Radomir Naumovic - Academia.edu (original) (raw)
Papers by Radomir Naumovic
Galenika Medical Journal, Dec 31, 2022
Nephrology Dialysis Transplantation
Background The aim of this study was to identify trends in total, deceased donor (DD) and living ... more Background The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. Results The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in...
Kidney International Reports, Feb 1, 2022
![Research paper thumbnail of [Peritonitis in patients on continuous ambulatory peritoneal dialysis]](https://attachments.academia-assets.com/108977994/thumbnails/1.jpg)
](PubMed, 1996
We analysed 27 patients (15 women and 12 men) on CAPD treatment longer than 6 months at the Clini... more We analysed 27 patients (15 women and 12 men) on CAPD treatment longer than 6 months at the Clinic of Nephrology, CCS, in Belgrade. Pts were between 22 and 72 years old (57.77 +/- 12.21 years). These pts had 47 episodes of peritonitis: 6 pts (22.22%) were without peritonitis, but 21 pts (78.22%) had between 1 and 5 episodes of peritonitis. We found 1 peritonitis /pts/year. Causes of peritonitis were mostly unknown (27/47) because treatment had began before taking culture of the peritoneal dyalisate. The most common causes of peritonitis were coagulase negative staphylococci: Staphylococcus aureus (8) and Staphylococci epidermidis (8). Laboratory showed: leucocytosis, hyperfibrinogenaemia, hypoproteinaemia and accelerated ESR. There was no connection between causes of chronic renal failure and frequency or peritonitis. During treatment of peritonitis in 2 pts we had to replace the peritoneal catheter and 5 pts went on haemodialyses. The other were recovered and continued CAPD treatment.
PubMed, Feb 24, 2016
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It... more Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
Current Medicinal Chemistry, Jul 19, 2016
International Urology and Nephrology, Jul 6, 2023
Kidney International Reports, Feb 1, 2022
International Journal of Medical Informatics, Aug 1, 2022
Herz, Jun 13, 2016
Aim. This study analyzed the prevalence of hypertension and the pattern of antihypertensive treat... more Aim. This study analyzed the prevalence of hypertension and the pattern of antihypertensive treatment before and after kidney transplantation. Patients and methods. The prevalence of hypertension and the class and daily dosage load of antihypertensive medications were analyzed in 116 patients before kidney transplantation and 1, 6, and 12 months after transplantation (67.2 % males, mean age 45.9 ± 11.4 years). Two patients died and eight had the allograft explanted, leaving 106 patients in the final analysis. Blood pressure (BP) was recorded on the day of transplantation and at every follow-up; it was considered uncontrolled at values > 130/80 mmHg.
Pathology Research and Practice, Oct 1, 2018
This prospective observational study included 665 consecutive patients who underwent renal biopsy... more This prospective observational study included 665 consecutive patients who underwent renal biopsy between January 2007 and the end of 2014. For each patient we recorded age, gender, the indication for renal biopsy and the pathohistological diagnosis. Previous to renal biopsy, all appropriate clinical exams and laboratory tests were made including testing for autoantibodies (anti-GBM, ANCA). Renal biopsy specimens were stained and analysed by light microscopy and immunohistochemistry using polyclonal antisera against human IgG, IgM, IgA, C3, C1q and, if necessary, kappa and lambda light chains. Electron microscopy was not performed because of technical limitations in the histopathology laboratory.. Six clinical syndromes were indications for renal biopsy: nephrotic syndrome (NS), acute nephritic syndrome (ANS), asymptomatic urinary abnormalities (AUA), haematuria (H), acute kidney injury (AKI) and chronic renal failure (CRF). NS was defined as proteinuria >3.5g/day/1.73m 2 and hypoproteinaemia or hypoalbuminaemia. ANS was defined as haematuria, hypertension, oedema, oliguria and reduced glomerular filtration rate. Non-nephrotic proteinuria with or without microscopic haematuria was considered as AUA. Haematuria
International Journal of Molecular Sciences
The complications of type 2 diabetes mellitus (T2DM) are well known and one of them is diabetic c... more The complications of type 2 diabetes mellitus (T2DM) are well known and one of them is diabetic chronic kidney disease (DCKD). Over time, it has become clear that patients with T2DM can have nondiabetic chronic kidney diseases (NDCKD), especially those that affect the glomeruli. Clinical indicators for identifying DCKD from NDCKD with high sensitivity and specificity have not yet been identified. Therefore, kidney biopsy remains the golden standard for DCKD diagnosis in patients with T2DM. Despite some indications for kidney biopsy, criteria for a biopsy differ between countries, regions, and doctors. The aim of the study was to analyze the biopsy findings in our T2DM population and the justification of the biopsy according to widely accepted criteria. This single center retrospective study analyzed data from 74 patients with T2DM who underwent kidney biopsy from January 2014 to January 2021. According to the biopsy data, we categorized31 patients in the DN group, patients with typi...
