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Papers by ROSHAN YADAV

International Journal For Multidisciplinary Research, Jan 7, 2023

The production of niosomes, which are non-ionic surfactant vessels, involves hydrating synthetic ... more The production of niosomes, which are non-ionic surfactant vessels, involves hydrating synthetic nonionic surfactants, either with or without the addition of cholesterol or another lipid. Due to their distinctive qualities, including biodegradability, biocompatibility, chemical stability, low production cost, ease of storage and handling, and low toxicity, non-ionic surfactant vesicles also known as niosomes have received a lot of attention in the field of modern drug delivery system. Niosomes are hydrated vesicular systems with a lamellar bilayer structure made of non-ionic surfactants with or without cholesterol, and they have a wide spectrum of solubilities that allow them to encapsulate a variety of bioactive chemicals. Niosomes have been tested as a delivery system for a variety of anti-cancer medications, genes, antigens, and other bioactive substances. This article focuses on recent developments in niosomal drug delivery, possible benefits over alternative delivery mechanisms, formulation techniques, characterisation techniques, and ongoing niosome research.

International Journal of Advanced Biochemistry Research

Journal of Universal College of Medical Sciences

INTRODUCTIONComputers and laptops have become an integral part of our daily life. We interact wit... more INTRODUCTIONComputers and laptops have become an integral part of our daily life. We interact with computer screens for minutes to hours depending upon our need, for entertainment or official purposes. Using computers has become a 21st century necessity. The expansion of information technologies in recent decades has resulted in increased use of video display terminals (VDT) in the workplace. The American Optometric Association (AOA) defines Computer Vision Syndrome (CVS) as the complex of eye and vision problems related to near work, which are experienced during or related to computer use. CVS is characterised by visual symptoms resulting from interaction with a computer display or its environment. This study aimed to assess the prevalence of computer vision syndrome among medical and engineering students of Rupandehi, Nepal. MATERIAL AND METHODS A cross‑sectional study was conducted among final year medical and engineering college students of Universal College of medical sciences...

International Journal of Scientific Research in Science, Engineering and Technology

Majority of power plants of India are running on coal. To reduce the greenhouse gas emitted from ... more Majority of power plants of India are running on coal. To reduce the greenhouse gas emitted from these coal-based power plants, the power generating stations intends to utilize agriculture residue-based pellets. Agro residue-based pellets combustion is renewable source of energy. The use of agro based briquettes in densified form reduces air pollution which is mainly due burning of stubble. Apart from generation of smog in winter season, stubble burning in fields also reduces soil fertility. Central Electricity Authority, Ministry of Power (MoP) issued an Advisory for utilization of agro remains or residue-based pellets for power generation. Co-firing in a coal fired thermal power plants states to promote the use of the biomass pellets. All pulverized based coal units of electrical power generating units shall make efforts for using 5-10% blend of biomass-based pellets. These pellets must be primarily from residual agriculture waste. The generating units must keep in account of all ...

Nepalese Journal of Ophthalmology

Introduction: Glaucoma is one of the common causes of blindness worldwide, and the leading cause ... more Introduction: Glaucoma is one of the common causes of blindness worldwide, and the leading cause of irreversible blindness .The overall prevalence of glaucoma in Nepal is 1.9%. Though poorly understood, primary open angle glaucoma (POAG) is believed to have a genetic or familial component that may occur through polygenic or multifactorial transmission. First-degree relatives of POAG patients have 4–16% risk of developing POAG. Given the circumstances and the prevalence of POAG in first degree relatives of POAG patients, screening the first degree relative/s accompanying the patient to the hospital can be a cost effective and viable tool for glaucoma screening that will not add any extra cost of travel and accommodation. Materials and methods: The authors performed a hospital-based cross-sectional study at a tertiary eye hospital in Nepal. All first-degree family members of POAG patients who accompanied them to the glaucoma clinic underwent a full ophthalmic examination.The optic dis...

