Rotimi OLUYOMBO - Academia.edu (original) (raw)

Papers by Rotimi OLUYOMBO

The Lancet Diabetes & Endocrinology, Dec 31, 2023

Journal of the American Society of Nephrology, Oct 1, 2021

Malawi Medical Journal, 2019

AimThis study aimed to determine the relationship between measures of obesity and serum lipid lev... more AimThis study aimed to determine the relationship between measures of obesity and serum lipid levels among hypertensive patients.MethodsThis was a cross-sectional study in which participants newly diagnosed with hypertension formed the study population. A range of demographic and anthropometric data was obtained, including weight, height, and waist and hip circumference. Fasting serum lipids were also measured, including total cholesterol, high density lipoprotein cholesterol (HDL-C) and triglycerides (TG). Low density lipoprotein cholesterol (LDL-C) was calculated using Friedewald formula. Statistical analysis was then carried out to determine the relationship between anthropometric indices and lipid profile levels. ResultsThe study population consisted of 124 male and 290 female subjects with a mean age of 66±16.95 years (range, 30–100 years).The female subjects were older than the male subjects (p=0.020). Our analysis showed that 85%, 58.5% and 30.7% of the study population had a...

British Journal of Medicine and Medical Research, 2017

Introduction: The Finnish Diabetes Risk Score (FINDRISC) questionnaire is a non-invasive, cheap, ... more Introduction: The Finnish Diabetes Risk Score (FINDRISC) questionnaire is a non-invasive, cheap, and easy to use screening tool to estimate future risk of diabetes development and detection of asymptomatic type 2 diabetes mellitus (T2DM) in other populations. This study aimed to evaluate usefulness of the FINDRISC to assessed future development of T2DM among a highrisk population. Methods: 750 participants recruited from semi-urban communities aged 18 years and older participated in this cross-sectional study. Data on the FINDRISC and fasting plasma glucose Original Research Article

Nigerian Journal of Clinical Practice, 2016

Background: Awareness and education on kidney disease impact on its effective management and will... more Background: Awareness and education on kidney disease impact on its effective management and will reduce the significant economic and public health burden. Knowledge of CKD and risk factors increases the perception of being at high risk and increasing health seeking behavior. We conducted a cross-sectional descriptive study to assess the level of awareness, knowledge and conventional risk factors of CKD in the community to strategize on preventive modalities using the information gathered from this population. Methods: We used a pretested structured questionnaire to draw information on sociodemography, knowledge and risk factors of CKD from 563 residents aged >18 years. Results: A total of 454 residents completed this study, mainly farmers, with a mean age of 45.8 ± 19.0 years and male: female ratio of 0.8:1. Only 33.7% had heard of kidney disease with 59.3% from the media and 35.3% from health workers; the level of knowledge of CKD was good in 27.1%. The majority (67.0%) do not know the correct location of the kidneys. Only 10.6% could mention at least one function of the kidneys with only 24.5% agreeing that NSAIDs can cause kidney disease. A laboratory test for kidney function was known by 4.4%; 45.9% and 47.8% believe that CKD can be cured by spiritual means and herbal concoctions respectively. Only 11.1% agreed that CKD can be hereditary. Abdominal obesity and cigarette smoking were seen in 14.6% and 16.6% respectively. Hypertension was seen in 26.5% while 17.8% actually knew they were hypertensive. Diabetes mellitus was found in 3.4%. None of the patients with CKD who had diabetes or hypertension was aware of kidney disease. Conclusion: There are a misconception and low level of awareness and knowledge of CKD, including those with risk factors, in the community. Efforts should be made to create awareness and educate people on CKD and prevention of its risk factors.

Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners, Dec 12, 2016

Objective: To determine the prevalence and subtypes of hypertension among semi-urban residents in... more Objective: To determine the prevalence and subtypes of hypertension among semi-urban residents in southwestern Nigeria. Methods: All adults aged 18 years or older in 10 semi-urban communities were recruited for the study. The blood pressure (BP) reading taken with a validated electronic BP monitor after at least 10 minutes of rest was used in the analysis. Hypertension was defined as BP ≥ 140/90 mmHg. Results: Seven hundred and fifty subjects with a mean age of 61.7 ± 18.2 years participated in the study. The prevalence of hypertension was 55.5%. Stage 2 hypertension was the most common, present among 225 (54.1%) of the participants with hypertension, and 191 (45.9%) had stage 1 hypertension. Of those with hypertension, systolic-diastolic hypertension (SDH) was present among 198/416 (47.6%), while isolated systolic hypertension (ISH) and isolated diastolic hypertension (IDH) were present among 181/416 (43.6%) and 37/416 (8.9%), respectively. The prevalence of hypertension increased significantly with age. Conclusion: The prevalence of hypertension was high in these semi-urban communities. Hence, increased awareness and integrating hypertension care into primary healthcare and other community health services in these areas may prove beneficial in ameliorating its adverse effects.