Central European Journal of Immunology, 2023
a 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly ... more a 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly progressive renal failure. She was admitted to the nephrology department due to severe deterioration of renal function with complaints of malaise, fever, dry cough and occasional epistaxis that appeared 2 months prior to admission. Histopathologic examination of a specimen from kidney biopsy and immunologic findings revealed aNCa positive pauci-immune crescentic glomerulonephritis. the patient had a history of ovarian granulosa cell tumor and lung metastases that were treated surgically with postoperative radiotherapy and chemotherapy. thoracic computed tomography showed tissue neoplasm in the right lung and ultrasound-guided percutaneous transthoracic biopsy confirmed granulosa cell tumor. that was a relapse, thirty-nine years after initial treatment of malignant disease and twenty-four years after surgical resection of metastases from both lungs. although the association between malignancy and vasculitis has been well known for decades, this is the first described case of aNCa vasculitis associated with any type of gynecological malignancy and glomerulonephritis.
Archives of clinical and medical case reports, 2021
Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation ... more Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation and structural changes in glomerular capillary walls and double-contoured glomerular basement membrane (GBM). Usually, it is connected with cryoglobulinemia which is defined by the presence of a circulating, a cold-precipitating immunoglobulin. The chemical and immunological features of the cryoglobulins are used to define three types of cryoglobulinemia. In this report we describe the third case of MPGN type II with essential cryoglobulinemia without HCV infection, which is usually defined in the literature as MPGN type II. Here, we present 61-years old woman previously diagnosed with MPGN in 2012 at another institution. At that time, she was not examined in terms of cryoglobulinemia. Initially she was treated with pulses of methylprednisolone, then oral corticosteroids until cessation when complete remission was achieved. Meanwhile, she had two relapses of the disease. In October 2020 we re-evaluated her and found out positive cryoglobulins in repeating testing. Serological studies for anti-neutrophil cytoplasmic antibodies (ANCA), myeloperoxidase and proteinase 3, anti-double stranded DNA antibodies, antihepatitis C antibodies, anti-HIV antibodies and anti-hepatitis B surface antibodies were all negative. Serum M protein or monoclonal IgM were not detected. Percutaneous renal biopsy was compatible with the diagnosis of
Medicinska istraživanja, 2016
Increasing disparity between the limited supply of deceased donor organs and the rising demand fo... more Increasing disparity between the limited supply of deceased donor organs and the rising demand for kidneys has led to considering alternative strategies for expanding the availability of organs for transplantation. The first definition of expanded criteria donor contained four different donor risk factors for graft failure: age, history of hypertension, cerebrovascular accident as a cause of death and final pre-procurement creatinine > 133μmol/l. Marginal donors are also those with diabetes or those with anatomical abnormalities. Other factors such as donor maintenance, surgeon related factors, perfusion and transportation of organs also have an influence on donor organ quality. The survival benefits seen in recipients of marginal kidney transplants are inferior compared to those in recipients of standard criteria donor kidneys, but significantly better than in those remaining on kidney waiting list.