2017 8th Annual Industrial Automation and Electromechanical Engineering Conference (IEMECON), 2017

The present text provides information regarding introductory concept of wireless power transfer b... more The present text provides information regarding introductory concept of wireless power transfer by studying some of the existing technologies and evaluate its quality factor as well as deals with certain methods of improving the efficiency of wireless power transfer. In addition to this, calculation and analysis has also been done for its figure of merit, transfer loss, quality factor and efficiency.

Journal of Pharmacognosy and Phytochemistry, 2017

Turmeric, botanically known as Curcuma longa, Linn, grows in tropical and subtropical regions thr... more Turmeric, botanically known as Curcuma longa, Linn, grows in tropical and subtropical regions throughout the world. The turmeric possesses high nutritional value. Extensive research within the last half a century has proven that most of these activities, associated with turmeric are due to curcumin. The medicinal properties of Turmeric include anti-inflammatory, anti-oxidant, anti-coagulant, anti-diabetic, anti-microbial, anti-ulcer, wound healing and anti-fertility activities. It is effectively used in diabetes, various malignant disease, Alzheimer’s disease and other chronic disease. The present paper reviews the Introduction, Geographical distribution, History, Cultivation, Uses, Strange facts, Side effects, Synonyms, Botanical description, Taxonomical classification, Nutritional value, Phytochemical constituents, and Pharmacological activities along with the current trends in research on Turmeric.

Birat Journal of Health Sciences, 2021

Introduction: Cataract is the main cause of bilateral blindness in Nepal. Surgery is the accepted... more Introduction: Cataract is the main cause of bilateral blindness in Nepal. Surgery is the accepted treatment option for cataract with Small incision Cataract Surgery (SICS) and Phacoemusification being the common procedures being performed with comparable results. Corneal astigmatism has been a byproduct of cataract surgery since the first limbal incision was made with improved techniques. Self-sealing scleral pocket incisions are stable and provides early healing, faster visual restoration and more importantly superior astigmatism control. A variety of scleral incisions are being used in manual SICS, with the aim of keeping the post-operative astigmatism to a minimum. Despite having many techniques of scleral incision, there have been only few studies which compares surgical induced astigmatism (SIA) between them Objective: To determine surgical induced astigmatism following frown, chevron and straight incision forms in suture-less small incision cataract surgery(SICS). Methodology:...

Original Research Ar cle Yadav RD et al 1. Ophthalmologist, Lumbini Eye Ins tute and Research Cen... more Original Research Ar cle Yadav RD et al 1. Ophthalmologist, Lumbini Eye Ins tute and Research Center, Bhairahawa, Nepal. 2. Associate Professor, Lumbini Eye Ins tute and Research Center, Bhairahawa, Nepal. 3. Lecturer, Universal Collage of Nursing Sciences, Bhairahawa, Nepal. * Corresponding Author Dr. Roshan Dev Yadav Lecturer General Ophthalmology Lumbini Eye Ins tute and Research Centre, Nepal Email ID: ro_rosn@yahoo.com ORCID ID: h ps://orcid.org/0000-0002-8356-3436 Affilia on © Authors retain copyright and grant the journal right of first publica on with the work simultaneously licensed under Crea ve Commons A ribu on License CC BY 4.0 that allows others to share the work with an acknowledgment of the work's authorship and ini al publica on in this journal. A R T I C L E I N F O Received : 30 July, 2020 Accepted : 17 January, 2021 Published : 15 June, 2021

Chitin and Chitosan are abundant and versatile biomaterials resembling with the properties of cel... more Chitin and Chitosan are abundant and versatile biomaterials resembling with the properties of cellulose. The deacetylate chitin derivative, chitosan is more useful and functional material of high potential in various fields due to its solubility and reactive free amino group (-NH2). Based on current research, this review helps to understand the wide range characteristics and applications of chitin and chitosan in various industrial and biomedical areas.

