Rafał Filip - Academia.edu (original) (raw)
Papers by Rafał Filip
Journal of Crohn's and Colitis
Background Endoscopic-post-operative-recurrence [ePOR] in Crohn’s disease [CD] after ileocecal re... more Background Endoscopic-post-operative-recurrence [ePOR] in Crohn’s disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and to compare anti-tumour necrosis factor [anti-TNF] therapy to vedolizumab [VDZ] and ustekinumab [UST] in a real-world setting. Methods A retrospective multicentre study of CD-adults after curative ICR on early prophylaxis was undertaken. ePOR was defined as a Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD ≥ 6. Multivariable logistic regression was used to evaluate risk factors, and inverse probability treatment weighting [IPTW] was applied to compare the effectiveness between agents. Results The study included 297 patients (53.9% males, age at diagnosis 24 years [19–32], age at ICR 34 years [26–43], 18.5% smokers, 27.6% biologic-naïve, 65.7% anti-TNF experienced, 28.6% two or more biologics and 17.2% previous surgery). Overall, 224, 39 and 34 patients received anti-TNF, ...
Canadian Journal of Gastroenterology and Hepatology
Each year, the incidence of nonalcoholic fatty liver (NAFLD) disease increases. NAFLD is a chroni... more Each year, the incidence of nonalcoholic fatty liver (NAFLD) disease increases. NAFLD is a chronic disease. One of the most common causes of NAFLD is an inadequate lifestyle, which is characterized by a lack or low physical activity and eating highly processed foods rich in saturated fat and salt and containing low amount of fiber. Moreover, disturbances in intestinal microbiome and the use of certain drugs may predispose to NAFLD. NAFLD is an increasingly described disease in patients with inflammatory bowel disease (IBD). Recent data also indicate a frequent coexistence of metabolic syndrome in this group of patients. Certain groups of drugs also increase the risk of developing inflammation, liver fibrosis, and cirrhosis. Particularly important in the development of NAFLD are steroids, which are used in the treatment of many diseases, for example, IBD. NAFLD is one of the most frequent parenteral manifestations of the disease in IBD patients. However, there is still insufficient i...
Journal of Clinical Medicine, 2021
Recent evidence indicates that a systemic state of inflammation may exert a negative effect on ma... more Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. The control group consists of 50 healthy volunteers. Total sperm count, sperm count, percentage of morphologically normal spermatozoa, viability, and progressive motility, are significantly lower in the study group than in healthy males (p < 0.001). The DNA fragmentation index (DFI) and oxidation-reduction potential (ORP) are significantly higher in the study group (28.9% and 1.55% on average, respectively) than in healthy males (14.6% and 0.79% on average, respectively). Bacteriospermia is more clearly observed in the study group (p = 0.037), and the most frequent pathogen is Enterococcus faecalis. The DFI and ORP are significantly higher in bacteria...
Introduction: In clinical ambulatory practice, patients often, rather than discontinuing treatmen... more Introduction: In clinical ambulatory practice, patients often, rather than discontinuing treatment, change to another one. This study aims to assess the reasons why patients with osteoporosis switch from one alendronate to another with a different brand name. Material and methods: A retrospective analysis of 747 bisphosphonate-treated patients was performed (651 female, average age 67.3 ± 8.9 years, BMI 26.5 ± 4.0 kg/m 2). The frequency and reasons for drug switching during the 19.4 ± 13.4 months of observation were analysed. Results: In 387 (51.8%) patients, treatment was not changed during the observation period, whereas in 360 (48.2%) patients, at least one drug switch occurred. Almost 40% of patients from that group (138 patients) switched from one alendronate to another alendronate with a different brand name. The most frequent reasons were: adverse event (36.9%), high price of the drug (23.2%) and request of patient (16.7%). Conclusions: A substantial proportion of persistent ...