West African journal of medicine, 2014

BACKGROUND Diabetes mellitus (DM) is a growing public health problem both in developing and devel... more BACKGROUND Diabetes mellitus (DM) is a growing public health problem both in developing and developed countries. The prevalence of diabetes has doubled in the last 20 years. This study aimed to assess the burden of type 2 diabetes in semi-urban communities in Ekiti, South-West Nigeria. STUDY DESIGN This study was part of a larger study to assess the prevalence of cardiovascular risk factors among adults (>18 years) dwellers in 10 semi-urban communities. A total of 750 respondents took part in the study, using stratified sampling method to recruit participants within these communities. They had their clinical history assessed, fasting blood glucose (FBG) determined and body mass indices measured. RESULTS Of the 750 participants recruited 529 (70.5%) were females, 51 (6.8%) had FBG >7.0mmol/L (126mg/dl), hence were diagnosed as having DM and 45 participants (6.0%) had Impaired fasting glucose (IFG). Both DM and IFG were higher in males than females but the differences not statis...

Cureus

COVID-19 disease and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis are both m... more COVID-19 disease and anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis are both multisystemic conditions. It is postulated there is a causal relationship between both conditions and this is supported by some case reports. The symptoms of COVID-19 can mimic those of vasculitis especially when the respiratory system is affected. Early diagnosis and treatment of ANCA-vasculitis cannot be overemphasized as this reduces the risk of severe organ damage. We report a 64-year-old lady with SARS-CoV-2 infection who developed ANCA-vasculitis with acute kidney injury and we reviewed the literature on this plausible association. We performed an electronic search of the MEDLINE, EMBASE, CINAHL, and EMCARE databases for research studies and case series and reports published in the English language between April 2020 and February 2022. Our review suggests that patients with COVID-19 infection who had proteinase 3-ANCA positive vasculitis with diffuse alveolar haemorrhage had fatal outcomes. We also noticed an increased incidence of active urine sediments. We emphasize the importance of a high index of suspicion for diagnosis and early treatment of vasculitis to ensure an improved outcome.

Cardiovascular Journal of Africa, 2016

Background: In addition to poor socioeconomic indices and a high prevalence of infectious disease... more Background: In addition to poor socioeconomic indices and a high prevalence of infectious diseases, there have been various reports of a rising prevalence of cardiovascular diseases, with associated morbidity and mortality in developing countries. These factors co-exist, resulting in a synergy, with serious complications, difficult-to-treat conditions and fatal outcomes. Hence this study was conducted to determine the clustering of cardiovascular disease risk factors and its pattern in semi-urban communities in southwestern Nigeria. Methods: This was a cross sectional study over seven months in 11 semi-urban communities in southwestern Nigeria. Results: The total number of participants was 1 285 but only 1 083, with 785 (65%) females, completed the data. Participants were 18 years and older, and 51.2% were over 60 years. The mean age was 55.12 ± 19.85 years. There were 2.6% current cigarette smokers, 22% drank alcohol and 12.2% added salt at the table, while 2% had been told by their doctors they had diabetes, and 23.6% had hypertension. The atherogenic index of plasma was at a high-risk level of 11.1%. Elevated total cholesterol and low-density lipoprotein cholesterol, and low high-density lipoprotein cholesterol levels were seen in 5.7, 3.7 and 65.1%, respectively. Prevalence of hypertension was 44.9%, diabetes was 5.2%, obesity with body mass index (BMI) > 30 kg/m 2 was 5.7%, and abdominal circumference was 25.7%. Prevalence of clusters of two, three, and four or more risk factors was 23.1, 15.5 and 8.4%, respectively. Increasing age 2.94 (95% CI: 1.30-6.67), BMI 1.18 (95% CI: 1.02-1.37), fasting plasma glucose level 1.03 (95% CI: 1.00-1.05), albuminuria 1.03 (95% CI: 1.00-1.05), systolic blood pressure 1.07 (95% CI: 1.04-1.10), diastolic blood pressure 1.06 (95% CI: 1.00-1.11) and female gender 2.94 (95% CI: 1.30-6.67) showed increased odds of clustering of two or more cardiovascular risk factors. Conclusion: Clustering of cardiovascular risk factors is prevalent in these communities. Patterns of clustering vary. This calls for aggressive and targeted public health interventions to prevent or reduce the burden of cardiovascular disease, as the consequences could be detrimental to the country.

Obstructive sleep apnoea (OSA) syndrome is a common disorder in the community. Association betwee... more Obstructive sleep apnoea (OSA) syndrome is a common disorder in the community. Association between hypertension and sleep apnoea and /or snoring has been described. The Berlin questionnaire is a validated instrument that is used to identify individuals who are at risk for OSA. The study aim to describe the prevalence of snoring and OSA among hypertensive subjects in South Western, Nigeria. This was a descriptive study conducted at the Cardiology clinic of Ladoke Akintola University of Technology LAUTECH Teaching Hospital, Osogbo, South West Nigeria. One hundred consecutive hypertensive patients were recruited from the clinic. The Berlin questionnaire and the Epworth sleepiness scale (ESS) were used to determine excessive daytime sleepiness and the risk of having OSA. Statistical analysis was done using SPSS 16.0. Data were summarized as means ± S.D and percentages. The study participants consisted of 40 males (40.0%). The demographic data were similar between both genders except tha...

