Rafał Kleczyk - Academia.edu (original) (raw)
Papers by Rafał Kleczyk
Folia Cardiologica, Nov 22, 2016
Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawe... more Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawego przedsionka przechodzącą przez otwór owalny do lewego przedsionka i zatorowością płucną Deep vein thrombosis of the lower limb in a young man complicated by the right atrium thrombus passing through the foramen ovale into the left atrium and pulmonary embolism
Folia Cardiologica, 2016
Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawe... more Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawego przedsionka przechodzącą przez otwór owalny do lewego przedsionka i zatorowością płucną Deep vein thrombosis of the lower limb in a young man complicated by the right atrium thrombus passing through the foramen ovale into the left atrium and pulmonary embolism
Resuscitation, 2014
Background. Measurement of BNP (brain natriuretic peptide) and troponin I in the diagnostics of h... more Background. Measurement of BNP (brain natriuretic peptide) and troponin I in the diagnostics of heart−vessel dis− ease allows assessment of heart dysfunction (BNP) and necrosis of the heart muscle (troponin). The effectiveness of these markers in the diagnostics of myocardium function in cardiac surgery patients has not been clearly estab− lished. Heart surgery with extracorporeal circulation can lead to varied extents of damage and impairment of heart function which influence troponin and BNP concentrations. Objectives. The aim of this study was to describe the dynamics of concentration changes in BNP and troponin I in the perioperative period in patients undergoing cardiac surgery with extracorporeal circulation to correct a valve defect. Material and Methods. BNP and troponin I concentrations were measured in 17 patients (10 women and 7 men) aged 27-79 years who had aortic, mitral, or tricuspidal heart valve defects and therefore underwent cardiac surgery. The measurements were made before and 24 hours after surgery. The control group consisted of 18 people with− out heart−vessel diseases aged 54-75 years. Results. Statistically significant higher concentrations of BNP in the patient group than in the control group were observed before (636.63 ± 472.13 pg/ml vs. 45.79 ± 21.92 pg/ml) and after cardiac surgery (628.22 ± 482.9 vs. 45.79 ± 21.92 pg/ml). BNP concentration did not change significantly before and after surgery. Patients in NYHA class III/IV had higher BNP concentrations before surgery than those in NYHA II (837.35 ± 580.96 pg/ml vs. 410.81 ± 116.96 pg/ml). The preoperative concentration of troponin I did not vary significantly from that of the control group. The concentration of troponin I was much higher 24 hours after the operation than the control group value. A difference in troponin I concentration in NYHA class II and class III/IV patients was not observed. Conclusions. The increase in troponin I 24 hours after valve surgery is probably a result of damage to cardiomy− ocytes during the operation. Moreover, the chronic pathophysiology connected with the valve defect caused con− tinuation of myocardium function disturbance after cardiac surgery. The positive correlation between BNP con− centration 24 hours after surgery and aortic cross−clamping time indicates a relationship between ischemia and BNP release (Adv Clin Exp Med 2007, 16, 3, 383-388).
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](Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS),... more Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS), endogenously freed dopamine determines motor and cognitive activities of an organism. It influences neurohormonal regulation of the body, among all, other catecholamines' production; it also regulates kidney's functioning, the cardiovascular system and alimentary canal. Dopamine (a natural catecholamine) containing specimens are often used for the sake of intensive medical care. A particular effect, which is natriuretic, inotropic and vasopressive, is expected under inpatient treatment conditions depending on a selected dose. In practice, however, a potential influence of such treatment on neurohormonal processes, among all, an impact on hypothalamo-hypophyseal-adrenal axis is rarely taken into account. Considering numerous adverse events, a risk of renal failure development and blood redistribution disorders in the mucous membrane of the gastrointestinal tract, a negative impac...
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS),... more Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS), endogenously freed dopamine determines motor and cognitive activities of an organism. It influences neurohormonal regulation of the body, among all, other catecholamines' production; it also regulates kidney's functioning, the cardiovascular system and alimentary canal. Dopamine (a natural catecholamine) containing specimens are often used for the sake of intensive medical care. A particular effect, which is natriuretic, inotropic and vasopressive, is expected under inpatient treatment conditions depending on a selected dose. In practice, however, a potential influence of such treatment on neurohormonal processes, among all, an impact on hypothalamo-hypophyseal-adrenal axis is rarely taken into account. Considering numerous adverse events, a risk of renal failure development and blood redistribution disorders in the mucous membrane of the gastrointestinal tract, a negative impac...