Asian Journal of Medical Sciences, 2021

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferati... more Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells. CML accounts for 20% of all leukemias affecting adults. Retinal lesions are the most common ocular manifestation of leukemia. They are found most often in adults and in patients with myeloid leukemia. Despite the significant efforts made by different groups to optimize treatment and outcome, there are still unmet needs and unanswered questions. Ophthalmologic manifestations are among the therapeutic challenge. Here we present a case of CML (chronic phase) with ophthalmologic manifestations as initial presentation, trying to shed light on this important type of presentation.

Highly porous 3Dimensional (3D) scaffold becomes a promising alternative approach for tissue repa... more Highly porous 3Dimensional (3D) scaffold becomes a promising alternative approach for tissue repairing. Tissue engineering (TE) is an interdisciplinary field involving principles of engineering and biological sciences to regenerate new tissue and organs using cells and scaffolds. Functional biomaterial research has focused on the development and improvement of scaffolding which has played an important role in the therapeutic approach in the current and future medicine. Scaffolds are one of the decisive factors for tissue engineering. It consists of natural polymers which have recently been developed more quickly and have gained more popularity. These include chitosan, a copolymer derived from the alkaline deacetylation of chitin. Expectations for use of these scaffolds are increasing as the knowledge regarding their chemical and biological properties expands, and new biomedical applications are investigated. Due to their different biological properties such as being biocompatible, bio adhesive, biodegradable, and bioactive, they have given the pattern for use in tissue engineering for repair and/or regeneration of different tissues including skin, bone, cartilage, nerves, liver and muscle. Here we highlight recent advances in the development of chitosan-based scaffolds with enhanced tissue regeneration capability.

Introduction: Fracture of the distal end of the radius is among the commonest skeletal injury wit... more Introduction: Fracture of the distal end of the radius is among the commonest skeletal injury with diverse treatment options. There is no clear consensus on functional outcomes about diverse treatment options. Objective: To evaluate the accuracy of reduction and compare the functional outcome between closed reduction supplemental percutaneous Kirschner wire fixation and conventional plaster cast immobilization for treatment of fracture distal end of the radius. Methodology: 60 patients with the distal end of radius fracture were selected and divided into two groups, group A (K-wire group): Patients with closed reduction and percutaneous K-wire fixation combined with plaster cast and group B (Cast group): Patients with closed reduction and conventional plaster cast immobilization randomly. Results: All patients in the cast group showed signs of clinical union compared to the k-wire group (96.66%) at 6 weeks. Meanwhile, all patients showed signs of both clinical and radiological union...

Asian Journal of Medical Sciences, 2021

Background: Infantile esotropia is misalignment of eyes from bifoveal fixation where surgical cor... more Background: Infantile esotropia is misalignment of eyes from bifoveal fixation where surgical correction at an early age usually presents with good outcomes. Aims and Objective: To compare the surgical outcome between bilateral medial rectus recession (BMR) and recession- resection (RR) surgery in infantile esotropia. Materials and Methods: The study was conducted in Lumbini Eye Institute, Bhairahawa, from December 2017 to December 2018. Patients with infantile esotropia who underwent surgical correction were included in the study. Patients were examined pre operatively, and post operatively at day one and third month, where the angle of deviation was measured and the level of binocular single vision (BSV) was assessed. Data was entered and analyzed using the SPSS program. Results: Total 79 patients were included in the study out of which 33 underwent BMR and 46 underwent RR. The mean pre-operative angle by PBCT was 52.58 PD (SD ±15.468) in the BMR group and 47.83 PD (SD ±12.140) in...

Biomedical Research and Clinical Reviews, 2021

Sandalwood (White Sandal) is the fragrant heartwood of some species of genus Santalum. The widely... more Sandalwood (White Sandal) is the fragrant heartwood of some species of genus Santalum. The widely distributed and economically important Santalum genus belongs to the family Santalaceae which includes 30 genera with about 400 species, many of which being completely or partially parasitic (John, 1947). The word Sandal has been derived from Chandana (Sanskrit), Chandan (Persian), Savtador (Greek) and Santal (French). There are references of Sandalwood in Indian mythology, folklore and ancient scripts. ‘Chandana’ the Sanskrit name ascribed to Santalum album L. was known and used in India from the earliest historic times and is frequently mentioned in the ancient Sanskrit writings, some of which dated before Christian era. Kautilya’s Arthashastra (320 B.C.) considered Sandal as one of the important forest products to increase royal revenue. Charaka Sanhitha, the major text book of internal medicine in Ayurveda (300 B.C.) quotes uses of Sandal over 160 time in the entire text. In treatme...