Scholarena journal of case reports, Mar 1, 2018
Nephrology Dialysis Transplantation, Jun 1, 2023
Background and Aims: The incidence of acute kidney injury (AKI) in people older than 60 years con... more Background and Aims: The incidence of acute kidney injury (AKI) in people older than 60 years constantly increasing and it is higher than in the rest of the population. Increased risk of AKI in the elderly is due to decreased functional reserves of the kidneys, aggressive surgical and diagnostic interventions, and frequent use of nephrotoxic drugs. The aim of this study was to analyze the incidence and causes of AKI in a patient older than 60 years during three different periods: the first period between 1974-1994 year, the second between 1997-2001 year, and the third period between 2014-2018 year. At the same time, we examined the most common causes of AKI over time. Method: The retrospective study included 927 patients with AKI treated in our clinic, 572 patients during the first period, 75 patients during the second period, and 280 patients in the third period. The diagnosis was made based on an absolute increase in serum creatinine by>26.5 umol/l, or an increase of 50% relative to basal values, or a decrease in urine output <0.5 ml/kg/h within 6 h. We analyzed causes and type of AKI, method of treatment, and mortality. Results: Incidence of AKI in patients older than 60 years in the period 1974-1994 is 19%, only three years later this percentage has risen to 64%, while in the last period this percentage was 82%. Conservative method of treatment was more often used in the last examined period 83.6% compared to 33% and 56.2% in previous periods. In the last examined period, HD was used in 16.4% of patients (in two previous periods 4% and 8.3% respectively). While PD was used by 50.5% in the period 1997-2001 and 31.3% in the period 1974-1994, in the last period PD was not used. Mortality has declined slightly over time but remains high (27.1%, then 29.6%, and recently 22%). Regarding the type of AKI during all three examined periods, statistically the most common is the prerenal type over 50%, and the renal type during the last five-year period increased by 26.4% compared to the previous 17.5% and 20.8% respectively. Conclusion: The incidence of AKI in people over the age of 60 is on the rise. Mortality, although still high, is noticeably declining compared to the previous periods, which may be a consequence of better treatment of both conservative and active dialysis treatment.
Nephrology Dialysis Transplantation, Jun 1, 2023
Figure 1: Comparison in terms of Trait and State-Anxiety in Peritoneal dialysis (PD) and Hemodial... more Figure 1: Comparison in terms of Trait and State-Anxiety in Peritoneal dialysis (PD) and Hemodialysis (HD) patients. We analysed the difference (delta) in STAI results for Trait and State Anxiety between the first and at the and eighth sessions.
Nephrology Dialysis Transplantation, Jun 1, 2023
significant relationship with the current vascular access. 68,18% of the patients with normal ABI... more significant relationship with the current vascular access. 68,18% of the patients with normal ABI have AVF-AVG and 60,87% of patients with abnormal ABI have tunneled CVC (p=0,022). In addition, the number of vascular accesses per patient, the mean duration of the accesses and the premature failures (3 months after creation) don't present statistically significant relation with frailty. Conclusion: The frailty score could be used as a tool for the choice of vascular access in hemodialysis patients. Further studies, in a larger number of patients, are required to define a reliable and easy to use frailty tool, which is best suited to dialysis access selection.
Nephrology Dialysis Transplantation, May 1, 2022
Galenika Medical Journal, Dec 31, 2022
Nephrology Dialysis Transplantation
Background The aim of this study was to identify trends in total, deceased donor (DD) and living ... more Background The aim of this study was to identify trends in total, deceased donor (DD) and living donor (LD) kidney transplantation (KT) rates in European countries. Methods The European Renal Association (ERA) Registry and the Global Observatory on Donation and Transplantation (GODT) databases were used to obtain the number of KTs in individual European countries between 2010 and 2018. General population counts were obtained from Eurostat or the national bureaus of statistics. The KT rate per million population (p.m.p.) and the average annual percentage change (APC) were calculated. Results The total KT rate in the 40 participating countries increased with 1.9% annually [95% confidence interval (CI) 1.5, 2.2] from 29.6 p.m.p. in 2010 to 34.7 p.m.p. in 2018, reflecting an increase of 3.4 p.m.p. in the DD-KT rate (from 21.6 p.m.p. to 25.0 p.m.p.; APC 1.9%; 95% CI 1.3, 2.4) and of 1.5 p.m.p. in the LD-KT rate (from 8.1 p.m.p. to 9.6 p.m.p.; APC 1.6%; 95% CI 1.0, 2.3). The trends in...