Purpose: To determine whether low dose aspirin has any deleterious effects on renal function in e... more Purpose: To determine whether low dose aspirin has any deleterious effects on renal function in elderly patients. Methods: We conducted a prospective pilot study of 30 Nigerians older than 60 years with various chronic ailments necessitating the use of low dose aspirin. Patients gave their consent, and institutional ethical clearance was obtained. Each patient’s baseline samples at enrolment (before commencing aspirin use) served as a control, and subsequent weekly samples were compared. The weekly mean of each parameter was calculated, and the differences of means from baseline were determined, and values were compared for statistical differences with the Statistical Package for the Social Sciences, version 16. Results: We found that a majority of patients (86.67%) had basal renal functions at chronic kidney disease stages 1 and 2. When compared with the corresponding baseline parameters, the mean weekly serum and urinary electrolytes, urea, creatinine, and uric acid parameters did...

Use of the Tego needlefree connector is associated with reduced incidence of catheter-related blo... more Use of the Tego needlefree connector is associated with reduced incidence of catheter-related bloodstream infections in hemodialysis patients steven M Brunelli1 levi Njord2 abigail e hunt1 scott P sibbel1 1DaVita clinical Research®,

Keeping pets as a companion is a global phenomenon. This relationship, however, is not entirely f... more Keeping pets as a companion is a global phenomenon. This relationship, however, is not entirely free of risk as some diseases can be transmitted to human beings. It is important to emphasize safety among pet owners, particularly in people with chronic illness as they may have increased vulnerability to infection which could arise from an intimate relationship. We report an uncommon etiology of sepsis complicated with infective endocarditis in a 63‐year old dog‐owner who was on hemodialysis. To the best of our knowledge, this is the first case of Capnocytophaga canimorsus infective endocarditis (IE) ever reported in a patient undergoing hemodialysis.

; 'Quantum chemical simulation of carbon nanotube nucleation on Al₂O₃ catalysts via CH₄ chemical ... more ; 'Quantum chemical simulation of carbon nanotube nucleation on Al₂O₃ catalysts via CH₄ chemical vapor deposition'.

The Internet Journal of Infectious Diseases, 2007

Nigerian Medical Practitioner, 2011

a Department of Internal Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria b Department of Int... more a Department of Internal Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria b Department of Internal Medicine, Endocrinology, Diabetes & Metabolism Unit, LAUTECH Teaching Hospital, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria c Federal Medical Centre, Ido-Ekiti, Ido-Ekiti, Nigeria d Department of Medicine, Endocrinology, Diabetes & Metabolism Unit, College of Medicine, University of Lagos, Lagos University Teaching Hospital, Idi-Araba, Lagos, Lagos State, Nigeria e Department of Community Medicine, Federal Medical Centre, Ido-Ekiti, Nigeria

Kidney transplantation offers the best modality of renal replacement therapy; however, requires o... more Kidney transplantation offers the best modality of renal replacement therapy; however, requires overcoming the challenging task of maintaining long-term graft survival. Chronic allograft dysfunction (CAD) is a continuum of a process that eventually leads to graft loss. CAD has been previously viewed as a dilemma; however, it has now been found to be associated with a spectrum of aetiologies and with a careful search for the specific kidney lesion and possible causes with appropriate intervention, graft longevity could be achieved. In this review, we analyse the various potential contributory factors to chronic allograft dysfunction intending to update and suggest interventions that could improve outcome.

Clinical Medicine Research

The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its corr... more The objective of the study was to determine the prevalence of Hyperuricemia and evaluate its correlation with target organ damage and electrocardiographic changes in newly diagnosed adult Nigerian hypertensive patients. It was a cross sectional study done at the University of Ilorin Teaching Hospital, Ilorin, Nigeria. 150 untreated newly diagnosed hypertensive patients 18 years and above and 115 age and sex-matched normotensive individuals were recruited into the study. Data obtained was analyzed using Epi-Info version 6.04 and Statistical Package for Social Sciences (SPSS) version 14 computer software packages. The prevalence of Hyperuricemia was 36.7% and 17.4% in hypertensive patients and normotensive controls respectively. Mean serum UA in hypertensive patients and normotensive controls was 0.4±0.1mmol/l and 0.3±0.1mmol/l respectively (p<0.0001). There was an association between Hyperuricemia and left ventricular hypertrophy (x 2 =23.97, p<0.0001). The study showed that Hyperuricemia is prevalent in adult Nigerians with newly diagnosed hypertension. Hyperuricemia was associated with left ventricular hypertrophy which is common target organ damage and confers an increased risk of cardiovascular events in systemic hypertension.