Some dietary components that may not be required for human existence may markedly infl uence the ... more Some dietary components that may not be required for human existence may markedly infl uence the quality of life by modifying physiologic processes. These compounds can infl uence, in combination or alone, numerous biological functions by serving as antioxidants, immunoregulators, regulators of gene expression, modulators of several cellular processes, including growth and apoptosis. Many diseases are associated with impaired cell proliferation or diff erentiation and, what is most important, also with deregulations in programmed cell death, which, in the end, can lead to the promotion of the diseases such as cancer. Biologically-active molecules are capable of modifying the biochemical pathways and/or infl uencing specifi c proteins regulating apoptosis in gastrointestinal cells, which can be used for both prevention and treatment. Dietary fi bres, cruciferous vegetables, fl ax and curcumin showed positive eff ect in the protection of colon cancer. Similarly, a strong inverse relationship between stomach as well as colon cancer risk and allium vegetables intake has been proved. Limonoids from citrus fruits are also considered as promising molecules with anticancer activity, such as perrillyl alcohol, which was tested in patients with advanced malignant tumours. Although the relationship between soy intake and cancer risk has not so far been clearly elucidated, it is known that isofl avones from soy may reduce the risk of estrogen-dependent breast cancer. Although functional foods of animal origin are not that well recognized, some of them, however, seem to be worthy of particular interest. Although interactions among nutrients have been inadequately examined, a few examples of negative and positive interactions exist, e.g. some components may provide benefi cial eff ects by infl uencing the structure and functions of the wall as well as environment of the gastrointestinal tract, including phytohaemagglutinin (PHA) and other components, such as alpha-ketoglutaric acid (AKG).
Nutrients, 2021
The prevalence of gastritis in humans is constantly growing and a prediction of an increase in th... more The prevalence of gastritis in humans is constantly growing and a prediction of an increase in this health problem is observed in many countries. For this reason, effective dietary therapies are sought that can alleviate the course of this disease. The objective of this study was to determine the effect of chemically pure oat beta-glucan preparations with different molar masses, low or high, used for 30 days in patients with histologically diagnosed chronic gastritis. The study enrolled 48 people of both genders of different ages recruited from 129 patients with a gastritis diagnosis. Before and after the therapy, hematological, biochemical, immunological and redox balance parameters were determined in the blood and the number of lactic acid bacteria and SCFA concentrations in the feces. Our results demonstrated a beneficial effect of oat beta-glucans with high molar mass in chronic gastritis in humans, resulting in reduced mucosal damage and healthy changes in SCFA fecal concentrat...
1Department of Biology, Lund University, Sweden Head of Department: prof. Christer Lofstedt, PhD ... more 1Department of Biology, Lund University, Sweden Head of Department: prof. Christer Lofstedt, PhD 2Department of Cytology, Bogomoletz Institute of Physiology, Kiev, Ukraine Head of Department: prof. Galyna Skibo, MD, PhD 3Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, Balice, Poland Head of Department: prof. Franciszek Brzoska, PhD 4Institute of Rural Medicine, Lublin, Poland Head of Department: prof. Iwona Bojar, MD, PhD
Aim: The aim of the study was to compare the endoscopic and histological changes in the upper GI ... more Aim: The aim of the study was to compare the endoscopic and histological changes in the upper GI tract after Aln and Sr treatment in patients with nausea, dysphagia and abdominal pain, which led to discontinuation of the therapy with alendronate (Aln) and strontium ranelate (Sr). Material and methods: 31 postmenopausal women treated with 70 mg/daily Aln or Sr 2.0 g/daily for reporting upper GI tract side effects such as abdominal pain and/or discomfort, nausea and vomiting which led to the discontinuation of the therapy within the last 7 days underwent gastroduodenoscopy with standardized biopsy. Results: In the whole study group, the most common side effects were dyspepsia and epigastric pain. In the stomach, the most frequent histopathological feature in both Aln and Sr groups was inactive chronic inflammation (p < 0.05). Visible erythema and/or friability were observed in 38% of patients in the Aln group and in 2 patients of the Sr group (20%) (p < 0.05). The frequency of m...
Ménétrier’s disease (MD) is a hypertrophic gastropathy with histological features such as foveola... more Ménétrier’s disease (MD) is a hypertrophic gastropathy with histological features such as foveolar hyperplasia of the gastric mucosa accompanied by mucus hypersecretion and glandular hypertrophy. In adults, the course of the disease in adults is complex and may lead to the necessity of gastrectomy. The aetiology of ulcerative colitis (UC) remains unknown and is probably multi-factorial. Apart from abdominal pain, diarrhoea and anaemia, progression of the disease can involve toxic megacolon, perforations, strictures and even intestinal tumours; therefore, after several years may lead to total colectomy. The combination of MD and UC is very rare. We report an unusual case of MD and UC coexistence. Surgical treatment was applied and the patient underwent total gastrectomy due to MD, and after several years proctocolectomy due to severe UC complicated by descending colon strictures and oesophago-colonic fistula. Streszczenie Choroba Ménétriera (CM) jest chorobą charakteryzującą się pogr...
