RASHMI VIRKAR - Academia.edu (original) (raw)
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Papers by RASHMI VIRKAR
Viral Immunology, 2016
Modern political leverage from western countries to Russia allows researchers to use domestic his... more Modern political leverage from western countries to Russia allows researchers to use domestic historical experience of 1920-1940s. International isolation of Soviet Russia induced the search of different ways out, including making concessionary agreements with foreign entrepreneurs. Since 1921 concessionary agreements were made between Soviet
The emergence of novel variants of SARS-CoV-2 in several countries has been associated with the i... more The emergence of novel variants of SARS-CoV-2 in several countries has been associated with the increased transmission/ reduced neutralization potential of antibodies against the Wuhan virus (wild type). Currently, India is recovering from an explosive second wave of COVID-19. This prospective study was conducted quarterly for one year (May 2020 to June 2021) at a tertiary care hospital, Pune city, western India. Receptor binding domain (RBD, n = 319) and full genome (n = 20) sequences from viral RNA positive nasopharyngeal swabs of COVID-19 patients representing first and second waves were used for analysis. We did not detect Brazil, South Africa and California variants. Till December, only wild type strain was prevalent. Concurrent with the upsurge of second wave in March-2021, 73% (33/45) of RBD sequences harboured L452R/E484Q mutations characteristic of Kappa variant. In April, co-circulation of Kappa (37%) and Delta (L452R/T478K, 59%) variants was recorded. During May and June,...
Viral Immunology, 2016
Modern political leverage from western countries to Russia allows researchers to use domestic his... more Modern political leverage from western countries to Russia allows researchers to use domestic historical experience of 1920-1940s. International isolation of Soviet Russia induced the search of different ways out, including making concessionary agreements with foreign entrepreneurs. Since 1921 concessionary agreements were made between Soviet
The emergence of novel variants of SARS-CoV-2 in several countries has been associated with the i... more The emergence of novel variants of SARS-CoV-2 in several countries has been associated with the increased transmission/ reduced neutralization potential of antibodies against the Wuhan virus (wild type). Currently, India is recovering from an explosive second wave of COVID-19. This prospective study was conducted quarterly for one year (May 2020 to June 2021) at a tertiary care hospital, Pune city, western India. Receptor binding domain (RBD, n = 319) and full genome (n = 20) sequences from viral RNA positive nasopharyngeal swabs of COVID-19 patients representing first and second waves were used for analysis. We did not detect Brazil, South Africa and California variants. Till December, only wild type strain was prevalent. Concurrent with the upsurge of second wave in March-2021, 73% (33/45) of RBD sequences harboured L452R/E484Q mutations characteristic of Kappa variant. In April, co-circulation of Kappa (37%) and Delta (L452R/T478K, 59%) variants was recorded. During May and June,...