Rafael Gonzalez - Academia.edu (original) (raw)

Papers by Rafael Gonzalez

SSRN Electronic Journal, 2000

Physica Status Solidi B-basic Solid State Physics, 2009

We have applied the full potential linearized augmented plane wave method (FP-LAPW) within the de... more We have applied the full potential linearized augmented plane wave method (FP-LAPW) within the density functional theory to investigate the structural and electronic properties of the Sc0.5In0.5N compound in the wurtzite and sodium chloride structures. We have analyzed the relative stability of this ternary compound in the two studied phases. We found that the wurtzite structure is the most stable phase, with the minimum ∼0.14 eV/(unit cell) lower than in the sodium chloride phase. A phase transition from wurtzite to sodium chloride structure was observed, with transition pressure ∼1.9 GPa. Our results predict a direct semiconductor in wurtzite structure and an indirect semiconductor in sodium chloride phase. We investigate the pressure effect on the electronic properties of this ternary compound in the two phases studied. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Industrial & Engineering Chemistry Research, 2014

2010 IEEE International Conference on Web Services, 2010

Automated web service composition has been tackled from different directions and to different pur... more Automated web service composition has been tackled from different directions and to different purposes. In addition, most of the approaches address the composition problem with underspecified requirements, returning compositions models that do not necessarily satisfy and fulfill end-users objectives. Satisfying the latter objectives is a difficult problem, especially from scratch, which requires stronger requirements and a further step of integration with service-based components in order to make service oriented computing and service composition a reality. In this work, we address this issue by presenting an innovative and integrated approach to service composition which consists of i) an automatic template process generator, that is able to generate abstract process templates and their hierarchy from past executions; ii) a novel and scalable approach to AI parametric-design techniques using a multi agent approach to configure and adapt services processes, heavily relying on the latter set of abstract process templates; iii) an optimization process that maximizes the overall quality of final compositions. Finally, we compare the scalability of these components with some experiments.

Applied spectroscopy, 2011

Soil has been utilized in criminal investigations for some time because of its prevalence and 15 ... more Soil has been utilized in criminal investigations for some time because of its prevalence and 15 transferability. It is usually the physical characteristics that are studied, however the research 16 carried out here aims to make use of the chemical profile of soil samples. The research we are 17 presenting in this work used sieved (2mm) soil samples taken from the top soil layer (about 18 10cm) that were then analysed using mid infrared spectroscopy. The spectra obtained were pre-19 treated and then input into two chemometric classification tools: Nonlinear iterative partial least 20 squares followed by linear discriminant analysis (NIPALS-LDA) and partial least squares 21 discriminant analysis (PLS-DA). The models produced show that it is possible to discriminate 22 between soil samples from different land use types and both approaches are comparable in 23 performance. NIPALS-LDA performs much better than PLS-DA in classifying samples to location 24 . 25 26

Journal of attention disorders, Jan 4, 2012

Revista española de anestesiología y reanimación, 2014

ICUs are areas where resistance problems are the largest, and they constitutes a major problem fo... more ICUs are areas where resistance problems are the largest, and they constitutes a major problem for the intensivist's clinical practice. Main resistance phenotypes among nosocomial microbiota are: i) vancomycin-resistance/heteroresistance and tolerance in grampositives (MRSA, enterococci) and ii) efflux pumps/enzymatic resistance mechanisms (ESBLs, AmpC, metallobetalactamases) in gramnegatives. These phenotypes are found at different rates in pathogens causing respiratory (nosocomial pneumonia/ventilator-associated pneumonia), bloodstream (primary bacteremia/catheter-associated bacteremia), urinary, intraabdominal and surgical wound infections and endocarditis in the ICU. New antibiotics are available to overcome non-susceptibility in grampositives; however, accumulation of resistance traits in gramnegatives has lead to multidrug resistance, a worrisome problem nowadays. This article reviews by microorganism/infection risk factors for multidrug resistance, suggesting adequate empirical treatments. Drugs, patient and environmental factors all play a role in the decision to prescribe/recommend antibiotic regimens in the specific ICU patient, implying that intensivists should be familiar with available drugs, environmental epidemiology and patient factors.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014