Journal of Pre-Clinical and Clinical Research, 2007
Although endoscopy techniques have undergone impressive development in recent years, there remain... more Although endoscopy techniques have undergone impressive development in recent years, there remains a need for better visualization in specific circumstances, e.g. detection of flat colorectal lesions. Less threatening and much less painful alternatives to conventional colonoscopy are also of a particular interest for patients. Many techniques are under investigation, but chromoendoscopy is a technique with proven clinical usefulness. Instead of real-time endoscopic imaging methods, such as narrow band imaging (NBI) and Fuji intelligent chromo endoscopy (FICE), also self-propelled colonoscopy devices Aer-O-Scope and Invendoscope are briefly discussed. Ideal endoscopy should have the ability to screen large mucosal areas, together with providing high diagnostic accuracy, and also need to be patient friendly. It is very probable that future success in clinical application will appertain to the combination
Cells, 2021
Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract a... more Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract are exerted during infant development and impact the maturation of intestinal mucosa and gut immune system. The impact of bacteria on the host gut immune system is partially mediated via released extracellular vesicles (EVs). The heterogeneity in EV content, size, and bacterial species origin can have an impact on intestinal cells, resulting in inflammation and an immune response, or facilitate pathogen entry into the gut wall. In mammals, maintaining the integrity of the gut barrier might also be an evolutionary function of maternal milk EVs. Recently, the usage of EVs has been explored as a novel therapeutic approach in several pathological conditions, including necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). In this review, we attempt to summarize the current knowledge of EV biology, followed by a discussion of the role that EVs play in gut maturation and the path...
Journal of Clinical Medicine, 2021
Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep ap... more Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD in patients with OSA. The study included 58 patients hospitalized due to clinical suspicion of sleep disorders during sleep. All patients underwent a sleep study, and blood samples were collected overnight for hormonal tests. Survey data concerning symptoms of GERD, gastroscopy, and esophageal pH monitoring results were included in the study. In patients with OSA, GERD was twice as common when compared to the group without OSA. Among subjects with severe sleep apnea (AHI > 30; n = 31; 53%), we observed lower ghrelin levels, especially in the second half of the night and in the morning (p5.00 = 0.0207; p7.00 = 0.0344); the presence of OSA had no effect on obestatin and leptin levels. N...
Archives of Medical Science, 2021
Various types of food additives are widely used in the food industry. Due to their properties ext... more Various types of food additives are widely used in the food industry. Due to their properties extending the usefulness for consuming food products, they give them different colours, consistency, or taste. The products are marked ‘E’ and the code is assigned to the subscription used. Many of the supplements affect human health negatively. Emulsifiers or stabilizers can lead to epithelial loads and the development of inflammation. Sucrose and other sweeteners may change the composition of the intestinal microflora and thus lead to intestinal blockage. Some additives classified as preservatives are available and may predispose to intestinal dysbiosis. Available substances belonging to food dyes may predispose to genotoxic and cytotoxic effects and cause inflammation in the intestines. Substances added to food can also cause disorders of intestinal homeostasis.
Nutrients, 2021
According to the available data, environmental pollution is a serious problem all over the world.... more According to the available data, environmental pollution is a serious problem all over the world. Between 2015 and 2016, pollution was responsible for approximately nine million deaths worldwide. They also include endocrine disrupting chemicals (EDCs) that can interfere with the functioning of the thyroid gland. They are characterized by high persistence in the environment. These substances can enter the body through the gastrointestinal tract, respiratory system, as well as contact with the skin and overcome the placental barrier. EDC can be found in food, water, and personal care products. They can get into food from the environment and as a result of their migration to food products and cosmetics from packaging. EDCs can disrupt the functioning of the thyroid gland through a number of mechanisms, including disrupting the activation of thyroid receptors and the expression of genes that are related to the metabolism, synthesis, and transport of thyroid hormones (HT). There is a nee...
Nutrients, 2020
A sedentary lifestyle and inadequate nutrition often leads to disturbances in intestinal homeosta... more A sedentary lifestyle and inadequate nutrition often leads to disturbances in intestinal homeostasis, which may predispose people to excess body weight and metabolic syndrome. Obesity is frequently observed in patients with inflammatory bowel diseases (IBD), similar to the general population. Obesity may exert a negative effect on the course of IBD as well as reduce the response to treatment. Moreover, it may also be an additional risk factor for vein thromboembolism during the flare. In both obesity and IBD, it is of great importance to implement proper dietary ingredients that exert desirable effect on gut microbiota. The key to reducing body mass index (BMI) and alleviating the course of IBD is preserving healthy intestinal microflora.