Birat Journal of Health Sciences, 2020

Introduction: Age- related Macular Degeneration (AMD) is the commonest cause of irreversible blin... more Introduction: Age- related Macular Degeneration (AMD) is the commonest cause of irreversible blindness and visual impairment in elderly, aged50 years or older contributing 8.7% of global blindness. Among the two types: “dry” and “wet”, the “wet” variant is treated using anti-VEGFs, mainly via two regimen – PRN or TREX. Objective: To study and compare the compliance, cost and visual outcome of “Treat-and- Extend (TREX)”versus “Pro Re Nata(PRN)” dosing of intravitrealbevacizumab in Wet AMD. Methodology: Sixty-four eyes of 64 patients with treatment naïve neovascular AMD were included and randomly divided into two groups, with each group comprising 32 eyes, by lottery system: “Group A [TREX]” and “Group B [PRN]”. Group A was treated with intravitrealbevacizumab [1.25mg/0.05ml] at presentation and at 1-month interval for 3 consecutive months [loading dose] and monthly till dry macula was obtained. Group B was treated with the same in “as needed” basis.Both Groups were followed up, for 1...

International Journal of Chemical Studies, 2020

(Rajasthan). Alternaria alternata was isolated from leaves of tomato and observed to be pathogeni... more (Rajasthan). Alternaria alternata was isolated from leaves of tomato and observed to be pathogenic under artificial conditions. It is cause heavy yield loss in rajasthan as well as in india. Among five systemic acquired resistance activators , salicylic acid was found most effective against Alternaria alternata in vivo conditions followed by , 2,4 Dichloroisonicotinic acid. All treatments as foilar spray were able to reduce disease severity over untreated control.

International Journal of Chemical Studies, 2020

(Rajasthan). Rhizoctonia root rot of okra caused by rhizcotonia solani is an important disease An... more (Rajasthan). Rhizoctonia root rot of okra caused by rhizcotonia solani is an important disease An attempt was more find out the efficacy of different plant extracts and fungicides were against in Rhizoctonia solani in vitro and in vivo conditions. Among five Plant extracts garlic clove was found most effective followed by neem and among five fungicides carbendazim was found most effective followed by propiconazole against Rhizoctonia solani in vitro conditions. In potted plant minimum disease severity were obtained in garlic and carbendazim and followed by neem and propiconazole. Garlic and carbendazim were found effective in management of root rot of okra caused by Rhizoctonia solani in vitro and in vivo conditions.

Journal of Nepal Medical Association, 2017

Introduction: The management of distal tibia fracture is challenging because of the limited soft ... more Introduction: The management of distal tibia fracture is challenging because of the limited soft tissue coverage and poor vascularity around the bone in that area. Minimally invasive percutaneous plate osteosynthesis is a novel technique in this regard but needs fluoroscopy. In unavailability of fluoroscopy or its technical malfunction, limited open reduction percutaneous plate osteosynthesis becomes useful. The aim of this study is to compare the outcomes of distal tibia fractures treated by LORPPO and MIPPO techniques in terms of duration of hospital stay, full weight bearing, union time and complications. Methods: Twenty-two cases of closed distal tibia fractures without articular involvement or comminution operated at Koshi Zonal Hospital, Nepal from March 2014 to May 2016 were included in this study. Total 11cases of which were treated by MIPPO whereas other 11 cases were treated by LORPPO. MIPPO technique was done only when the fluoroscopy was available. Results: In MIPPO, the...