To analyze if treatment with adrenaline (epinephrine) plus terlipressin plus corticoids achieves ... more To analyze if treatment with adrenaline (epinephrine) plus terlipressin plus corticoids achieves higher return of spontaneous circulation than adrenaline in an experimental infant animal model of asphyxial cardiac arrest. Prospective randomized animal study. Experimental department in a University Hospital. Forty-nine piglets were studied. Cardiac arrest was induced by at least 10 minutes of removal of mechanical ventilation and was followed by manual external chest compressions and mechanical ventilation. After 3 minutes of resuscitation, piglets that did not achieve return of spontaneous circulation were randomized to two groups: adrenaline 0.02 mg kg every 3 minutes (20 animals) and adrenaline 0.02 mg kg every 3 minutes plus terlipressin 20 μg kg every 6 minutes plus hydrocortisone 30 mg kg one dose (22 animals). Resuscitation was discontinued when return of spontaneous circulation was achieved or after 24 minutes. Return of spontaneous circulation was achieved in 14 piglets (28.5%), 14.2% with only cardiac massage and ventilation. Return of spontaneous circulation was achieved in 25% of piglets treated with adrenaline and in 9.1% of those treated with adrenaline plus terlipressin plus hydrocortisone (p = 0.167). Return of spontaneous circulation was achieved in 45.4% of animals with pulseless electric activity, 20% with asystole, and 0% with ventricular fibrillation (p = 0.037). Shorter duration of cardiac arrest, higher mean blood pressure and EtCO2 and lower PaCO2 before resuscitation, and higher mean blood pressure during resuscitation were associated with higher return of spontaneous circulation. Treatment with adrenaline plus terlipressin plus corticoids does not achieve higher return of spontaneous circulation than that with adrenaline in an infant animal model of asphyxial cardiac arrest.

International journal of imaging systems and technology, 2014

The use of focused ultrasonic waves to modulate neural structures has gained recent interest due ... more The use of focused ultrasonic waves to modulate neural structures has gained recent interest due to its potential in treating neurological disorders non-invasively. While several papers have focused on the use of ultrasound neuromodulation on peripheral nerves, none of these studies have been performed on the vagus nerve. We present preliminary observations on the effects of focused pulsed ultrasound (FPUS) on the conduction of the left cervical vagus nerve of a Long Evans rat. Ultrasound energy was applied at a frequency of 1.1 MHz, and at spatial-peak, temporal average intensities that ranged from 13.6 to 93.4 W/cm(2). Vagus nerve inhibition was observed in most cases. Results of this preliminary study suggested that there is a proportional relationship between acoustic intensity and the level of nerve inhibition.

Revista chilena de neuro-psiquiatría, 2012

SSRN Electronic Journal, 2000

ABSTRACT

2010 20th International Conference on Electronics Communications and Computers (CONIELECOMP), 2010

ABSTRACT

2010 20th International Conference on Electronics Communications and Computers (CONIELECOMP), 2010

... Alberto García-Caraveo, Ángel Soto, Rafael González, Pedro Bañuelos-Sánchez Departament of Co... more ... Alberto García-Caraveo, Ángel Soto, Rafael González, Pedro Bañuelos-Sánchez Departament of Computers, Electronics and Mechatronics. ... resulting on higher efficiency, higher switching frequency, smaller size, lower weight and lower electromagnetic interference (EMI). ...

Viral Immunology, 2009

It has been recently reported that CD8(+) T cells from healthy human peripheral blood express the... more It has been recently reported that CD8(+) T cells from healthy human peripheral blood express the tolerogenic HLA-G molecule originally described in trophoblasts. The majority of these CD8(+)HLA-G(+) cells exhibit a naïve phenotype and are FoxP3 negative, and they have been classified as a novel subset of regulatory T cells based on their potent suppressive function. We have investigated if this new cell population is expanded during HIV-1 infection. The results presented here show an increase in the percentage of CD8(+)HLA-G(+) cells within the total CD8 T-cell population in HIV-1(+) patients. As in healthy controls, these CD8(+)HLA-G(+) are mostly naïve T cells. However, we have also observed that only in HIV-1-infected patients are there effector and effector memory cells that express HLA-G.