Journal of Nutrition and Metabolism, 2020
Inflammatory bowel diseases is a group of inflammatory diseases. The pathogenesis of diseases is ... more Inflammatory bowel diseases is a group of inflammatory diseases. The pathogenesis of diseases is multifactorial, which may include a Western-type diet. Diseases occur with periods of recurrence and remission. Many factors can have a beneficial effect on reducing the frequency of recurrence and prolonging the remission period. Such ingredients include dietary fibre, mono- and polyunsaturated fatty acids, certain vitamins (D, C, and E), flavonoids, and minerals such as zinc and selenium. Properly selected nutrition might be an integral part of the treatment of patients with Crohn’s disease or ulcerative colitis.
Annals of Agricultural and Environmental Medicine, 2019
Introduction. Overweight and obesity, as well as a gonadal function, are pivotal factors influenc... more Introduction. Overweight and obesity, as well as a gonadal function, are pivotal factors influencing bone tissue metabolism. Materials and method. The aim of the study was to determine the effect of dietary induced obesity (DIO) on bone tissue metabolism in sham-operated (SHO) or ovariectomized (OVX) adult female Wistar rats. Additionally, the influence of DIO in SHO or OVX on the concentration of sclerostin in the blood serum was analyzed. After SHO or OVX, the rats were placed in groups (n=8) and either received a standard diet (11.5 MJ/kg) (SHO-CON; OVX-CON) or a high-energy diet (17.6 MJ/kg) (SHO-FAT; OVX-FAT). The experiment lasted for 90 days and allowed for the establishment of osteopenia in OVX females and obesity in the rats that had received the high-energy diet. Results. The results of the study demonstrate that obesity or/and ovariectomy increases the resorption of femora and tibiae, hence decreasing the densitometric and mechanical parameters affecting the bone structure in adult females rats. The strongest osteodegenerative effect was seen in the OVX-FAT females. Interestingly, the degree of bone tissue degradation caused exclusively by ovariectomy was similar to that found in the obese sham-operated rats. Conclusions. Bone losses invoked by DIO seem to be independent from the Wnt/β-catenin pathway inhibition induced by sclerostin. While further study is necessary, the obtained results suggest that the usage of sclerostin anti-body in the treatment of osteoporosis can be ineffective, and in obese patients the undertaking of such therapy should be reassessed.
Clinical Interventions in Aging, 2018
Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholi... more Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholic fatty liver disease (NAFLD), and therefore, not surprisingly, the global prevalence of NAFLD increases in parallel with both obesity and type 2 diabetes. Although deterioration of bone homeostasis in patients with NAFLD is commonly observed, its etiology has not been fully elucidated yet. It was shown in several studies that bone tissue seems to be independently associated with NAFLD. A mechanistic perspective puts the liver at the center of mutual interdependencies obviously involving adipose tissue and muscles and also the bone matrix and bone cells, which are relatively novel. In this review, various pathophysiological mechanisms and possible mediating molecules that may interplay between NAFLD and bone tissue are described. Chronic inflammation, vitamin D3, growth hormone, insulin-like growth factor 1, osteopontin, fetuin-A, irisin, osteocalcin, and osteoprotegerin from osteoblasts have been proposed as mediators of mutual interactions among the skeleton, fatty tissue, and liver. Although to date there are still many issues that have not been elucidated, growing evidence suggests that screening and surveillance of bone mineral density in patients with NAFLD should be considered in future strategies and guidelines for NAFLD management.
European Journal of Clinical and Experimental Medicine, 2018
Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. ... more Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. There has been a regular increase in the number of IBD cases. Patients exclude whole food groups from their diet fearing the emergence of disease symptoms or due to learning from unreliable sources. Doing so, they might deepen the already existing vitamin deficiencies which occur along with the shortage of many minerals. These deficiencies might intensify the disease process or cause a new one. The most common deficits pointed out by numerous researchers concern vitamin D, calcium, cobalamin, folic acid and iron. It is well worth introducing selenium, zinc and ascorbic acid into a diet because of their immunomodulating effect. Important aspect of the healing process is a personalized diet which is designed to compensate for, or prevent vitamin and mineral deficiencies. Aim. The purpose of the study was to review the literature about vitamin and mineral deficiency in Inflammatory Bowel Diseases. Materials and method.
