Rafael Fraiha - Academia.edu (original) (raw)
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Papers by Rafael Fraiha
Revista da Sociedade Brasileira de Medicina Tropical
Introduction: Studies have demonstrated that pathogens react to the harsh conditions in human tis... more Introduction: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. Methods: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. Results: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. Conclusions: These findings highlight the role of host stress in the virulence of S. epidermidis.
Revista da Sociedade Brasileira de Medicina Tropical
Introduction: Studies have demonstrated that pathogens react to the harsh conditions in human tis... more Introduction: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. Methods: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. Results: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. Conclusions: These findings highlight the role of host stress in the virulence of S. epidermidis.