Kidney International Reports, Feb 1, 2022
PubMed, 1996
We analysed 27 patients (15 women and 12 men) on CAPD treatment longer than 6 months at the Clini... more We analysed 27 patients (15 women and 12 men) on CAPD treatment longer than 6 months at the Clinic of Nephrology, CCS, in Belgrade. Pts were between 22 and 72 years old (57.77 +/- 12.21 years). These pts had 47 episodes of peritonitis: 6 pts (22.22%) were without peritonitis, but 21 pts (78.22%) had between 1 and 5 episodes of peritonitis. We found 1 peritonitis /pts/year. Causes of peritonitis were mostly unknown (27/47) because treatment had began before taking culture of the peritoneal dyalisate. The most common causes of peritonitis were coagulase negative staphylococci: Staphylococcus aureus (8) and Staphylococci epidermidis (8). Laboratory showed: leucocytosis, hyperfibrinogenaemia, hypoproteinaemia and accelerated ESR. There was no connection between causes of chronic renal failure and frequency or peritonitis. During treatment of peritonitis in 2 pts we had to replace the peritoneal catheter and 5 pts went on haemodialyses. The other were recovered and continued CAPD treatment.
PubMed, Feb 24, 2016
Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It... more Free radical-mediated injury releases proinflammatory cytokines and activates innate immunity. It has been suggested that the early innate response and the ischemic tissue damage play roles in the development of adaptive responses, which may lead to acute kidney rejection. Various durations of hypothermic kidney storage before transplantation add to ischemic tissue damage. The final stage of ischemic injury occurs during reperfusion that develops hours or days after the initial insult. Repair and regeneration processes occur together with cellular apoptosis, autophagy and necrosis and a favorable outcome is expected if regeneration prevails. Along the entire transplantation time course, there is a great demand for novel immune and nonimmune injury biomarkers. The use of these markers can be of great help in the monitoring of kidney injury in potential kidney donors, where acute kidney damage can be overlooked, in predicting acute transplant dysfunction during the early post-transplant periods, or in predicting chronic changes in long term followup. Numerous investigations have demonstrated that biomarkers that have the highest predictive value in acute kidney injury include NGAL, Cystatin C, KIM-1, IL-18, and L-FABP. Most investigations show that the ideal biomarker to fulfill all the needs in renal transplant has not been identified yet. Although, in many animal models, new biomarkers are emerging for predicting acute and chronic allograft damage, in human allograft analysis they are still not routinely accepted and renal biopsy still remains the gold standard.
Current Medicinal Chemistry, Jul 19, 2016
International Urology and Nephrology, Jul 6, 2023
Kidney International Reports, Feb 1, 2022
International Journal of Medical Informatics, Aug 1, 2022
Herz, Jun 13, 2016
Aim. This study analyzed the prevalence of hypertension and the pattern of antihypertensive treat... more Aim. This study analyzed the prevalence of hypertension and the pattern of antihypertensive treatment before and after kidney transplantation. Patients and methods. The prevalence of hypertension and the class and daily dosage load of antihypertensive medications were analyzed in 116 patients before kidney transplantation and 1, 6, and 12 months after transplantation (67.2 % males, mean age 45.9 ± 11.4 years). Two patients died and eight had the allograft explanted, leaving 106 patients in the final analysis. Blood pressure (BP) was recorded on the day of transplantation and at every follow-up; it was considered uncontrolled at values > 130/80 mmHg.