European Journal of Clinical and Experimental Medicine, 2018
Journal of Crohn's and Colitis
Background Endoscopic-post-operative-recurrence [ePOR] in Crohn’s disease [CD] after ileocecal re... more Background Endoscopic-post-operative-recurrence [ePOR] in Crohn’s disease [CD] after ileocecal resection [ICR] is a major concern. We aimed to evaluate the effectiveness of early prophylaxis with biologics and to compare anti-tumour necrosis factor [anti-TNF] therapy to vedolizumab [VDZ] and ustekinumab [UST] in a real-world setting. Methods A retrospective multicentre study of CD-adults after curative ICR on early prophylaxis was undertaken. ePOR was defined as a Rutgeerts score [RS] ≥ i2 or colonic-segmental-SES-CD ≥ 6. Multivariable logistic regression was used to evaluate risk factors, and inverse probability treatment weighting [IPTW] was applied to compare the effectiveness between agents. Results The study included 297 patients (53.9% males, age at diagnosis 24 years [19–32], age at ICR 34 years [26–43], 18.5% smokers, 27.6% biologic-naïve, 65.7% anti-TNF experienced, 28.6% two or more biologics and 17.2% previous surgery). Overall, 224, 39 and 34 patients received anti-TNF, ...
Canadian Journal of Gastroenterology and Hepatology
Each year, the incidence of nonalcoholic fatty liver (NAFLD) disease increases. NAFLD is a chroni... more Each year, the incidence of nonalcoholic fatty liver (NAFLD) disease increases. NAFLD is a chronic disease. One of the most common causes of NAFLD is an inadequate lifestyle, which is characterized by a lack or low physical activity and eating highly processed foods rich in saturated fat and salt and containing low amount of fiber. Moreover, disturbances in intestinal microbiome and the use of certain drugs may predispose to NAFLD. NAFLD is an increasingly described disease in patients with inflammatory bowel disease (IBD). Recent data also indicate a frequent coexistence of metabolic syndrome in this group of patients. Certain groups of drugs also increase the risk of developing inflammation, liver fibrosis, and cirrhosis. Particularly important in the development of NAFLD are steroids, which are used in the treatment of many diseases, for example, IBD. NAFLD is one of the most frequent parenteral manifestations of the disease in IBD patients. However, there is still insufficient i...
Journal of Clinical Medicine, 2021
Recent evidence indicates that a systemic state of inflammation may exert a negative effect on ma... more Recent evidence indicates that a systemic state of inflammation may exert a negative effect on male fertility. The aim of this study is to evaluate sperm quality parameters in male patients with ulcerative colitis (UC). Between December 2019 and December 2020 semen analyses are performed in 50 patients with UC in clinical remission. The control group consists of 50 healthy volunteers. Total sperm count, sperm count, percentage of morphologically normal spermatozoa, viability, and progressive motility, are significantly lower in the study group than in healthy males (p < 0.001). The DNA fragmentation index (DFI) and oxidation-reduction potential (ORP) are significantly higher in the study group (28.9% and 1.55% on average, respectively) than in healthy males (14.6% and 0.79% on average, respectively). Bacteriospermia is more clearly observed in the study group (p = 0.037), and the most frequent pathogen is Enterococcus faecalis. The DFI and ORP are significantly higher in bacteria...
Introduction: In clinical ambulatory practice, patients often, rather than discontinuing treatmen... more Introduction: In clinical ambulatory practice, patients often, rather than discontinuing treatment, change to another one. This study aims to assess the reasons why patients with osteoporosis switch from one alendronate to another with a different brand name. Material and methods: A retrospective analysis of 747 bisphosphonate-treated patients was performed (651 female, average age 67.3 ± 8.9 years, BMI 26.5 ± 4.0 kg/m 2). The frequency and reasons for drug switching during the 19.4 ± 13.4 months of observation were analysed. Results: In 387 (51.8%) patients, treatment was not changed during the observation period, whereas in 360 (48.2%) patients, at least one drug switch occurred. Almost 40% of patients from that group (138 patients) switched from one alendronate to another alendronate with a different brand name. The most frequent reasons were: adverse event (36.9%), high price of the drug (23.2%) and request of patient (16.7%). Conclusions: A substantial proportion of persistent ...
Some dietary components that may not be required for human existence may markedly infl uence the ... more Some dietary components that may not be required for human existence may markedly infl uence the quality of life by modifying physiologic processes. These compounds can infl uence, in combination or alone, numerous biological functions by serving as antioxidants, immunoregulators, regulators of gene expression, modulators of several cellular processes, including growth and apoptosis. Many diseases are associated with impaired cell proliferation or diff erentiation and, what is most important, also with deregulations in programmed cell death, which, in the end, can lead to the promotion of the diseases such as cancer. Biologically-active molecules are capable of modifying the biochemical pathways and/or infl uencing specifi c proteins regulating apoptosis in gastrointestinal cells, which can be used for both prevention and treatment. Dietary fi bres, cruciferous vegetables, fl ax and curcumin showed positive eff ect in the protection of colon cancer. Similarly, a strong inverse relationship between stomach as well as colon cancer risk and allium vegetables intake has been proved. Limonoids from citrus fruits are also considered as promising molecules with anticancer activity, such as perrillyl alcohol, which was tested in patients with advanced malignant tumours. Although the relationship between soy intake and cancer risk has not so far been clearly elucidated, it is known that isofl avones from soy may reduce the risk of estrogen-dependent breast cancer. Although functional foods of animal origin are not that well recognized, some of them, however, seem to be worthy of particular interest. Although interactions among nutrients have been inadequately examined, a few examples of negative and positive interactions exist, e.g. some components may provide benefi cial eff ects by infl uencing the structure and functions of the wall as well as environment of the gastrointestinal tract, including phytohaemagglutinin (PHA) and other components, such as alpha-ketoglutaric acid (AKG).
