, p < 0.05), and HP/Cr (r = 0.18, p < 0.05). After adjustment for BMI, the significance of these relationships disappeared, demonstrating the lack of effect of serum leptin on BMD and bone turnover independent of body weight. On the other hand, the relationship between BMD and fat mass remained statistically significant after adjusting for serum leptin (r = 0.15, p < 0.05). Controlling for BMI eliminated the significant inverse correlation between IGF-1 and leptin; significant differences in leptin levels were found among women in the lower and higher quartile of IGF-1, suggesting that leptin production may be inhibited only at high values of serum IGF-1. We conclude that serum IGF-1 and serum leptin have no direct effect on bone mass and bone turnover.
Journal of Internal Medicine, Oct 13, 2001
Clinical Oral Implants Research, Apr 5, 2010
Frontiers in Endocrinology
In these recent years many people are adopting a vegetarian type diet due to the numerous positiv... more In these recent years many people are adopting a vegetarian type diet due to the numerous positive health effects of this regimen such as the reduction of the incidence of many chronic disorders like diabetes, hypertension, obesity and cancer. However this diet is quite restrictive and so it could be possible to have a deficiency in some specific nutrients, increasing the risk of osteoporosis and fractures. Although there are conflicting results on the effects of the vegetarian diet on bone health and fracture incidence, it is always recommendable in vegetarian people to have an adequate intake of calcium and vitamin D, through an increased intake of supplements, natural and fortified foods, an adequate intake of protein, fruit, vegetables, as well as vitamin B12. The aim of this literature review is to revise the actual knowledge of the effect of some nutrients and vegetarian diets on bone health.
In vitro studies indicate that parathyroid hormone (PTH) decrease osteoprotegerin (OPG) secretion... more In vitro studies indicate that parathyroid hormone (PTH) decrease osteoprotegerin (OPG) secretion by the osteoblasts and increase RANKL production. Studies in healthy men have shown a negative correlation between endogenus PTH and serum OPG; moreover a decrease of serum OPG with an increase of serum RANKL have been reported by an interventional study where postmenopausal women with glucocorticoid osteoporosis were treated with intermittent injections of PTH. The aim of this study is to evaluate the behaviour of serum OPG and RANKL in women with established postmenopausal osteoporosis treated for six months with teriparatide (20 μg/die). We enroled 21 women (aged 71.5±7.8 years) with one or more vertebral fractures and a T-score at densitometric examination of lumbar spine or proximal femur lower than –2.5. Patients on treatment were included in the study after a three months wash-out period. As control group, we studied 15 age-matched women. A blood sample was drawn from each patien...
The aim of our study was to evaluate the reproducibility and the diagnostic accuracy of a new dev... more The aim of our study was to evaluate the reproducibility and the diagnostic accuracy of a new device for the assessment of bone mineral density (BMD) of the heel, called dual X-ray and laser (DXL Calscan). This technique associates X-ray absorptiometry to the measure of heel thickness with a laser beam. The calcaneus BMD, calcaneus quantitative sonography (QUS), and lumbar spine and total-body BMD, were evaluated in 40 postmenopausal women. On the basis of the BMD T-score measured by dual-energy X-ray absorptiometry (DXA) of L2‐L4, 20 women were classified as osteoporotic and 20 women were considered nonosteoporotic according to the WHO classification. The short-term coefficient of variation of the DXL was 2.4% and 1.7% in osteoporotic and nonosteoporotic women, respectively. The calcaneus BMD was lower in osteoporotic than in nonosteoporotic women. Among osteoporotic patients, 14 patients had a T-score lower than ‐2.5 at Calscan, whereas only 4 patients classified as nonosteoporoti...
Internal and Emergency Medicine, 2018
Drugs under experimental and clinical research, 1992
To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven p... more To evaluate the metabolic effects of unmodified eel calcitonin, nine normal subjects and eleven patients with Paget's disease of the bone entered the study. Eel calcitonin was administered via rectal mucosa at the dosage of 100 and 200 MRCU. Plasma calcium, plasma phosphate and plasma cAMP were measured at a baseline and after 10, 20, 30, 60, 90, 120, 180, 240 min. Rectal administration of 100 MRCU of eel calcitonin decreased plasma calcium and phosphate levels in normal subjects; the hypocalcaemic and hypophosphatemic effects were more marked and statistically significant in Paget's disease patients. Using 200 MRCU of eel calcitonin, statistically significant reductions in plasma calcium levels were observed in controls and in Paget's disease patients. Plasma phosphate decreased after rectal administration of the hormone, but not significantly. A slight but not significant increase in plasma cAMP was observed in normal subjects after the administration of 200 MRCU. Thes...
Minerva endocrinologica
With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10... more With the advent of dual-energy x-ray absorptiometry (DXA) total body scans can be done in only 10-20 minutes rather than the 60-80 minutes required by dual-photon absorptiometry (DPA). The DXA approach replace the Gd153 radionuclide source of DPA and provides substantially greater output intensity. The higher radiation flux achievable provides several advantages over conventional DPA: this makes total body scans routinely accessible. The measures of the entire skeleton and its major subregions cut down the problems of representativeness and relocation. The short term precision (coefficient of variation) was 0.5% for total body-bone mineral density (BMD) and about 1% for regional-BMD. We studied 885 women; study cohort consisted of 161 healthy postmenopausal women, 357 healthy postmenopausal women and 367 osteoporotic women with one or more vertebral crushes. The results indicate that bone mass begin decreasing during the last period of the premenopausal phase; the advent of menopaus...
Journal of Internal Medicine, 2008
Current Therapeutic Research, 1996
... INTRODUCTION Postmenopausal osteoporosis is a metabolic bone disease characterized by Address... more ... INTRODUCTION Postmenopausal osteoporosis is a metabolic bone disease characterized by Address correspondence to: Prof. Angelo Caniggia, Metabolic Bone Disease Center, University of Siena, P. zza dells Selva, 7, 53100 Siena, Italy. ... In: Christiansen C, Riis B, eds. ...
Clinical Oral Implants Research, 2010
Objectives: This study investigated the correlation of quantitative ultrasound with bone quality ... more Objectives: This study investigated the correlation of quantitative ultrasound with bone quality as evaluable from implant final insertion torque.Material and methods: Implants were planned at diaphyses (group 1) and epiphyses (group 2) of 16 rabbit femurs where amplitude‐dependent speed of sound (Ad‐SOS) was measured. The insertion torque from 7‐mm‐long implants placed at planned sites was recorded. The correlation between cutting torque and Ad‐SOS was evaluated using Spearman's coefficient.Results: Statistics were based on data from 15 diaphyses and 13 epiphyses. The mean insertion torque was 8.8 N cm while the mean Ad‐SOS was 1710.9 m/s. A negative correlation resulted between insertion torque and Ad‐SOS.Conclusions: In the rabbit bone model investigated, quantitative ultrasound correlates inversely with implant insertion torque. Although this correlation remains to be verified in humans because rabbit femur does not convincingly represents different human bone qualities, it ...