Journal of Organometallic Chemistry, 1981

(diphenylphosphino)ethane or c&1,2-bis(diphenylphosphino)ethylene)_ Carbon monoxide displaces the... more (diphenylphosphino)ethane or c&1,2-bis(diphenylphosphino)ethylene)_ Carbon monoxide displaces the COD group from the complexes giving either CMOq)(COM or CWOq)WO)LI, and the latter undergo osidative addition reactions with SnCl,, Me,SiCl, Me,SnCl, MeI, allylbromide, PhCOCl, MeCOCl, Cl,, Brz, TlCl, and HCl leading to novel iridium(II1) complexes.

Journal of Clinical Immunology, 2002

Human immunodeficiency virus-1 (HIV-1) infected patients show a gradual loss of natural killer (N... more Human immunodeficiency virus-1 (HIV-1) infected patients show a gradual loss of natural killer (NK) cells that correlates with disease progression. However, the effect of HIV-1 infection on different NK cell subsets has not been fully characterized. In healthy individuals most NK cells are CD3−CD56+ and two different subpopulations, CD56dim and CD56bright, can be distinguished by the mean fluorescence intensity. Although it was originally suggested that CD56bright NK cells represent the precursors of the CD56dim subpopulation, recent cumulative data indicate that CD56bright and CD56dim NK cells are phenotypically, functionally, and developmentally different NK cell subsets. In this study, the analysis of CD56bright and CD56dim NK subsets showed that neither the number nor the phenotype of CD56bright NK cells were significantly altered in treatment-naive HIV-1-infected individuals, whereas the number of CD56dim NK cells was decreased. We also have studied NK cell subsets defined by the expression of CD56 in combination with CD16, CD161, or CD94 molecules. Our results demonstrated a preferential decrease of CD3−CD56+ NK cells coexpressing CD16 and CD161 but lacking CD94 molecules. On the contrary an increased percentage of NK cells that do not express CD56 molecules but express CD16, CD161, or CD94 was also found in HIV-1-infected individuals. As it has been proposed that these CD56-negative NK cells expressing other NK cell receptors represent immature NK cells with low cytolytic capacity, our results support that a defective differentiation from immature CD56 negative NK cells to mature CD56dim NK cells occurs in HIV-1 infection.

SSRN Electronic Journal, 2000

Physica Status Solidi B-basic Solid State Physics, 2009

We have applied the full potential linearized augmented plane wave method (FP-LAPW) within the de... more We have applied the full potential linearized augmented plane wave method (FP-LAPW) within the density functional theory to investigate the structural and electronic properties of the Sc0.5In0.5N compound in the wurtzite and sodium chloride structures. We have analyzed the relative stability of this ternary compound in the two studied phases. We found that the wurtzite structure is the most stable phase, with the minimum ∼0.14 eV/(unit cell) lower than in the sodium chloride phase. A phase transition from wurtzite to sodium chloride structure was observed, with transition pressure ∼1.9 GPa. Our results predict a direct semiconductor in wurtzite structure and an indirect semiconductor in sodium chloride phase. We investigate the pressure effect on the electronic properties of this ternary compound in the two phases studied. (© 2009 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)

Industrial & Engineering Chemistry Research, 2014

2010 IEEE International Conference on Web Services, 2010

Automated web service composition has been tackled from different directions and to different pur... more Automated web service composition has been tackled from different directions and to different purposes. In addition, most of the approaches address the composition problem with underspecified requirements, returning compositions models that do not necessarily satisfy and fulfill end-users objectives. Satisfying the latter objectives is a difficult problem, especially from scratch, which requires stronger requirements and a further step of integration with service-based components in order to make service oriented computing and service composition a reality. In this work, we address this issue by presenting an innovative and integrated approach to service composition which consists of i) an automatic template process generator, that is able to generate abstract process templates and their hierarchy from past executions; ii) a novel and scalable approach to AI parametric-design techniques using a multi agent approach to configure and adapt services processes, heavily relying on the latter set of abstract process templates; iii) an optimization process that maximizes the overall quality of final compositions. Finally, we compare the scalability of these components with some experiments.