Nutrients, 2021
The prevalence of gastritis in humans is constantly growing and a prediction of an increase in th... more The prevalence of gastritis in humans is constantly growing and a prediction of an increase in this health problem is observed in many countries. For this reason, effective dietary therapies are sought that can alleviate the course of this disease. The objective of this study was to determine the effect of chemically pure oat beta-glucan preparations with different molar masses, low or high, used for 30 days in patients with histologically diagnosed chronic gastritis. The study enrolled 48 people of both genders of different ages recruited from 129 patients with a gastritis diagnosis. Before and after the therapy, hematological, biochemical, immunological and redox balance parameters were determined in the blood and the number of lactic acid bacteria and SCFA concentrations in the feces. Our results demonstrated a beneficial effect of oat beta-glucans with high molar mass in chronic gastritis in humans, resulting in reduced mucosal damage and healthy changes in SCFA fecal concentrat...
1Department of Biology, Lund University, Sweden Head of Department: prof. Christer Lofstedt, PhD ... more 1Department of Biology, Lund University, Sweden Head of Department: prof. Christer Lofstedt, PhD 2Department of Cytology, Bogomoletz Institute of Physiology, Kiev, Ukraine Head of Department: prof. Galyna Skibo, MD, PhD 3Department of Animal Nutrition and Feed Science, National Research Institute of Animal Production, Balice, Poland Head of Department: prof. Franciszek Brzoska, PhD 4Institute of Rural Medicine, Lublin, Poland Head of Department: prof. Iwona Bojar, MD, PhD
Aim: The aim of the study was to compare the endoscopic and histological changes in the upper GI ... more Aim: The aim of the study was to compare the endoscopic and histological changes in the upper GI tract after Aln and Sr treatment in patients with nausea, dysphagia and abdominal pain, which led to discontinuation of the therapy with alendronate (Aln) and strontium ranelate (Sr). Material and methods: 31 postmenopausal women treated with 70 mg/daily Aln or Sr 2.0 g/daily for reporting upper GI tract side effects such as abdominal pain and/or discomfort, nausea and vomiting which led to the discontinuation of the therapy within the last 7 days underwent gastroduodenoscopy with standardized biopsy. Results: In the whole study group, the most common side effects were dyspepsia and epigastric pain. In the stomach, the most frequent histopathological feature in both Aln and Sr groups was inactive chronic inflammation (p < 0.05). Visible erythema and/or friability were observed in 38% of patients in the Aln group and in 2 patients of the Sr group (20%) (p < 0.05). The frequency of m...
Ménétrier’s disease (MD) is a hypertrophic gastropathy with histological features such as foveola... more Ménétrier’s disease (MD) is a hypertrophic gastropathy with histological features such as foveolar hyperplasia of the gastric mucosa accompanied by mucus hypersecretion and glandular hypertrophy. In adults, the course of the disease in adults is complex and may lead to the necessity of gastrectomy. The aetiology of ulcerative colitis (UC) remains unknown and is probably multi-factorial. Apart from abdominal pain, diarrhoea and anaemia, progression of the disease can involve toxic megacolon, perforations, strictures and even intestinal tumours; therefore, after several years may lead to total colectomy. The combination of MD and UC is very rare. We report an unusual case of MD and UC coexistence. Surgical treatment was applied and the patient underwent total gastrectomy due to MD, and after several years proctocolectomy due to severe UC complicated by descending colon strictures and oesophago-colonic fistula. Streszczenie Choroba Ménétriera (CM) jest chorobą charakteryzującą się pogr...