International Journal For Multidisciplinary Research, Jan 7, 2023

The production of niosomes, which are non-ionic surfactant vessels, involves hydrating synthetic ... more The production of niosomes, which are non-ionic surfactant vessels, involves hydrating synthetic nonionic surfactants, either with or without the addition of cholesterol or another lipid. Due to their distinctive qualities, including biodegradability, biocompatibility, chemical stability, low production cost, ease of storage and handling, and low toxicity, non-ionic surfactant vesicles also known as niosomes have received a lot of attention in the field of modern drug delivery system. Niosomes are hydrated vesicular systems with a lamellar bilayer structure made of non-ionic surfactants with or without cholesterol, and they have a wide spectrum of solubilities that allow them to encapsulate a variety of bioactive chemicals. Niosomes have been tested as a delivery system for a variety of anti-cancer medications, genes, antigens, and other bioactive substances. This article focuses on recent developments in niosomal drug delivery, possible benefits over alternative delivery mechanisms, formulation techniques, characterisation techniques, and ongoing niosome research.

International Journal of Advanced Biochemistry Research

Journal of Universal College of Medical Sciences

INTRODUCTIONComputers and laptops have become an integral part of our daily life. We interact wit... more INTRODUCTIONComputers and laptops have become an integral part of our daily life. We interact with computer screens for minutes to hours depending upon our need, for entertainment or official purposes. Using computers has become a 21st century necessity. The expansion of information technologies in recent decades has resulted in increased use of video display terminals (VDT) in the workplace. The American Optometric Association (AOA) defines Computer Vision Syndrome (CVS) as the complex of eye and vision problems related to near work, which are experienced during or related to computer use. CVS is characterised by visual symptoms resulting from interaction with a computer display or its environment. This study aimed to assess the prevalence of computer vision syndrome among medical and engineering students of Rupandehi, Nepal. MATERIAL AND METHODS A cross‑sectional study was conducted among final year medical and engineering college students of Universal College of medical sciences...

International Journal of Scientific Research in Science, Engineering and Technology

Majority of power plants of India are running on coal. To reduce the greenhouse gas emitted from ... more Majority of power plants of India are running on coal. To reduce the greenhouse gas emitted from these coal-based power plants, the power generating stations intends to utilize agriculture residue-based pellets. Agro residue-based pellets combustion is renewable source of energy. The use of agro based briquettes in densified form reduces air pollution which is mainly due burning of stubble. Apart from generation of smog in winter season, stubble burning in fields also reduces soil fertility. Central Electricity Authority, Ministry of Power (MoP) issued an Advisory for utilization of agro remains or residue-based pellets for power generation. Co-firing in a coal fired thermal power plants states to promote the use of the biomass pellets. All pulverized based coal units of electrical power generating units shall make efforts for using 5-10% blend of biomass-based pellets. These pellets must be primarily from residual agriculture waste. The generating units must keep in account of all ...

Nepalese Journal of Ophthalmology

Introduction: Glaucoma is one of the common causes of blindness worldwide, and the leading cause ... more Introduction: Glaucoma is one of the common causes of blindness worldwide, and the leading cause of irreversible blindness .The overall prevalence of glaucoma in Nepal is 1.9%. Though poorly understood, primary open angle glaucoma (POAG) is believed to have a genetic or familial component that may occur through polygenic or multifactorial transmission. First-degree relatives of POAG patients have 4–16% risk of developing POAG. Given the circumstances and the prevalence of POAG in first degree relatives of POAG patients, screening the first degree relative/s accompanying the patient to the hospital can be a cost effective and viable tool for glaucoma screening that will not add any extra cost of travel and accommodation. Materials and methods: The authors performed a hospital-based cross-sectional study at a tertiary eye hospital in Nepal. All first-degree family members of POAG patients who accompanied them to the glaucoma clinic underwent a full ophthalmic examination.The optic dis...