Applied spectroscopy, 2011

Soil has been utilized in criminal investigations for some time because of its prevalence and 15 ... more Soil has been utilized in criminal investigations for some time because of its prevalence and 15 transferability. It is usually the physical characteristics that are studied, however the research 16 carried out here aims to make use of the chemical profile of soil samples. The research we are 17 presenting in this work used sieved (2mm) soil samples taken from the top soil layer (about 18 10cm) that were then analysed using mid infrared spectroscopy. The spectra obtained were pre-19 treated and then input into two chemometric classification tools: Nonlinear iterative partial least 20 squares followed by linear discriminant analysis (NIPALS-LDA) and partial least squares 21 discriminant analysis (PLS-DA). The models produced show that it is possible to discriminate 22 between soil samples from different land use types and both approaches are comparable in 23 performance. NIPALS-LDA performs much better than PLS-DA in classifying samples to location 24 . 25 26

Journal of attention disorders, Jan 4, 2012

Revista española de anestesiología y reanimación, 2014

ICUs are areas where resistance problems are the largest, and they constitutes a major problem fo... more ICUs are areas where resistance problems are the largest, and they constitutes a major problem for the intensivist's clinical practice. Main resistance phenotypes among nosocomial microbiota are: i) vancomycin-resistance/heteroresistance and tolerance in grampositives (MRSA, enterococci) and ii) efflux pumps/enzymatic resistance mechanisms (ESBLs, AmpC, metallobetalactamases) in gramnegatives. These phenotypes are found at different rates in pathogens causing respiratory (nosocomial pneumonia/ventilator-associated pneumonia), bloodstream (primary bacteremia/catheter-associated bacteremia), urinary, intraabdominal and surgical wound infections and endocarditis in the ICU. New antibiotics are available to overcome non-susceptibility in grampositives; however, accumulation of resistance traits in gramnegatives has lead to multidrug resistance, a worrisome problem nowadays. This article reviews by microorganism/infection risk factors for multidrug resistance, suggesting adequate empirical treatments. Drugs, patient and environmental factors all play a role in the decision to prescribe/recommend antibiotic regimens in the specific ICU patient, implying that intensivists should be familiar with available drugs, environmental epidemiology and patient factors.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2014

To analyze if treatment with adrenaline (epinephrine) plus terlipressin plus corticoids achieves ... more To analyze if treatment with adrenaline (epinephrine) plus terlipressin plus corticoids achieves higher return of spontaneous circulation than adrenaline in an experimental infant animal model of asphyxial cardiac arrest. Prospective randomized animal study. Experimental department in a University Hospital. Forty-nine piglets were studied. Cardiac arrest was induced by at least 10 minutes of removal of mechanical ventilation and was followed by manual external chest compressions and mechanical ventilation. After 3 minutes of resuscitation, piglets that did not achieve return of spontaneous circulation were randomized to two groups: adrenaline 0.02 mg kg every 3 minutes (20 animals) and adrenaline 0.02 mg kg every 3 minutes plus terlipressin 20 μg kg every 6 minutes plus hydrocortisone 30 mg kg one dose (22 animals). Resuscitation was discontinued when return of spontaneous circulation was achieved or after 24 minutes. Return of spontaneous circulation was achieved in 14 piglets (28.5%), 14.2% with only cardiac massage and ventilation. Return of spontaneous circulation was achieved in 25% of piglets treated with adrenaline and in 9.1% of those treated with adrenaline plus terlipressin plus hydrocortisone (p = 0.167). Return of spontaneous circulation was achieved in 45.4% of animals with pulseless electric activity, 20% with asystole, and 0% with ventricular fibrillation (p = 0.037). Shorter duration of cardiac arrest, higher mean blood pressure and EtCO2 and lower PaCO2 before resuscitation, and higher mean blood pressure during resuscitation were associated with higher return of spontaneous circulation. Treatment with adrenaline plus terlipressin plus corticoids does not achieve higher return of spontaneous circulation than that with adrenaline in an infant animal model of asphyxial cardiac arrest.