Journal of Pre-Clinical and Clinical Research, 2007
Although endoscopy techniques have undergone impressive development in recent years, there remain... more Although endoscopy techniques have undergone impressive development in recent years, there remains a need for better visualization in specific circumstances, e.g. detection of flat colorectal lesions. Less threatening and much less painful alternatives to conventional colonoscopy are also of a particular interest for patients. Many techniques are under investigation, but chromoendoscopy is a technique with proven clinical usefulness. Instead of real-time endoscopic imaging methods, such as narrow band imaging (NBI) and Fuji intelligent chromo endoscopy (FICE), also self-propelled colonoscopy devices Aer-O-Scope and Invendoscope are briefly discussed. Ideal endoscopy should have the ability to screen large mucosal areas, together with providing high diagnostic accuracy, and also need to be patient friendly. It is very probable that future success in clinical application will appertain to the combination
Cells, 2021
Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract a... more Some of the most fundamental influences of microorganisms inhabiting the human intestinal tract are exerted during infant development and impact the maturation of intestinal mucosa and gut immune system. The impact of bacteria on the host gut immune system is partially mediated via released extracellular vesicles (EVs). The heterogeneity in EV content, size, and bacterial species origin can have an impact on intestinal cells, resulting in inflammation and an immune response, or facilitate pathogen entry into the gut wall. In mammals, maintaining the integrity of the gut barrier might also be an evolutionary function of maternal milk EVs. Recently, the usage of EVs has been explored as a novel therapeutic approach in several pathological conditions, including necrotizing enterocolitis (NEC) and inflammatory bowel disease (IBD). In this review, we attempt to summarize the current knowledge of EV biology, followed by a discussion of the role that EVs play in gut maturation and the path...
Journal of Clinical Medicine, 2021
Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep ap... more Gastroesophageal reflux disease (GERD) is commonly observed in patients with obstructive sleep apnea (OSA). Hormonal disorders observed in OSA may be relevant in the development of GERD. The aim of the study was to assess the correlations between ghrelin, obestatin, leptin, and the intensity of GERD in patients with OSA. The study included 58 patients hospitalized due to clinical suspicion of sleep disorders during sleep. All patients underwent a sleep study, and blood samples were collected overnight for hormonal tests. Survey data concerning symptoms of GERD, gastroscopy, and esophageal pH monitoring results were included in the study. In patients with OSA, GERD was twice as common when compared to the group without OSA. Among subjects with severe sleep apnea (AHI > 30; n = 31; 53%), we observed lower ghrelin levels, especially in the second half of the night and in the morning (p5.00 = 0.0207; p7.00 = 0.0344); the presence of OSA had no effect on obestatin and leptin levels. N...
Archives of Medical Science, 2021
Various types of food additives are widely used in the food industry. Due to their properties ext... more Various types of food additives are widely used in the food industry. Due to their properties extending the usefulness for consuming food products, they give them different colours, consistency, or taste. The products are marked ‘E’ and the code is assigned to the subscription used. Many of the supplements affect human health negatively. Emulsifiers or stabilizers can lead to epithelial loads and the development of inflammation. Sucrose and other sweeteners may change the composition of the intestinal microflora and thus lead to intestinal blockage. Some additives classified as preservatives are available and may predispose to intestinal dysbiosis. Available substances belonging to food dyes may predispose to genotoxic and cytotoxic effects and cause inflammation in the intestines. Substances added to food can also cause disorders of intestinal homeostasis.
Nutrients, 2021
According to the available data, environmental pollution is a serious problem all over the world.... more According to the available data, environmental pollution is a serious problem all over the world. Between 2015 and 2016, pollution was responsible for approximately nine million deaths worldwide. They also include endocrine disrupting chemicals (EDCs) that can interfere with the functioning of the thyroid gland. They are characterized by high persistence in the environment. These substances can enter the body through the gastrointestinal tract, respiratory system, as well as contact with the skin and overcome the placental barrier. EDC can be found in food, water, and personal care products. They can get into food from the environment and as a result of their migration to food products and cosmetics from packaging. EDCs can disrupt the functioning of the thyroid gland through a number of mechanisms, including disrupting the activation of thyroid receptors and the expression of genes that are related to the metabolism, synthesis, and transport of thyroid hormones (HT). There is a nee...
Nutrients, 2020
A sedentary lifestyle and inadequate nutrition often leads to disturbances in intestinal homeosta... more A sedentary lifestyle and inadequate nutrition often leads to disturbances in intestinal homeostasis, which may predispose people to excess body weight and metabolic syndrome. Obesity is frequently observed in patients with inflammatory bowel diseases (IBD), similar to the general population. Obesity may exert a negative effect on the course of IBD as well as reduce the response to treatment. Moreover, it may also be an additional risk factor for vein thromboembolism during the flare. In both obesity and IBD, it is of great importance to implement proper dietary ingredients that exert desirable effect on gut microbiota. The key to reducing body mass index (BMI) and alleviating the course of IBD is preserving healthy intestinal microflora.