Pathology Research and Practice, Oct 1, 2018
This prospective observational study included 665 consecutive patients who underwent renal biopsy... more This prospective observational study included 665 consecutive patients who underwent renal biopsy between January 2007 and the end of 2014. For each patient we recorded age, gender, the indication for renal biopsy and the pathohistological diagnosis. Previous to renal biopsy, all appropriate clinical exams and laboratory tests were made including testing for autoantibodies (anti-GBM, ANCA). Renal biopsy specimens were stained and analysed by light microscopy and immunohistochemistry using polyclonal antisera against human IgG, IgM, IgA, C3, C1q and, if necessary, kappa and lambda light chains. Electron microscopy was not performed because of technical limitations in the histopathology laboratory.. Six clinical syndromes were indications for renal biopsy: nephrotic syndrome (NS), acute nephritic syndrome (ANS), asymptomatic urinary abnormalities (AUA), haematuria (H), acute kidney injury (AKI) and chronic renal failure (CRF). NS was defined as proteinuria >3.5g/day/1.73m 2 and hypoproteinaemia or hypoalbuminaemia. ANS was defined as haematuria, hypertension, oedema, oliguria and reduced glomerular filtration rate. Non-nephrotic proteinuria with or without microscopic haematuria was considered as AUA. Haematuria
International Journal of Molecular Sciences
The complications of type 2 diabetes mellitus (T2DM) are well known and one of them is diabetic c... more The complications of type 2 diabetes mellitus (T2DM) are well known and one of them is diabetic chronic kidney disease (DCKD). Over time, it has become clear that patients with T2DM can have nondiabetic chronic kidney diseases (NDCKD), especially those that affect the glomeruli. Clinical indicators for identifying DCKD from NDCKD with high sensitivity and specificity have not yet been identified. Therefore, kidney biopsy remains the golden standard for DCKD diagnosis in patients with T2DM. Despite some indications for kidney biopsy, criteria for a biopsy differ between countries, regions, and doctors. The aim of the study was to analyze the biopsy findings in our T2DM population and the justification of the biopsy according to widely accepted criteria. This single center retrospective study analyzed data from 74 patients with T2DM who underwent kidney biopsy from January 2014 to January 2021. According to the biopsy data, we categorized31 patients in the DN group, patients with typi...
Central European Journal of Immunology, 2023
a 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly ... more a 69-year-old woman presented with severe anemia, proteinuria, microscopic hematuria and rapidly progressive renal failure. She was admitted to the nephrology department due to severe deterioration of renal function with complaints of malaise, fever, dry cough and occasional epistaxis that appeared 2 months prior to admission. Histopathologic examination of a specimen from kidney biopsy and immunologic findings revealed aNCa positive pauci-immune crescentic glomerulonephritis. the patient had a history of ovarian granulosa cell tumor and lung metastases that were treated surgically with postoperative radiotherapy and chemotherapy. thoracic computed tomography showed tissue neoplasm in the right lung and ultrasound-guided percutaneous transthoracic biopsy confirmed granulosa cell tumor. that was a relapse, thirty-nine years after initial treatment of malignant disease and twenty-four years after surgical resection of metastases from both lungs. although the association between malignancy and vasculitis has been well known for decades, this is the first described case of aNCa vasculitis associated with any type of gynecological malignancy and glomerulonephritis.
Archives of clinical and medical case reports, 2021
Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation ... more Membranoproliferative glomerulonephritis (MPGN) is characterized by mesangial cell proliferation and structural changes in glomerular capillary walls and double-contoured glomerular basement membrane (GBM). Usually, it is connected with cryoglobulinemia which is defined by the presence of a circulating, a cold-precipitating immunoglobulin. The chemical and immunological features of the cryoglobulins are used to define three types of cryoglobulinemia. In this report we describe the third case of MPGN type II with essential cryoglobulinemia without HCV infection, which is usually defined in the literature as MPGN type II. Here, we present 61-years old woman previously diagnosed with MPGN in 2012 at another institution. At that time, she was not examined in terms of cryoglobulinemia. Initially she was treated with pulses of methylprednisolone, then oral corticosteroids until cessation when complete remission was achieved. Meanwhile, she had two relapses of the disease. In October 2020 we re-evaluated her and found out positive cryoglobulins in repeating testing. Serological studies for anti-neutrophil cytoplasmic antibodies (ANCA), myeloperoxidase and proteinase 3, anti-double stranded DNA antibodies, antihepatitis C antibodies, anti-HIV antibodies and anti-hepatitis B surface antibodies were all negative. Serum M protein or monoclonal IgM were not detected. Percutaneous renal biopsy was compatible with the diagnosis of
Medicinska istraživanja, 2016
Increasing disparity between the limited supply of deceased donor organs and the rising demand fo... more Increasing disparity between the limited supply of deceased donor organs and the rising demand for kidneys has led to considering alternative strategies for expanding the availability of organs for transplantation. The first definition of expanded criteria donor contained four different donor risk factors for graft failure: age, history of hypertension, cerebrovascular accident as a cause of death and final pre-procurement creatinine > 133μmol/l. Marginal donors are also those with diabetes or those with anatomical abnormalities. Other factors such as donor maintenance, surgeon related factors, perfusion and transportation of organs also have an influence on donor organ quality. The survival benefits seen in recipients of marginal kidney transplants are inferior compared to those in recipients of standard criteria donor kidneys, but significantly better than in those remaining on kidney waiting list.