2017 8th Annual Industrial Automation and Electromechanical Engineering Conference (IEMECON), 2017

The present text provides information regarding introductory concept of wireless power transfer b... more The present text provides information regarding introductory concept of wireless power transfer by studying some of the existing technologies and evaluate its quality factor as well as deals with certain methods of improving the efficiency of wireless power transfer. In addition to this, calculation and analysis has also been done for its figure of merit, transfer loss, quality factor and efficiency.

Journal of Pharmacognosy and Phytochemistry, 2017

Turmeric, botanically known as Curcuma longa, Linn, grows in tropical and subtropical regions thr... more Turmeric, botanically known as Curcuma longa, Linn, grows in tropical and subtropical regions throughout the world. The turmeric possesses high nutritional value. Extensive research within the last half a century has proven that most of these activities, associated with turmeric are due to curcumin. The medicinal properties of Turmeric include anti-inflammatory, anti-oxidant, anti-coagulant, anti-diabetic, anti-microbial, anti-ulcer, wound healing and anti-fertility activities. It is effectively used in diabetes, various malignant disease, Alzheimer’s disease and other chronic disease. The present paper reviews the Introduction, Geographical distribution, History, Cultivation, Uses, Strange facts, Side effects, Synonyms, Botanical description, Taxonomical classification, Nutritional value, Phytochemical constituents, and Pharmacological activities along with the current trends in research on Turmeric.

Birat Journal of Health Sciences, 2021

Introduction: Cataract is the main cause of bilateral blindness in Nepal. Surgery is the accepted... more Introduction: Cataract is the main cause of bilateral blindness in Nepal. Surgery is the accepted treatment option for cataract with Small incision Cataract Surgery (SICS) and Phacoemusification being the common procedures being performed with comparable results. Corneal astigmatism has been a byproduct of cataract surgery since the first limbal incision was made with improved techniques. Self-sealing scleral pocket incisions are stable and provides early healing, faster visual restoration and more importantly superior astigmatism control. A variety of scleral incisions are being used in manual SICS, with the aim of keeping the post-operative astigmatism to a minimum. Despite having many techniques of scleral incision, there have been only few studies which compares surgical induced astigmatism (SIA) between them Objective: To determine surgical induced astigmatism following frown, chevron and straight incision forms in suture-less small incision cataract surgery(SICS). Methodology:...

Original Research Ar cle Yadav RD et al 1. Ophthalmologist, Lumbini Eye Ins tute and Research Cen... more Original Research Ar cle Yadav RD et al 1. Ophthalmologist, Lumbini Eye Ins tute and Research Center, Bhairahawa, Nepal. 2. Associate Professor, Lumbini Eye Ins tute and Research Center, Bhairahawa, Nepal. 3. Lecturer, Universal Collage of Nursing Sciences, Bhairahawa, Nepal. * Corresponding Author Dr. Roshan Dev Yadav Lecturer General Ophthalmology Lumbini Eye Ins tute and Research Centre, Nepal Email ID: ro_rosn@yahoo.com ORCID ID: h ps://orcid.org/0000-0002-8356-3436 Affilia on © Authors retain copyright and grant the journal right of first publica on with the work simultaneously licensed under Crea ve Commons A ribu on License CC BY 4.0 that allows others to share the work with an acknowledgment of the work's authorship and ini al publica on in this journal. A R T I C L E I N F O Received : 30 July, 2020 Accepted : 17 January, 2021 Published : 15 June, 2021

Chitin and Chitosan are abundant and versatile biomaterials resembling with the properties of cel... more Chitin and Chitosan are abundant and versatile biomaterials resembling with the properties of cellulose. The deacetylate chitin derivative, chitosan is more useful and functional material of high potential in various fields due to its solubility and reactive free amino group (-NH2). Based on current research, this review helps to understand the wide range characteristics and applications of chitin and chitosan in various industrial and biomedical areas.