Journal of Nutrition and Metabolism, 2020
Inflammatory bowel diseases is a group of inflammatory diseases. The pathogenesis of diseases is ... more Inflammatory bowel diseases is a group of inflammatory diseases. The pathogenesis of diseases is multifactorial, which may include a Western-type diet. Diseases occur with periods of recurrence and remission. Many factors can have a beneficial effect on reducing the frequency of recurrence and prolonging the remission period. Such ingredients include dietary fibre, mono- and polyunsaturated fatty acids, certain vitamins (D, C, and E), flavonoids, and minerals such as zinc and selenium. Properly selected nutrition might be an integral part of the treatment of patients with Crohn’s disease or ulcerative colitis.
Annals of Agricultural and Environmental Medicine, 2019
Introduction. Overweight and obesity, as well as a gonadal function, are pivotal factors influenc... more Introduction. Overweight and obesity, as well as a gonadal function, are pivotal factors influencing bone tissue metabolism. Materials and method. The aim of the study was to determine the effect of dietary induced obesity (DIO) on bone tissue metabolism in sham-operated (SHO) or ovariectomized (OVX) adult female Wistar rats. Additionally, the influence of DIO in SHO or OVX on the concentration of sclerostin in the blood serum was analyzed. After SHO or OVX, the rats were placed in groups (n=8) and either received a standard diet (11.5 MJ/kg) (SHO-CON; OVX-CON) or a high-energy diet (17.6 MJ/kg) (SHO-FAT; OVX-FAT). The experiment lasted for 90 days and allowed for the establishment of osteopenia in OVX females and obesity in the rats that had received the high-energy diet. Results. The results of the study demonstrate that obesity or/and ovariectomy increases the resorption of femora and tibiae, hence decreasing the densitometric and mechanical parameters affecting the bone structure in adult females rats. The strongest osteodegenerative effect was seen in the OVX-FAT females. Interestingly, the degree of bone tissue degradation caused exclusively by ovariectomy was similar to that found in the obese sham-operated rats. Conclusions. Bone losses invoked by DIO seem to be independent from the Wnt/β-catenin pathway inhibition induced by sclerostin. While further study is necessary, the obtained results suggest that the usage of sclerostin anti-body in the treatment of osteoporosis can be ineffective, and in obese patients the undertaking of such therapy should be reassessed.
Clinical Interventions in Aging, 2018
Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholi... more Excess fat deposition and insulin resistance are considered the main risk factors for nonalcoholic fatty liver disease (NAFLD), and therefore, not surprisingly, the global prevalence of NAFLD increases in parallel with both obesity and type 2 diabetes. Although deterioration of bone homeostasis in patients with NAFLD is commonly observed, its etiology has not been fully elucidated yet. It was shown in several studies that bone tissue seems to be independently associated with NAFLD. A mechanistic perspective puts the liver at the center of mutual interdependencies obviously involving adipose tissue and muscles and also the bone matrix and bone cells, which are relatively novel. In this review, various pathophysiological mechanisms and possible mediating molecules that may interplay between NAFLD and bone tissue are described. Chronic inflammation, vitamin D3, growth hormone, insulin-like growth factor 1, osteopontin, fetuin-A, irisin, osteocalcin, and osteoprotegerin from osteoblasts have been proposed as mediators of mutual interactions among the skeleton, fatty tissue, and liver. Although to date there are still many issues that have not been elucidated, growing evidence suggests that screening and surveillance of bone mineral density in patients with NAFLD should be considered in future strategies and guidelines for NAFLD management.
European Journal of Clinical and Experimental Medicine, 2018
Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. ... more Introduction. Inflammatory bowel disease (IBD) is group of global range inflammatory conditions. There has been a regular increase in the number of IBD cases. Patients exclude whole food groups from their diet fearing the emergence of disease symptoms or due to learning from unreliable sources. Doing so, they might deepen the already existing vitamin deficiencies which occur along with the shortage of many minerals. These deficiencies might intensify the disease process or cause a new one. The most common deficits pointed out by numerous researchers concern vitamin D, calcium, cobalamin, folic acid and iron. It is well worth introducing selenium, zinc and ascorbic acid into a diet because of their immunomodulating effect. Important aspect of the healing process is a personalized diet which is designed to compensate for, or prevent vitamin and mineral deficiencies. Aim. The purpose of the study was to review the literature about vitamin and mineral deficiency in Inflammatory Bowel Diseases. Materials and method.
European Journal of Clinical and Experimental Medicine, 2018