Rachel Tyndale - Academia.edu (original) (raw)
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Papers by Rachel Tyndale
Trends in Pharmacological Sciences, Dec 1, 2011
Nicotine & Tobacco Research, Oct 20, 2022
Genetic Epidemiology, Aug 16, 2020
Nicotine & Tobacco Research, May 18, 2017
Drug and Alcohol Dependence, Sep 1, 2018
Trends in Molecular Medicine, Feb 1, 2018
European Journal of Neuroscience, Apr 1, 2010
Neuropharmacology, Dec 1, 2008
Nicotine & Tobacco Research, Aug 24, 2018
Pharmacogenetics and Genomics, Sep 1, 2012
Neuropsychopharmacology, Mar 3, 2023
BMC Medical Research Methodology, Apr 29, 2023
International Journal for Population Data Science, Feb 11, 2021
International Journal of Population Data Science
BackgroundThe objective of this project is to determine the effectiveness of targeting a communit... more BackgroundThe objective of this project is to determine the effectiveness of targeting a community with a high smoking rate with the distribution of free-of-charge nicotine patches in order to promote tobacco cessation. Methods/DesignOne small community with an elevated smoking rate (compared to national and provincial averages) has been identified. All households in the community will be sent a letter offering one smoker (18 years or older; 10 or more cigarettes per day) in the household a free-of-charge mailed five-week supply of nicotine patches (up to a total of 800 five-week kits will be available for distribution). Participants receiving nicotine patches will be asked to complete a six-month follow-up survey assessing tobacco cessation defined as 30-day point prevalence abstinence. In addition, attempts will be made to employ ongoing national population surveys containing cigarette smoking variables to compare changes in smoking prevalence in the target community to other comm...
Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Precision care may engage smokers and providers in treatment but is understudie... more OBJECTIVES/GOALS: Precision care may engage smokers and providers in treatment but is understudied in the community. We piloted guideline-based care (GBC) alone or with Respiragene, a lung cancer polygenic risk score (PRS, 1-10), or metabolism-informed choice of medication using the nicotine metabolite ratio (NMR). METHODS/STUDY POPULATION: Daily smokers (n = 58) with stored biospecimens in the Southern Community Cohort Study were randomized 1:1:1 to GBC, PRS, or NMR, counseled to quit smoking, and co-selected FDA-approved cessation medication (nicotine replacement, varenicline) with a tobacco counselor. In PRS, precision motivational counseling was guided by PRS (i.e., lung cancer risk 10-40-fold that of never-smokers). In NMR, precision medication recommendations consisted of varenicline for faster metabolizers (NMR≥0.31) and nicotine replacement for slow metabolizers (NMR<0.31). Feasibility was defined as achieving at least 50% provider engagement (med prescription) and at lea...
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, Jan 18, 2017
![Research paper thumbnail of Fatty Acid Amide Hydrolase Binding in Brain of Cannabis Users: Imaging With the Novel Radiotracer [11C]CURB](https://attachments.academia-assets.com/120585895/thumbnails/1.jpg)
](Biological Psychiatry, 2016
BMC genomics, Jan 23, 2015
We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subje... more We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subjects. RNA sequencing techniques were designed to detect both coding and non-coding RNA, splice isoform composition, and allelic expression. Brain regions were selected from five subjects with a documented history of smoking and five non-smokers. Paired-end RNA sequencing was performed on SOLiD instruments to a depth of >40 million reads, using linearly amplified, ribosomally depleted RNA. Sequencing libraries were prepared with both poly-dT and random hexamer primers to detect all RNA classes, including long non-coding (lncRNA), intronic and intergenic transcripts, and transcripts lacking poly-A tails, providing additional data not previously available. The study was designed to generate a database of the complete transcriptomes in brain region for gene network analyses and discovery of regulatory variants. Of 20,318 protein coding and 18,080 lncRNA genes annotated from GENCODE and lnc...
Trends in Pharmacological Sciences, Dec 1, 2011
Nicotine & Tobacco Research, Oct 20, 2022
Genetic Epidemiology, Aug 16, 2020
Nicotine & Tobacco Research, May 18, 2017
Drug and Alcohol Dependence, Sep 1, 2018
Trends in Molecular Medicine, Feb 1, 2018
European Journal of Neuroscience, Apr 1, 2010
Neuropharmacology, Dec 1, 2008
Nicotine & Tobacco Research, Aug 24, 2018
Pharmacogenetics and Genomics, Sep 1, 2012
Neuropsychopharmacology, Mar 3, 2023
BMC Medical Research Methodology, Apr 29, 2023
International Journal for Population Data Science, Feb 11, 2021
International Journal of Population Data Science
BackgroundThe objective of this project is to determine the effectiveness of targeting a communit... more BackgroundThe objective of this project is to determine the effectiveness of targeting a community with a high smoking rate with the distribution of free-of-charge nicotine patches in order to promote tobacco cessation. Methods/DesignOne small community with an elevated smoking rate (compared to national and provincial averages) has been identified. All households in the community will be sent a letter offering one smoker (18 years or older; 10 or more cigarettes per day) in the household a free-of-charge mailed five-week supply of nicotine patches (up to a total of 800 five-week kits will be available for distribution). Participants receiving nicotine patches will be asked to complete a six-month follow-up survey assessing tobacco cessation defined as 30-day point prevalence abstinence. In addition, attempts will be made to employ ongoing national population surveys containing cigarette smoking variables to compare changes in smoking prevalence in the target community to other comm...
Journal of Clinical and Translational Science, 2020
OBJECTIVES/GOALS: Precision care may engage smokers and providers in treatment but is understudie... more OBJECTIVES/GOALS: Precision care may engage smokers and providers in treatment but is understudied in the community. We piloted guideline-based care (GBC) alone or with Respiragene, a lung cancer polygenic risk score (PRS, 1-10), or metabolism-informed choice of medication using the nicotine metabolite ratio (NMR). METHODS/STUDY POPULATION: Daily smokers (n = 58) with stored biospecimens in the Southern Community Cohort Study were randomized 1:1:1 to GBC, PRS, or NMR, counseled to quit smoking, and co-selected FDA-approved cessation medication (nicotine replacement, varenicline) with a tobacco counselor. In PRS, precision motivational counseling was guided by PRS (i.e., lung cancer risk 10-40-fold that of never-smokers). In NMR, precision medication recommendations consisted of varenicline for faster metabolizers (NMR≥0.31) and nicotine replacement for slow metabolizers (NMR<0.31). Feasibility was defined as achieving at least 50% provider engagement (med prescription) and at lea...
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, Jan 18, 2017
Biological Psychiatry, 2016
BMC genomics, Jan 23, 2015
We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subje... more We used RNA sequencing to analyze transcript profiles of ten autopsy brain regions from ten subjects. RNA sequencing techniques were designed to detect both coding and non-coding RNA, splice isoform composition, and allelic expression. Brain regions were selected from five subjects with a documented history of smoking and five non-smokers. Paired-end RNA sequencing was performed on SOLiD instruments to a depth of >40 million reads, using linearly amplified, ribosomally depleted RNA. Sequencing libraries were prepared with both poly-dT and random hexamer primers to detect all RNA classes, including long non-coding (lncRNA), intronic and intergenic transcripts, and transcripts lacking poly-A tails, providing additional data not previously available. The study was designed to generate a database of the complete transcriptomes in brain region for gene network analyses and discovery of regulatory variants. Of 20,318 protein coding and 18,080 lncRNA genes annotated from GENCODE and lnc...