International journal of imaging systems and technology, 2014

The use of focused ultrasonic waves to modulate neural structures has gained recent interest due ... more The use of focused ultrasonic waves to modulate neural structures has gained recent interest due to its potential in treating neurological disorders non-invasively. While several papers have focused on the use of ultrasound neuromodulation on peripheral nerves, none of these studies have been performed on the vagus nerve. We present preliminary observations on the effects of focused pulsed ultrasound (FPUS) on the conduction of the left cervical vagus nerve of a Long Evans rat. Ultrasound energy was applied at a frequency of 1.1 MHz, and at spatial-peak, temporal average intensities that ranged from 13.6 to 93.4 W/cm(2). Vagus nerve inhibition was observed in most cases. Results of this preliminary study suggested that there is a proportional relationship between acoustic intensity and the level of nerve inhibition.

Revista chilena de neuro-psiquiatría, 2012

SSRN Electronic Journal, 2000

ABSTRACT

2010 20th International Conference on Electronics Communications and Computers (CONIELECOMP), 2010

ABSTRACT

2010 20th International Conference on Electronics Communications and Computers (CONIELECOMP), 2010

... Alberto García-Caraveo, Ángel Soto, Rafael González, Pedro Bañuelos-Sánchez Departament of Co... more ... Alberto García-Caraveo, Ángel Soto, Rafael González, Pedro Bañuelos-Sánchez Departament of Computers, Electronics and Mechatronics. ... resulting on higher efficiency, higher switching frequency, smaller size, lower weight and lower electromagnetic interference (EMI). ...

Viral Immunology, 2009

It has been recently reported that CD8(+) T cells from healthy human peripheral blood express the... more It has been recently reported that CD8(+) T cells from healthy human peripheral blood express the tolerogenic HLA-G molecule originally described in trophoblasts. The majority of these CD8(+)HLA-G(+) cells exhibit a naïve phenotype and are FoxP3 negative, and they have been classified as a novel subset of regulatory T cells based on their potent suppressive function. We have investigated if this new cell population is expanded during HIV-1 infection. The results presented here show an increase in the percentage of CD8(+)HLA-G(+) cells within the total CD8 T-cell population in HIV-1(+) patients. As in healthy controls, these CD8(+)HLA-G(+) are mostly naïve T cells. However, we have also observed that only in HIV-1-infected patients are there effector and effector memory cells that express HLA-G.

Journal of Organometallic Chemistry, 1981

(diphenylphosphino)ethane or c&1,2-bis(diphenylphosphino)ethylene)_ Carbon monoxide displaces the... more (diphenylphosphino)ethane or c&1,2-bis(diphenylphosphino)ethylene)_ Carbon monoxide displaces the COD group from the complexes giving either CMOq)(COM or CWOq)WO)LI, and the latter undergo osidative addition reactions with SnCl,, Me,SiCl, Me,SnCl, MeI, allylbromide, PhCOCl, MeCOCl, Cl,, Brz, TlCl, and HCl leading to novel iridium(II1) complexes.

Journal of Clinical Immunology, 2002

Human immunodeficiency virus-1 (HIV-1) infected patients show a gradual loss of natural killer (N... more Human immunodeficiency virus-1 (HIV-1) infected patients show a gradual loss of natural killer (NK) cells that correlates with disease progression. However, the effect of HIV-1 infection on different NK cell subsets has not been fully characterized. In healthy individuals most NK cells are CD3−CD56+ and two different subpopulations, CD56dim and CD56bright, can be distinguished by the mean fluorescence intensity. Although it was originally suggested that CD56bright NK cells represent the precursors of the CD56dim subpopulation, recent cumulative data indicate that CD56bright and CD56dim NK cells are phenotypically, functionally, and developmentally different NK cell subsets. In this study, the analysis of CD56bright and CD56dim NK subsets showed that neither the number nor the phenotype of CD56bright NK cells were significantly altered in treatment-naive HIV-1-infected individuals, whereas the number of CD56dim NK cells was decreased. We also have studied NK cell subsets defined by the expression of CD56 in combination with CD16, CD161, or CD94 molecules. Our results demonstrated a preferential decrease of CD3−CD56+ NK cells coexpressing CD16 and CD161 but lacking CD94 molecules. On the contrary an increased percentage of NK cells that do not express CD56 molecules but express CD16, CD161, or CD94 was also found in HIV-1-infected individuals. As it has been proposed that these CD56-negative NK cells expressing other NK cell receptors represent immature NK cells with low cytolytic capacity, our results support that a defective differentiation from immature CD56 negative NK cells to mature CD56dim NK cells occurs in HIV-1 infection.