Scholarena journal of case reports, Mar 1, 2018
Nephrology Dialysis Transplantation, Jun 1, 2023
Background and Aims: The incidence of acute kidney injury (AKI) in people older than 60 years con... more Background and Aims: The incidence of acute kidney injury (AKI) in people older than 60 years constantly increasing and it is higher than in the rest of the population. Increased risk of AKI in the elderly is due to decreased functional reserves of the kidneys, aggressive surgical and diagnostic interventions, and frequent use of nephrotoxic drugs. The aim of this study was to analyze the incidence and causes of AKI in a patient older than 60 years during three different periods: the first period between 1974-1994 year, the second between 1997-2001 year, and the third period between 2014-2018 year. At the same time, we examined the most common causes of AKI over time. Method: The retrospective study included 927 patients with AKI treated in our clinic, 572 patients during the first period, 75 patients during the second period, and 280 patients in the third period. The diagnosis was made based on an absolute increase in serum creatinine by>26.5 umol/l, or an increase of 50% relative to basal values, or a decrease in urine output <0.5 ml/kg/h within 6 h. We analyzed causes and type of AKI, method of treatment, and mortality. Results: Incidence of AKI in patients older than 60 years in the period 1974-1994 is 19%, only three years later this percentage has risen to 64%, while in the last period this percentage was 82%. Conservative method of treatment was more often used in the last examined period 83.6% compared to 33% and 56.2% in previous periods. In the last examined period, HD was used in 16.4% of patients (in two previous periods 4% and 8.3% respectively). While PD was used by 50.5% in the period 1997-2001 and 31.3% in the period 1974-1994, in the last period PD was not used. Mortality has declined slightly over time but remains high (27.1%, then 29.6%, and recently 22%). Regarding the type of AKI during all three examined periods, statistically the most common is the prerenal type over 50%, and the renal type during the last five-year period increased by 26.4% compared to the previous 17.5% and 20.8% respectively. Conclusion: The incidence of AKI in people over the age of 60 is on the rise. Mortality, although still high, is noticeably declining compared to the previous periods, which may be a consequence of better treatment of both conservative and active dialysis treatment.
Nephrology Dialysis Transplantation, Jun 1, 2023
Figure 1: Comparison in terms of Trait and State-Anxiety in Peritoneal dialysis (PD) and Hemodial... more Figure 1: Comparison in terms of Trait and State-Anxiety in Peritoneal dialysis (PD) and Hemodialysis (HD) patients. We analysed the difference (delta) in STAI results for Trait and State Anxiety between the first and at the and eighth sessions.
Nephrology Dialysis Transplantation, Jun 1, 2023
significant relationship with the current vascular access. 68,18% of the patients with normal ABI... more significant relationship with the current vascular access. 68,18% of the patients with normal ABI have AVF-AVG and 60,87% of patients with abnormal ABI have tunneled CVC (p=0,022). In addition, the number of vascular accesses per patient, the mean duration of the accesses and the premature failures (3 months after creation) don't present statistically significant relation with frailty. Conclusion: The frailty score could be used as a tool for the choice of vascular access in hemodialysis patients. Further studies, in a larger number of patients, are required to define a reliable and easy to use frailty tool, which is best suited to dialysis access selection.
Nephrology Dialysis Transplantation, May 1, 2022