Folia Cardiologica, Nov 22, 2016
Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawe... more Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawego przedsionka przechodzącą przez otwór owalny do lewego przedsionka i zatorowością płucną Deep vein thrombosis of the lower limb in a young man complicated by the right atrium thrombus passing through the foramen ovale into the left atrium and pulmonary embolism
Folia Cardiologica, 2016
Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawe... more Zakrzepowe zapalenie żył głębokich kończyny dolnej u młodego mężczyzny powikłane skrzepliną prawego przedsionka przechodzącą przez otwór owalny do lewego przedsionka i zatorowością płucną Deep vein thrombosis of the lower limb in a young man complicated by the right atrium thrombus passing through the foramen ovale into the left atrium and pulmonary embolism
Resuscitation, 2014
Background. Measurement of BNP (brain natriuretic peptide) and troponin I in the diagnostics of h... more Background. Measurement of BNP (brain natriuretic peptide) and troponin I in the diagnostics of heart−vessel dis− ease allows assessment of heart dysfunction (BNP) and necrosis of the heart muscle (troponin). The effectiveness of these markers in the diagnostics of myocardium function in cardiac surgery patients has not been clearly estab− lished. Heart surgery with extracorporeal circulation can lead to varied extents of damage and impairment of heart function which influence troponin and BNP concentrations. Objectives. The aim of this study was to describe the dynamics of concentration changes in BNP and troponin I in the perioperative period in patients undergoing cardiac surgery with extracorporeal circulation to correct a valve defect. Material and Methods. BNP and troponin I concentrations were measured in 17 patients (10 women and 7 men) aged 27-79 years who had aortic, mitral, or tricuspidal heart valve defects and therefore underwent cardiac surgery. The measurements were made before and 24 hours after surgery. The control group consisted of 18 people with− out heart−vessel diseases aged 54-75 years. Results. Statistically significant higher concentrations of BNP in the patient group than in the control group were observed before (636.63 ± 472.13 pg/ml vs. 45.79 ± 21.92 pg/ml) and after cardiac surgery (628.22 ± 482.9 vs. 45.79 ± 21.92 pg/ml). BNP concentration did not change significantly before and after surgery. Patients in NYHA class III/IV had higher BNP concentrations before surgery than those in NYHA II (837.35 ± 580.96 pg/ml vs. 410.81 ± 116.96 pg/ml). The preoperative concentration of troponin I did not vary significantly from that of the control group. The concentration of troponin I was much higher 24 hours after the operation than the control group value. A difference in troponin I concentration in NYHA class II and class III/IV patients was not observed. Conclusions. The increase in troponin I 24 hours after valve surgery is probably a result of damage to cardiomy− ocytes during the operation. Moreover, the chronic pathophysiology connected with the valve defect caused con− tinuation of myocardium function disturbance after cardiac surgery. The positive correlation between BNP con− centration 24 hours after surgery and aortic cross−clamping time indicates a relationship between ischemia and BNP release (Adv Clin Exp Med 2007, 16, 3, 383-388).
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS),... more Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS), endogenously freed dopamine determines motor and cognitive activities of an organism. It influences neurohormonal regulation of the body, among all, other catecholamines' production; it also regulates kidney's functioning, the cardiovascular system and alimentary canal. Dopamine (a natural catecholamine) containing specimens are often used for the sake of intensive medical care. A particular effect, which is natriuretic, inotropic and vasopressive, is expected under inpatient treatment conditions depending on a selected dose. In practice, however, a potential influence of such treatment on neurohormonal processes, among all, an impact on hypothalamo-hypophyseal-adrenal axis is rarely taken into account. Considering numerous adverse events, a risk of renal failure development and blood redistribution disorders in the mucous membrane of the gastrointestinal tract, a negative impac...
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2010
Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS),... more Due to a big amount of dopaminergic receptors set in the vertebrate central nervous system (CNS), endogenously freed dopamine determines motor and cognitive activities of an organism. It influences neurohormonal regulation of the body, among all, other catecholamines' production; it also regulates kidney's functioning, the cardiovascular system and alimentary canal. Dopamine (a natural catecholamine) containing specimens are often used for the sake of intensive medical care. A particular effect, which is natriuretic, inotropic and vasopressive, is expected under inpatient treatment conditions depending on a selected dose. In practice, however, a potential influence of such treatment on neurohormonal processes, among all, an impact on hypothalamo-hypophyseal-adrenal axis is rarely taken into account. Considering numerous adverse events, a risk of renal failure development and blood redistribution disorders in the mucous membrane of the gastrointestinal tract, a negative impac...