Asian Journal of Medical Sciences, 2021

Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferati... more Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. Consequently, the peripheral blood cell profile shows an increased number of granulocytes and their immature precursors, including occasional blast cells. CML accounts for 20% of all leukemias affecting adults. Retinal lesions are the most common ocular manifestation of leukemia. They are found most often in adults and in patients with myeloid leukemia. Despite the significant efforts made by different groups to optimize treatment and outcome, there are still unmet needs and unanswered questions. Ophthalmologic manifestations are among the therapeutic challenge. Here we present a case of CML (chronic phase) with ophthalmologic manifestations as initial presentation, trying to shed light on this important type of presentation.

Highly porous 3Dimensional (3D) scaffold becomes a promising alternative approach for tissue repa... more Highly porous 3Dimensional (3D) scaffold becomes a promising alternative approach for tissue repairing. Tissue engineering (TE) is an interdisciplinary field involving principles of engineering and biological sciences to regenerate new tissue and organs using cells and scaffolds. Functional biomaterial research has focused on the development and improvement of scaffolding which has played an important role in the therapeutic approach in the current and future medicine. Scaffolds are one of the decisive factors for tissue engineering. It consists of natural polymers which have recently been developed more quickly and have gained more popularity. These include chitosan, a copolymer derived from the alkaline deacetylation of chitin. Expectations for use of these scaffolds are increasing as the knowledge regarding their chemical and biological properties expands, and new biomedical applications are investigated. Due to their different biological properties such as being biocompatible, bio adhesive, biodegradable, and bioactive, they have given the pattern for use in tissue engineering for repair and/or regeneration of different tissues including skin, bone, cartilage, nerves, liver and muscle. Here we highlight recent advances in the development of chitosan-based scaffolds with enhanced tissue regeneration capability.

Introduction: Fracture of the distal end of the radius is among the commonest skeletal injury wit... more Introduction: Fracture of the distal end of the radius is among the commonest skeletal injury with diverse treatment options. There is no clear consensus on functional outcomes about diverse treatment options. Objective: To evaluate the accuracy of reduction and compare the functional outcome between closed reduction supplemental percutaneous Kirschner wire fixation and conventional plaster cast immobilization for treatment of fracture distal end of the radius. Methodology: 60 patients with the distal end of radius fracture were selected and divided into two groups, group A (K-wire group): Patients with closed reduction and percutaneous K-wire fixation combined with plaster cast and group B (Cast group): Patients with closed reduction and conventional plaster cast immobilization randomly. Results: All patients in the cast group showed signs of clinical union compared to the k-wire group (96.66%) at 6 weeks. Meanwhile, all patients showed signs of both clinical and radiological union...

Asian Journal of Medical Sciences, 2021

Background: Infantile esotropia is misalignment of eyes from bifoveal fixation where surgical cor... more Background: Infantile esotropia is misalignment of eyes from bifoveal fixation where surgical correction at an early age usually presents with good outcomes. Aims and Objective: To compare the surgical outcome between bilateral medial rectus recession (BMR) and recession- resection (RR) surgery in infantile esotropia. Materials and Methods: The study was conducted in Lumbini Eye Institute, Bhairahawa, from December 2017 to December 2018. Patients with infantile esotropia who underwent surgical correction were included in the study. Patients were examined pre operatively, and post operatively at day one and third month, where the angle of deviation was measured and the level of binocular single vision (BSV) was assessed. Data was entered and analyzed using the SPSS program. Results: Total 79 patients were included in the study out of which 33 underwent BMR and 46 underwent RR. The mean pre-operative angle by PBCT was 52.58 PD (SD ±15.468) in the BMR group and 47.83 PD (SD ±12.140) in...

