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Current Topics in Contact Dermatitis, 1989
A 32-year-old housewife and schoolteacher presented annually from 1983 to 1986 with a seasonal Ap... more A 32-year-old housewife and schoolteacher presented annually from 1983 to 1986 with a seasonal April-to-September dermatitis of the exposed skin of her face, neck, and limbs, with extreme swelling of the eyelids. Her dermatitis was most severe at home, where it was not prevented by staying inside. It was improved by continuous rain, holidays by the sea, holidays abroad, and systemic steroids. She had a past history of earring dermatitis, but otherwise a completely negative personal and family history of eczema, asthma, or hay fever. She was a keen gardener.
Occupational Medicine, 1994
The construction of the Channel Tunnel is one of the largest civil engineering projects ever unde... more The construction of the Channel Tunnel is one of the largest civil engineering projects ever undertaken. The British drive employed 5900 underground workers, and a number developed dermatitis during 1990/1991. As a result, the Translink Joint Venture (TLJV) Medical Centre set up a surveillance programme aiming to monitor and investigate the men working closely with cement as well as other groups of workers with skin problems. Men attended the Medical Centre voluntarily and were assessed, including history, examination and patch tests to a series of 15 test substances (from the European standard series) where indicated. A programme of education about the hazards of working with cement was instituted, including leaflets, videos, local newspaper articles and personal explanation by the Medical Centre staff. Between January 1990 and January 1992, 1138 men were seen at the Medical Centre regarding their skin and 332 were diagnosed as having occupational dermatitis, past or present. Patch tests were performed on 180 men from all trades. Of the 800 grouters, 466 (58 per cent) were assessed and 111 had a history of occupational dermatitis at some time. Many gave a history of a single episode of dermatitis during a particularly hot and wet phase of tunnelling. Patch tests performed on 86 grouters showed allergy to chromate in 56 (65 per cent). Of the 466 grouters assessed, 17 per cent had positive patch tests to chromate but men with no skin problems past or present were not patch tested. Cobalt allergy was often found with chromate allergy (50 out of 56).(ABSTRACT TRUNCATED AT 250 WORDS)
Contact Dermatitis, 1983
Allergic contact sensitivity to 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, a ... more Allergic contact sensitivity to 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, a diamino intermediate in the synthesis of a novel H2 antagonist, Ranitidine is reported in an industrial chemist with hand dermatitis, who had been working for a prolonged period on the conversion of this intermediate to its fumarate salt.
Contact Dermatitis, 2007
While the frequency of patch test reactivity to many cosmetic allergens has decreased over the la... more While the frequency of patch test reactivity to many cosmetic allergens has decreased over the last 20 years, we have previously shown that in our clinic, the patch test reactivity to p‐phenylenediamine (PPD) has remained stubbornly high between 2.5% and 4.2% in the years when patch testing was performed with 1% PPD. Further retrospective analysis of the PPD patch test frequency over the last 6 years shows an increasing rate of PPD patch test frequency, showing an upward linear trend. This increasing trend cannot be fully explained by any increase in patch testing of Southern Asian patients or of sensitization caused by PPD exposure from ‘temporary henna tattoos’. An alternative explanation may be the increasing use of permanent hair dyes.
Current Topics in Contact Dermatitis, 1989
A 32-year-old housewife and schoolteacher presented annually from 1983 to 1986 with a seasonal Ap... more A 32-year-old housewife and schoolteacher presented annually from 1983 to 1986 with a seasonal April-to-September dermatitis of the exposed skin of her face, neck, and limbs, with extreme swelling of the eyelids. Her dermatitis was most severe at home, where it was not prevented by staying inside. It was improved by continuous rain, holidays by the sea, holidays abroad, and systemic steroids. She had a past history of earring dermatitis, but otherwise a completely negative personal and family history of eczema, asthma, or hay fever. She was a keen gardener.
Occupational Medicine, 1994
The construction of the Channel Tunnel is one of the largest civil engineering projects ever unde... more The construction of the Channel Tunnel is one of the largest civil engineering projects ever undertaken. The British drive employed 5900 underground workers, and a number developed dermatitis during 1990/1991. As a result, the Translink Joint Venture (TLJV) Medical Centre set up a surveillance programme aiming to monitor and investigate the men working closely with cement as well as other groups of workers with skin problems. Men attended the Medical Centre voluntarily and were assessed, including history, examination and patch tests to a series of 15 test substances (from the European standard series) where indicated. A programme of education about the hazards of working with cement was instituted, including leaflets, videos, local newspaper articles and personal explanation by the Medical Centre staff. Between January 1990 and January 1992, 1138 men were seen at the Medical Centre regarding their skin and 332 were diagnosed as having occupational dermatitis, past or present. Patch tests were performed on 180 men from all trades. Of the 800 grouters, 466 (58 per cent) were assessed and 111 had a history of occupational dermatitis at some time. Many gave a history of a single episode of dermatitis during a particularly hot and wet phase of tunnelling. Patch tests performed on 86 grouters showed allergy to chromate in 56 (65 per cent). Of the 466 grouters assessed, 17 per cent had positive patch tests to chromate but men with no skin problems past or present were not patch tested. Cobalt allergy was often found with chromate allergy (50 out of 56).(ABSTRACT TRUNCATED AT 250 WORDS)
Contact Dermatitis, 1983
Allergic contact sensitivity to 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, a ... more Allergic contact sensitivity to 5-[(2-aminoethyl)thiomethyl]-N, N-dimethyl-2-furanmethanamine, a diamino intermediate in the synthesis of a novel H2 antagonist, Ranitidine is reported in an industrial chemist with hand dermatitis, who had been working for a prolonged period on the conversion of this intermediate to its fumarate salt.
Contact Dermatitis, 2007
While the frequency of patch test reactivity to many cosmetic allergens has decreased over the la... more While the frequency of patch test reactivity to many cosmetic allergens has decreased over the last 20 years, we have previously shown that in our clinic, the patch test reactivity to p‐phenylenediamine (PPD) has remained stubbornly high between 2.5% and 4.2% in the years when patch testing was performed with 1% PPD. Further retrospective analysis of the PPD patch test frequency over the last 6 years shows an increasing rate of PPD patch test frequency, showing an upward linear trend. This increasing trend cannot be fully explained by any increase in patch testing of Southern Asian patients or of sensitization caused by PPD exposure from ‘temporary henna tattoos’. An alternative explanation may be the increasing use of permanent hair dyes.