Biomedical Research and Clinical Reviews, 2021

Sandalwood (White Sandal) is the fragrant heartwood of some species of genus Santalum. The widely... more Sandalwood (White Sandal) is the fragrant heartwood of some species of genus Santalum. The widely distributed and economically important Santalum genus belongs to the family Santalaceae which includes 30 genera with about 400 species, many of which being completely or partially parasitic (John, 1947). The word Sandal has been derived from Chandana (Sanskrit), Chandan (Persian), Savtador (Greek) and Santal (French). There are references of Sandalwood in Indian mythology, folklore and ancient scripts. ‘Chandana’ the Sanskrit name ascribed to Santalum album L. was known and used in India from the earliest historic times and is frequently mentioned in the ancient Sanskrit writings, some of which dated before Christian era. Kautilya’s Arthashastra (320 B.C.) considered Sandal as one of the important forest products to increase royal revenue. Charaka Sanhitha, the major text book of internal medicine in Ayurveda (300 B.C.) quotes uses of Sandal over 160 time in the entire text. In treatme...

Birat Journal of Health Sciences, 2020

Introduction: Age- related Macular Degeneration (AMD) is the commonest cause of irreversible blin... more Introduction: Age- related Macular Degeneration (AMD) is the commonest cause of irreversible blindness and visual impairment in elderly, aged50 years or older contributing 8.7% of global blindness. Among the two types: “dry” and “wet”, the “wet” variant is treated using anti-VEGFs, mainly via two regimen – PRN or TREX. Objective: To study and compare the compliance, cost and visual outcome of “Treat-and- Extend (TREX)”versus “Pro Re Nata(PRN)” dosing of intravitrealbevacizumab in Wet AMD. Methodology: Sixty-four eyes of 64 patients with treatment naïve neovascular AMD were included and randomly divided into two groups, with each group comprising 32 eyes, by lottery system: “Group A [TREX]” and “Group B [PRN]”. Group A was treated with intravitrealbevacizumab [1.25mg/0.05ml] at presentation and at 1-month interval for 3 consecutive months [loading dose] and monthly till dry macula was obtained. Group B was treated with the same in “as needed” basis.Both Groups were followed up, for 1...

International Journal of Chemical Studies, 2020

(Rajasthan). Alternaria alternata was isolated from leaves of tomato and observed to be pathogeni... more (Rajasthan). Alternaria alternata was isolated from leaves of tomato and observed to be pathogenic under artificial conditions. It is cause heavy yield loss in rajasthan as well as in india. Among five systemic acquired resistance activators , salicylic acid was found most effective against Alternaria alternata in vivo conditions followed by , 2,4 Dichloroisonicotinic acid. All treatments as foilar spray were able to reduce disease severity over untreated control.

International Journal of Chemical Studies, 2020

(Rajasthan). Rhizoctonia root rot of okra caused by rhizcotonia solani is an important disease An... more (Rajasthan). Rhizoctonia root rot of okra caused by rhizcotonia solani is an important disease An attempt was more find out the efficacy of different plant extracts and fungicides were against in Rhizoctonia solani in vitro and in vivo conditions. Among five Plant extracts garlic clove was found most effective followed by neem and among five fungicides carbendazim was found most effective followed by propiconazole against Rhizoctonia solani in vitro conditions. In potted plant minimum disease severity were obtained in garlic and carbendazim and followed by neem and propiconazole. Garlic and carbendazim were found effective in management of root rot of okra caused by Rhizoctonia solani in vitro and in vivo conditions.

Journal of Nepal Medical Association, 2017

Introduction: The management of distal tibia fracture is challenging because of the limited soft ... more Introduction: The management of distal tibia fracture is challenging because of the limited soft tissue coverage and poor vascularity around the bone in that area. Minimally invasive percutaneous plate osteosynthesis is a novel technique in this regard but needs fluoroscopy. In unavailability of fluoroscopy or its technical malfunction, limited open reduction percutaneous plate osteosynthesis becomes useful. The aim of this study is to compare the outcomes of distal tibia fractures treated by LORPPO and MIPPO techniques in terms of duration of hospital stay, full weight bearing, union time and complications. Methods: Twenty-two cases of closed distal tibia fractures without articular involvement or comminution operated at Koshi Zonal Hospital, Nepal from March 2014 to May 2016 were included in this study. Total 11cases of which were treated by MIPPO whereas other 11 cases were treated by LORPPO. MIPPO technique was done only when the fluoroscopy was available. Results: In MIPPO, the...